LOCUS       NM_005883              10179 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens APC regulator of WNT signaling pathway 2 (APC2),
            transcript variant 1, mRNA.
ACCESSION   NM_005883
VERSION     NM_005883.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10179)
  AUTHORS   Jin,L., Li,Y., Luo,S., Peng,Q., Zhai,Q.X., Zhai,J.X., Gao,L.D.,
            Guo,J.J., Song,W., Yi,Y.H., He,N. and Chen,Y.J.
  TITLE     Reprint of: Recessive APC2 missense variants associated with
            epilepsies without neurodevelopmental disorders
  JOURNAL   Seizure 116, 87-92 (2024)
   PUBMED   38523034
  REMARK    GeneRIF: Reprint of: Recessive APC2 missense variants associated
            with epilepsies without neurodevelopmental disorders.
REFERENCE   2  (bases 1 to 10179)
  AUTHORS   Jin,L., Li,Y., Luo,S., Peng,Q., Zhai,Q.X., Zhai,J.X., Gao,L.D.,
            Guo,J.J., Song,W., Yi,Y.H., He,N. and Chen,Y.J.
  TITLE     Recessive APC2 missense variants associated with epilepsies without
            neurodevelopmental disorders
  JOURNAL   Seizure 111, 172-177 (2023)
   PUBMED   37657306
  REMARK    GeneRIF: Recessive APC2 missense variants associated with
            epilepsies without neurodevelopmental disorders.
REFERENCE   3  (bases 1 to 10179)
  AUTHORS   Dong,Y., Wu,B., Wang,X., Lu,F., Li,Q. and Zhao,Q.
  TITLE     High miR-3648 expression and low APC2 expression are associated
            with shorter survival and tumor progression in NSCLC
  JOURNAL   Histol Histopathol 37 (4), 355-364 (2022)
   PUBMED   34927228
  REMARK    GeneRIF: High miR-3648 expression and low APC2 expression are
            associated with shorter survival and tumor progression in NSCLC.
REFERENCE   4  (bases 1 to 10179)
  AUTHORS   Pehlivan,S., Serin,I., Nursal,A.F., Oyaci,Y., Gundes,I. and
            Pehlivan,M.
  TITLE     What are the roles of global DNA and APC 2 gene promotor
            hypermethylation in multiple myeloma?
  JOURNAL   Mol Biol Rep 48 (12), 7875-7882 (2021)
   PUBMED   34637096
  REMARK    GeneRIF: What are the roles of global DNA and APC 2 gene promotor
            hypermethylation in multiple myeloma?
REFERENCE   5  (bases 1 to 10179)
  AUTHORS   Jarrett,C.R., Blancato,J., Cao,T., Bressette,D.S., Cepeda,M.,
            Young,P.E., King,C.R. and Byers,S.W.
  TITLE     Human APC2 localization and allelic imbalance
  JOURNAL   Cancer Res 61 (21), 7978-7984 (2001)
   PUBMED   11691822
REFERENCE   6  (bases 1 to 10179)
  AUTHORS   Nakagawa,H., Koyama,K., Murata,Y., Morito,M., Akiyama,T. and
            Nakamura,Y.
  TITLE     EB3, a novel member of the EB1 family preferentially expressed in
            the central nervous system, binds to a CNS-specific APC homologue
  JOURNAL   Oncogene 19 (2), 210-216 (2000)
   PUBMED   10644998
REFERENCE   7  (bases 1 to 10179)
  AUTHORS   Nakagawa,H., Koyama,K., Murata,Y., Morito,M., Akiyama,T. and
            Nakamura,Y.
  TITLE     APCL, a central nervous system-specific homologue of adenomatous
            polyposis coli tumor suppressor, binds to p53-binding protein 2 and
            translocates it to the perinucleus
  JOURNAL   Cancer Res 60 (1), 101-105 (2000)
   PUBMED   10646860
REFERENCE   8  (bases 1 to 10179)
  AUTHORS   van Es,J.H., Kirkpatrick,C., van de Wetering,M., Molenaar,M.,
            Miles,A., Kuipers,J., Destree,O., Peifer,M. and Clevers,H.
