LOCUS       NM_019043               2633 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family B member
            1 interacting protein (APBB1IP), mRNA.
ACCESSION   NM_019043
VERSION     NM_019043.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2633)
  AUTHORS   Torres-Gomez,A., Fiyouzi,T., Guerra-Espinosa,C., Cardenes,B.,
            Clares,I., Toribio,V., Reche,P.A., Cabanas,C. and Lafuente,E.M.
  TITLE     Expression of the phagocytic receptors alphaMbeta2 and alphaXbeta2
            is controlled by RIAM, VASP and Vinculin in
            neutrophil-differentiated HL-60 cells
  JOURNAL   Front Immunol 13, 951280 (2022)
   PUBMED   36238292
  REMARK    GeneRIF: Expression of the phagocytic receptors alphaMbeta2 and
            alphaXbeta2 is controlled by RIAM, VASP and Vinculin in
            neutrophil-differentiated HL-60 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2633)
  AUTHORS   Sari-Ak,D., Torres-Gomez,A., Yazicioglu,Y.F., Christofides,A.,
            Patsoukis,N., Lafuente,E.M. and Boussiotis,V.A.
  TITLE     Structural, biochemical, and functional properties of the
            Rap1-Interacting Adaptor Molecule (RIAM)
  JOURNAL   Biomed J 45 (2), 289-298 (2022)
   PUBMED   34601137
  REMARK    GeneRIF: Structural, biochemical, and functional properties of the
            Rap1-Interacting Adaptor Molecule (RIAM).
            Review article
REFERENCE   3  (bases 1 to 2633)
  AUTHORS   Cho,E.A., Zhang,P., Kumar,V., Kavalchuk,M., Zhang,H., Huang,Q.,
            Duncan,J.S. and Wu,J.
  TITLE     Phosphorylation of RIAM by src promotes integrin activation by
            unmasking the PH domain of RIAM
  JOURNAL   Structure 29 (4), 320-329 (2021)
   PUBMED   33275877
  REMARK    GeneRIF: Phosphorylation of RIAM by src promotes integrin
            activation by unmasking the PH domain of RIAM.
REFERENCE   4  (bases 1 to 2633)
  AUTHORS   Vigouroux,C., Henriot,V. and Le Clainche,C.
  TITLE     Talin dissociates from RIAM and associates to vinculin sequentially
            in response to the actomyosin force
  JOURNAL   Nat Commun 11 (1), 3116 (2020)
   PUBMED   32561773
  REMARK    GeneRIF: Talin dissociates from RIAM and associates to vinculin
            sequentially in response to the actomyosin force.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2633)
  AUTHORS   Torres-Gomez,A., Sanchez-Trincado,J.L., Toribio,V., Torres-Ruiz,R.,
            Rodriguez-Perales,S., Yanez-Mo,M., Reche,P.A., Cabanas,C. and
            Lafuente,E.M.
  TITLE     RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In
            Signaling Driving Particle Engulfment
  JOURNAL   Cells 9 (5), 1166 (2020)
   PUBMED   32397169
  REMARK    GeneRIF: RIAM-VASP Module Relays Integrin Complement Receptors in
            Outside-In Signaling Driving Particle Engulfment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2633)
  AUTHORS   Lafuente,E.M., van Puijenbroek,A.A., Krause,M., Carman,C.V.,
            Freeman,G.J., Berezovskaya,A., Constantine,E., Springer,T.A.,
            Gertler,F.B. and Boussiotis,V.A.
  TITLE     RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and
            mediates Rap1-induced adhesion
  JOURNAL   Dev Cell 7 (4), 585-595 (2004)
   PUBMED   15469846
REFERENCE   7  (bases 1 to 2633)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 2633)
  AUTHORS   Inagaki,T., Suzuki,S., Miyamoto,T., Takeda,T., Yamashita,K.,
            Komatsu,A., Yamauchi,K. and Hashizume,K.
