LOCUS       NM_020531               2202 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens adipocyte plasma membrane associated protein (APMAP),
            mRNA.
ACCESSION   NM_020531
VERSION     NM_020531.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2202)
  AUTHORS   Kamber,R.A., Nishiga,Y., Morton,B., Banuelos,A.M., Barkal,A.A.,
            Vences-Catalan,F., Gu,M., Fernandez,D., Seoane,J.A., Yao,D.,
            Liu,K., Lin,S., Spees,K., Curtis,C., Jerby-Arnon,L., Weissman,I.L.,
            Sage,J. and Bassik,M.C.
  TITLE     Inter-cellular CRISPR screens reveal regulators of cancer cell
            phagocytosis
  JOURNAL   Nature 597 (7877), 549-554 (2021)
   PUBMED   34497417
  REMARK    GeneRIF: Inter-cellular CRISPR screens reveal regulators of cancer
            cell phagocytosis.
REFERENCE   2  (bases 1 to 2202)
  AUTHORS   Haley,S.A., O'Hara,B.A. and Atwood,W.J.
  TITLE     Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV)
            infection in human glial cells
  JOURNAL   Virology 548, 17-24 (2020)
   PUBMED   32838939
  REMARK    GeneRIF: Adipocyte Plasma Membrane Protein (APMAP) promotes JC
            Virus (JCPyV) infection in human glial cells.
REFERENCE   3  (bases 1 to 2202)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2202)
  AUTHORS   Ye,X., Gui,X., Freed,D.C., Ku,Z., Li,L., Chen,Y., Xiong,W., Fan,X.,
            Su,H., He,X., Rustandi,R.R., Loughney,J.W., Ma,N., Espeseth,A.S.,
            Liu,J., Zhu,H., Wang,D., Zhang,N., Fu,T.M. and An,Z.
  TITLE     Identification of adipocyte plasma membrane-associated protein as a
            novel modulator of human cytomegalovirus infection
  JOURNAL   PLoS Pathog 15 (7), e1007914 (2019)
   PUBMED   31356650
  REMARK    GeneRIF: results suggest that APMAP functions as a modulator
            promoting human cytomegalovirus (HCMV) infection in multiple cell
            types and is an important player in the complex HCMV infection
            mechanism
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2202)
  AUTHORS   Pessentheiner,A.R., Huber,K., Pelzmann,H.J., Prokesch,A.,
            Radner,F.P.W., Wolinski,H., Lindroos-Christensen,J., Hoefler,G.,
            Rulicke,T., Birner-Gruenberger,R., Bilban,M. and
            Bogner-Strauss,J.G.
  TITLE     APMAP interacts with lysyl oxidase-like proteins, and disruption of
            Apmap leads to beneficial visceral adipose tissue expansion
  JOURNAL   FASEB J 31 (9), 4088-4103 (2017)
   PUBMED   28559441
  REMARK    GeneRIF: These data suggest that APMAP is a novel regulator of
            extracellular matrix components, and establish that APMAP is a
            potential target to mitigate obesity-associated insulin resistance.
REFERENCE   6  (bases 1 to 2202)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 2202)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
REFERENCE   8  (bases 1 to 2202)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 2202)
  AUTHORS   Albrektsen,T., Richter,H.E., Clausen,J.T. and Fleckner,J.
  TITLE     Identification of a novel integral plasma membrane protein induced
            during adipocyte differentiation
  JOURNAL   Biochem J 359 (Pt 2), 393-402 (2001)
   PUBMED   11583587
REFERENCE   10 (bases 1 to 2202)
  AUTHORS   Morita,M., Hara,Y., Tamai,Y., Arakawa,H. and Nishimura,S.
  TITLE     Genomic construct and mapping of the gene for CMAP
            (leukocystatin/cystatin F, CST7) and identification of a proximal
            novel gene, BSCv (C20orf3)
  JOURNAL   Genomics 67 (1), 87-91 (2000)
   PUBMED   10945474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG773501.1, CF131759.1, AK026866.1 and AL035661.16.