  TITLE     Identification of APC2, a homologue of the adenomatous polyposis
            coli tumour suppressor
  JOURNAL   Curr Biol 9 (2), 105-108 (1999)
   PUBMED   10021369
REFERENCE   9  (bases 1 to 10179)
  AUTHORS   Nakagawa,H., Murata,Y., Koyama,K., Fujiyama,A., Miyoshi,Y.,
            Monden,M., Akiyama,T. and Nakamura,Y.
  TITLE     Identification of a brain-specific APC homologue, APCL, and its
            interaction with beta-catenin
  JOURNAL   Cancer Res 58 (22), 5176-5181 (1998)
   PUBMED   9823329
REFERENCE   10 (bases 1 to 10179)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027307.5 and BC032573.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 12, 2020 this sequence version replaced NM_005883.2.
            
            Summary: This gene encodes a strongly conserved protein that has an
            N-terminal coiled-coil domain followed by an armadillo domain, five
            20-amino acid repeats, and two SAMP domains. This protein promotes
            the assembly of a multiprotein complex that recruits and
            phosphorylates the Wnt effector beta-catenin and targets
            beta-catenin for ubiquitylation and proteasomal degradation. This
            protein therefore plays a role in the reduction of cytoplasmic
            levels of beta-catenin which in turn reduces activation of Wnt
            target genes that play a pivotal role in the pathogenesis of
            various human cancers. The protein encoded by this gene is closely
            related to the adenomatous polyposis coli (APC) tumor-suppressor
            protein and has similar tumor-suppressor effects. This gene also
            plays a role in actin assembly, cell-cell adhesion, and microtubule
            network formation through its interaction with cytoskeletal
            proteins. This gene has its highest expression in the central
            nervous system and is involved in brain development through
            cytoskeletal regulation in neurons. Alternative splicing produces
            multiple transcript variants encoding distinct isoforms. [provided
            by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032573.1, ERR4352443.514173.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590469.6/ ENSP00000467073.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC027307.5         39944-39971
            29-2344             BC032573.1         1-2316
            2345-10179          AC027307.5         55233-63067
FEATURES             Location/Qualifiers
     source          1..10179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..10179
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /note="APC regulator of WNT signaling pathway 2"
                     /db_xref="GeneID:10297"
                     /db_xref="HGNC:HGNC:24036"
                     /db_xref="MIM:612034"
     exon            1..218
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            219..377
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..7148
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenomatous polyposis coli like; adenomatous polyposis
                     coli protein 2; APC2, WNT signaling pathway regulator;
                     adenomatosis polyposis coli 2"
                     /codon_start=1
                     /product="adenomatous polyposis coli protein 2 isoform 1"
                     /protein_id="NP_005874.1"
                     /db_xref="CCDS:CCDS12068.1"
