LOCUS       NM_001640               2879 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens acylaminoacyl-peptide hydrolase (APEH), mRNA.
ACCESSION   NM_001640
VERSION     NM_001640.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Tangri,A., Lighty,K., Loganathan,J., Mesmar,F., Podicheti,R.,
            Zhang,C., Iwanicki,M., Drapkin,R., Nakshatri,H. and Mitra,S.
  TITLE     Deubiquitinase UCHL1 Maintains Protein Homeostasis through the
            PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma
  JOURNAL   Mol Cancer Res 19 (7), 1168-1181 (2021)
   PUBMED   33753553
  REMARK    GeneRIF: Deubiquitinase UCHL1 Maintains Protein Homeostasis through
            the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian
            Carcinoma.
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Gogliettino,M., Cocca,E., Sandomenico,A., Gratino,L., Iaccarino,E.,
            Calvanese,L., Rossi,M. and Palmieri,G.
  TITLE     Selective inhibition of acylpeptide hydrolase in SAOS-2
            osteosarcoma cells: is this enzyme a viable anticancer target?
  JOURNAL   Mol Biol Rep 48 (2), 1505-1519 (2021)
   PUBMED   33471263
  REMARK    GeneRIF: Selective inhibition of acylpeptide hydrolase in SAOS-2
            osteosarcoma cells: is this enzyme a viable anticancer target?
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Sharma,K.K. and Ortwerth,B.J.
  TITLE     Description of an acylpeptide hydrolase from lens
  JOURNAL   Exp Eye Res 54 (6), 1005-1010 (1992)
   PUBMED   1521574
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Ginzinger,D.G., Shridhar,V., Baldini,A., Taggart,R.T., Miller,O.J.
            and Smith,D.I.
  TITLE     The human loci DNF15S2 and D3S94 have a high degree of sequence
            similarity to acyl-peptide hydrolase and are located at 3p21.3
  JOURNAL   Am J Hum Genet 50 (4), 826-833 (1992)
   PUBMED   1550126
REFERENCE   8  (bases 1 to 2879)
  AUTHORS   Scaloni,A., Jones,W.M., Barra,D., Pospischil,M., Sassa,S.,
            Popowicz,A., Manning,L.R., Schneewind,O. and Manning,J.M.
  TITLE     Acylpeptide hydrolase: inhibitors and some active site residues of
            the human enzyme
  JOURNAL   J Biol Chem 267 (6), 3811-3818 (1992)
   PUBMED   1740429
REFERENCE   9  (bases 1 to 2879)
  AUTHORS   Erlandsson,R., Boldog,F., Persson,B., Zabarovsky,E.R.,
            Allikmets,R.L., Sumegi,J., Klein,G. and Jornvall,H.
  TITLE     The gene from the short arm of chromosome 3, at D3F15S2, frequently
            deleted in renal cell carcinoma, encodes acylpeptide hydrolase
  JOURNAL   Oncogene 6 (7), 1293-1295 (1991)
   PUBMED   1861871
REFERENCE   10 (bases 1 to 2879)
  AUTHORS   Jones,W.M., Scaloni,A., Bossa,F., Popowicz,A.M., Schneewind,O. and
            Manning,J.M.
  TITLE     Genetic relationship between acylpeptide hydrolase and acylase, two
            hydrolytic enzymes with similar binding but different catalytic
            specificities
  JOURNAL   Proc Natl Acad Sci U S A 88 (6), 2194-2198 (1991)
   PUBMED   2006156
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099668.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_001640.3.
