LOCUS       NM_001257325            1906 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family B member
            1 (APBB1), transcript variant 7, mRNA.
ACCESSION   NM_001257325
VERSION     NM_001257325.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Revol,R.S., Koistinen,N.A., Menon,P.K., Chicote-Gonzalez,A.,
            Iverfeldt,K. and Strom,A.L.
  TITLE     Alpha-secretase dependent nuclear localization of the amyloid-beta
            precursor protein-binding protein Fe65 promotes DNA repair
  JOURNAL   Mol Cell Neurosci 127, 103903 (2023)
   PUBMED   37918552
  REMARK    GeneRIF: Alpha-secretase dependent nuclear localization of the
            amyloid-beta precursor protein-binding protein Fe65 promotes DNA
            repair.
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Chau,D.D., Li,W., Chan,W.W.R., Sun,J.K., Zhai,Y., Chow,H.M. and
            Lau,K.F.
  TITLE     Insulin stimulates atypical protein kinase C-mediated
            phosphorylation of the neuronal adaptor FE65 to potentiate neurite
            outgrowth by activating ARF6-Rac1 signaling
  JOURNAL   FASEB J 36 (11), e22594 (2022)
   PUBMED   36250347
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Hu,Q., Hearn,M.G., Jin,L.W., Bressler,S.L. and Martin,G.M.
  TITLE     Alternatively spliced isoforms of FE65 serve as neuron-specific and
            non-neuronal markers
  JOURNAL   J Neurosci Res 58 (5), 632-640 (1999)
   PUBMED   10561691
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Zambrano,N., Buxbaum,J.D., Minopoli,G., Fiore,F., De Candia,P., De
            Renzis,S., Faraonio,R., Sabo,S., Cheetham,J., Sudol,M. and Russo,T.
  TITLE     Interaction of the phosphotyrosine interaction/phosphotyrosine
            binding-related domains of Fe65 with wild-type and mutant
            Alzheimer's beta-amyloid precursor proteins
  JOURNAL   J Biol Chem 272 (10), 6399-6405 (1997)
   PUBMED   9045663
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   McLoughlin,D.M. and Miller,C.C.
  TITLE     The intracellular cytoplasmic domain of the Alzheimer's disease
            amyloid precursor protein interacts with phosphotyrosine-binding
            domain proteins in the yeast two-hybrid system
  JOURNAL   FEBS Lett 397 (2-3), 197-200 (1996)
   PUBMED   8955346
REFERENCE   9  (bases 1 to 1906)
  AUTHORS   Borg,J.P., Ooi,J., Levy,E. and Margolis,B.
  TITLE     The phosphotyrosine interaction domains of X11 and FE65 bind to
            distinct sites on the YENPTY motif of amyloid precursor protein
  JOURNAL   Mol Cell Biol 16 (11), 6229-6241 (1996)
   PUBMED   8887653
REFERENCE   10 (bases 1 to 1906)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC306210.1, DC319935.1,
            AK293554.1 and BC010854.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001257325.2.
            
            Summary: The protein encoded by this gene is a member of the Fe65
            protein family. It is an adaptor protein localized in the nucleus.
            It interacts with the Alzheimer's disease amyloid precursor protein
            (APP), transcription factor CP2/LSF/LBP1 and the low-density
            lipoprotein receptor-related protein. APP functions as a cytosolic
            anchoring site that can prevent the gene product's nuclear
            translocation. This encoded protein could play an important role in
            the pathogenesis of Alzheimer's disease. It is thought to regulate
            transcription. Also it is observed to block cell cycle progression
            by downregulating thymidylate synthase expression. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Mar 2012].
