LOCUS       NM_133172               2146 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family B member
            3 (APBB3), transcript variant 3, mRNA.
ACCESSION   NM_133172
VERSION     NM_133172.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     Characterization of an amyloid precursor protein-binding protein
            Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction
            domains
  JOURNAL   Biochem J 367 (Pt 3), 687-695 (2002)
   PUBMED   12153398
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     Genome structure and chromosomal mapping of the gene for Fe65L2
            interacting with Alzheimer's beta-amyloid precursor protein
  JOURNAL   Biochem Biophys Res Commun 258 (2), 385-389 (1999)
   PUBMED   10329396
REFERENCE   8  (bases 1 to 2146)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     Molecular cloning of human Fe65L2 and its interaction with the
            Alzheimer's beta-amyloid precursor protein
  JOURNAL   Neurosci Lett 261 (3), 143-146 (1999)
   PUBMED   10081969
REFERENCE   9  (bases 1 to 2146)
  AUTHORS   Duilio,A., Faraonio,R., Minopoli,G., Zambrano,N. and Russo,T.
  TITLE     Fe65L2: a new member of the Fe65 protein family interacting with
            the intracellular domain of the Alzheimer's beta-amyloid precursor
            protein
  JOURNAL   Biochem J 330 (Pt 1) (Pt 1), 513-519 (1998)
   PUBMED   9461550
REFERENCE   10 (bases 1 to 2146)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013158.1, AF224708.1,
            AB209839.1 and BF448559.1.
            
            On Aug 11, 2020 this sequence version replaced NM_133172.2.
            
            Summary: The protein encoded by this gene is a member of the APBB
            protein family. It is found in the cytoplasm and binds to the
            intracellular domain of the Alzheimer's disease beta-amyloid
            precursor protein (APP) as well as to other APP-like proteins. It
            is thought that the protein encoded by this gene may modulate the
            internalization of APP. Multiple transcript variants encoding
            several different isoforms have been found for this gene. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks a 6 nt miniexon in the
            coding region but maintains the same reading frame as transcript
            variant 4. As a result, variant 3 encodes isoform c which lacks 2
            internal aa as compared to isoform d encoded by transcript variant
            4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF224708.1, SRR12514507.439819.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-979               BC013158.1         7-985
            980-1058            AF224708.1         647-725
            1059-2145           AB209839.1         778-1864
            2146-2146           BF448559.1         10-10               c
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..2146
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /note="amyloid beta precursor protein binding family B
                     member 3"
                     /db_xref="GeneID:10307"
                     /db_xref="HGNC:HGNC:20708"
                     /db_xref="MIM:602711"
     exon            1..402
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1829
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /note="isoform c is encoded by transcript variant 3;
                     FE65-like protein 2; amyloid precursor interacting
                     protein; protein Fe65-like 2; amyloid beta (A4) precursor
                     protein-binding, family B, member 3"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     B member 3 isoform c"
                     /protein_id="NP_573418.2"
                     /db_xref="CCDS:CCDS4228.1"
                     /db_xref="GeneID:10307"
                     /db_xref="HGNC:HGNC:20708"
                     /db_xref="MIM:602711"
                     /translation="MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGT
                     YYWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSW
