LOCUS       NM_001257323            2004 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family B member
            1 (APBB1), transcript variant 8, mRNA.
ACCESSION   NM_001257323
VERSION     NM_001257323.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2004)
  AUTHORS   Revol,R.S., Koistinen,N.A., Menon,P.K., Chicote-Gonzalez,A.,
            Iverfeldt,K. and Strom,A.L.
  TITLE     Alpha-secretase dependent nuclear localization of the amyloid-beta
            precursor protein-binding protein Fe65 promotes DNA repair
  JOURNAL   Mol Cell Neurosci 127, 103903 (2023)
   PUBMED   37918552
  REMARK    GeneRIF: Alpha-secretase dependent nuclear localization of the
            amyloid-beta precursor protein-binding protein Fe65 promotes DNA
            repair.
REFERENCE   2  (bases 1 to 2004)
  AUTHORS   Chau,D.D., Li,W., Chan,W.W.R., Sun,J.K., Zhai,Y., Chow,H.M. and
            Lau,K.F.
  TITLE     Insulin stimulates atypical protein kinase C-mediated
            phosphorylation of the neuronal adaptor FE65 to potentiate neurite
            outgrowth by activating ARF6-Rac1 signaling
  JOURNAL   FASEB J 36 (11), e22594 (2022)
   PUBMED   36250347
REFERENCE   3  (bases 1 to 2004)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2004)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2004)
  AUTHORS   Hu,Q., Hearn,M.G., Jin,L.W., Bressler,S.L. and Martin,G.M.
  TITLE     Alternatively spliced isoforms of FE65 serve as neuron-specific and
            non-neuronal markers
  JOURNAL   J Neurosci Res 58 (5), 632-640 (1999)
   PUBMED   10561691
REFERENCE   6  (bases 1 to 2004)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (bases 1 to 2004)
  AUTHORS   Zambrano,N., Buxbaum,J.D., Minopoli,G., Fiore,F., De Candia,P., De
            Renzis,S., Faraonio,R., Sabo,S., Cheetham,J., Sudol,M. and Russo,T.
  TITLE     Interaction of the phosphotyrosine interaction/phosphotyrosine
            binding-related domains of Fe65 with wild-type and mutant
            Alzheimer's beta-amyloid precursor proteins
  JOURNAL   J Biol Chem 272 (10), 6399-6405 (1997)
   PUBMED   9045663
REFERENCE   8  (bases 1 to 2004)
  AUTHORS   McLoughlin,D.M. and Miller,C.C.
  TITLE     The intracellular cytoplasmic domain of the Alzheimer's disease
            amyloid precursor protein interacts with phosphotyrosine-binding
            domain proteins in the yeast two-hybrid system
  JOURNAL   FEBS Lett 397 (2-3), 197-200 (1996)
   PUBMED   8955346
REFERENCE   9  (bases 1 to 2004)
  AUTHORS   Borg,J.P., Ooi,J., Levy,E. and Margolis,B.
  TITLE     The phosphotyrosine interaction domains of X11 and FE65 bind to
            distinct sites on the YENPTY motif of amyloid precursor protein
  JOURNAL   Mol Cell Biol 16 (11), 6229-6241 (1996)
   PUBMED   8887653
REFERENCE   10 (bases 1 to 2004)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC316489.1, AK295241.1 and
            BC010854.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001257323.2.
            
            Summary: The protein encoded by this gene is a member of the Fe65
            protein family. It is an adaptor protein localized in the nucleus.
            It interacts with the Alzheimer's disease amyloid precursor protein
            (APP), transcription factor CP2/LSF/LBP1 and the low-density
            lipoprotein receptor-related protein. APP functions as a cytosolic
            anchoring site that can prevent the gene product's nuclear
            translocation. This encoded protein could play an important role in
            the pathogenesis of Alzheimer's disease. It is thought to regulate
            transcription. Also it is observed to block cell cycle progression
            by downregulating thymidylate synthase expression. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Mar 2012].