            
            Transcript Variant: This variant (7) represents use of an alternate
            promoter and thus differs in the 5' UTR and 5' coding region
            compared to variant 1. These differences cause translation
            initiation at an alternate start codon and result in an isoform (e)
            with a shorter and distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DC306210.1         1-27
            28-601              DC319935.1         1-574
            602-840             AK293554.1         570-808
            841-1906            BC010854.2         1566-2631
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1906
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
     exon            1..85
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1497
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="isoform e is encoded by transcript variant 7;
                     stat-like protein; adaptor protein FE65a2; amyloid beta
                     (A4) precursor protein-binding, family B, member 1 (Fe65)"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform e"
                     /protein_id="NP_001244254.1"
                     /db_xref="CCDS:CCDS66016.1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
                     /translation="MTQMRDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQ
                     WEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEG
                     TLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVN
                     NCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVW
                     GVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARC
                     LVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESV
                     LSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAA
                     GPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRV
                     GWTVRRGVQSLWGSLKPKRLGAHTP"
     exon            86..261
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            262..318
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            319..404
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            405..468
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            469..618
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            619..746
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            747..752
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            753..867
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            868..952
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1036
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1152
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1329
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1906
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="major polyA site"
ORIGIN      
        1 aagagttaga ggacgcatga gcgggttaca gggttggagt ggtgtggctc tgccggcaga
       61 caagggtgta tgacacagat gcgagattcc ttctggaacc ccaacgcctt cgagacggat
      121 tccgacctgc cggctggatg gatgagggtc caggacacct cagggaccta ttactggcac
      181 atcccaacag ggaccaccca gtgggaaccc cccggccggg cctccccctc acaggggagc
      241 agcccccaag aggagtccca gctcacctgg acaggttttg ctcatggaga aggctttgag
      301 gatggagaat tttggaagga tgaacccagt gatgaggccc caatggagct gggactgaag
      361 gaacctgagg aggggacgtt gaccttccca gctcagagcc tcagcccaga gccgttgccc
      421 caagaggagg agaagcttcc cccacggaat accaacccag ggatcaagtg tttcgccgtg
      481 cgctccctag gctgggtaga gatgaccgag gaggagctgg cccctggacg cagcagtgtg
      541 gcagtcaaca attgcatccg tcagctctct taccacaaaa acaacctgca tgaccccatg
      601 tctgggggct ggggggaagg aaaggatctg ctactgcagc tggaggatga gacactaaag
      661 ctagtggagc cacagagcca ggcactgctg cacgcccaac ccatcatcag catccgcgtg
      721 tggggcgtcg ggcgggacag tggaagagag agggactttg cctacgtagc tcgtgataag
      781 ctgacccaga tgctcaagtg ccacgtgttt cgctgtgagg cacctgccaa gaacatcgcc
      841 accagcctgc atgagatctg ctctaagatc atggccgaac ggcgtaatgc ccgctgcttg
      901 gtaaatggac tctccctgga ccactctaaa cttgtggatg tccctttcca agtggaattc
      961 ccagcgccta agaatgagtt ggtccagaag ttccaagtct attacctggg gaatgtacct
     1021 gttgctaaac ctgttggggt agatgtgatt aatggggccc tcgagtcagt cctgtcctcc
     1081 agcagccgtg aacaatggac cccaagtcat gtcagtgtgg cccctgctac cctcaccatc
     1141 ttgcaccagc agacagaggc agtgctggga gagtgtcggg tgcgtttcct ctccttcctg
     1201 gccgtgggca gagatgtcca cacgtttgca ttcatcatgg ctgccggccc agcctccttc
     1261 tgctgccaca tgttctggtg cgagcccaat gctgccagcc tctcagaggc tgtgcaggct
     1321 gcgtgcatgc ttcgctacca gaagtgtctg gatgcccgtt cccaggcctc cacctcctgc
     1381 ctcccagcac cccctgctga gtctgtggca cggcgtgtag ggtggactgt ccgcaggggt
     1441 gttcagtcgc tgtggggctc cctgaagccc aaacggctgg gggcccatac cccatgaaga
     1501 agcccccacc ttccctccac ctgcttgtgt tgggccccag ggaactaaag ggtgtgggtc
     1561 agggaggggt ctagaggcta ttcctaggcc tcaggcctcc caaatatgcc cctccccagt
     1621 agctacggtt ccctgcctag gagctgggga gggagagatc taatcccttc aaggaagtga
     1681 taacactgga gtggtaacaa gaggagcagg aagcaaggcc agccctggtt ctccatcccc
     1741 atgtgtttca ggtggaacag gaggaactgg tccaggccag gcctcatcct cctggaccca
     1801 gcaggggcag aaggaggaag ggactggtcc aggcatgggt cccttccccc tgctccatgg
     1861 gcacctctgc tgtattgata tcactaataa agtctgtctg cactgc
//
