LOCUS       NM_001142276            3697 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens amyloid beta precursor like protein 2 (APLP2),
            transcript variant 2, mRNA.
ACCESSION   NM_001142276
VERSION     NM_001142276.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Tao,Z., Huang,J. and Li,J.
  TITLE     Comprehensive intratumoral heterogeneity landscaping of liver
            hepatocellular carcinoma and discerning of APLP2 in cancer
            progression
  JOURNAL   Environ Toxicol 39 (2), 612-625 (2024)
   PUBMED   37515494
  REMARK    GeneRIF: Comprehensive intratumoral heterogeneity landscaping of
            liver hepatocellular carcinoma and discerning of APLP2 in cancer
            progression.
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Huang,X., Yang,J., Xi,H., Zhang,M., Oh,Y., Jin,Z. and Zheng,Z.
  TITLE     Implication of Amyloid Precursor-like Protein 2 Expression in
            Cutaneous Squamous Cell Carcinoma Pathogenesis
  JOURNAL   In Vivo 38 (1), 399-408 (2024)
   PUBMED   38148084
  REMARK    GeneRIF: Implication of Amyloid Precursor-like Protein 2 Expression
            in Cutaneous Squamous Cell Carcinoma Pathogenesis.
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Chen,J., Tang,F., Li,H., Wu,X., Yang,Y., Liu,Z., Huang,X., Wang,J.,
            Zheng,R., Wang,L., Liu,H., Xu,J., Wang,P. and Liu,F.
  TITLE     Mycobacterium tuberculosis suppresses APLP2 expression to enhance
            its survival in macrophage
  JOURNAL   Int Immunopharmacol 124 (Pt B), 111058 (2023)
   PUBMED   37844466
  REMARK    GeneRIF: Mycobacterium tuberculosis suppresses APLP2 expression to
            enhance its survival in macrophage.
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3697)
  AUTHORS   Yanagida,K., Maruyama,R., Tagami,S., Kudo,T., Okochi,M. and
            Fukumori,A.
  TITLE     APLP2 is predominantly cleaved by beta-secretase and
            gamma-secretase in the human brain
  JOURNAL   Psychogeriatrics 23 (2), 311-318 (2023)
   PUBMED   36691315
  REMARK    GeneRIF: APLP2 is predominantly cleaved by beta-secretase and
            gamma-secretase in the human brain.
REFERENCE   6  (bases 1 to 3697)
  AUTHORS   Blangy,A., Vidal,F., Cuzin,F., Yang,Y.H., Boulukos,K. and
            Rassoulzadegan,M.
  TITLE     CDEBP, a site-specific DNA-binding protein of the 'APP-like'
            family, is required during the early development of the mouse
  JOURNAL   J Cell Sci 108 (Pt 2), 675-683 (1995)
   PUBMED   7539437
REFERENCE   7  (bases 1 to 3697)
  AUTHORS   von der Kammer,H., Hanes,J., Klaudiny,J. and Scheit,K.H.
  TITLE     A human amyloid precursor-like protein is highly homologous to a
            mouse sequence-specific DNA-binding protein
  JOURNAL   DNA Cell Biol 13 (11), 1137-1143 (1994)
   PUBMED   7702756
REFERENCE   8  (bases 1 to 3697)
  AUTHORS   Bush,A.I., Pettingell,W.H. Jr., de Paradis,M., Tanzi,R.E. and
            Wasco,W.
  TITLE     The amyloid beta-protein precursor and its mammalian homologues.
            Evidence for a zinc-modulated heparin-binding superfamily
  JOURNAL   J Biol Chem 269 (43), 26618-26621 (1994)
   PUBMED   7929392
REFERENCE   9  (bases 1 to 3697)
  AUTHORS   von der Kammer,H., Loffler,C., Hanes,J., Klaudiny,J., Scheit,K.H.
            and Hansmann,I.
  TITLE     The gene for the amyloid precursor-like protein APLP2 is assigned
            to human chromosome 11q23-q25
  JOURNAL   Genomics 20 (2), 308-311 (1994)
   PUBMED   8020984
REFERENCE   10 (bases 1 to 3697)
  AUTHORS   Wasco,W., Gurubhagavatula,S., Paradis,M.D., Romano,D.M.,
            Sisodia,S.S., Hyman,B.T., Neve,R.L. and Tanzi,R.E.
  TITLE     Isolation and characterization of APLP2 encoding a homologue of the
            Alzheimer's associated amyloid beta protein precursor
  JOURNAL   Nat Genet 5 (1), 95-100 (1993)
   PUBMED   8220435
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC336210.1, BC000373.2,
            AK056883.1 and BM992563.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001142276.1.