            
            Summary:  This gene encodes the enzyme acylpeptide hydrolase, which
            catalyzes the hydrolysis of the terminal acetylated amino acid
            preferentially from small acetylated peptides. The acetyl amino
            acid formed by this hydrolase is further processed to acetate and a
            free amino acid by an aminoacylase. This gene is located within the
            same region of chromosome 3 (3p21) as the aminoacylase gene, and
            deletions at this locus are also associated with a decrease in
            aminoacylase activity. The acylpeptide hydrolase is a
            homotetrameric protein of 300 kDa with each subunit consisting of
            732 amino acid residues. It can play an important role in
            destroying oxidatively damaged proteins in living cells. Deletions
            of this gene locus are found in various types of carcinomas,
            including small cell lung carcinoma and renal cell carcinoma.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.209063.1,
                                           SRR1803611.42799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296456.10/ ENSP00000296456.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC099668.2         61860-61922         c
            64-196              AC099668.2         61652-61784         c
            197-323             AC099668.2         60964-61090         c
            324-417             AC099668.2         60486-60579         c
            418-493             AC099668.2         60307-60382         c
            494-657             AC099668.2         60054-60217         c
            658-795             AC099668.2         59758-59895         c
            796-887             AC099668.2         59573-59664         c
            888-928             AC099668.2         59456-59496         c
            929-1050            AC099668.2         59249-59370         c
            1051-1111           AC099668.2         58640-58700         c
            1112-1209           AC099668.2         57324-57421         c
            1210-1261           AC099668.2         56629-56680         c
            1262-1350           AC099668.2         55644-55732         c
            1351-1489           AC099668.2         55034-55172         c
            1490-1573           AC099668.2         54468-54551         c
            1574-1654           AC099668.2         54306-54386         c
            1655-1743           AC099668.2         53837-53925         c
            1744-1934           AC099668.2         53537-53727         c
            1935-2037           AC099668.2         53328-53430         c
            2038-2144           AC099668.2         53127-53233         c
            2145-2879           AC099668.2         52302-53036         c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2879
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /note="acylaminoacyl-peptide hydrolase"
                     /db_xref="GeneID:327"
                     /db_xref="HGNC:HGNC:586"
                     /db_xref="MIM:102645"
     exon            1..63
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..2250
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /EC_number="3.4.19.1"
                     /note="acylaminoacyl-peptidase; oxidized protein
                     hydrolase; acyl-peptide hydrolase; N-acylaminoacyl-peptide
                     hydrolase"
                     /codon_start=1
                     /product="acylamino-acid-releasing enzyme"
                     /protein_id="NP_001631.3"
                     /db_xref="CCDS:CCDS2801.1"
                     /db_xref="GeneID:327"
                     /db_xref="HGNC:HGNC:586"
                     /db_xref="MIM:102645"
                     /translation="MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGQYR
                     TVHTEWTQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTM
                     KAVLRKAGGTGPGEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSET
                     HLLYVAEKKRPKAESFFQTKALDVSASDDEIARLKKPDQAIKGDQFVFYEDWGENMVS
                     KSIPVLCVLDVESGNISVLEGVPENVSPGQAFWAPGDAGVVFVGWWHEPFRLGIRFCT
                     NRRSALYYVDLIGGKCELLSDDSLAVSSPRLSPDQCRIVYLQYPSLIPHHQCSQLCLY
                     DWYTKVTSVVVDVVPRQLGENFSGIYCSLLPLGCWSADSQRVVFDSAQRSRQDLFAVD
                     TQVGTVTSLTAGGSGGSWKLLTIDQDLMVAQFSTPSLPPTLKVGFLPSAGKEQSVLWV
                     SLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEAILLQPGSPPDKTQVPMVVMPHG
                     GPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFA
                     VEQVLQEEHFDASHVALMGGSHGGFISCHLIGQYPETYRACVARNPVINIASMLGSTD
                     IPDWCVVEAGFPFSSDCLPDLSVWAEMLDKSPIRYIPQVKTPLLLMLGQEDRRVPFKQ
                     GMEYYRALKTRNVPVRLLLYPKSTHALSEVEVESDSFMNAVLWLRTHLGS"
     exon            64..196
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            197..323
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            324..417
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            418..493
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            494..657