                     /db_xref="GeneID:10297"
                     /db_xref="HGNC:HGNC:24036"
                     /db_xref="MIM:612034"
                     /translation="MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETS
                     GMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAA
                     RTPEGSPVHGSGPSKDSFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQ
                     GLSKRLDELPHVETQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASR
                     LEQIDKELLEAQDRVQQTEPQALLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVV
                     FWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGA
                     PGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARD
                     GGPEGGGAGSAPIPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEM
                     HKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASDSEELHQV
                     VSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWNLSAHSTE
                     NKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLVATREDYRQVLRDH
                     NCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLVHSKHKM
                     IAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARHLAQALE
                     HLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPAS
                     PAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQ
                     LVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLR
                     LKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDLDLP
                     GCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPGISPGARKQAW
                     LPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGG
                     DLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSS
                     SSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQ
                     TMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVR
                     FTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRR
                     REEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVP
                     APAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSAR
                     QAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQ
                     SLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPS
                     KAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDP
                     GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRER
                     GEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSV
                     GSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGV
                     PAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRS
                     LHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGAL
                     PGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAG
                     TEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAES
                     AASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPAR
                     RTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGE
                     PRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAV
                     VQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEG
                     LGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASATLLE"
     exon            378..468
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            469..649
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            650..758
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            759..875
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            876..953
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1052
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1443
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1539
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1679
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1757
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1874
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2089
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..10179
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10156..10161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /note="hexamer: AATAAA"
     polyA_site      10179
                     /gene="APC2"
                     /gene_synonym="APCL; MRT74"
                     /note="major polyA site"
ORIGIN      
        1 gcggtggtct cgcccagcgc taggagcggc agcgccgcct gcccaggccc ggaccgggct
       61 ttgtccgccc cggagcccct gcccgcgccg cggagacccc ggagcccgcg cgctccgagg
      121 ccaccccggg ccgggatttc cggtggggcc cgcggagccg cgcagaggga ggaggcccca
      181 gacccaggcg ccccgccagc ccagctgcac gtaagcggac gctgcaggag ctgaagatgg
      241 cgagctccgt ggcgccctac gagcagctgg tgaggcaggt ggaggccttg aaggctgaga
      301 acagccacct gaggcaggag ctaagggaca actccagcca cctgtccaag ctggagacag
      361 agacgtcggg catgaaggag gtcctgaagc acctacaggg aaaactggag caggaggccc
      421 gagtgctggt gtcctcgggg cagacggagg tgctggagca gctgaaggcc ctacagatgg
      481 acatcaccag cctgtacaac ctcaagttcc agccgcccac cctgggcccg gagcctgccg
      541 cccggacccc cgagggcagc ccagtacacg gctccgggcc ctccaaggac agctttgggg
      601 agctgagccg ggccaccatc cggctgctgg aggaactgga ccgggaacgg tgtttcctgc
      661 tgaatgagat tgagaaggag gagaaggaga agctctggta ctactctcag ctgcagggcc
      721 tgtccaagcg cctggacgag ctgccgcacg tggagacgca gttctcgatg cagatggacc
      781 tgatccggca gcagcttgag ttcgaggccc agcacatccg ctcgctgatg gaggagcgct
      841 tcggcacctc ggacgagatg gtgcagcggg cacagatccg cgcctcgcgc ctggagcaga
      901 ttgacaagga gctgctggag gcgcaggacc gagtgcagca gacggagccc caggccttgc
      961 tggcggtgaa gtcggtgccg gtggacgagg accccgagac agaggtcccc acacaccctg
     1021 aggatggcac ccctcagccg ggcaacagca aggtggaggt ggtcttctgg ctgttgtcca
     1081 tgttggcgac gcgcgaccag gaggatacag cgcgcacgct gctggccatg tccagctcgc
     1141 ccgagagctg cgtggccatg cgccgctcgg gctgtctgcc tctgctgctg caaatcctcc
     1201 acggcaccga ggccgcggcc gggggtcgcg ccggggcccc aggggcaccg ggcgccaagg
     1261 acgcacgcat gcgcgccaac gcggcgctgc acaacatcgt cttctcgcag ccggaccagg
     1321 gcctggcgcg caaggagatg cgcgtcctgc acgtgctgga gcagatccgg gcctactgcg
     1381 agacctgctg ggactggctg caggcccgag acggcgggcc cgagggaggt ggcgccggca
     1441 gcgccccgat ccccatcgag ccgcagatct gccaggccac ctgtgctgtt atgaagctgt
     1501 cctttgatga ggagtaccgc cgtgccatga acgagctagg tgggctgcag gccgtggcag
     1561 agctgctgca ggttgactat gagatgcaca agatgacccg ggacccgctg aacctggcgc
     1621 tgcgccgcta cgcgggcatg accctcacca acctcacctt tggggacgtt gccaacaagg
     1681 ccaccctgtg tgcgcgccgc ggctgcatgg aggccatcgt ggcccagctg gcctccgaca
     1741 gtgaggagct ccaccaggtg gtgtccagca tccttcggaa cttgtcctgg agggccgaca
     1801 tcaacagcaa gaaggtgctg agggaggcgg gcagcgtgac tgccctggtg cagtgtgtcc
     1861 tgcgggccac caaggagtcc accctgaaga gcgtgctgag cgccctgtgg aatctgtctg