                     YGGESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPP
                     DGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRPISAPARDF
                     AFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISP
                     EDLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPT
                     MLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQC
                     AAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPG
                     GPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP"
     exon            403..566
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            567..643
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            644..704
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            705..851
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            852..979
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1115
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1200
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1284
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1400
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1592
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..2146
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="APBB3"
                     /gene_synonym="FE65L2; SRA"
                     /note="major polyA site"
ORIGIN      
        1 gcatgttcgg cgtgtcggtc ttcaggcgcc tgatgagttc atagttgggc ggtggtgtca
       61 gcggtttcgc tggcgttcgt gggcctcccc cggacccaca cacggaaaca cgcaaccatt
      121 cggggatcca gacgcccgtt tacacgcacc acccctgggc gggctgtgcg gctcaggccc
      181 tcccccggga ccggcccgtg tcccgccccg tgtcccgccc cgtatttgtg cggcgccagc
      241 tggccccgca gcctgcggcg cagagaggct gggcttgcag gcgcagtagc tccagaggtc
      301 gcgctgggct gagagtgcgg gccggcagag gctggcgggg agcagccggg gttatgctgg
      361 gcaaggatta catgctggcc atcattctgg tcaactgcga tgatgacttg tggggggacc
      421 acagtctgga ggtggaggct ggcctgcctc ctggctggag gaagatccac gatgctgcag
      481 gtacttacta ctggcatgta cccagcggta gcacccagtg gcagcgccca acctgggaac
      541 taggagatgc agaggaccca ggcacgggaa cggaggggat ctggggactg cggcccccca
      601 aagggagatc cttctccagc ctggagagtt cactggaccg gagtaactct ctgtcctggt
      661 atggtgggga atcctacatc cagagcatgg agccaggggc taagtgcttt gcagtccgct
      721 ctctgggctg ggtagaggta cctgaagagg acctggcacc ggggaagagc agtattgcag
      781 tcaataactg tatccagcag ctggcccaga cccgcagccg gagccagcct ccagatggtg
      841 cctggggtga gggccagaac atgctgatga tcctgaagaa ggatgccatg agcctagtga
      901 atcccctgga ccacagtctg atccactgcc agcctctggt gcacatccgt gtgtggggcg
      961 tggggagctc caagggccgc cccatctctg cccctgctag ggacttcgct tttgtggcaa
     1021 gtgacaaaga tagctgtatg ctcaagtgcc atgtgttttg ctgtgatgtc cctgccaagg
     1081 ccattgccag tgccctacat gggctttgtg cccagatctt gtcagagcga gtagaggtca
     1141 gtggtgatgc ctcttgctgc tccccagacc ccatctctcc tgaagacctg ccacggcaag
     1201 tggagctgct ggatgcggta agccaagctg ctcagaagta cgaggcactg tatatgggga
     1261 cactgccagt caccaaggcc atgggcatgg atgtgctgaa cgaggccatt ggtaccctca
     1321 ccgccagggg ggaccggaat gcctgggtcc ccaccatgct cagtgtgtct gactctctca
     1381 tgactgcaca ccccattcag gcagaggcca gtacagagga ggagccattg tggcagtgcc
     1441 ctgtgcgcct tgtgacattt attggtgttg gccgcgaccc acacaccttt ggcctcatcg
     1501 ctgacctggg ccgtcagagc ttccagtgcg cagccttctg gtgccagccc catgcagggg
     1561 gactctctga agctgtgcag gctgcctgta tggttcagta ccagaagtgt cttgtggcct
     1621 ctgcagctcg aggcaaggcc tggggtgccc aggcccgtgc ccgcctgcgg ctcaagcgga
     1681 ccagctccat ggattcccca ggaggtcccc tgcccctccc cctgctcaaa ggaggggttg
     1741 gcggtgcagg ggcaacccct cgaaagcggg gtgtcttctc ttttcttgat gccttccggc
     1801 tgaaaccctc tctgctccat atgccctaaa cttatctggg aaggctgggg aagtaggctc
     1861 tgggtccatg cctaactctg taccgtttta ttcctcaagg cctatagcct gtcactcctt
     1921 gaagccttct ctgcctgtcc ctccgatcct tgtccaccgt ctatttattg cccaatttat
     1981 tgtttatacg gatgactggg aggcactgca ccacaacgta ggaccctggc tcccctttcc
     2041 ttgggtcctt gtgttccttg cccctgtcca accctggaca gttggctcta cctcagtaac
     2101 actttatagc aaaatcagtg caaataaaaa tccctcagtg acctca
//
