LOCUS       NM_001024807            2370 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens amyloid beta precursor like protein 1 (APLP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001024807
VERSION     NM_001024807.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Mao,X., Gu,H., Kim,D., Kimura,Y., Wang,N., Xu,E., Kumbhar,R.,
            Ming,X., Wang,H., Chen,C., Zhang,S., Jia,C., Liu,Y., Bian,H.,
            Karuppagounder,S.S., Akkentli,F., Chen,Q., Jia,L., Hwang,H.,
            Lee,S.H., Ke,X., Chang,M., Li,A., Yang,J., Rastegar,C.,
            Sriparna,M., Ge,P., Brahmachari,S., Kim,S., Zhang,S., Shimoda,Y.,
            Saar,M., Liu,H., Kweon,S.H., Ying,M., Workman,C.J., Vignali,D.A.A.,
            Muller,U.C., Liu,C., Ko,H.S., Dawson,V.L. and Dawson,T.M.
  TITLE     Aplp1 interacts with Lag3 to facilitate transmission of pathologic
            alpha-synuclein
  JOURNAL   Nat Commun 15 (1), 4663 (2024)
   PUBMED   38821932
  REMARK    GeneRIF: Aplp1 interacts with Lag3 to facilitate transmission of
            pathologic alpha-synuclein.
            Erratum:[Nat Commun. 2024 Jul 30;15(1):6413. doi:
            10.1038/s41467-024-50640-2.. PMID: 39080298]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Schauenburg,L., Liebsch,F., Eravci,M., Mayer,M.C., Weise,C. and
            Multhaup,G.
  TITLE     APLP1 is endoproteolytically cleaved by gamma-secretase without
            previous ectodomain shedding
  JOURNAL   Sci Rep 8 (1), 1916 (2018)
   PUBMED   29382944
  REMARK    GeneRIF: The direct cleavage of APLP1 is a novel feature of the
            gamma-secretase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Dunsing,V., Mayer,M., Liebsch,F., Multhaup,G. and Chiantia,S.
  TITLE     Direct evidence of amyloid precursor-like protein 1 trans
            interactions in cell-cell adhesion platforms investigated via
            fluorescence fluctuation spectroscopy
  JOURNAL   Mol Biol Cell 28 (25), 3609-3620 (2017)
   PUBMED   29021345
  REMARK    GeneRIF: Results provide direct evidence that APLP1 functions as a
            neuronal zinc-dependent adhesion protein and allow a more detailed
            understanding of the molecular mechanisms driving the formation of
            APLP1 adhesion platforms.
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Zheng,L.J., Su,Y.Y., Wang,Y.F., Zhong,J., Liang,X., Zheng,G.,
            Lu,G.M. and Zhang,L.J.
  TITLE     Altered spontaneous brain activity pattern in cognitively normal
            young adults carrying mutations of APP, presenilin-1/2 and APOE
            epsilon4
  JOURNAL   Eur J Radiol 95, 18-23 (2017)
   PUBMED   28987665
  REMARK    GeneRIF: The results show that in cognitively normal young adults
            carrying APlp1 mutations showed different spontaneous brain
            activity patterns without cerebral structural differences.
REFERENCE   6  (bases 1 to 2370)
  AUTHORS   Paliga,K., Peraus,G., Kreger,S., Durrwang,U., Hesse,L.,
            Multhaup,G., Masters,C.L., Beyreuther,K. and Weidemann,A.
  TITLE     Human amyloid precursor-like protein 1--cDNA cloning, ectopic
            expression in COS-7 cells and identification of soluble forms in
            the cerebrospinal fluid
  JOURNAL   Eur J Biochem 250 (2), 354-363 (1997)
   PUBMED   9428684
REFERENCE   7  (bases 1 to 2370)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
REFERENCE   8  (bases 1 to 2370)
  AUTHORS   Kim,T.W., Wu,K., Xu,J.L., McAuliffe,G., Tanzi,R.E., Wasco,W. and
            Black,I.B.
