LOCUS       NM_005161               3660 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens apelin receptor (APLNR), transcript variant 1, mRNA.
ACCESSION   NM_005161
VERSION     NM_005161.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3660)
  AUTHORS   Liu,Y., Li,N., Guo,Y., Zhou,Q., Yang,Y., Lu,J., Tian,Z., Zhou,J.,
            Yan,S., Li,X., Shi,L., Jiang,S., Ge,J., Feng,R., Huang,D., Zeng,Z.,
            Fan,S., Xiong,W., Li,G. and Zhang,W.
  TITLE     APLNR inhibited nasopharyngeal carcinoma growth and immune escape
            by downregulating PD-L1
  JOURNAL   Int Immunopharmacol 137, 112523 (2024)
   PUBMED   38909500
  REMARK    GeneRIF: APLNR inhibited nasopharyngeal carcinoma growth and immune
            escape by downregulating PD-L1.
REFERENCE   2  (bases 1 to 3660)
  AUTHORS   Shi,N., Wang,Y., Xia,Z., Zhang,J., Jia,S., Jiao,Y., Wang,C.,
            Wang,X., Zhao,J., Zhang,J. and Jiang,D.
  TITLE     The regulatory role of the apelin/APJ axis in scarring:
            Identification of upstream and downstream mechanisms
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167125 (2024)
   PUBMED   38508477
  REMARK    GeneRIF: The regulatory role of the apelin/APJ axis in scarring:
            Identification of upstream and downstream mechanisms.
REFERENCE   3  (bases 1 to 3660)
  AUTHORS   Wang,W.W., Ji,S.Y., Zhang,W., Zhang,J., Cai,C., Hu,R., Zang,S.K.,
            Miao,L., Xu,H., Chen,L.N., Yang,Z., Guo,J., Qin,J., Shen,D.D.,
            Liang,P., Zhang,Y. and Zhang,Y.
  TITLE     Structure-based design of non-hypertrophic apelin receptor
            modulator
  JOURNAL   Cell 187 (6), 1460-1475 (2024)
   PUBMED   38428423
REFERENCE   4  (bases 1 to 3660)
  AUTHORS   Tian,Y., Wang,R., Liu,L., Zhang,W., Liu,H., Jiang,L. and Jiang,Y.
  TITLE     The regulatory effects of the apelin/APJ system on depression: A
            prospective therapeutic target
  JOURNAL   Neuropeptides 102, 102382 (2023)
   PUBMED   37716179
  REMARK    GeneRIF: The regulatory effects of the apelin/APJ system on
            depression: A prospective therapeutic target.
            Review article
REFERENCE   5  (bases 1 to 3660)
  AUTHORS   Medhurst,A.D., Jennings,C.A., Robbins,M.J., Davis,R.P., Ellis,C.,
            Winborn,K.Y., Lawrie,K.W., Hervieu,G., Riley,G., Bolaky,J.E.,
            Herrity,N.C., Murdock,P. and Darker,J.G.
  TITLE     Pharmacological and immunohistochemical characterization of the APJ
            receptor and its endogenous ligand apelin
  JOURNAL   J Neurochem 84 (5), 1162-1172 (2003)
   PUBMED   12603839
REFERENCE   6  (bases 1 to 3660)
  AUTHORS   Katugampola,S.D., Maguire,J.J., Matthewson,S.R. and Davenport,A.P.
  TITLE     [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing
            the APJ orphan receptor in human and rat tissues with evidence for
            a vasoconstrictor role in man
  JOURNAL   Br J Pharmacol 132 (6), 1255-1260 (2001)
   PUBMED   11250876
REFERENCE   7  (bases 1 to 3660)
  AUTHORS   O'Carroll,A.M., Selby,T.L., Palkovits,M. and Lolait,S.J.
  TITLE     Distribution of mRNA encoding B78/apj, the rat homologue of the
            human APJ receptor, and its endogenous ligand apelin in brain and
            peripheral tissues
  JOURNAL   Biochim Biophys Acta 1492 (1), 72-80 (2000)
   PUBMED   11004481
REFERENCE   8  (bases 1 to 3660)
  AUTHORS   Tatemoto,K., Hosoya,M., Habata,Y., Fujii,R., Kakegawa,T., Zou,M.X.,
            Kawamata,Y., Fukusumi,S., Hinuma,S., Kitada,C., Kurokawa,T.,
            Onda,H. and Fujino,M.
  TITLE     Isolation and characterization of a novel endogenous peptide ligand
            for the human APJ receptor
  JOURNAL   Biochem Biophys Res Commun 251 (2), 471-476 (1998)
   PUBMED   9792798
REFERENCE   9  (bases 1 to 3660)
  AUTHORS   Matsumoto,M., Hidaka,K., Akiho,H., Tada,S., Okada,M. and
            Yamaguchi,T.