            
            On Nov 22, 2018 this sequence version replaced NM_020531.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1101923.1,
                                           SRR3476690.1092271.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217456.3/ ENSP00000217456.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BG773501.1         236-239
            5-601               CF131759.1         12-608
            602-2183            AK026866.1         138-1719
            2184-2202           AL035661.16        38831-38849         c
FEATURES             Location/Qualifiers
     source          1..2202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..2202
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /note="adipocyte plasma membrane associated protein"
                     /db_xref="GeneID:57136"
                     /db_xref="HGNC:HGNC:13238"
                     /db_xref="MIM:615884"
     exon            1..158
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1314
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /note="protein BSCv"
                     /codon_start=1
                     /product="adipocyte plasma membrane-associated protein"
                     /protein_id="NP_065392.1"
                     /db_xref="CCDS:CCDS13166.1"
                     /db_xref="GeneID:57136"
                     /db_xref="HGNC:HGNC:13238"
                     /db_xref="MIM:615884"
                     /translation="MSEADGLRQRRPLRPQVVTDDDGQAPEAKDGSSFSGRVFRVTFL
                     MLAVSLTVPLLGAMMLLESPIDPQPLSFKEPPLLLGVLHPNTKLRQAERLFENQLVGP
                     ESIAHIGDVMFTGTADGRVVKLENGEIETIARFGSGPCKTRDDEPVCGRPLGIRAGPN
                     GTLFVADAYKGLFEVNPWKREVKLLLSSETPIEGKNMSFVNDLTVTQDGRKIYFTDSS
                     SKWQRRDYLLLVMEGTDDGRLLEYDTVTREVKVLLDQLRFPNGVQLSPAEDFVLVAET
                     TMARIRRVYVSGLMKGGADLFVENMPGFPDNIRPSSSGGYWVGMSTIRPNPGFSMLDF
                     LSERPWIKRMIFKLFSQETVMKFVPRYSLVLELSDSGAFRRSLHDPDGLVATYISEVH
                     EHDGHLYLGSFRSPFLCRLSLQAV"
     exon            159..275
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            276..391
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            392..484
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..601
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            602..776
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            777..911
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1104
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..2202
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /note="hexamer: AATAAA"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /note="hexamer: GATAAA"
     polyA_site      2183
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
                     /note="major polyA site"
     polyA_site      2202
                     /gene="APMAP"
                     /gene_synonym="BSCv; C20orf3"
ORIGIN      
        1 ggagtctgag ccggcgccgc tcagtgtgag gtggtttctg cgggtgaggc tggcgcccgt
       61 accatgagcg aggcggacgg gctgcgacag cgccggcccc tgcggccgca ggtcgtcaca
      121 gacgatgatg gccaggcccc ggaggctaag gacggcagct cctttagcgg cagagttttc
      181 cgagtgacct tcttgatgct ggctgtttct ctcaccgttc ccctgcttgg agccatgatg
      241 ctgctggaat ctcctataga tccacagcct ctcagcttca aagaaccccc gctcttgctt
      301 ggtgttctgc atccaaatac gaagctgcga caggcagaaa ggctgtttga aaatcaactt
      361 gttggaccgg agtccatagc acatattggg gatgtgatgt ttactgggac agcagatggc
      421 cgggtcgtaa aacttgaaaa tggtgaaata gagaccattg cccggtttgg ttcgggccct
      481 tgcaaaaccc gagatgatga gcctgtgtgt gggagacccc tgggtatccg tgcagggccc
      541 aatgggactc tctttgtggc cgatgcatac aagggactat ttgaagtaaa tccctggaaa
      601 cgtgaagtga aactgctgct gtcctccgag acacccattg aggggaagaa catgtccttt
      661 gtgaatgatc ttacagtcac tcaggatggg aggaagattt atttcaccga ttctagcagc
      721 aaatggcaaa gacgagacta cctgcttctg gtgatggagg gcacagatga cgggcgcctg
      781 ctggagtatg atactgtgac cagggaagta aaagttttat tggaccagct gcggttcccg
      841 aatggagtcc agctgtctcc tgcagaagac tttgtcctgg tggcagaaac aaccatggcc
      901 aggatacgaa gagtctacgt ttctggcctg atgaagggcg gggctgatct gtttgtggag
      961 aacatgcctg gatttccaga caacatccgg cccagcagct ctggggggta ctgggtgggc
     1021 atgtcgacca tccgccctaa ccctgggttt tccatgctgg atttcttatc tgagagaccc
     1081 tggattaaaa ggatgatttt taagctcttt agtcaagaga cggtgatgaa gtttgtgccg
     1141 cggtacagcc tcgtcctaga actcagcgac agcggtgcct tccggagaag cctgcatgat
     1201 cccgatgggc tggtggccac ctacatcagc gaggtgcacg aacacgatgg gcacctgtac
     1261 ctgggctctt tcaggtcccc cttcctctgc agactcagcc tccaggctgt ttagccctcc
     1321 cagatagctg cccctgccac gcaggccagg agtcttcaca ctcaggcacc aggcctggtc
     1381 caggaggagc tgtggacaca gtcgtggttc aagtgtccac atgcacctgt tagtccctga
     1441 gaggtggtgg gaatggctgc ttcattcctc gaggatgccc gggccccacc tgggcttgtc
     1501 tttctgttta gagggaagtg taacatatct gccatgagga acataaattc atgtaaagcc
     1561 attttctctt aaacaaaaca aaactttcta agtacagtca ttctctagga tttgggaagc
     1621 tccttgcact tggaacaggg ctcaggtggg tggagcagta aggcactacc cagagagctt
     1681 gctgctgcgg ccctgtcctg cggcctcaaa gttcttcttt actatatata acgtgcggtc
     1741 atacctttct tcgttgtggt ggggatggaa gagcagaggg agcatggccc aggggtgttg
     1801 aggccagcgg tgagagccgt gttagccaag acatggaact gtgttctcaa gggttatgtg
     1861 gggcgtgggc tctccatagt gtgtatgaaa agcttgttga ctctagcggc tcagagagga
     1921 ctttgctggg tttctttctg tgaatatctc cgtgctgacc atgctggaat tggatgattc
     1981 tgcaattcgg gacctactgc aggggtccgt ttagtaacgt cttgtctgtg atctttgttc
     2041 ttgacctcta gaccccaaga tgtgaacagt gcacgtgtta atgtcatctt tgctcatgtg
     2101 ttataagccc caagttgctg tatattttca caagtatgtc tacacactgg tcatgatttt
     2161 gataataaat aacgataaat cgacttctgc tgattaacct tt
//