  TITLE     Selective localization of amyloid precursor-like protein 1 in the
            cerebral cortex postsynaptic density
  JOURNAL   Brain Res Mol Brain Res 32 (1), 36-44 (1995)
   PUBMED   7494461
REFERENCE   9  (bases 1 to 2370)
  AUTHORS   Bush,A.I., Pettingell,W.H. Jr., de Paradis,M., Tanzi,R.E. and
            Wasco,W.
  TITLE     The amyloid beta-protein precursor and its mammalian homologues.
            Evidence for a zinc-modulated heparin-binding superfamily
  JOURNAL   J Biol Chem 269 (43), 26618-26621 (1994)
   PUBMED   7929392
REFERENCE   10 (bases 1 to 2370)
  AUTHORS   Wasco,W., Brook,J.D. and Tanzi,R.E.
  TITLE     The amyloid precursor-like protein (APLP) gene maps to the long arm
            of human chromosome 19
  JOURNAL   Genomics 15 (1), 237-239 (1993)
   PUBMED   8432545
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013850.1, BC032983.1 and
            HY304113.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001024807.2.
            
            Summary: This gene encodes a member of the highly conserved amyloid
            precursor protein gene family. The encoded protein is a
            membrane-associated glycoprotein that is cleaved by secretases in a
            manner similar to amyloid beta A4 precursor protein cleavage. This
            cleavage liberates an intracellular cytoplasmic fragment that may
            act as a transcriptional activator. The encoded protein may also
            play a role in synaptic maturation during cortical development.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013850.1, SRR14038191.1239238.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221891.9/ ENSP00000221891.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               BC013850.1         13-306
            295-295             BC032983.1         297-297
            296-2367            BC013850.1         308-2379
            2368-2370           HY304113.1         35-37               c
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..2370
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /note="amyloid beta precursor like protein 1"
                     /db_xref="GeneID:333"
                     /db_xref="HGNC:HGNC:597"
                     /db_xref="MIM:104775"
     exon            1..210
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2019
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; amyloid-like protein 1; amyloid precursor-like
                     protein 1; amyloid beta (A4) precursor-like protein 1"
                     /codon_start=1
                     /product="amyloid beta precursor like protein 1 isoform 1
                     precursor"
                     /protein_id="NP_001019978.1"
                     /db_xref="CCDS:CCDS32997.1"
                     /db_xref="GeneID:333"
                     /db_xref="HGNC:HGNC:597"
                     /db_xref="MIM:104775"
                     /translation="MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGS
                     PGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPEL
                     QIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLH
                     QERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDP
                     SGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSH
                     TLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAM
                     ADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAAL
                     EGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVH
                     THLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKG
                     GLQPPDSKDADTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEI
                     QRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPML
                     TLEEQQLRELQRHGYENPTYRFLEERP"
     exon            211..354
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            355..487
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            488..600
