LOCUS       NM_145689               2658 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family B member
            1 (APBB1), transcript variant 2, mRNA.
ACCESSION   NM_145689
VERSION     NM_145689.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2658)
  AUTHORS   Revol,R.S., Koistinen,N.A., Menon,P.K., Chicote-Gonzalez,A.,
            Iverfeldt,K. and Strom,A.L.
  TITLE     Alpha-secretase dependent nuclear localization of the amyloid-beta
            precursor protein-binding protein Fe65 promotes DNA repair
  JOURNAL   Mol Cell Neurosci 127, 103903 (2023)
   PUBMED   37918552
  REMARK    GeneRIF: Alpha-secretase dependent nuclear localization of the
            amyloid-beta precursor protein-binding protein Fe65 promotes DNA
            repair.
REFERENCE   2  (bases 1 to 2658)
  AUTHORS   Chau,D.D., Li,W., Chan,W.W.R., Sun,J.K., Zhai,Y., Chow,H.M. and
            Lau,K.F.
  TITLE     Insulin stimulates atypical protein kinase C-mediated
            phosphorylation of the neuronal adaptor FE65 to potentiate neurite
            outgrowth by activating ARF6-Rac1 signaling
  JOURNAL   FASEB J 36 (11), e22594 (2022)
   PUBMED   36250347
REFERENCE   3  (bases 1 to 2658)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2658)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2658)
  AUTHORS   Hu,Q., Hearn,M.G., Jin,L.W., Bressler,S.L. and Martin,G.M.
  TITLE     Alternatively spliced isoforms of FE65 serve as neuron-specific and
            non-neuronal markers
  JOURNAL   J Neurosci Res 58 (5), 632-640 (1999)
   PUBMED   10561691
REFERENCE   6  (bases 1 to 2658)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (bases 1 to 2658)
  AUTHORS   Zambrano,N., Buxbaum,J.D., Minopoli,G., Fiore,F., De Candia,P., De
            Renzis,S., Faraonio,R., Sabo,S., Cheetham,J., Sudol,M. and Russo,T.
  TITLE     Interaction of the phosphotyrosine interaction/phosphotyrosine
            binding-related domains of Fe65 with wild-type and mutant
            Alzheimer's beta-amyloid precursor proteins
  JOURNAL   J Biol Chem 272 (10), 6399-6405 (1997)
   PUBMED   9045663
REFERENCE   8  (bases 1 to 2658)
  AUTHORS   McLoughlin,D.M. and Miller,C.C.
  TITLE     The intracellular cytoplasmic domain of the Alzheimer's disease
            amyloid precursor protein interacts with phosphotyrosine-binding
            domain proteins in the yeast two-hybrid system
  JOURNAL   FEBS Lett 397 (2-3), 197-200 (1996)
   PUBMED   8955346
REFERENCE   9  (bases 1 to 2658)
  AUTHORS   Borg,J.P., Ooi,J., Levy,E. and Margolis,B.
  TITLE     The phosphotyrosine interaction domains of X11 and FE65 bind to
            distinct sites on the YENPTY motif of amyloid precursor protein
  JOURNAL   Mol Cell Biol 16 (11), 6229-6241 (1996)
   PUBMED   8887653
REFERENCE   10 (bases 1 to 2658)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY138432.1 and BC010854.2.
            
            On May 31, 2019 this sequence version replaced NM_145689.2.
            
            Summary: The protein encoded by this gene is a member of the Fe65
            protein family. It is an adaptor protein localized in the nucleus.
            It interacts with the Alzheimer's disease amyloid precursor protein
            (APP), transcription factor CP2/LSF/LBP1 and the low-density
            lipoprotein receptor-related protein. APP functions as a cytosolic
            anchoring site that can prevent the gene product's nuclear
            translocation. This encoded protein could play an important role in
            the pathogenesis of Alzheimer's disease. It is thought to regulate
            transcription. Also it is observed to block cell cycle progression
            by downregulating thymidylate synthase expression. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Mar 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate, in-frame exon in the coding region compared to
            variant 1. This results in a protein that maintains the reading
            frame but is a shorter isoform (b, also known as delta E9),
            compared to isoform a. This encoded isoform (b) is widely expressed
            in all non-neuronal cells but is not expressed in differentiated
            neurons.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.158311.1, BC010854.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                HY138432.1         19-57
            40-2658             BC010854.2         13-2631
FEATURES             Location/Qualifiers
     source          1..2658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2658
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
     exon            1..108
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            109..843
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2249
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="isoform b is encoded by transcript variant 2;
                     stat-like protein; adaptor protein FE65a2; amyloid beta
                     (A4) precursor protein-binding, family B, member 1 (Fe65)"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform b"
                     /protein_id="NP_663722.1"
                     /db_xref="CCDS:CCDS31410.1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
