LOCUS       NM_001142930            3726 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens apoptosis inhibitor 5 (API5), transcript variant 1,
            mRNA.
ACCESSION   NM_001142930
VERSION     NM_001142930.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   Kuttanamkuzhi,A., Panda,D., Malaviya,R., Gaidhani,G. and Lahiri,M.
  TITLE     Altered expression of anti-apoptotic protein Api5 affects breast
            tumorigenesis
  JOURNAL   BMC Cancer 23 (1), 374 (2023)
   PUBMED   37095445
  REMARK    GeneRIF: Altered expression of anti-apoptotic protein Api5 affects
            breast tumorigenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Matsuzawa-Ishimoto,Y., Yao,X., Koide,A., Ueberheide,B.M.,
            Axelrad,J.E., Reis,B.S., Parsa,R., Neil,J.A., Devlin,J.C.,
            Rudensky,E., Dewan,M.Z., Cammer,M., Blumberg,R.S., Ding,Y.,
            Ruggles,K.V., Mucida,D., Koide,S. and Cadwell,K.
  TITLE     The gammadelta IEL effector API5 masks genetic susceptibility to
            Paneth cell death
  JOURNAL   Nature 610 (7932), 547-554 (2022)
   PUBMED   36198790
  REMARK    GeneRIF: The gammadelta IEL effector API5 masks genetic
            susceptibility to Paneth cell death.
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Deng,T., Hu,B., Wang,X., Yan,Y., Zhou,J., Lin,L., Xu,Y., Zheng,X.
            and Zhou,J.
  TITLE     DeSUMOylation of Apoptosis Inhibitor 5 by Avibirnavirus VP3
            Supports Virus Replication
  JOURNAL   mBio 12 (4), e0198521 (2021)
   PUBMED   34372697
  REMARK    GeneRIF: DeSUMOylation of Apoptosis Inhibitor 5 by Avibirnavirus
            VP3 Supports Virus Replication.
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Sharma,V.K. and Lahiri,M.
  TITLE     Interplay between p300 and HDAC1 regulate acetylation and stability
            of Api5 to regulate cell proliferation
  JOURNAL   Sci Rep 11 (1), 16427 (2021)
   PUBMED   34385547
  REMARK    GeneRIF: Interplay between p300 and HDAC1 regulate acetylation and
            stability of Api5 to regulate cell proliferation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3726)
  AUTHORS   Li,Z., Hu,C.Y., Mo,B.Q., Xu,J.D. and Zhao,Y.
  TITLE     [Effect of beta-carotene on gene expression of breast cancer cells]
  JOURNAL   Ai Zheng 22 (4), 380-384 (2003)
   PUBMED   12703993
REFERENCE   7  (bases 1 to 3726)
  AUTHORS   Van den Berghe,L., Laurell,H., Huez,I., Zanibellato,C., Prats,H.
            and Bugler,B.
  TITLE     FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a
            nuclear putatively antiapoptotic factor, interacts specifically
            with FGF-2
  JOURNAL   Mol Endocrinol 14 (11), 1709-1724 (2000)
   PUBMED   11075807
REFERENCE   8  (bases 1 to 3726)
  AUTHORS   Kim,J.W., Cho,H.S., Kim,J.H., Hur,S.Y., Kim,T.E., Lee,J.M.,
            Kim,I.K. and Namkoong,S.E.
  TITLE     AAC-11 overexpression induces invasion and protects cervical cancer
            cells from apoptosis
  JOURNAL   Lab Invest 80 (4), 587-594 (2000)
   PUBMED   10780674
REFERENCE   9  (bases 1 to 3726)
  AUTHORS   Gianfrancesco,F., Esposito,T., Ciccodicola,A., D'Esposito,M.,
            Mazzarella,R., D'Urso,M. and Forabosco,A.
  TITLE     Molecular cloning and fine mapping of API5L1, a novel human gene
            strongly related to an antiapoptotic gene
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 164-166 (1999)
   PUBMED   10393420
REFERENCE   10 (bases 1 to 3726)
  AUTHORS   Tewari,M., Yu,M., Ross,B., Dean,C., Giordano,A. and Rubin,R.
  TITLE     AAC-11, a novel cDNA that inhibits apoptosis after growth factor
            withdrawal
  JOURNAL   Cancer Res 57 (18), 4063-4069 (1997)
   PUBMED   9307294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087276.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001142930.1.
            
            Summary: This gene encodes an apoptosis inhibitory protein whose
            expression prevents apoptosis after growth factor deprivation. This
            protein suppresses the transcription factor E2F1-induced apoptosis
            and also interacts with, and negatively regulates Acinus, a nuclear
            factor involved in apoptotic DNA fragmentation. Its depletion
            enhances the cytotoxic action of the chemotherapeutic drugs.