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            601..734
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            735..913
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1044
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1119
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1278
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1407
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1507
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1615
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1642
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1713
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1776
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1920
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2370
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2349..2354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /note="hexamer: AATAAA"
     polyA_site      2370
                     /gene="APLP1"
                     /gene_synonym="APLP"
                     /note="major polyA site"
ORIGIN      
        1 ctgtcaccgc tggggccggg ccgggcggga gtgcagggga cgtgagggcg caagggccgg
       61 gacatggggc ccgccagccc cgctgctcgc ggtctaagtc gccgcccggg ccagccgccg
      121 ctgccgctgc tgctgccact attgctgctg cttctgcgcg cgcagcccgc catcgggagc
      181 ctggccggtg ggagccccgg cgcggccgag gccccggggt cggcccaggt ggctggacta
      241 tgcgggcgcc taacccttca ccgggacctg cgcaccggcc gctgggaacc agacccacag
      301 cgctctcgac gctgtctccg ggacccgcag cgcgtgctgg agtactgcag acagatgtac
      361 ccggagctgc agattgcacg tgtggagcag gctacgcagg ccatccccat ggagcgctgg
      421 tgcgggggtt cccggagcgg cagctgcgcc cacccccacc accaggttgt gcccttccgc
      481 tgcctgcctg gtgaatttgt gagtgaggcc ctgctggtgc ctgaaggctg ccggttcttg
      541 caccaggagc gcatggacca atgtgagagt tcaacccgga ggcatcagga ggcacaggag
      601 gcctgcagct cccagggcct catcctgcac ggctcgggca tgctcttacc ctgtggctcg
      661 gatcggttcc gtggtgtgga gtatgtgtgc tgtccccctc cagggacccc cgacccatct
      721 gggacagcag ttggtgaccc ctccacccgg tcctggcccc cggggagcag agtagagggg
      781 gctgaggacg aggaagagga ggaatccttc ccacagccag tagatgatta cttcgtggag
      841 cctccgcagg ctgaagagga agaggaaacg gtcccacccc caagctccca tacacttgca
      901 gtggtcggca aagtcactcc caccccgagg cccacagacg gtgtggatat ttactttggc
      961 atgcctgggg aaatcagtga gcacgagggg ttcctgaggg ccaagatgga cctggaggag
     1021 cgtaggatgc gccagattaa tgaggtgatg cgtgaatggg ccatggcaga caaccagtcc
     1081 aagaacctgc ctaaagccga cagacaggcc ctgaatgagc acttccagtc cattctgcag
     1141 actctggagg agcaggtgtc tggtgagcga cagcgcctgg tggaaaccca cgccacccgc
     1201 gtcatcgccc ttatcaacga ccagcgccgg gctgccttgg agggcttcct ggcagccctg
     1261 caggcagatc cgcctcaggc ggagcgtgtc ctgttggccc tgcggcgcta cctgcgtgcg
     1321 gagcagaagg aacagaggca cacgctgcgc cactaccagc atgtggccgc cgtggatccc
     1381 gagaaggcac agcagatgcg cttccaggtg catacccacc ttcaagtgat tgaggagagg
     1441 gtgaatcaga gcctgggcct gcttgaccag aacccccacc tggctcagga gctgcggccc
     1501 caaatccagg aactcctcca ctctgaacac ctgggtccca gtgaattgga agcccctgcc
     1561 cctgggggca gcagcgagga caagggtggg ctgcagcctc cagattccaa ggatgcagac
     1621 acccccatga cccttccaaa agggtccaca gaacaagatg ctgcatcccc tgagaaagag
     1681 aagatgaacc cgctggaaca gtatgagcga aaggtgaatg cgtctgttcc aaggggtttc
     1741 cctttccact catcggagat tcagagggat gagctggcac cagctgggac aggggtgtcc
     1801 cgtgaggctg tgtcgggtct gctgatcatg ggagcgggcg gaggctccct catcgtcctc
     1861 tccatgctgc tcctgcgcag gaagaagccc tacggggcta tcagccatgg cgtggtggag
     1921 gtggacccca tgctgaccct ggaggagcag cagctccgcg aactgcagcg gcacggctat
     1981 gagaacccca cttaccgctt cctggaggaa cgaccctgac ccggccccct tcaccccttc
     2041 agccgagccc agacctcccc tcttcctgga gccccagaac cccaactccc agcctagggc
     2101 agcagggagt cttgaagtga tcatttcaca cccttttgtg agacggctgg aaattcttat
     2161 ttcccctttc caattccaaa attccatccc taagaattcc cagatagtcc cagcagcctc
     2221 cccacgtggc acctcctcac cttaatttat tttttaagtt tatttatggc tctttaaggt
     2281 gaccgccacc ttggtcctag tgtctattcc ctggaattca ccctctcatg tttccctact
     2341 aacatcccaa taaagtcctc ttccctacca
//