  TITLE     The retinoic acid-responsive proline-rich protein is identified in
            promyeloleukemic HL-60 cells
  JOURNAL   J Biol Chem 278 (51), 51685-51692 (2003)
   PUBMED   14530287
  REMARK    GeneRIF: all-trans-retinoic acid-inducible RARP1 selectively
            affects signal transduction and may contribute to myeloid and
            megakaryocytic differentiation.(RARP1)
REFERENCE   9  (bases 1 to 2633)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   10 (bases 1 to 2633)
  AUTHORS   Law,D.A., Nannizzi-Alaimo,L. and Phillips,D.R.
  TITLE     Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb
            IIIa) tyrosine phosphorylation induced by platelet aggregation
  JOURNAL   J Biol Chem 271 (18), 10811-10815 (1996)
   PUBMED   8631894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM150270.1, BM556115.1 and BC054516.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019043.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC054516.1, AY152730.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376236.9/ ENSP00000365411.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BM150270.1         6-34
            30-218              BM556115.1         1-189
            219-2633            BC054516.1         1-2415
FEATURES             Location/Qualifiers
     source          1..2633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..2633
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /note="amyloid beta precursor protein binding family B
                     member 1 interacting protein"
                     /db_xref="GeneID:54518"
                     /db_xref="HGNC:HGNC:17379"
                     /db_xref="MIM:609036"
     exon            1..115
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            116..317
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2318
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /note="proline rich EVH1 ligand 1; Rap1-GTP-interacting
                     adaptor molecule; retinoic acid-responsive proline-rich
                     protein 1; proline-rich protein 73; Rap1-interacting
                     adaptor molecule; PREL-1; RARP-1; APBB1-interacting
                     protein 1; rap1-GTP-interacting adapter molecule;
                     MLLT10/APBB1IP reciprocal fusion; MLLT10/APBB1IP
                     reciprocal fusion protein"
                     /codon_start=1
                     /product="amyloid beta A4 precursor protein-binding family
                     B member 1-interacting protein"
                     /protein_id="NP_061916.3"
                     /db_xref="CCDS:CCDS31167.1"
                     /db_xref="GeneID:54518"
                     /db_xref="HGNC:HGNC:17379"
                     /db_xref="MIM:609036"
                     /translation="MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFN
                     YSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQAS
                     IFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKA
                     DKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVD
                     WCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLD
                     NRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLL
                     RASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKE
                     SQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLGTVNAAA
                     PAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRA
                     PHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDP
                     ELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVA
                     KRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS"
     exon            318..389
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            390..477
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            478..770
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            771..848
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1008
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1130