            
            Transcript Variant: This variant (8) represents use of an alternate
            promoter and thus differs in the 5' UTR and 5' coding region, and
            lacks an alternate, in-frame exon in the coding region compared to
            variant 1. These differences cause translation initiation at an
            alternate start codon and result in an isoform (f) that is shorter
            with a distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295241.1, SRR3476690.1116845.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DC316489.1         1-35
            36-1063             AK295241.1         1-1028
            1064-2004           BC010854.2         1691-2631
FEATURES             Location/Qualifiers
     source          1..2004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2004
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
     exon            1..189
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1595
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="isoform f is encoded by transcript variant 8;
                     stat-like protein; adaptor protein FE65a2; amyloid beta
                     (A4) precursor protein-binding, family B, member 1 (Fe65)"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform f"
                     /protein_id="NP_001244252.1"
                     /db_xref="CCDS:CCDS58114.1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
                     /translation="MSAMFSQDFFLAIILQDSSADSFWNPNAFETDSDLPAGWMRVQD
                     TSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPS
                     DEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEM
                     TEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQS
                     QALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEI
                     CSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKP
                     VGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAV
                     GRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSC
                     LPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP"
     exon            190..365
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            366..422
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            423..508
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            509..572
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            573..722
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            723..850
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            851..965
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1050
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1134
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1250
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1427
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2004
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="hexamer: AATAAA"
     polyA_site      2004
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="major polyA site"
ORIGIN      
        1 agacgctctg ccctggtgag aagggggcgg gatgagcttt tctctgcagc ccagcaccag
       61 gctgtgagcc cagctggctg ggctggaggg gctgtgagga gggagggtgg aggcaggagg
      121 ggccgggaat gagcgccatg ttctcccagg actttttcct ggccattatc ctgcaggaca
      181 gcagcgcaga ttccttctgg aaccccaacg ccttcgagac ggattccgac ctgccggctg
      241 gatggatgag ggtccaggac acctcaggga cctattactg gcacatccca acagggacca
      301 cccagtggga accccccggc cgggcctccc cctcacaggg gagcagcccc caagaggagt
      361 cccagctcac ctggacaggt tttgctcatg gagaaggctt tgaggatgga gaattttgga
      421 aggatgaacc cagtgatgag gccccaatgg agctgggact gaaggaacct gaggagggga
      481 cgttgacctt cccagctcag agcctcagcc cagagccgtt gccccaagag gaggagaagc
      541 ttcccccacg gaataccaac ccagggatca agtgtttcgc cgtgcgctcc ctaggctggg
      601 tagagatgac cgaggaggag ctggcccctg gacgcagcag tgtggcagtc aacaattgca
      661 tccgtcagct ctcttaccac aaaaacaacc tgcatgaccc catgtctggg ggctgggggg
      721 aaggaaagga tctgctactg cagctggagg atgagacact aaagctagtg gagccacaga
      781 gccaggcact gctgcacgcc caacccatca tcagcatccg cgtgtggggc gtcgggcggg
      841 acagtggaag ggactttgcc tacgtagctc gtgataagct gacccagatg ctcaagtgcc
      901 acgtgtttcg ctgtgaggca cctgccaaga acatcgccac cagcctgcat gagatctgct
      961 ctaagatcat ggccgaacgg cgtaatgccc gctgcttggt aaatggactc tccctggacc
     1021 actctaaact tgtggatgtc cctttccaag tggaattccc agcgcctaag aatgagttgg
     1081 tccagaagtt ccaagtctat tacctgggga atgtacctgt tgctaaacct gttggggtag
     1141 atgtgattaa tggggccctc gagtcagtcc tgtcctccag cagccgtgaa caatggaccc
     1201 caagtcatgt cagtgtggcc cctgctaccc tcaccatctt gcaccagcag acagaggcag
     1261 tgctgggaga gtgtcgggtg cgtttcctct ccttcctggc cgtgggcaga gatgtccaca
     1321 cgtttgcatt catcatggct gccggcccag cctccttctg ctgccacatg ttctggtgcg
     1381 agcccaatgc tgccagcctc tcagaggctg tgcaggctgc gtgcatgctt cgctaccaga
     1441 agtgtctgga tgcccgttcc caggcctcca cctcctgcct cccagcaccc cctgctgagt
     1501 ctgtggcacg gcgtgtaggg tggactgtcc gcaggggtgt tcagtcgctg tggggctccc
     1561 tgaagcccaa acggctgggg gcccataccc catgaagaag cccccacctt ccctccacct
     1621 gcttgtgttg ggccccaggg aactaaaggg tgtgggtcag ggaggggtct agaggctatt
     1681 cctaggcctc aggcctccca aatatgcccc tccccagtag ctacggttcc ctgcctagga
     1741 gctggggagg gagagatcta atcccttcaa ggaagtgata acactggagt ggtaacaaga
     1801 ggagcaggaa gcaaggccag ccctggttct ccatccccat gtgtttcagg tggaacagga
     1861 ggaactggtc caggccaggc ctcatcctcc tggacccagc aggggcagaa ggaggaaggg
     1921 actggtccag gcatgggtcc cttccccctg ctccatgggc acctctgctg tattgatatc
     1981 actaataaag tctgtctgca ctgc
//