     1921 cacacagcac agagaacaag gcggccatct gccaggtgga tggcgccctg ggcttcctgg
     1981 tgagcaccct gacctacaag tgtcagagca actcgctggc catcatcgag agcggcggcg
     2041 gcatcctccg caatgtgtcc agcctcgtcg ccacccgtga ggactacagg caggtgctcc
     2101 gggatcacaa ctgtctgcag acgctgctgc agcatctgac ttcgcacagc ctgaccatcg
     2161 tgagcaacgc gtgcggcacg ctctggaacc tgtcggcccg cagcgcccgt gaccaggagc
     2221 tgctgtggga cctgggcgcc gtgggcatgc tgcgtaatct ggtgcactcc aagcacaaga
     2281 tgatcgccat gggcagcgcc gccgccctgc gcaacctgct ggcccatcgg cccgccaagc
     2341 accaggcggc cgccaccgcc gtgtccccag gcagctgcgt gcccagcctg tacgtgcgca
     2401 agcagcgggc gctggaggcc gagctggacg cacggcacct cgcgcaggcg ctggagcacc
     2461 tggagaagca gggcccgccg gcagccgagg ccgccactaa gaagccgctg ccgcccctgc
     2521 gacacctgga cggcctggcc caagactatg cttccgattc gggctgcttt gacgacgacg
     2581 atgcaccgtc atccctggct gcggccgcgg ccaccgggga gccagccagc cctgccgcgc
     2641 tgtccctctt cctgggcagc cccttcctgc aggggcaggc gctggctcgc accccgccca
     2701 cccgccgagg cggcaaggag gcagagaagg acaccagtgg ggaggcagcc gtggcggcca
     2761 aggccaaggc caagctggcg cttgcagtgg cgcgcatcga ccagctggtg gaggacatct
     2821 ccgccctgca cacctcgtcc gacgatagct tcagcctcag ctctggagac ccgggacagg
     2881 aggcgccacg ggagggccgc gcccagtcct gctcgccatg ccgcggcccg gagggcgggc
     2941 ggcgagaggc aggaagccgg gcgcacccgc tgctgcggct caaggcggcc cacgccagcc
     3001 tctccaacga cagcctcaac agcggcagtg ccagcgacgg gtactgccca cgcgaacata
     3061 tgctgccctg cccgctggcc gcactggctt cgcgccgcga ggaccccagg tgtgggcagc
     3121 ctcggcccag ccggcttgac cttgacctgc ccggctgcca ggccgagccc ccggcccgcg
     3181 aggccacctc cgccgacgcc cgcgtgcgca ccatcaagct gtcgcctacc tatcagcacg
     3241 tgccactgct tgagggtgcc tcaagggcgg gtgcagagcc cctcgcgggg cctggaatct
     3301 ctccaggggc ccggaagcag gcctggctgc cggcagacca cctgagcaag gttcccgaga
     3361 agctggcggc tgccccgctg tctgtggcca gcaaggcact gcagaaactg gcggcgcaag
     3421 aggggccact ctcgctgtcc cgatgcagct ccctttcctc gctgtcctcg gccggccgcc
     3481 caggccccag cgagggtggt gacctggatg acagtgactc ctccctggag gggctggagg
     3541 aggccggccc cagcgaggct gagctggaca gcacgtggcg ggcgcccggg gccacctcgc
     3601 tgcccgtagc cattccggct ccccggcgta accgaggccg gggcctgggg gtggaagacg
     3661 ccacgccgtc cagctcgtcg gagaactacg tgcaggagac accgcttgtg ctgagccgct
     3721 gcagctctgt gagctcgctg ggcagcttcg agagcccgtc catcgccagc tccatcccca
     3781 gtgaaccttg cagcgggcag ggcagcggca ccatcagccc tagcgagctg cccgacagcc
     3841 ccggacagac catgcctccc agccggagca agacgccacc gctggcgccc gcgccacagg
     3901 gtccccccga ggccacccag ttcagcctgc agtgggagag ctacgtgaag cgcttcctgg
     3961 acatcgccga ctgccgggag cgctgccggc tgccatctga gctggacgca ggcagcgtgc
     4021 gctttaccgt ggagaagcca gacgagaact tctcgtgcgc ctccagcctc agcgcgctgg
     4081 ccttgcacga gcactacgtg cagcaggacg tggagctgcg gctgctgccc tcggcctgcc
     4141 ccgagcgcgg cgggggcgcc gggggcgccg gcctccactt tgcagggcac cggcggcggg
     4201 aggaggggcc ggcgcccacg ggttctcgcc ctcgcggcgc cgcggaccag gagctggaac
     4261 tgctgcggga gtgcctggga gccgccgtgc ctgcccggct gcgcaaggtg gcctccgcgc
     4321 tggtgccagg tcgccgcgca ctccccgtgc ccgtctacat gttggtgccc gccccggccc
     4381 cggcccagga ggacgactcc tgcactgact ccgcggaggg cacgccggtc aacttctcta
     4441 gcgccgcctc gctcagcgac gagacgctgc agggaccccc cagggaccag cccgggggac
     4501 cagcgggcag gcaaagaccc accggccgcc ccacctctgc cagacaggcc atggggcacc
     4561 ggcacaaggc gggaggcgcc ggccgcagcg cggagcagtc tcggggcgcg ggcaagaaca
     4621 gagcagggct ggagctgccc ctgggccggc ccccgagcgc ccccgcagac aaggacggct