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1217
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1361
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1472
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1571
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1686
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1790
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2633
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2608..2613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /note="hexamer: AATAAA"
     polyA_site      2633
                     /gene="APBB1IP"
                     /gene_synonym="INAG1; PREL1; RARP1; RIAM"
                     /note="major polyA site"
ORIGIN      
        1 agtctttggt ggaaccatca ctaggcccca atcccttagt ccctcttgcg tcgaggctgc
       61 aaaatggttc cattcgccag gagacgctcc tgagagaagg gcgcgcgcgg cacaggggcc
      121 ttccttgcac ctcggagcaa agcagctcgg atagcgccac acgtctgcgc gctgcgtggg
      181 aagggcaggg ctgacagcac ttcctccccg gggcagcgac ctggagcccg ggtgcggcag
      241 tctgcaccgc gcgtcgcttt cccggccgga gtctcgccgc cttcccgcgc cccgcagcgc
      301 cccgcagagc agtcgagatg ggtgagtcaa gtgaagacat agaccaaatg ttcagcactt
      361 tgctgggaga gatggatctt ctgactcaga gtttaggagt tgacactctc cctcctcctg
      421 accctaatcc acccagagct gaatttaact acagtgtggg gtttaaagat ttaaatgagt
      481 ccttaaatgc actggaagac caagatttag atgctctcat ggcagatctg gtagcagaca
      541 taagtgaggc tgagcagagg acaatccagg cacagaaaga gtccttgcag aatcaacatc
      601 attcagcatc tctacaagca tcaattttca gtggtgcagc ctctcttggt tatggaacaa
      661 atgttgctgc cactggtatc agccaatatg aggatgactt accacctcca ccagccgatc
      721 ctgtgttaga ccttccactg ccaccaccac ctcctgaacc tctctctcag gaagaggaag
      781 aagcccaagc caaggctgat aaaattaagc tggcgctgga aaaactgaag gaggccaagg
      841 ttaagaagct cgtcgtcaag gtgcacatga atgataacag cacaaagtca ctgatggtgg
      901 atgagcggca gctggcccga gatgttctgg acaacctttt cgagaaaact cattgtgact
      961 gcaatgtaga ctggtgtctt tatgaaatct acccggaact acaaattgag aggttttttg
     1021 aagaccatga aaatgttgtt gaagtcttat cagactggac aagagacaca gaaaataaaa
     1081 tactattttt ggagaaagag gagaaatatg ctgtatttaa aaacccccag aatttctact
     1141 tggataacag aggaaaaaaa gaaagcaagg aaactaatga gaaaatgaat gctaagaaca
     1201 aggaatcctt acttgaggaa agtttctgtg gaacatctat cattgtacca gaactggaag
     1261 gagctcttta tttgaaagaa gatggaaaga aatcctggaa aaggcgctat tttcttttac
     1321 gggcttctgg aatttattat gtacccaaag gaaagactaa gacatctcga gatctggcgt
     1381 gttttataca gtttgaaaat gtcaacattt actatgggac tcagcataaa atgaaatata
     1441 aagcgcccac tgactattgc tttgttttaa agcaccccca aattcagaag gagtcccagt
     1501 atatcaagta tctctgctgt gatgacacaa gaacccttaa ccagtgggtc atgggaatac
     1561 ggatagccaa gtatgggaag actctctatg ataactacca gcgggctgtg gcaaaggctg
     1621 gacttgcctc tcggtggaca aacttgggga cagtcaatgc agctgcacca gctcagccat
     1681 ctacaggacc taaaacaggc accacccagc ccaatggaca gattccccag gctacacatt
     1741 ctgtcagtgc tgttctccaa gaggcccaga gacatgctga aacatcgaag gataagaagc
     1801 cagccctcgg gaaccaccac gacccggcag tgccccgggc cccgcacgcc cccaagtcca
     1861 gcctgccccc gccccctccg gtgcggaggt cctccgacac cagcggcagt cccgccacgc
     1921 ccctcaaggc caagggcaca ggcggcgggg gcttgcccgc cccacccgac gacttcctgc
     1981 cgccgccgcc accgccgccg cccctcgatg accctgagct cccgccgccg cccccggact
     2041 tcatggagcc gcccccagac ttcgtgcccc cgcccccgcc gtcgtacgca gggatcgcgg
     2101 gctcagagct gcccccgccg ccgccgccgc cgcccgcgcc cgcgcccgcc cccgtccccg
     2161 actccgccag gccgcccccc gcggtggcca agaggcctcc tgtgcccccc aagaggcaag
     2221 agaacccagg gcaccccggc ggagcaggag gcggggagca agatttcatg tcagacctca
     2281 tgaaagcttt gcaaaagaag agaggcaacg tgtcctaggg acgggcatga tgagtgttcc
     2341 agagggagaa gcatcgctga ccccgagcgc aggttttgct agcagattgc cctgacatct
     2401 tgttcatttc agataaaatg tgatgggaaa cttctcactg atgtgctcaa gtacaggcat
     2461 aaccattaac ccagtagagt tcagaatatc tgcccaaatg tacatatcgt tcccatgtat
     2521 tttaacctaa atggaatgta tcttcccttc caagctgcct aaagcgctgt tttaggttca
     2581 tttattttat tatgttcaga agcatcaaat aaaagttaaa cgtttttccg gaa
//