            
            Summary: This gene encodes amyloid precursor- like protein 2
            (APLP2), which is a member of the APP (amyloid precursor protein)
            family including APP, APLP1 and APLP2. This protein is ubiquitously
            expressed. It contains heparin-, copper- and zinc- binding domains
            at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the
            middle region, and transmembrane and intracellular domains at the
            C-terminus. This protein interacts with major histocompatibility
            complex (MHC) class I molecules. The synergy of this protein and
            the APP is required to mediate neuromuscular transmission, spatial
            learning and synaptic plasticity. This protein has been implicated
            in the pathogenesis of Alzheimer's disease. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region, compared to variant 1. It encodes isoform 2 which
            lacks an internal segment in the C-terminal region, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1573892.1,
                                           SRR7346977.1574718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338167.10/ ENSP00000345444.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DC336210.1         74-100
            28-2525             BC000373.2         1-2498
            2526-3696           AK056883.1         2024-3194
            3697-3697           BM992563.1         22-22               c
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..3697
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /note="amyloid beta precursor like protein 2"
                     /db_xref="GeneID:334"
                     /db_xref="HGNC:HGNC:598"
                     /db_xref="MIM:104776"
     exon            1..189
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2340
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; amyloid precursor protein homolog HSD-2; CDEI
                     box-binding protein; amyloid beta (A4) precursor-like
                     protein 2; testicular tissue protein Li 23; sperm membrane
                     protein YWK-II"
                     /codon_start=1
                     /product="amyloid beta precursor like protein 2 isoform 2
                     precursor"
                     /protein_id="NP_001135748.1"
                     /db_xref="CCDS:CCDS44773.1"
                     /db_xref="GeneID:334"
                     /db_xref="HGNC:HGNC:598"
                     /db_xref="MIM:104776"
                     /translation="MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTG
                     FAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITN
                     VMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVC
                     ENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEE
                     EDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYD
                     TFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGK
                     CVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQK
                     AKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQ
                     QLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTI
                     RHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQ
                     EQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEGSGVGEQDGGLI
                     GAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSA
                     LIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYEN
                     PTYKYLEQMQI"
     exon            190..363
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            364..487
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            488..600
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            601..797
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1006
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1174
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1305
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1380
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1539
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1668
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1768
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1921
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2007
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2082
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2238
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..3697
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3678..3683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /note="hexamer: AATAAA"
     polyA_site      3697
                     /gene="APLP2"