     4681 caaagcccgg ccggacccgc ggggacgggg cgctccagtc gctgtgcctc acgacgccca
     4741 ctgaggaggc cgtgtactgc ttctacggca acgactcgga cgaggagccc ccggcggccg
     4801 cgcccacgcc aacccaccgg cgcacatcgg ccatccctcg cgcttttacg cgggagcgtc
     4861 cgcagggccg gaaggaggcc cctgccccgt ccaaggctgc accagctgcc ccgccgcccg
     4921 cccggaccca gcccagcctc attgctgacg agaccccgcc ctgctactcc ctgagctcct
     4981 ccgccagctc cctcagcgag cccgagccct cggagccgcc ggccgtccat ccacgaggcc
     5041 gggagcccgc ggtcaccaag gacccgggcc caggaggcgg acgcgacagc tcgcccagcc
     5101 cgcgggccgc ggaggagctt ctgcagcggt gcatcagctc ggccctgccc aggcgccggc
     5161 cccccgtgtc tggcctgcgg cgccgcaagc cccgagccac ccggctggat gagcggcccg
     5221 cagaggggtc ccgggaacgc ggcgaggagg cagcgggctc ggaccgggcc tccgacctgg
     5281 atagcgtgga gtggcgcgcc atccaggagg gcgccaattc aattgtcacg tggctgcacc
     5341 aggcagcagc tgccacgcgg gaggcctcgt ccgagtccga ctccatcctg tccttcgtat
     5401 ccgggctgtc agtgggatcc accctacagc cccccaagca caggaaggga cgacaggcgg
     5461 agggagaaat gggcagtgcc cggcggccag agaaaagggg cgcagcctca gtcaagacca
     5521 gcgggagccc ccgttcccct gcaggccccg agaagccacg tggcacacag aagaccacgc
     5581 ccggggtgcc agctgtgctc cggggacgaa cagtgatcta cgtccccagc ccggcacccc
     5641 gtgcccagcc caaagggacc cccggccccc gcgccacacc gcggaaggtg gcgccccctt
     5701 gcctggcaca gcccgcggct ccagccaaag tcccgagccc cgggcagcag cggtcgcgga
     5761 gcctacaccg gcctgccaag acctcggagc tggcgacgct gagccagccc cccagaagcg
     5821 ccacaccgcc cgcccgcctc gccaagaccc cctcctccag ctcctcccag acctcgcccg
     5881 cctcccagcc cctgcccaga aagcgccccc cggtcaccca ggctgctggg gccctgcccg
     5941 gccccggagc ctccccggtg cccaaaacgc cggcgcgcac ccttctggcg aagcagcaca
     6001 agacgcagag atcgcccgtg cggatcccgt tcatgcagag gccggcccgg cgtgggccgc
     6061 caccgctggc tcgggcagtc ccggagccgg gccccagggg ccgggcgggg accgaggcgg
     6121 gcccgggggc gcgcgggggc cgcctgggcc tggtgcgtgt ggcctcagcc ctctccagcg
     6181 gcagcgagtc ctccgaccgc tcgggcttcc ggcgacagct aaccttcatc aaggagtcgc
     6241 cgggcttgcg gcgccgccgc tccgagctgt cctcggccga gtccgcggcc tctgcccccc
     6301 agggcgcctc gccccgccgc ggccggcccg cgctgcccgc cgtcttcctc tgctcctcgc
     6361 gctgcgaaga gctccgagcg gcaccccggc agggcccggc cccggcccgg cagcggcccc
     6421 ccgcggcccg acccagccct ggcgagcgcc ctgcccggcg caccacctcc gagagcccgt
     6481 cccgcctgcc tgtgcgcgcg cccgccgccc ggccggagac tgtcaagcgc tacgcgtcgc
     6541 tgccgcacat cagcgtggcc cgcaggcccg acggcgccgt ccccgcggcc cctgcctcag
     6601 ccgacgccgc gcgccgcagc agcgacgggg agccccggcc gctccccagg gtggccgcgc
     6661 cgggcacgac ctggcggcgc atccgagatg aggacgtgcc ccacatcctg cgcagcacgc
     6721 ttcccgccac ggccctgcca ctgcggggct ccacgcccga ggacgccccg gccgggcccc
     6781 cgccgcgcaa gaccagcgac gccgtggtcc agaccgagga ggtcgccgcc cccaagacca
     6841 actccagcac gtccccgagc ctggagacca gggagccccc cggggccccc gccggcggcc
     6901 agctctccct cctcggcagc gacgtggacg gtcccagcct cgccaaggct cccatctccg
     6961 cacccttcgt gcacgagggc ctgggggtcg ccgtgggggg cttccccgcc agccggcacg
     7021 gctcccccag ccgctcggcc cgagtacccc ccttcaacta tgtgcccagc cccatggtgg
     7081 tcgcagccac caccgactcg gccgcggaga aagccccggc cactgcctcc gccaccctcc
     7141 tggaatagtg gcctaggccg gccttctgga acgttctctc ccggccctgc ggcgcggtct
     7201 ggctgcccca tgggcctgcg ctgtagacgt cccccatagg tcgccccagg gcctctgccc
     7261 acccgagccc caccactctc agaacccccg cccagcgcac ggcgacctcg cgcctcaccg
     7321 gaagaccttg cctctgtgcc gcggaggtcc aggaggaaac ggggcggccg ctaggcctca
     7381 agtcccgacc gtggagcgct ggcaagggcg tcctggccca gccctgagcg cgcggccctt
