LOCUS       NP_573419                486 aa            linear   PRI 21-SEP-2024
DEFINITION  amyloid-beta A4 precursor protein-binding family B member 3 isoform
            b [Homo sapiens].
ACCESSION   NP_573419
VERSION     NP_573419.2
DBSOURCE    REFSEQ: accession NM_133173.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 486)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 486)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 486)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (residues 1 to 486)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 486)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 486)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     Characterization of an amyloid precursor protein-binding protein
            Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction
            domains
  JOURNAL   Biochem J 367 (Pt 3), 687-695 (2002)
   PUBMED   12153398
REFERENCE   7  (residues 1 to 486)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     Genome structure and chromosomal mapping of the gene for Fe65L2
            interacting with Alzheimer's beta-amyloid precursor protein
  JOURNAL   Biochem Biophys Res Commun 258 (2), 385-389 (1999)
   PUBMED   10329396
REFERENCE   8  (residues 1 to 486)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     Molecular cloning of human Fe65L2 and its interaction with the
            Alzheimer's beta-amyloid precursor protein
  JOURNAL   Neurosci Lett 261 (3), 143-146 (1999)
   PUBMED   10081969
REFERENCE   9  (residues 1 to 486)
  AUTHORS   Duilio,A., Faraonio,R., Minopoli,G., Zambrano,N. and Russo,T.
  TITLE     Fe65L2: a new member of the Fe65 protein family interacting with
            the intracellular domain of the Alzheimer's beta-amyloid precursor
            protein
  JOURNAL   Biochem J 330 (Pt 1) (Pt 1), 513-519 (1998)
   PUBMED   9461550
REFERENCE   10 (residues 1 to 486)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013158.1, AB209839.1 and
            BF448559.1.
            
            On May 13, 2006 this sequence version replaced NP_573419.1.
            
            Summary: The protein encoded by this gene is a member of the APBB
            protein family. It is found in the cytoplasm and binds to the
            intracellular domain of the Alzheimer's disease beta-amyloid
            precursor protein (APP) as well as to other APP-like proteins. It
            is thought that the protein encoded by this gene may modulate the
            internalization of APP. Multiple transcript variants encoding
            several different isoforms have been found for this gene. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks a 21 nt miniexon in the
            coding region but maintains the same reading frame as transcript
            variant 4. As a result, variant 2 encodes isoform b which lacks 7
            internal aa as compared to the longest isoform (d) encoded by
            transcript variant 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013158.1, AK075280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357560.9/ ENSP00000350171.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     Protein         1..486
                     /product="amyloid-beta A4 precursor protein-binding family
                     B member 3 isoform b"
                     /note="FE65-like protein 2; amyloid precursor interacting
                     protein; protein Fe65-like 2; amyloid beta (A4) precursor
                     protein-binding, family B, member 3"
                     /calculated_mol_wt=52454
     Region          30..61
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(45,56)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          116..254
                     /region_name="PTB1_Fe65"
                     /note="Fe65 N-terminal Phosphotyrosine-binding (PTB)
                     domain; cd01272"
                     /db_xref="CDD:269970"
     Site            order(131,199,218)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269970"
     Site            order(198..203,218,240,244)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269970"
     Region          283..413
                     /region_name="PTB2_Fe65"
                     /note="Fe65 C-terminal Phosphotyrosine-binding (PTB)
                     domain; cd01271"
                     /db_xref="CDD:269969"
     Site            order(294,372,391)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269969"
     Site            order(305,307,359..360,362..369,371,379,385,395,397,400,
                     404,407..408,410..411)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269969"
     CDS             1..486
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /coded_by="NM_133173.3:354..1814"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS4229.1"
                     /db_xref="GeneID:10307"
                     /db_xref="HGNC:HGNC:20708"
                     /db_xref="MIM:602711"
ORIGIN      
        1 mlgkdymlai ilvncdddlw gdhsleveag lppgwrkihd aagtyywhvp sgstqwqrpt
       61 welgdaedpg tgtegiwglr ppkgrsfssl essldrsnsl swyggesyiq smepgakcfa
      121 vrslgwvevp eedlapgkss iavnnciqql aqtrsrsqpp dgawgegqnm lmilkkdams
      181 lvnpldhsli hcqplvhirv wgvgsskgrd rdfafvasdk dscmlkchvf ccdvpakaia
      241 salhglcaqi lservevsgd asccspdpis pedlprqvel ldavsqaaqk yealymgtlp
      301 vtkamgmdvl neaigtltar gdrnawvptm lsvsdslmta hpiqaeaste eeplwqcpvr
      361 lvtfigvgrd phtfgliadl grqsfqcaaf wcqphaggls eavqaacmvq yqkclvasaa
      421 rgkawgaqar arlrlkrtss mdspggplpl pllkggvgga gatprkrgvf sfldafrlkp
      481 sllhmp
//