  TITLE     Low stringency hybridization study of the dopamine D4 receptor
            revealed D4-like mRNA distribution of the orphan
            seven-transmembrane receptor, APJ, in human brain
  JOURNAL   Neurosci Lett 219 (2), 119-122 (1996)
   PUBMED   8971794
REFERENCE   10 (bases 1 to 3660)
  AUTHORS   O'Dowd,B.F., Heiber,M., Chan,A., Heng,H.H., Tsui,L.C.,
            Kennedy,J.L., Shi,X., Petronis,A., George,S.R. and Nguyen,T.
  TITLE     A human gene that shows identity with the gene encoding the
            angiotensin receptor is located on chromosome 11
  JOURNAL   Gene 136 (1-2), 355-360 (1993)
   PUBMED   8294032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001786.4.
            
            On Feb 16, 2021 this sequence version replaced NM_005161.5.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor gene family. The encoded protein is related to the
            angiotensin receptor, but is actually an apelin receptor that
            inhibits adenylate cyclase activity and plays a counter-regulatory
            role against the pressure action of angiotensin II by exerting
            hypertensive effect. It functions in the cardiovascular and central
            nervous systems, in glucose metabolism, in embryonic and tumor
            angiogenesis and as a human immunodeficiency virus (HIV-1)
            coreceptor. Two transcript variants resulting from alternative
            splicing have been identified. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK075252.1, AK315542.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000606794.2/ ENSP00000475344.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3660              AP001786.4         144181-147840       c
FEATURES             Location/Qualifiers
     source          1..3660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..3660
                     /gene="APLNR"
                     /gene_synonym="AGTRL1; APJ; APJR; HG11"
                     /note="apelin receptor"
                     /db_xref="GeneID:187"
                     /db_xref="HGNC:HGNC:339"
                     /db_xref="MIM:600052"
     exon            1..3660
                     /gene="APLNR"
                     /gene_synonym="AGTRL1; APJ; APJR; HG11"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1389
                     /gene="APLNR"
                     /gene_synonym="AGTRL1; APJ; APJR; HG11"
                     /note="APJ (apelin) receptor; angiotensin receptor-like 1;
                     angiotensin II receptor-like 1; G protein-coupled receptor
                     APJ; HG11 orphan receptor; APJ receptor; G-protein coupled
                     receptor HG11"
                     /codon_start=1
                     /product="apelin receptor"
                     /protein_id="NP_005152.1"
                     /db_xref="CCDS:CCDS7950.1"
                     /db_xref="GeneID:187"
                     /db_xref="HGNC:HGNC:339"
                     /db_xref="MIM:600052"
                     /translation="MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTT
                     GNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFC
                     KLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALL
                     AMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIML
                     TCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSL
                     LHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGT
                     SHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD"
     regulatory      3642..3647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APLNR"
                     /gene_synonym="AGTRL1; APJ; APJR; HG11"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="APLNR"
                     /gene_synonym="AGTRL1; APJ; APJR; HG11"
                     /note="major polyA site"
ORIGIN      
        1 gtcttaactg agacgggggt aaggcaagag agggtggagg aaattctgca ggagacaggc
       61 ttcctccagg gtctggagaa cccagaggca gctcctcctg agtgctggga aggactctgg
      121 gcatcttcag cccttcttac tctctgaggc tcaagccaga aattcaggct gcttgcagag
      181 tgggtgacag agccacggag ctggtgtccc tgggaccctc tgcccgtctt ctctccactc
      241 cccagcatgg aggaaggtgg tgattttgac aactactatg gggcagacaa ccagtctgag