            Multiple alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.57111.1,
                                           SRR1803615.23605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000531273.6/ ENSP00000431391.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC087276.13        169270-169470       c
            202-363             AC087276.13        162665-162826       c
            364-457             AC087276.13        160552-160645       c
            458-523             AC087276.13        159990-160055       c
            524-675             AC087276.13        159330-159481       c
            676-882             AC087276.13        157830-158036       c
            883-987             AC087276.13        154855-154959       c
            988-1077            AC087276.13        153588-153677       c
            1078-1259           AC087276.13        152573-152754       c
            1260-1353           AC087276.13        151408-151501       c
            1354-1410           AC087276.13        150902-150958       c
            1411-1487           AC087276.13        146112-146188       c
            1488-1624           AC087276.13        145472-145608       c
            1625-3726           AC087276.13        136937-139038       c
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p12"
     gene            1..3726
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /note="apoptosis inhibitor 5"
                     /db_xref="GeneID:8539"
                     /db_xref="HGNC:HGNC:594"
                     /db_xref="MIM:609774"
     exon            1..201
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1707
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /note="isoform a is encoded by transcript variant 1;
                     fibroblast growth factor 2-interacting factor 2;
                     migration-inducing protein MIG8; FIF; antiapoptosis clone
                     11 protein; cell migration-inducing gene 8 protein"
                     /codon_start=1
                     /product="apoptosis inhibitor 5 isoform a"
                     /protein_id="NP_001136402.1"
                     /db_xref="CCDS:CCDS44572.1"
                     /db_xref="GeneID:8539"
                     /db_xref="HGNC:HGNC:594"
                     /db_xref="MIM:609774"
                     /translation="MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRL
                     AAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADIL
                     TQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLK
                     TLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVA
                     EQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTP
                     VEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNE
                     EPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLR
                     LALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVE
                     IGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYEQRGAFRGSRG
                     GRGWGTRGNRSRGRLY"
     exon            202..363
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            364..457
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            458..523
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            524..675
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            676..882
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            883..987
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1077
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1259
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1353
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1410
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1487
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1624
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..3726
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /note="hexamer: AATAAA"
     polyA_site      3726
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /note="major polyA site"
ORIGIN      
        1 gtgactggcg gctgcactgg cggcagctgg aggtgtaata gtgcgggtag tgggtttgga
       61 gaagttccga ggcggcggtg gcgccggtca ggacaaggat agcggaaccg ggccctgggc
      121 ttgtcgctca ccatgccgac agtagaggag ctttaccgca attatggcat cctggccgat
      181 gccacggagc aagtgggcca gcataaagat gcctatcaag tgatattgga tggtgtgaaa