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            658..795
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            796..887
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            888..928
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1050
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1111
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1209
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1261
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1350
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1489
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1573
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1654
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1743
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1934
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2037
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2144
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2879
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2394..2399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /note="hexamer: AATAAA"
     polyA_site      2411
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /note="major polyA site"
     regulatory      2861..2866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
                     /note="hexamer: CATAAA"
     polyA_site      2879
                     /gene="APEH"
                     /gene_synonym="AARE; ACPH; APH; D3F15S2; D3S48E; DNF15S2;
                     OPH"
ORIGIN      
        1 acttccgggc gcgagcacgc cccgcctcgc cccggcggca gagaggagac tatggaacgt
       61 caggtgctgc tgagcgagcc cgaggaggcg gcggctctgt atcggggcct tagccgccag
      121 cccgcgctga gcgccgcctg cctgggcccg gaggtcacca cgcagtacgg cggccaatac
      181 cggacggtgc acactgagtg gacccagagg gacctggaac gcatggagaa cattcgattc
      241 tgccgccaat acctggtgtt ccatgacggg gactcagtgg tgtttgcagg acctgcaggc
      301 aacagtgtgg agacccgggg ggaactgctg agcagagagt ctccttcagg caccatgaaa
      361 gctgtgctgc gcaaggctgg aggcacgggc cctggggaag agaagcagtt cctggaggtc
      421 tgggagaaga accggaagct caagagcttc aacctgtcag cgctggagaa acatgggcct
      481 gtttatgagg atgactgctt tggctgcctg tcctggtcgc actcggagac acacttgttg
      541 tatgtggcag agaagaagcg ccccaaggcc gagtccttct ttcagaccaa agccttggac
      601 gtcagtgcca gcgatgatga gatagccagg ctgaagaagc cagaccaagc catcaagggg
      661 gatcagtttg tgttttatga agactgggga gaaaacatgg tttccaaaag catccctgtg
      721 ctctgcgtgc tggatgtcga gagtggcaac atctctgtgc ttgagggggt ccctgagaat
      781 gtgtcccctg gacaggcatt ttgggcccct ggagatgctg gtgtggtgtt tgtgggctgg
      841 tggcatgagc ccttccggtt gggcatccgc ttttgcacca atcgcaggtc agccctgtat
      901 tatgtggacc tcatcggggg gaagtgtgag ctcctctcgg atgactccct ggctgtctct
      961 tctccccggc tgagcccaga ccaatgtcgc attgtctacc tgcagtaccc atctctgatc
     1021 ccccatcacc aatgcagcca gctgtgcctg tatgactggt ataccaaggt tacctcagtg
     1081 gtggtagatg ttgtgcctcg gcagctggga gagaacttct ctgggatcta ctgcagcctt
     1141 ctgcctttgg gatgctggtc agctgacagc cagagagtgg tctttgactc ggctcagcgc
     1201 agccggcagg acctgtttgc tgtggacacc caagtgggca ctgtgacctc cctcacagct
     1261 ggagggtcag gtgggagctg gaagttgctc acaattgacc aggacctcat ggtggcacag
     1321 ttttccacac ccagcctacc tccaaccctg aaagttgggt tcctgccttc tgcagggaag
     1381 gagcagtcag tgttgtgggt gtccctggag gaggccgagc ccattcccga catccactgg
     1441 ggcatccggg tgctacagcc acccccagag caagagaatg tgcagtatgc tggccttgac
     1501 tttgaagcaa tcctgctgca gcctggcagc cctccagata agacccaagt gcccatggtg
     1561 gtcatgcccc acggggggcc ccattcatcc tttgtcactg cctggatgct gttcccagcc
     1621 atgctttgca agatgggctt tgcggtacta ctagtgaact atcgtggctc cacgggcttt
     1681 ggccaggaca gcatcctctc cctcccaggc aatgtgggcc accaggatgt gaaggatgtc
     1741 cagtttgcag tggaacaggt gctccaggag gaacactttg atgcaagcca tgtggccctt
     1801 atgggtggtt cccatggtgg cttcatttcc tgccacttga ttggtcagta cccagagacc
     1861 tacagggcct gcgtggcccg gaaccccgtg atcaacatcg cctccatgtt gggctccact
     1921 gacatccctg actggtgcgt ggtggaggct ggctttcctt tcagcagtga ctgcctgcca
     1981 gacctcagcg tgtgggctga gatgctggac aaatcgccca tcagatacat ccctcaggtg
     2041 aagacaccac tgttactgat gttgggccag gaggaccggc gtgtgccctt caagcagggc
     2101 atggagtatt accgtgccct caagacccgg aatgtgcctg ttcggctcct gctctatccc
     2161 aaaagcaccc acgcattatc agaggtggag gtggagtcag acagcttcat gaatgctgtg
     2221 ctctggctac gcacacactt gggcagctga agccctgcca ttctgcatga gctgatcagc
     2281 ctgtgccaca cttcgctctt gaggagctca acggtctggc agggcagcag gaggctttct
     2341 gggctctgga ctccacggat gcgtgggcag aggaatgtgg gctatgtagt cataataaat
     2401 taggacacag agcctggttc ctgctggtac tttgtaccaa accatcccca accccacctc
     2461 ccactctggg gtgcagagac cctaggttct gggtgtggca gccacaaggg cttcatctgc
     2521 ctccagtgtg agaagggagg gaacagtgag aggcttagcc tctgcctgtc ctggcaacca
     2581 ggactctgta ccagcctagc ttccctgctg cagccccttc cattagcaac tactctgtac
     2641 cacccttccc aagagtatgt ctggaggact agtgtgaggc cctgtctttc cacggcaccc
     2701 atgggcaaaa gtagtcccag ggacattgcc ttggttgggg aagcccctag gctggacaga
     2761 tcacctagcc cagggtgtgc tgggctcaag ccacccgagc cctagcaagg agtcactgac
     2821 acatttcctg gaagcaaagg ctaagaagca tctgtacagg cataaagagg aaacatggc
//
