LOCUS       NM_153360               3887 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens APC down-regulated 1 like (APCDD1L), transcript
            variant 1, mRNA.
ACCESSION   NM_153360
VERSION     NM_153360.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3887)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3887)
  AUTHORS   Jukkola,T., Sinjushina,N. and Partanen,J.
  TITLE     Drapc1 expression during mouse embryonic development
  JOURNAL   Gene Expr Patterns 4 (6), 755-762 (2004)
   PUBMED   15465500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL118513.17, DA665037.1, AK074647.1 and BQ018966.1.
            
            On May 17, 2019 this sequence version replaced NM_153360.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074647.1, BC101758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151887, SAMEA2162328
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371149.8/ ENSP00000360191.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AL118513.17        66217-66677         c
            462-506             DA665037.1         1-45
            507-2515            AK074647.1         1-2009
            2516-3243           AL118513.17        11023-11750         c
            3244-3887           BQ018966.1         14-657              c
FEATURES             Location/Qualifiers
     source          1..3887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..3887
                     /gene="APCDD1L"
                     /note="APC down-regulated 1 like"
                     /db_xref="GeneID:164284"
                     /db_xref="HGNC:HGNC:26892"
     exon            1..741
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             693..2198
                     /gene="APCDD1L"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein APCDD1-like; adenomatosis polyposis
                     coli down-regulated 1 like"
                     /codon_start=1
                     /product="protein APCDD1-like isoform 1 precursor"
                     /protein_id="NP_699191.1"
                     /db_xref="CCDS:CCDS13467.1"
                     /db_xref="GeneID:164284"
                     /db_xref="HGNC:HGNC:26892"
                     /translation="MPAAMLPYACVLVLLGAHTAPAAGEAGGSCLRWEPHCQQPLPDR
                     VPSTAILPPRLNGPWISTGCEVRPGPEFLTRAYTFYPSRLFRAHQFYYEDPFCGEPAH
                     SLLVKGKVRLRRASWVTRGATEADYHLHKVGIVFHSRRALVDVTGRLNQTRAGRDCAR
                     RLPPARAWLPGALYELRSARAQGDCLEALGLTMHELSLVRVQRRLQPQPRASPRLVEE
                     LYLGDIHTDPAERRHYRPTGYQRPLQSALHHVQPCPACGLIARSDVHHPPVLPPPLAL
                     PLHLGGWWVSSGCEVRPAVLFLTRLFTFHGHSRSWEGYYHHFSDPACRQPTFTVYAAG
                     RYTRGTPSTRVRGGTELVFEVTRAHVTPMDQVTTAMLNFSEPSSCGGAGAWSMGTERD
                     VTATNGCLPLGIRLPHVEYELFKMEQDPLGQSLLFIGQRPTDGSSPDTPEKRPTSYQA
                     PLVLCHGEAPDFSRPPQHRPSLQKHPSTGGLHIAPFPLLPLVLGLAFLHWL"
     exon            742..880
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1433
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..3887
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3870..3875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APCDD1L"
                     /note="hexamer: ATTAAA"
     polyA_site      3887
                     /gene="APCDD1L"
                     /note="major polyA site"
ORIGIN      
        1 acactttgcc tagatgcgtt tgggtgtggt ggggagcggg tgacggcctc atttacagac
       61 agaggccggg gctggcttct aggcgaccgg gttggccact ttcactgcgc ttctgggttt
      121 gctgggatcc aagttgacgc gacttttcca ggagtagctg gaagacctga atagaaactt
      181 caggggtccc aggactggcg gggcttagag gaactccccg ccccgcttgc ccttccaggg
      241 aacggcctgg ctaggggtgc gctttgacgc aaggagcgca tcgctctgcc ttggccggga
      301 ccagagcttg ggggaggcct ccttgcccac tgcgaagact ttggggaagg cgacggccag
      361 gggacggaca tctgggggag ggctgggggt ctgaatggca ggagctgcac cagggggctg
      421 tgcgcgctgc gcgggtgtgc gcgcctcgcc gggggctgtc tccacctctt ctggcaagtt
      481 ggacctatga gtgcgcagct ccgcttacaa ctatcaacag ccgggaaggc tgagcgcgtg
      541 tgagcgccga ggggggcgca ggaccctcgc aacttcttcg caggactcca gcctggccgc