      241 ggtggtacta aggaaaagcg attagcagct caatttattc cgaaattctt taagcatttt
      301 ccagaattgg ctgattctgc tatcaatgca cagttagacc tctgtgagga tgaagatgta
      361 tctattcgac gtcaagcaat taaagaactg cctcaatttg ccactggaga aaatcttcct
      421 cgagtggcag atatactaac gcaacttttg cagacagatg actctgcaga atttaaccta
      481 gtgaacaatg ccctattaag tatatttaaa atggatgcaa aagggacttt aggtgggttg
      541 ttcagccaaa tacttcaagg agaggacatt gttagagaac gagcaattaa attcctttct
      601 acaaaactta agactttacc agatgaagtc ttaacaaagg aagtggaaga gcttatacta
      661 actgaatcca aaaaggtcct agaagatgtg actggtgaag aatttgttct atttatgaag
      721 atactgtctg ggttaaaaag cttacagaca gtgagtggaa gacagcaact tgtagagttg
      781 gtggctgaac aggccgacct agaacagacc ttcaatccct cggatcctga ctgtgtggac
      841 aggctcttac agtgcactcg gcaggcagta cccctcttct ctaaaaatgt ccattccaca
      901 aggtttgtga catatttctg tgagcaggtt ctccctaacc tcggtacctt gactacccca
      961 gtggaaggtc ttgatataca gttggaggta ttgaaattgt tggcggagat gagttcattt
     1021 tgtggtgaca tggaaaaact agaaacaaat ttaaggaaac tatttgataa gttattggaa
     1081 tacatgcccc tccctccaga agaggcagaa aatggagaga atgctggtaa tgaagaaccc
     1141 aagctacagt tcagttatgt ggaatgtttg ttgtacagtt ttcaccagtt gggccgaaaa
     1201 cttccagatt tcttaacagc caaactgaat gcagaaaagc tcaaagattt caaaatcagg
     1261 ctgcagtact ttgcacgggg cctgcaagtt tatatcagac aacttcgctt agctctccag
     1321 ggtaaaacgg gtgaggcctt aaaaacagaa gagaacaaga ttaaagtcgt tgcattgaaa
     1381 ataacaaaca atatcaatgt tttaatcaag gatctcttcc acattcctcc ttcttataag
     1441 agcacagtaa cactatcctg gaaacctgta caaaaggttg agattgggca aaagagagcc
     1501 agtgaagata caacttcagg ttcaccaccc aagaaatctt cagcaggacc aaaaagagat
     1561 gccaggcaga tttataaccc tcccagtggg aaatatagca gcaatttggg caactttaat
     1621 tatgagcaga gaggagcctt caggggaagt agaggtggcc gaggttgggg cacacgagga
     1681 aatcgtagtc ggggaagact ctactgaata agacatcagc attcttcagc attgtcatga
     1741 gcttaatata cttaaattct actactcatt ggattgccgg ggatgtccct ttaaacagac
     1801 tgctgccttc agctaaaaac ttaatgttct ttataccttt gtatgtatga cctacttttg
     1861 taacagacca tggttgtgtc caaggtaaaa ccacagtgat atttttggat gctttgtctg
     1921 caatcttgac ttgtttttgc agtatcatta ttcagacttc aaattgtgaa tcttttaaac
     1981 atcttgataa tttgttgttg agagctgttc attctaaaat gtaatgaaat tcagtctagt
     2041 tctgctgata aagatcatca gttttgaaag gttactgatt ttcctcttcc ctcttagttt
     2101 tttacccaat atatggagaa gagtaatggt caatcttaac attttgtttt aattgtttaa
     2161 taaagctgct gggcagtggt gcagcattcc tacctagtgt cataaaagca aaatacttac
     2221 atagctttct taaaatatag gaatgacatt acatttttag gagaaagtaa gttgctttgc
     2281 accgcctact taattctttt ccatatattg tgatacaaac ttttgaatat ggaatcttac
     2341 tatttgaata gaaatgtgta tgtataatat acatacatac ataagcatat atgtgtgtgt
     2401 gtgtgtgtat atatatatat atgcatgctg tgaaacttga ctacacaaca taaatcactt
     2461 tttaaattcc aggaacgggt agtctgacac ggtgattatc cttttgaggc tgaatccgtt
     2521 attaacttgt tatttaggtt tttactccca gtagcaaggg attctaagtt agttgcactt
     2581 acatgattat tgttatttaa aactaagaat aaaggctgca ttttcaaaga taaattggaa
     2641 ttgctgttgg tgaaataaca accaaaatac tgaatctgat gtacatacag gtttctacag
     2701 gaagagatgg tataatttac aatttggaga tttaataacc agggctaccc agaaaaagtg
     2761 acttgataac atggtaccaa taagtaaggg atgctctctc ggtttgcttt tgccactttc
     2821 aagattttaa cttctcaggt tattaatcaa aattattgta taagttagcc aatagaattt
     2881 ttaggttaaa acaacagatg gggggtttgt ggagtgttta atgtcatggg catttttagt
     2941 aggatagacc ctttgttctg catttgaatg tttcgtatat ttttgtttca cagttaatct
     3001 tccctcccca agtttgctat tcaaatcaac tgcctgaatg acatttctag tagtctgatg
     3061 tatttttctg aggaatagtt tgtgattcca atgcaggtgt cttcattacc attacctcta
     3121 cactgcagaa gaagcaaaac tcctttatta gaattactgc acatgtgtat ggggaaaata
     3181 gttctgaaag gctagaatga tacaagtgag caaaagttgg tcagcttggc tatggagtgg
     3241 tggcaataat ctctaaacat tccaaaagac catgagctga acctaaactc ccttggaatc
     3301 tgaacaaagg aatataaaat tgccatttga aaactgacca gctaatctgg acctcagaga
     3361 tagatcagcc agtggcccaa agccatttca agtacagaaa ttatagagac tacagctaaa
     3421 taaatttgaa cattaaatat aattttacca ctttttgtct ttataagcat atttgtaaac
     3481 tcagaactga gcagaagtga ctttactttc tcaagtttga tactgagttg actgttccct
     3541 tatccctcac ccttcccctt ccctttccta aggcaatagt gcacaactta ggttattttt
     3601 gcttccgaat ttgaatgaaa aacttaatgc catggatttt tttcttttgc aagacacctg
     3661 tttatcatct tgtttaaatg taaatgtccc cttatgcttt tgaaataaat ttccttttgt
     3721 aatttt
//