                     /translation="MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATA
                     VGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQE
                     PEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEE
                     EEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAAS
                     DEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTG
                     TTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEP
                     EEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSV
                     AVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
                     RVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR
                     CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALES
                     VLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMA
                     AGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARR
                     VGWTVRRGVQSLWGSLKPKRLGAHTP"
     exon            844..1019
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1076
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1162
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1226
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1376
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1504
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1619
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1704
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1788
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1904
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2081
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2658
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="hexamer: AATAAA"
     polyA_site      2658
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="major polyA site"
ORIGIN      
        1 cttccccgcg cggccgcggc gccgcacagc cgccgccatt cgggctccag ccccgtccgc
       61 gcgtctcccg gcgtgggtgc gggaccaggg cgctgcgggg cgcgcaggga gctgccaagg
      121 ccatgtctgt tccatcatca ctgagccagt cggccattaa tgccaacagc cacggaggcc
      181 ccgcactgag cctacccctg cctctgcacg ctgcccacaa ccagctgctc aacgccaagc
      241 tgcaggccac agctgtggga cccaaggacc tgcgcagcgc catgggggag ggtggtgggc
      301 ctgagccagg ccctgccaat gccaagtggc taaaagaggg ccagaaccag ctccggcggg
      361 ccgccacggc ccaccgtgac cagaatcgca atgtgacctt gaccttggcg gaggaggcca
      421 gccaggagcc tgagatggca cccttgggcc ccaaaggcct gatacacctg tactctgagc
      481 tggagctctc agctcacaac gcagccaacc gaggcctacg aggacctggc ctgatcatca
      541 gcactcaaga gcaggggcca gatgagggag aggagaaggc ggccggggag gccgaggagg
      601 aggaggagga tgatgatgat gaagaggagg aggaggactt atcttctccc ccagggctgc
      661 ctgagcccct ggagagtgtg gaggcccctc ccaggcccca agcccttaca gatggccccc
      721 gggaacacag caagagtgcc agcctcctgt ttggcatgcg gaacagtgca gccagtgatg
      781 aggactcaag ctgggctacc ttatcccagg gcagcccctc ctatggctcc ccagaggaca
      841 cagattcctt ctggaacccc aacgccttcg agacggattc cgacctgccg gctggatgga
      901 tgagggtcca ggacacctca gggacctatt actggcacat cccaacaggg accacccagt
      961 gggaaccccc cggccgggcc tccccctcac aggggagcag cccccaagag gagtcccagc
     1021 tcacctggac aggttttgct catggagaag gctttgagga tggagaattt tggaaggatg
     1081 aacccagtga tgaggcccca atggagctgg gactgaagga acctgaggag gggacgttga
     1141 ccttcccagc tcagagcctc agcccagagc cgttgcccca agaggaggag aagcttcccc
     1201 cacggaatac caacccaggg atcaagtgtt tcgccgtgcg ctccctaggc tgggtagaga
     1261 tgaccgagga ggagctggcc cctggacgca gcagtgtggc agtcaacaat tgcatccgtc
     1321 agctctctta ccacaaaaac aacctgcatg accccatgtc tgggggctgg ggggaaggaa
     1381 aggatctgct actgcagctg gaggatgaga cactaaagct agtggagcca cagagccagg
     1441 cactgctgca cgcccaaccc atcatcagca tccgcgtgtg gggcgtcggg cgggacagtg
     1501 gaagggactt tgcctacgta gctcgtgata agctgaccca gatgctcaag tgccacgtgt
     1561 ttcgctgtga ggcacctgcc aagaacatcg ccaccagcct gcatgagatc tgctctaaga
     1621 tcatggccga acggcgtaat gcccgctgct tggtaaatgg actctccctg gaccactcta
     1681 aacttgtgga tgtccctttc caagtggaat tcccagcgcc taagaatgag ttggtccaga
     1741 agttccaagt ctattacctg gggaatgtac ctgttgctaa acctgttggg gtagatgtga
     1801 ttaatggggc cctcgagtca gtcctgtcct ccagcagccg tgaacaatgg accccaagtc
     1861 atgtcagtgt ggcccctgct accctcacca tcttgcacca gcagacagag gcagtgctgg
     1921 gagagtgtcg ggtgcgtttc ctctccttcc tggccgtggg cagagatgtc cacacgtttg
     1981 cattcatcat ggctgccggc ccagcctcct tctgctgcca catgttctgg tgcgagccca
     2041 atgctgccag cctctcagag gctgtgcagg ctgcgtgcat gcttcgctac cagaagtgtc
     2101 tggatgcccg ttcccaggcc tccacctcct gcctcccagc accccctgct gagtctgtgg
     2161 cacggcgtgt agggtggact gtccgcaggg gtgttcagtc gctgtggggc tccctgaagc
     2221 ccaaacggct gggggcccat accccatgaa gaagccccca ccttccctcc acctgcttgt
     2281 gttgggcccc agggaactaa agggtgtggg tcagggaggg gtctagaggc tattcctagg
     2341 cctcaggcct cccaaatatg cccctcccca gtagctacgg ttccctgcct aggagctggg
     2401 gagggagaga tctaatccct tcaaggaagt gataacactg gagtggtaac aagaggagca
     2461 ggaagcaagg ccagccctgg ttctccatcc ccatgtgttt caggtggaac aggaggaact
     2521 ggtccaggcc aggcctcatc ctcctggacc cagcaggggc agaaggagga agggactggt
     2581 ccaggcatgg gtcccttccc cctgctccat gggcacctct gctgtattga tatcactaat
     2641 aaagtctgtc tgcactgc
//