      601 cggcgcccgc agccgtccga gagccctgcg cccgcgcctc cccttgcgca ccgtggcagc
      661 gcccggcggg cggtcctgcc agccccgacg ggatgcccgc agccatgctc ccctacgctt
      721 gcgtcctggt gcttttggga gcccacactg caccggcggc tggggaggcc gggggcagct
      781 gcctgcgctg ggaaccccac tgccagcagc ccttgccaga tagagtgccc agcactgcga
      841 tcctgcctcc acgccttaat ggaccttgga tctccacagg ctgcgaggtg cgcccaggac
      901 cggagttcct gacccgcgcc tacaccttct accccagccg gctctttcga gcccaccagt
      961 tctactacga ggaccccttc tgcggggaac ctgcccactc gctgctcgtc aagggcaaag
     1021 tccgcctgcg ccgggcctcc tgggtcaccc ggggagccac cgaggccgac taccacctgc
     1081 acaaggtggg catcgtcttc cacagccgcc gggccctggt cgacgtcacc gggcgcctca
     1141 accagacccg cgccggccgg gactgcgcgc ggcggctgcc tccggcccgg gcctggctgc
     1201 ctggggcgct gtacgagctg cggagcgccc gggctcaggg ggactgcctg gaggcgctgg
     1261 gcctcaccat gcacgagctc agcctggtcc gcgtgcagcg ccgcctgcag ccgcagcccc
     1321 gggcgtcgcc ccggctggtg gaggagctgt acctggggga catccacacc gacccggcgg
     1381 agaggcggca ctaccggccc acgggctacc agcgcccgct gcagagcgca ctgcaccacg
     1441 tgcagccgtg cccagcctgt ggcctcattg cccgctccga tgtgcaccac ccgcccgtgc
     1501 tgccgccccc tctggccctg cccctgcacc tgggcggctg gtgggtcagc tcggggtgcg
     1561 aggtgcgccc agcagtcctg ttcctcaccc ggctcttcac tttccacggg cacagccgct
     1621 cctgggaagg gtattaccac cacttctcag acccagcctg ccggcagccc accttcaccg
     1681 tgtatgccgc cggccgctac accaggggca cgccatccac cagggtccgc ggcggcaccg
     1741 agctggtgtt tgaggtcaca cgggcccatg tgacccccat ggaccaggtc accacggcca
     1801 tgctcaactt ctctgagcca agcagctgtg ggggtgcggg ggcctggtcc atgggcactg
     1861 agcgggatgt cacagccacc aacggctgcc taccgctggg catccggctc ccgcatgtgg
     1921 agtacgagct tttcaagatg gaacaagacc ccctcgggca aagcctgctc ttcatcggac
     1981 aaaggcccac cgatggctca agtcccgata ccccagagaa acgtcccacc tcctaccaag
     2041 cacccctggt gctctgtcat ggggaggccc ccgacttctc caggccaccg cagcacaggc
     2101 catcgctgca gaagcacccc agcacagggg gtcttcacat agcccccttc ccacttctgc
     2161 ccctagttct agggctggcc ttcctccact ggctatgaca ttggacttga catcaggatg
     2221 gcggctctgg acacccattc aacccttcag actccctcct ggcagctgta gggaaggaac
     2281 cattctcctc tgctctgtca tggatggatg cacagcccca ctgcttccaa actctgcctg
     2341 tgtcccatgt ggctcaggac atgagcttaa cccctgcaaa gcctatacca catcccacag
     2401 cccgggtccc cagtcaagca cttggatgcg gcagtgatgt tcatcgctac gtgagtttct
     2461 aaagatcact cccaattttt ctactttcct catccttggc agctcgccaa caggtgcagt
     2521 cagggggcca cacggaacac ccccatccca tgttcccccc agttcttccc atcctgaccc
     2581 ttgggattcc aagatgggag caagaggaga tcctgaggct ctgcctaggg acgaggccta
     2641 cagttctgcc atgtctgtag gttgttgttt aaagattatt aattcgaatt tagcaatacg
     2701 atctctaagt ggtgccatga attaaagatg ccacttcggg ctttcagtgc ttctcagctt
     2761 ttgggcaaag ggcttgtgtc ttcaggggca gctcagcttt cctgagtcct gactgctggc
     2821 attcgtctgc atttgcctgt gcttctgcga gtcggacctc aagctgccaa cactgcatgt
     2881 ggataaatcc agttttcccg ggccagcatg caaaatgaag aggactccat ctaagctgag
     2941 aagcatggcc tccccagagc agcctgcggc ctccaagcct tcctggccca ggcaaatgcc
     3001 agtgtgcacc aggctggctg ctgggggcag gtctttggag gggagcagca tttccagcct
     3061 tctgaacata gttaatagta atgacagccg taacactaac gcgctctgca attcgccctg
     3121 cccagccatc ctcggttgcc aagattgcct gtgcctgcct gacaaaggaa gagaatctcc
     3181 gaatgtgtat ctttgggccc accctaggga gaggtcgggg tcaccaggct acatggcgac
     3241 atctaggcag ctccgccttg cccagcctcc ttgccataat cctaatatat tggtgtcctc
     3301 tgctcagagg ggactgtcat catggtggga acaggctgtg cctccccagg gactctgccc
     3361 atgttcccag ggcctcatct gtacactgtg aaattaactg gcatcctggt gggcccaagg
     3421 gttttcagga ctgggggcca atgactcacc ccctccttcc tcctcctgat ccctatctct
     3481 agctcttatc acagattttg aacaattgtc tgtgaggtta atgatggttt cagagggaag
     3541 cccttttcct ccctgagact gtgtggggtt cagtcagcct gctgaaattg cttccactta
     3601 ttacccatcc ttcctcttaa aaaaaaaaaa agcccaccaa gttagtattc tctgtagctc
     3661 tcagacagct acaagtgttc ctggcatatt taccaaagta caagaaatca ttacattatt
     3721 tacggtctca gactacatca gggttggggg agctcctggt ggggatggca gtgggtgtcg
     3781 atgatatgtc cacggctgag caggtcttgt atccgaagct tgaagtaacc atgccaccat
     3841 ttatcatcaa atttgaacct tttaataaaa ttaaacagcc tgaaaaa
//
