LOCUS       NM_001304787            4058 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens APC down-regulated 1 like (APCDD1L), transcript
            variant 2, mRNA.
ACCESSION   NM_001304787
VERSION     NM_001304787.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4058)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4058)
  AUTHORS   Jukkola,T., Sinjushina,N. and Partanen,J.
  TITLE     Drapc1 expression during mouse embryonic development
  JOURNAL   Gene Expr Patterns 4 (6), 755-762 (2004)
   PUBMED   15465500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL118513.17, DA665037.1, AK293299.1, AK074647.1 and BQ018966.1.
            
            On May 31, 2019 this sequence version replaced NM_001304787.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' region and initiates translation at an alternate start
            codon, compared to variant 1. The encoded isoform (2) has a
            distinct N-terminus and is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293299.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2151887,
                                           SAMEA2162328 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AL118513.17        66217-66677         c
            462-502             DA665037.1         1-41
            503-950             AK293299.1         1-448
            951-2686            AK074647.1         274-2009
            2687-3414           AL118513.17        11023-11750         c
            3415-4058           BQ018966.1         14-657              c
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..4058
                     /gene="APCDD1L"
                     /note="APC down-regulated 1 like"
                     /db_xref="GeneID:164284"
                     /db_xref="HGNC:HGNC:26892"
     exon            1..741
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     exon            742..912
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             831..2369
                     /gene="APCDD1L"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein APCDD1-like; adenomatosis polyposis coli
                     down-regulated 1 like"
                     /codon_start=1
                     /product="protein APCDD1-like isoform 2"
                     /protein_id="NP_001291716.1"
                     /db_xref="GeneID:164284"
                     /db_xref="HGNC:HGNC:26892"
                     /translation="MAENSGPGVRPPGWEAQINIISTRLALAHTAPAAGEAGGSCLRW
                     EPHCQQPLPDRVPSTAILPPRLNGPWISTGCEVRPGPEFLTRAYTFYPSRLFRAHQFY
                     YEDPFCGEPAHSLLVKGKVRLRRASWVTRGATEADYHLHKVGIVFHSRRALVDVTGRL
                     NQTRAGRDCARRLPPARAWLPGALYELRSARAQGDCLEALGLTMHELSLVRVQRRLQP
                     QPRASPRLVEELYLGDIHTDPAERRHYRPTGYQRPLQSALHHVQPCPACGLIARSDVH
                     HPPVLPPPLALPLHLGGWWVSSGCEVRPAVLFLTRLFTFHGHSRSWEGYYHHFSDPAC
                     RQPTFTVYAAGRYTRGTPSTRVRGGTELVFEVTRAHVTPMDQVTTAMLNFSEPSSCGG
                     AGAWSMGTERDVTATNGCLPLGIRLPHVEYELFKMEQDPLGQSLLFIGQRPTDGSSPD
                     TPEKRPTSYQAPLVLCHGEAPDFSRPPQHRPSLQKHPSTGGLHIAPFPLLPLVLGLAF
                     LHWL"
     exon            913..1051
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1604
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..4058
                     /gene="APCDD1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APCDD1L"
                     /note="hexamer: ATTAAA"
     polyA_site      4058
                     /gene="APCDD1L"
                     /note="major polyA site"
ORIGIN      
        1 acactttgcc tagatgcgtt tgggtgtggt ggggagcggg tgacggcctc atttacagac
       61 agaggccggg gctggcttct aggcgaccgg gttggccact ttcactgcgc ttctgggttt
      121 gctgggatcc aagttgacgc gacttttcca ggagtagctg gaagacctga atagaaactt
      181 caggggtccc aggactggcg gggcttagag gaactccccg ccccgcttgc ccttccaggg
      241 aacggcctgg ctaggggtgc gctttgacgc aaggagcgca tcgctctgcc ttggccggga
      301 ccagagcttg ggggaggcct ccttgcccac tgcgaagact ttggggaagg cgacggccag
      361 gggacggaca tctgggggag ggctgggggt ctgaatggca ggagctgcac cagggggctg
      421 tgcgcgctgc gcgggtgtgc gcgcctcgcc gggggctgtc tccacctctt ctggcaagtt
      481 ggacctatga gtgcgcagct ccgcttacaa ctatcaacag ccgggaaggc tgagcgcgtg
      541 tgagcgccga ggggggcgca ggaccctcgc aacttcttcg caggactcca gcctggccgc
