LOCUS       NM_015957               1246 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens APAF1 interacting protein (APIP), mRNA.
ACCESSION   NM_015957
VERSION     NM_015957.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1246)
  AUTHORS   Li,J., Wang,R., Li,M., Zhang,Z., Jin,S. and Ma,H.
  TITLE     APIP regulated by YAP propels methionine cycle and metastasis in
            head and neck squamous cell carcinoma
  JOURNAL   Cancer Lett 588, 216756 (2024)
   PUBMED   38423248
  REMARK    GeneRIF: APIP regulated by YAP propels methionine cycle and
            metastasis in head and neck squamous cell carcinoma.
REFERENCE   2  (bases 1 to 1246)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1246)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1246)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1246)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1246)
  AUTHORS   Moravcikova,E., Krepela,E., Prochazka,J., Rousalova,I., Cermak,J.
            and Benkova,K.
  TITLE     Down-regulated expression of apoptosis-associated genes APIP and
            UACA in non-small cell lung carcinoma
  JOURNAL   Int J Oncol 40 (6), 2111-2121 (2012)
   PUBMED   22407486
  REMARK    GeneRIF: The down-regulation of APIP and UACA expression suggests
            that the threshold to activate the apoptosome apparatus may be
            decreased in non-small cell lung cancer cells.
REFERENCE   7  (bases 1 to 1246)
  AUTHORS   Wright,F.A., Strug,L.J., Doshi,V.K., Commander,C.W., Blackman,S.M.,
            Sun,L., Berthiaume,Y., Cutler,D., Cojocaru,A., Collaco,J.M.,
            Corey,M., Dorfman,R., Goddard,K., Green,D., Kent,J.W. Jr.,
            Lange,E.M., Lee,S., Li,W., Luo,J., Mayhew,G.M., Naughton,K.M.,
            Pace,R.G., Pare,P., Rommens,J.M., Sandford,A., Stonebraker,J.R.,
            Sun,W., Taylor,C., Vanscoy,L.L., Zou,F., Blangero,J., Zielenski,J.,
            O'Neal,W.K., Drumm,M.L., Durie,P.R., Knowles,M.R. and Cutting,G.R.
  TITLE     Genome-wide association and linkage identify modifier loci of lung
            disease severity in cystic fibrosis at 11p13 and 20q13.2
  JOURNAL   Nat Genet 43 (6), 539-546 (2011)
   PUBMED   21602797
REFERENCE   8  (bases 1 to 1246)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1246)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   10 (bases 1 to 1246)
  AUTHORS   Cho,D.H., Hong,Y.M., Lee,H.J., Woo,H.N., Pyo,J.O., Mak,T.W. and
            Jung,Y.K.
  TITLE     Induced inhibition of ischemic/hypoxic injury by APIP, a novel
            Apaf-1-interacting protein
  JOURNAL   J Biol Chem 279 (38), 39942-39950 (2004)
   PUBMED   15262985
  REMARK    GeneRIF: APIP functions to inhibit muscle ischemic damage by
            binding to Apaf-1 in the Apaf-1/caspase-9 apoptosis pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107928.3, BP200131.1, BC009077.1 and AF088034.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015957.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.129302.1,
                                           SRR5189667.244568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395787.4/ ENSP00000379133.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC107928.3         148099-148124       c
            27-54               BP200131.1         148-175
            55-1171             BC009077.1         1-1117
            1172-1246           AF088034.1         561-635
FEATURES             Location/Qualifiers
     source          1..1246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..1246
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /note="APAF1 interacting protein"
                     /db_xref="GeneID:51074"
                     /db_xref="HGNC:HGNC:17581"
                     /db_xref="MIM:612491"
     exon            1..152
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..824
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /EC_number="4.2.1.109"
                     /note="probable methylthioribulose-1-phosphate
                     dehydratase; MTRu-1-P dehydratase"
                     /codon_start=1
                     /product="methylthioribulose-1-phosphate dehydratase"
                     /protein_id="NP_057041.2"
                     /db_xref="CCDS:CCDS7895.1"
                     /db_xref="GeneID:51074"
                     /db_xref="HGNC:HGNC:17581"
                     /db_xref="MIM:612491"
                     /translation="MSGCDAREGDCCSRRCGAQDKEHPRYLIPELCKQFYHLGWVTGT
                     GGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFM
                     NAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLV
                     VPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLF
                     DIAVSMKKVGLDPSQLPVGENGIV"
     exon            153..253
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            254..302
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            303..420
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            421..556
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            557..724
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1246
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /note="hexamer: AATAAA"
     polyA_site      1173
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /note="major polyA site"
     regulatory      1221..1226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
                     /note="hexamer: AATAAA"
     polyA_site      1246
                     /gene="APIP"
                     /gene_synonym="APIP2; CGI-29; CGI29; hAPIP; MMRP19"
ORIGIN      
        1 gattgcattt gcggcctcgc tgccgtatcc caggctaagc gccgcgcgca aagccgtgcg
       61 gagattggag gccgcgcggg tccctggtct gggccatgtc tggctgtgat gctcgggagg
      121 gagactgttg ttcccggaga tgcggcgcgc aggacaagga gcatccaaga tacctgatcc
      181 cagaactttg caaacagttt taccatttag gctgggtcac tgggactgga ggaggaatta
      241 gcttgaagca tggcgatgaa atctacattg ctccttcagg agtgcaaaag gaacgaattc
      301 agcctgaaga catgtttgtt tgtgatataa atgaaaagga cataagtgga ccttcgccat
      361 cgaagaagct aaaaaaaagc cagtgtactc ctcttttcat gaatgcttac acaatgagag
      421 gagcaggtgc agtgattcat acccactcta aagctgctgt gatggccaca cttctctttc
      481 caggacggga gtttaaaatt acacatcaag agatgataaa aggaataaag aaatgtactt
      541 ccggagggta ttatagatat gatgatatgt tagtggtacc cattattgag aatacacctg
      601 aggagaaaga cctcaaagat agaatggctc atgcaatgaa tgaataccca gactcctgtg
      661 cagtactggt cagacgtcat ggagtatatg tgtgggggga aacatgggag aaggccaaaa
      721 ccatgtgtga gtgttatgac tatttatttg atattgccgt atcaatgaag aaagtaggac
      781 ttgatccttc acagctccca gttggagaaa atggaattgt ctaagccaaa agaaagtcta
      841 attatataca gagataaagc taaacgtaat tattatttaa atgaaagcta tttttttaaa
      901 tgaattgaaa tttttcatga tgctactaat ttgccactaa atactgcaaa tggtcaccct
      961 gaatctcttc tgacattgga tgttatttgc ttatattctt ataattttaa atgagggcac
     1021 agtgaaatga aaattttata ctctatgttt ctgtttattt ttaaatcctt aacagcaaaa
     1081 tatttgcctt taatttcttt tttatatata ctctcagaga attcctctta atttttaaag
     1141 atgctggtga taataaaatt cattagaaaa tttcctcatt gtggaatgag cattctcttg
     1201 ttttaatgtt ggtgtcagaa aataaatatg aaacattaag tccaaa
//