      301 tgtgagtaca cagactggaa atcctcgggg gccctcatcc ctgccatcta catgttggtc
      361 ttcctcctgg gcaccacggg caacggtctg gtgctctgga ccgtgtttcg gagcagccgg
      421 gagaagaggc gctcagctga tatcttcatt gctagcctgg cggtggctga cctgaccttc
      481 gtggtgacgc tgcccctgtg ggctacctac acgtaccggg actatgactg gccctttggg
      541 accttcttct gcaagctcag cagctacctc atcttcgtca acatgtacgc cagcgtcttc
      601 tgcctcaccg gcctcagctt cgaccgctac ctggccatcg tgaggccagt ggccaatgct
      661 cggctgaggc tgcgggtcag cggggccgtg gccacggcag ttctttgggt gctggccgcc
      721 ctcctggcca tgcctgtcat ggtgttacgc accaccgggg acttggagaa caccactaag
      781 gtgcagtgct acatggacta ctccatggtg gccactgtga gctcagagtg ggcctgggag
      841 gtgggccttg gggtctcgtc caccaccgtg ggctttgtgg tgcccttcac catcatgctg
      901 acctgttact tcttcatcgc ccaaaccatc gctggccact tccgcaagga acgcatcgag
      961 ggcctgcgga agcggcgccg gctgctcagc atcatcgtgg tgctggtggt gacctttgcc
     1021 ctgtgctgga tgccctacca cctggtgaag acgctgtaca tgctgggcag cctgctgcac
     1081 tggccctgtg actttgacct cttcctcatg aacatcttcc cctactgcac ctgcatcagc
     1141 tacgtcaaca gctgcctcaa ccccttcctc tatgcctttt tcgacccccg cttccgccag
     1201 gcctgcacct ccatgctctg ctgtggccag agcaggtgcg caggcacctc ccacagcagc
     1261 agtggggaga agtcagccag ctactcttcg gggcacagcc aggggcccgg ccccaacatg
     1321 ggcaagggtg gagaacagat gcacgagaaa tccatcccct acagccagga gacccttgtg
     1381 gttgactagg gctgggagca gagagaagcc tggcgccctc ggccctcccc ggcctttgcc
     1441 cttgctttct gaaaatcagg tagtgtggct actccttgtc ctatgcacat cctttaactg
     1501 tcccctgatt ctgccccgcc ctgtcctcct ctactgcttt attctttctc agaggtttgt
     1561 ggtttagggg aaagagactg ggctctacag acctgaccct gcacaagcca tttaatctca
     1621 ctcagcctca gtttctccat tggtatgaaa tgggggaaag tcatattgat cctaaaatgt
     1681 tgaagcctga gtctggacgc agtaaaagct tgtttccctc tgctgctttc ttagatctgc
     1741 aatcgtcttt cctcccttct ttccttgtag tttttccccc accactctct gcagctgccg
     1801 ctccttatcc ctgccttctg gcaccaatcc cctcctacag ctcgtccccc tccctccatc
     1861 catccttctc ccctgtctac tttcttgttc tgaagggcta ctaagggtta aggatcccaa
     1921 agcttgcaga gactgaccct gtttaagctt tctatcctgt tttctgagtg tgaggcaggg
     1981 aatgggctgg ggccgggggt gggctgtgtg tcagcagata attagtgctc cagcccttag
     2041 atctgggagc tccagagctt gccctaaaat tggatcactt ccctgtcatt ttgggcattg
     2101 gggctagtgt gattcctgca gttcccccat ggcaccatga cactgactag atatgctttc
     2161 tccaaattgt ccgcagaccc tttcatcctt cctctatttt ctatgagaat tggaaggcag
     2221 cagggctgat gaatggatgt actccttggt ttcattatgt gagtggggag ttgggaaggg
     2281 caactagaga gagaggatgg aggggtgtct gcatttagtc cagacactgc ttggctcgct
     2341 ccccgagtcc tcctgtttct gacttcctgc ataactgtga gctgaagggt ttcctcatct
     2401 ccccatctta ccccatcata ctgatttctt tcttgggcac tggtgctact tggtgccaag
     2461 aatcatgttg tttgggatgg agatgcctgc ctcttgtctg tgtgtgttgt acttatatgt
     2521 ctatatggat gagcctggca tgaacagcag tgtgcctggg tcatttggac aaacctcctc
     2581 ccacccccca atccactgca actctgctgt tcacacatta cccttggcag ggggtggtgg
     2641 ggggcaggga cacactgagg caatgaaaaa tgtagaataa aaatgagtcc accccctact
     2701 ggatttgggg gctccaacgg ctggtccgtg ctttaggagc gaagttaatg tttgcaccag
     2761 gcttcctgta gggagatccc tccccaaagc agctggcgcc aaggcttggg ggcgtcctac
     2821 tgagctgggt tcctgctcct tcttgggctc catgaaggaa gtaagaggct agttgagagc
     2881 ctcccttggc ccctttccgg tgcctccccg cctggcttca aatttatgag cattgccctc
     2941 atcgtccttt cttgttccag ggtcagtggc cctcttccta aggaggcctc ctgcttgcca
     3001 tgggccaaaa ggcacggggt gggttttttc tctccctacc ctcaggattg gacctcttgg
     3061 cttctgctgg attggggatc tgggaatagg gactggagca agtgtgcaga tagcatgatg
     3121 tctacactgc cagagagacc gtgaggatga aattaatagt ggggcctttg tgagctagag
     3181 gctgggagtg tctattccgg gttttgttct tggaggacta tgaaagtgaa ggacaagaca
     3241 tgagcgatgg agataagaaa agcccagctt gatgtgaatg gacatcttga ccctccctgg
     3301 aatgacgcca gctctggggg cagagggagg aggagagggg aaggggctcc tcacagccta
     3361 gtctccccat cttaagatag catctttcac agagtcacct cctctgccca gagctgtcct
     3421 caaagcatcc agtgaacact ggaagaggct tctagaaggg aagaaattgt ccctctgagg
     3481 ccgccgtggg tgacctgcag agacttcctg cctggaactc atctgtgaac tgggacagaa
     3541 gcagaggagg ctgcctgctg tgataccccc ttacctcccc cagtgccttc ttcagaatat
     3601 ctgcactgtc ttctgatcct gttagtcact gtggttcatc aaataaaact gtttgtgcaa
//