      601 cggcgcccgc agccgtccga gagccctgcg cccgcgcctc cccttgcgca ccgtggcagc
      661 gcccggcggg cggtcctgcc agccccgacg ggatgcccgc agccatgctc ccctacgctt
      721 gcgtcctggt gcttttggga ggggcccagt caccactgac aaaaatgaca gtaaccacag
      781 ttgaagtgtg cccagctggg ggctcatccc caagcaccct cacattatga atggctgaga
      841 attctggccc tggagttaga ccacctggct gggaagccca gatcaacatc atatcaaccc
      901 gtctggcttt ggcccacact gcaccggcgg ctggggaggc cgggggcagc tgcctgcgct
      961 gggaacccca ctgccagcag cccttgccag atagagtgcc cagcactgcg atcctgcctc
     1021 cacgccttaa tggaccttgg atctccacag gctgcgaggt gcgcccagga ccggagttcc
     1081 tgacccgcgc ctacaccttc taccccagcc ggctctttcg agcccaccag ttctactacg
     1141 aggacccctt ctgcggggaa cctgcccact cgctgctcgt caagggcaaa gtccgcctgc
     1201 gccgggcctc ctgggtcacc cggggagcca ccgaggccga ctaccacctg cacaaggtgg
     1261 gcatcgtctt ccacagccgc cgggccctgg tcgacgtcac cgggcgcctc aaccagaccc
     1321 gcgccggccg ggactgcgcg cggcggctgc ctccggcccg ggcctggctg cctggggcgc
     1381 tgtacgagct gcggagcgcc cgggctcagg gggactgcct ggaggcgctg ggcctcacca
     1441 tgcacgagct cagcctggtc cgcgtgcagc gccgcctgca gccgcagccc cgggcgtcgc
     1501 cccggctggt ggaggagctg tacctggggg acatccacac cgacccggcg gagaggcggc
     1561 actaccggcc cacgggctac cagcgcccgc tgcagagcgc actgcaccac gtgcagccgt
     1621 gcccagcctg tggcctcatt gcccgctccg atgtgcacca cccgcccgtg ctgccgcccc
     1681 ctctggccct gcccctgcac ctgggcggct ggtgggtcag ctcggggtgc gaggtgcgcc
     1741 cagcagtcct gttcctcacc cggctcttca ctttccacgg gcacagccgc tcctgggaag
     1801 ggtattacca ccacttctca gacccagcct gccggcagcc caccttcacc gtgtatgccg
     1861 ccggccgcta caccaggggc acgccatcca ccagggtccg cggcggcacc gagctggtgt
     1921 ttgaggtcac acgggcccat gtgaccccca tggaccaggt caccacggcc atgctcaact
     1981 tctctgagcc aagcagctgt gggggtgcgg gggcctggtc catgggcact gagcgggatg
     2041 tcacagccac caacggctgc ctaccgctgg gcatccggct cccgcatgtg gagtacgagc
     2101 ttttcaagat ggaacaagac cccctcgggc aaagcctgct cttcatcgga caaaggccca
     2161 ccgatggctc aagtcccgat accccagaga aacgtcccac ctcctaccaa gcacccctgg
     2221 tgctctgtca tggggaggcc cccgacttct ccaggccacc gcagcacagg ccatcgctgc
     2281 agaagcaccc cagcacaggg ggtcttcaca tagccccctt cccacttctg cccctagttc
     2341 tagggctggc cttcctccac tggctatgac attggacttg acatcaggat ggcggctctg
     2401 gacacccatt caacccttca gactccctcc tggcagctgt agggaaggaa ccattctcct
     2461 ctgctctgtc atggatggat gcacagcccc actgcttcca aactctgcct gtgtcccatg
     2521 tggctcagga catgagctta acccctgcaa agcctatacc acatcccaca gcccgggtcc
     2581 ccagtcaagc acttggatgc ggcagtgatg ttcatcgcta cgtgagtttc taaagatcac
     2641 tcccaatttt tctactttcc tcatccttgg cagctcgcca acaggtgcag tcagggggcc
     2701 acacggaaca cccccatccc atgttccccc cagttcttcc catcctgacc cttgggattc
     2761 caagatggga gcaagaggag atcctgaggc tctgcctagg gacgaggcct acagttctgc
     2821 catgtctgta ggttgttgtt taaagattat taattcgaat ttagcaatac gatctctaag
     2881 tggtgccatg aattaaagat gccacttcgg gctttcagtg cttctcagct tttgggcaaa
     2941 gggcttgtgt cttcaggggc agctcagctt tcctgagtcc tgactgctgg cattcgtctg
     3001 catttgcctg tgcttctgcg agtcggacct caagctgcca acactgcatg tggataaatc
     3061 cagttttccc gggccagcat gcaaaatgaa gaggactcca tctaagctga gaagcatggc
     3121 ctccccagag cagcctgcgg cctccaagcc ttcctggccc aggcaaatgc cagtgtgcac
     3181 caggctggct gctgggggca ggtctttgga ggggagcagc atttccagcc ttctgaacat
     3241 agttaatagt aatgacagcc gtaacactaa cgcgctctgc aattcgccct gcccagccat
     3301 cctcggttgc caagattgcc tgtgcctgcc tgacaaagga agagaatctc cgaatgtgta
     3361 tctttgggcc caccctaggg agaggtcggg gtcaccaggc tacatggcga catctaggca
     3421 gctccgcctt gcccagcctc cttgccataa tcctaatata ttggtgtcct ctgctcagag
     3481 gggactgtca tcatggtggg aacaggctgt gcctccccag ggactctgcc catgttccca
     3541 gggcctcatc tgtacactgt gaaattaact ggcatcctgg tgggcccaag ggttttcagg
     3601 actgggggcc aatgactcac cccctccttc ctcctcctga tccctatctc tagctcttat
     3661 cacagatttt gaacaattgt ctgtgaggtt aatgatggtt tcagagggaa gcccttttcc
     3721 tccctgagac tgtgtggggt tcagtcagcc tgctgaaatt gcttccactt attacccatc
     3781 cttcctctta aaaaaaaaaa aagcccacca agttagtatt ctctgtagct ctcagacagc
     3841 tacaagtgtt cctggcatat ttaccaaagt acaagaaatc attacattat ttacggtctc
     3901 agactacatc agggttgggg gagctcctgg tggggatggc agtgggtgtc gatgatatgt
     3961 ccacggctga gcaggtcttg tatccgaagc ttgaagtaac catgccacca tttatcatca
     4021 aatttgaacc ttttaataaa attaaacagc ctgaaaaa
//