     7441 cccctgtcgg aagccgttgc ttgaccccgg gcgagggagg cggtagcctc cgggtccggg
     7501 tctgggtctg ggtccgctgc ttcgcaggga cagcgctggg gaggtgacgg cgcccgccgc
     7561 aggtggggcg aggctggggg agggcggcgc cgcggcgggc ctgccagctg ggggcctttg
     7621 cggcgcgcag gggcgaagcc tgtaatcact gcagccgccg gtaattcgct aatgagggct
     7681 ttgcagggat tgttttcatt ctcagcccca gctgtgggag tgcgggtggg ggtgtggccg
     7741 agccccggca ggaagccccg cccagacggt gttcagggaa cccggagccc aagcgctccg
     7801 gcggagccca aaagggtggg ggtgggaggg gcagaggcca acggatcccc ctgcctgtcg
     7861 caccccttgg cgggagacgg gaaggcagcg ggctgcgtac gatgggaccc tggtgcagac
     7921 gccgggccgg ctgacatttg gaccccatcc cagaggagat gctggctacc agctggggcg
     7981 accccaaggg tcgctggagt cagtatcggc ccggcgcagc cgcggcgggc gaggccaatg
     8041 gaaaggagac tgaggggagt cccggcagtg agcccgaggc cctgggacct ggagcccgcg
     8101 ctggcctctc cccagcggag cctgcacgtt acggagacca tcacatgtgg gcgtggtcag
     8161 tgcccaggac cgcaccgctg ctcatcttgt cccttttcaa ttcccttctg gttcatgatg
     8221 cataaagcgc taggccctag aactccagaa acagcacagc tggggcgggg acccagcctt
     8281 gccctccacc cgaggctctg ggacaaggcg ggaggttcgg gggccttccg gcaggtgaac
     8341 gcagggctgg agagtatttg gtgccagatg aggtgaaagc ttatagaagg gcctgagggg
     8401 ctcggctgcc tcatcccctg gcgggggagg ctgggagctg ggcctcctgc gtggggtggg
     8461 actcgcaggg gccgggtctc cgtgactggg gcaacgcctc gtcctgcaga gggagccgac
     8521 gacctctttt ctgcagaaaa gctccagcag gcgctgcctt cacccacgga tctgcccagg
     8581 ctgaaggcac acgctcaatg ccccacgtgc cttctccagg aggaacgaag cagggtttga
     8641 gggttgggtg gatggagctc agaaggaaac cccagcccca ccacggatga caccatccct
     8701 cccgtcccat ccccagcatg ggcaaggcca gcctttctgg cagaaggagc tgtcctcaac
     8761 tcagggccgc tgtgagcaaa gctgacccca gcccccaccc ccagttaaca ctgctgcttc
     8821 tctgaatgca tgtcacgctg caccccatgc tccgggccca caccctgcag gacaaggagc
     8881 tccagacagg acgtccataa gtcaccgagg tgtgccaccc agcaggtgct ggaggtgccc
     8941 aatgctccct cctaggacct cgcagccagg caaggctgtc aggttgtttt gggggaagag
     9001 ggggtcatgg atggctgagc agagagcggg gaaaatgcag gctgagtggg gcgacctcct
     9061 gcctgccagg agcccccttt caggacacag cgggggtctc acacttgctg tccccatcca
     9121 tggcccgagg gggaacctgg tggtctcttc tgagcttttg gacttgggga tgccaaacac
     9181 gtgctcaccc tcacactcgc cccggcccgc tgcgccccta attgccaaag ggtagggaaa
     9241 tggcgaagcc agccaccagg tcgctggtga cagggccagg gttatgcagg aaggtggtgc
     9301 ggcattgcct tccacatatg taagtctctg ggcggcgccc tcccagctcc ctgcctctgt
     9361 ttccccatgt gggccgtggg gaactcccag agctacctct tgggggagcg tggtggcagc
     9421 gatgatgggg agacgcctgg aagctcacag aacttgggtc tggctggctc ctgcccgtga
     9481 cgccttgccc agcagcaagg tgcgcaacat ggctgccagc cccgcctccc acccccaccc
     9541 cgagtcctga gctcactttc gccttctcca tcccctgccg tgggggccac agccacacct
     9601 caccgcccag tccagctgtc tccagaaggg gacaggcagt ccgcggtctc tggacaatca
     9661 actcaaggta cgcccactgc aaggcctccc tcccaccgcg gcccctgcct ggccacctgg
     9721 cctctctgca ccagggtgac aaggggtcct cgtctgcccc ccaatgctcc agggccagtc
     9781 ctaaggagct gagggtctga ggacgcaggg agggtggagg tgtcctgagg ctgatggaca
     9841 gtgaccgcca ctggccccca acatgaccac acgtgggtgc tgaactcggg gcgccgtgcc
     9901 caccggcatg gtcctcccga gctccgacag cattacctca cccggcccca tctgttgccc
     9961 cggtccagcc ctgatggcgc gcgcctggtc tgtctgattc ccctagccgc caccccacgt
    10021 ttctgtaccg ggtctctgca gtgttaaacg gacgtgtaaa tagtggtaaa tagtgaaagc
    10081 ctgtccttcc ctaaatgtaa agccatctgt ccggcgtaag gacgacaccg tcagctgtcc
    10141 gactcgcaca catttaataa actgagctct tgcattgcc
//