                     /gene_synonym="APLP-2; APPH; APPL2; CDEBP"
                     /note="major polyA site"
ORIGIN      
        1 agatgcttct gggtcgcggt gtgctaagcg aggagtccga gtgtgtgagc ttgagagccg
       61 cgcgctagag cgacccggcg agggatggcg gccaccggga ccgcggccgc cgcagccacg
      121 ggcaggctcc tgcttctgct gctggtgggg ctcacggcgc ctgccttggc gctggccggc
      181 tacatcgagg ctcttgcagc caatgccgga acaggatttg ctgttgctga gcctcaaatc
      241 gcaatgtttt gtgggaagtt aaatatgcat gtgaacattc agactgggaa atgggaacct
      301 gatccaacag gcaccaagag ctgctttgaa acaaaagaag aagttcttca gtactgtcag
      361 gagatgtatc cagagctaca gatcacaaat gtgatggagg caaaccagcg ggttagtatt
      421 gacaactggt gccggaggga caaaaagcaa tgcaagagtc gctttgttac acctttcaag
      481 tgtctcgtgg gtgaatttgt aagtgatgtc ctgctagttc cagaaaagtg ccagtttttc
      541 cacaaagagc ggatggaggt gtgtgagaat caccagcact ggcacacggt agtcaaagag
      601 gcatgtctga ctcagggaat gaccttatat agctacggca tgctgctccc atgtggggta
      661 gaccagttcc atggcactga atatgtgtgc tgccctcaga caaagattat tggatctgtg
      721 tcaaaagaag aggaagagga agatgaagag gaagaggaag aggaagatga agaggaagac
      781 tatgatgttt ataaaagtga atttcctact gaagcagatc tggaagactt cacagaagca
      841 gctgtggatg aggatgatga ggatgaggaa gaaggggagg aagtggtgga ggaccgagat
      901 tactactatg acaccttcaa aggagatgac tacaatgagg agaatcctac tgaacccggc
      961 agcgacggca ccatgtcaga caaggaaatt actcatgatg tcaaagctgt ctgctcccag
     1021 gaggcgatga cggggccctg ccgggccgtg atgcctcgtt ggtacttcga cctctccaag
     1081 ggaaagtgcg tgcgctttat atatggtggc tgcggcggca acaggaacaa ttttgagtct
     1141 gaggattatt gtatggctgt gtgtaaagcg atgattcctc caactcctct gccaaccaat
     1201 gatgttgatg tgtatttcga gacctctgca gatgataatg agcatgctcg cttccagaag
     1261 gctaaggagc agctggagat tcggcaccgc aaccgaatgg acagggtaaa gaaggaatgg
     1321 gaagaggcag agcttcaagc taagaacctc cccaaagcag agaggcagac tctgattcag
     1381 cacttccaag ccatggttaa agctttagag aaggaagcag ccagtgagaa gcagcagctg
     1441 gtggagaccc acctggcccg agtggaagct atgctgaatg accgccgtcg gatggctctg
     1501 gagaactacc tggctgcctt gcagtctgac ccgccacggc ctcatcgcat tctccaggcc
     1561 ttacggcgtt atgtccgtgc tgagaacaaa gatcgcttac ataccatccg tcattaccag
     1621 catgtgttgg ctgttgaccc agaaaaggcg gcccagatga aatcccaggt gatgacacat
     1681 ctccacgtga ttgaagaaag gaggaaccaa agcctctctc tgctctacaa agtaccttat
     1741 gtagcccaag aaattcaaga ggaaattgat gagctccttc aggagcagcg tgcagatatg
     1801 gaccagttca ctgcctcaat ctcagagacc cctgtggacg tccgggtgag ctctgaggag
     1861 agtgaggaga tcccaccgtt ccaccccttc caccccttcc cagccctacc tgagaacgaa
     1921 ggatctggag tgggagagca ggatggggga ctgatcggtg ccgaagagaa agtgattaac
     1981 agtaagaata aagtggatga aaacatggtc attgacgaga ctctggatgt taaggaaatg
     2041 attttcaatg ccgagagagt tggaggcctc gaggaagagc gggaatccgt gggcccactg
     2101 cgggaggact tcagtctgag tagcagtgct ctcattggcc tgctggtcat cgcagtggcc
     2161 attgccacgg tcatcgtcat cagcctggtg atgctgagga agaggcagta tggcaccatc
     2221 agccacggga tcgtggaggt tgatccaatg ctcaccccag aagagcgtca cctgaacaag
     2281 atgcagaacc atggctatga gaaccccacc tacaaatacc tggagcagat gcagatttag
     2341 gtggcaggga gcgcggcagc cctggcggag ggatgcaggt gggccggaag atcccacgat
     2401 tccgatcgac tgccaagcag cagccgctgc caggggctgc gtctgacatc ctgacctcct
     2461 ggactgtagg actatataaa gtactactgt agaactgcaa tttccattct tttaaatggg
     2521 tgaaaaatgg taatataaca atatatgata tataaacctt aaatgaaaaa aatgatctat
     2581 tgcagatatt tgatgtagtt ttctttttta aattaatcag aaaccccact tccattgtat
     2641 tgtctgacac atgctctcaa tatataataa atgggaaatg tcgattttca ataatagact
     2701 tatatgcagg ctgtcgttcc ggttatgttg tgtaagtcaa ctcttcagcc tcattcactg
     2761 tcctggcttt tatttaaaga aaaaaaaggc agtattccct ttttaaatga gctttcagga
     2821 agttgctgag aaatggggtg gaatagggaa ctgtaatggc cactgaagca cgtgagagac
     2881 cctcgcaaaa tgatgtgaaa ggaccagttt cttgaagtcc agtgtttcca cggctggata
     2941 cctgtgtgtc tccataaaag tcctgtcacc aaggacgtta aaggcatttt attccagcgt
     3001 cttctagaga gcttagtgta tacagatgag ggtgtccgct gctgctttcc ttcggaatcc
     3061 agtgcttcca cagagattag cctgtagctt atatttgaca ttcttcactg tctgttgttt
     3121 acctaccgta gctttttacc gttcacttcc ccttccaact atgtccagat gtgcaggctc
     3181 ctcctctctg gactttctcc aaaggcactg accctcggcc tctactttgt cccctcacct
     3241 ccaccccctc ctgtcaccgg ccttgtgaca ttcactcaga gaagaccaca ccaaggaggc
     3301 ggccgctggc ccaggagaga acacggggag gtttgtttgt gtgaaaggaa agtagtccag
     3361 gctgtccctg aaactgagtc tgtggacact gtggaaagct ttgaacaatt gtgttttcgt
     3421 cacaggagtc tttgtaatgc ttgtacagtt gatgtcgatg ctcactgctt ctgctttttc
     3481 tttcttttta ttttaaatct gaaggttctg gtaacctgtg gtgtattttt attttcctgt
     3541 gactgttttt gttttgtttt tttccttttt cctccccttt gaccctattc atgtctctac
     3601 ccactatgca cagattaaac ttcacctaca aactccttaa tatgatctgt ggagaatgta
     3661 cacagtttaa acacatcaat aaatacttta acttcca
//
