LOCUS       NM_001639                925 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens amyloid P component, serum (APCS), mRNA.
ACCESSION   NM_001639
VERSION     NM_001639.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 925)
  AUTHORS   Wang,L., Liang,D., Huang,Y., Chen,Y., Yang,X., Huang,Z., Jiang,Y.,
            Su,H., Wang,L., Pathak,J.L. and Ge,L.
  TITLE     SAP deficiency aggravates periodontitis possibly via C5a-C5aR
            signaling-mediated defective macrophage phagocytosis of
            Porphyromonas gingivalis
  JOURNAL   J Adv Res 50, 55-68 (2023)
   PUBMED   36243399
  REMARK    GeneRIF: SAP deficiency aggravates periodontitis possibly via
            C5a-C5aR signaling-mediated defective macrophage phagocytosis of
            Porphyromonas gingivalis.
REFERENCE   2  (bases 1 to 925)
  AUTHORS   Levitte,S., Peale,F.V., Jhun,I., McBride,J. and Neighbors,M.
  TITLE     Local Pentraxin-2 Deficit Is a Feature of Intestinal Fibrosis in
            Crohn's Disease
  JOURNAL   Dig Dis Sci 68 (7), 2975-2980 (2023)
   PUBMED   36884186
  REMARK    GeneRIF: Local Pentraxin-2 Deficit Is a Feature of Intestinal
            Fibrosis in Crohn's Disease.
REFERENCE   3  (bases 1 to 925)
  AUTHORS   Kaur,B., Dixit,R., Bakshi,S., Konar,M., Sinha,S.K., Duseja,A.K. and
            Sharma,S.
  TITLE     Proteomic-based identification of APCS as candidate protein for
            diagnosis of patients exhibiting anti-tubercular drug induced liver
            injury
  JOURNAL   Sci Rep 13 (1), 10135 (2023)
   PUBMED   37349331
  REMARK    GeneRIF: Proteomic-based identification of APCS as candidate
            protein for diagnosis of patients exhibiting anti-tubercular drug
            induced liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 925)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 925)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 925)
  AUTHORS   Swanson,S.J., Christner,R.B. and Mortensen,R.F.
  TITLE     Human serum amyloid P-component (SAP) selectively binds to
            immobilized or bound forms of C-reactive protein (CRP)
  JOURNAL   Biochim Biophys Acta 1160 (3), 309-316 (1992)
   PUBMED   1477104
REFERENCE   7  (bases 1 to 925)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 925)
  AUTHORS   Ohnishi,S., Maeda,S., Shimada,K. and Arao,T.
  TITLE     Isolation and characterization of the complete complementary and
            genomic DNA sequences of human serum amyloid P component
  JOURNAL   J Biochem 100 (4), 849-858 (1986)
   PUBMED   3029048
REFERENCE   9  (bases 1 to 925)
  AUTHORS   Mantzouranis,E.C., Dowton,S.B., Whitehead,A.S., Edge,M.D.,
            Bruns,G.A. and Colten,H.R.
  TITLE     Human serum amyloid P component. cDNA isolation, complete sequence
            of pre-serum amyloid P component, and localization of the gene to
            chromosome 1
  JOURNAL   J Biol Chem 260 (12), 7752-7756 (1985)
   PUBMED   2987268
REFERENCE   10 (bases 1 to 925)
  AUTHORS   Thompson,A.R. and Enfield,D.L.
  TITLE     Human plasma P component: isolation and characterization
  JOURNAL   Biochemistry 17 (20), 4304-4311 (1978)
   PUBMED   81686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X04608.1, AL445528.16 and
            BC007058.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001639.3.
            
            Summary: The protein encoded by this gene is a glycoprotein,
            belonging to the pentraxin family of proteins, which has a
            characteristic pentameric organization. These family members have
            considerable sequence homology which is thought to be the result of
            gene duplication. The binding of the encoded protein to proteins in
            the pathological amyloid cross-beta fold suggests its possible role
            as a chaperone. This protein is also thought to control the
            degradation of chromatin. It has been demonstrated that this
            protein binds to apoptotic cells at an early stage, which raises
            the possibility that it is involved in dealing with apoptotic cells
            in vivo. [provided by RefSeq, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007058.1, FJ460512.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255040.3/ ENSP00000255040.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               X04608.1           1-527
            528-528             AL445528.16        6714-6714
            529-925             BC007058.1         529-925
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..925
                     /gene="APCS"
                     /gene_synonym="HEL-S-92n; PTX2; SAP"
                     /note="amyloid P component, serum"
                     /db_xref="GeneID:325"
                     /db_xref="HGNC:HGNC:584"
                     /db_xref="MIM:104770"
     exon            1..160
                     /gene="APCS"
                     /gene_synonym="HEL-S-92n; PTX2; SAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..768
                     /gene="APCS"
                     /gene_synonym="HEL-S-92n; PTX2; SAP"
                     /note="pentaxin-related; 9.5S alpha-1-glycoprotein; serum
                     amyloid P-component; epididymis secretory sperm binding
                     protein Li 92n; pentraxin-related; pentraxin-2"
                     /codon_start=1
                     /product="serum amyloid P-component precursor"
                     /protein_id="NP_001630.1"
                     /db_xref="CCDS:CCDS1186.1"
                     /db_xref="GeneID:325"
                     /db_xref="HGNC:HGNC:584"
                     /db_xref="MIM:104770"
                     /translation="MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITP
                     LEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSK
                     VIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYG
                     GKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIK
                     PLVWV"
     exon            161..925
                     /gene="APCS"
                     /gene_synonym="HEL-S-92n; PTX2; SAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      897..902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APCS"
                     /gene_synonym="HEL-S-92n; PTX2; SAP"
                     /note="hexamer: ATTAAA"
     polyA_site      925
                     /gene="APCS"
                     /gene_synonym="HEL-S-92n; PTX2; SAP"
                     /note="major polyA site"
ORIGIN      
        1 gggcatgaat atcagacgct agggggacag ccactgtgtt gtctgctacc ctcatcctgg
       61 tcactgcttc tgctataaca gccctaggcc aggaatatga acaagccgct gctttggatc
      121 tctgtcctca ccagcctcct ggaagccttt gctcacacag acctcagtgg gaaggtgttt
      181 gtatttccta gagaatctgt tactgatcat gtaaacttga tcacaccgct ggagaagcct
      241 ctacagaact ttaccttgtg ttttcgagcc tatagtgatc tctctcgtgc ctacagcctc
      301 ttctcctaca atacccaagg cagggataat gagctactag tttataaaga aagagttgga
      361 gagtatagtc tatacattgg aagacacaaa gttacatcca aagttatcga aaagttcccg
      421 gctccagtgc acatctgtgt gagctgggag tcctcatcag gtattgctga attttggatc
      481 aatgggacac ctttggtgaa aaagggtctg cgacagggtt actttgtaga agctcagccc
      541 aagattgtcc tggggcagga acaggattcc tatgggggca agtttgatag gagccagtcc
      601 tttgtgggag agattgggga tttgtacatg tgggactctg tgctgccccc agaaaatatc
      661 ctgtctgcct atcagggtac ccctctccct gccaatatcc tggactggca ggctctgaac
      721 tatgaaatca gaggatatgt catcatcaaa cccttggtgt gggtctgagg tcttgactca
      781 acgagagcac ttgaaaatga aatgactgtc taagagatct ggtcaaagca actggatact
      841 agatcttaca tctgcagctc tttcttcttt gaatttccta tctgtatgtc tgcctaatta
      901 aaaaaatata tattgtatta tgcta
//
