LOCUS       NM_001257321            2162 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family B member
            1 (APBB1), transcript variant 4, mRNA.
ACCESSION   NM_001257321
VERSION     NM_001257321.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Revol,R.S., Koistinen,N.A., Menon,P.K., Chicote-Gonzalez,A.,
            Iverfeldt,K. and Strom,A.L.
  TITLE     Alpha-secretase dependent nuclear localization of the amyloid-beta
            precursor protein-binding protein Fe65 promotes DNA repair
  JOURNAL   Mol Cell Neurosci 127, 103903 (2023)
   PUBMED   37918552
  REMARK    GeneRIF: Alpha-secretase dependent nuclear localization of the
            amyloid-beta precursor protein-binding protein Fe65 promotes DNA
            repair.
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Chau,D.D., Li,W., Chan,W.W.R., Sun,J.K., Zhai,Y., Chow,H.M. and
            Lau,K.F.
  TITLE     Insulin stimulates atypical protein kinase C-mediated
            phosphorylation of the neuronal adaptor FE65 to potentiate neurite
            outgrowth by activating ARF6-Rac1 signaling
  JOURNAL   FASEB J 36 (11), e22594 (2022)
   PUBMED   36250347
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Hu,Q., Hearn,M.G., Jin,L.W., Bressler,S.L. and Martin,G.M.
  TITLE     Alternatively spliced isoforms of FE65 serve as neuron-specific and
            non-neuronal markers
  JOURNAL   J Neurosci Res 58 (5), 632-640 (1999)
   PUBMED   10561691
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   Zambrano,N., Buxbaum,J.D., Minopoli,G., Fiore,F., De Candia,P., De
            Renzis,S., Faraonio,R., Sabo,S., Cheetham,J., Sudol,M. and Russo,T.
  TITLE     Interaction of the phosphotyrosine interaction/phosphotyrosine
            binding-related domains of Fe65 with wild-type and mutant
            Alzheimer's beta-amyloid precursor proteins
  JOURNAL   J Biol Chem 272 (10), 6399-6405 (1997)
   PUBMED   9045663
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   McLoughlin,D.M. and Miller,C.C.
  TITLE     The intracellular cytoplasmic domain of the Alzheimer's disease
            amyloid precursor protein interacts with phosphotyrosine-binding
            domain proteins in the yeast two-hybrid system
  JOURNAL   FEBS Lett 397 (2-3), 197-200 (1996)
   PUBMED   8955346
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Borg,J.P., Ooi,J., Levy,E. and Margolis,B.
  TITLE     The phosphotyrosine interaction domains of X11 and FE65 bind to
            distinct sites on the YENPTY motif of amyloid precursor protein
  JOURNAL   Mol Cell Biol 16 (11), 6229-6241 (1996)
   PUBMED   8887653
REFERENCE   10 (bases 1 to 2162)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297550.1, EF103274.2 and
            BM145723.1.
            
            On Oct 1, 2013 this sequence version replaced NM_001257321.1.
            
            Summary: The protein encoded by this gene is a member of the Fe65
            protein family. It is an adaptor protein localized in the nucleus.
            It interacts with the Alzheimer's disease amyloid precursor protein
            (APP), transcription factor CP2/LSF/LBP1 and the low-density
            lipoprotein receptor-related protein. APP functions as a cytosolic
            anchoring site that can prevent the gene product's nuclear
            translocation. This encoded protein could play an important role in
            the pathogenesis of Alzheimer's disease. It is thought to regulate
            transcription. Also it is observed to block cell cycle progression
            by downregulating thymidylate synthase expression. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Mar 2012].
            
            Transcript Variant: This variant (4) represents use of an alternate
            promoter and thus differs in the 5' UTR and 5' coding region
            compared to variant 1. These differences cause translation
            initiation at a downstream start codon and result in an isoform (d)
            with a shorter N-terminus, compared to isoform 1. Variants 4, 5,
            and 6 all encode the same isoform (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-766               AK297550.1         2-767
            767-2146            EF103274.2         575-1954
            2147-2162           BM145723.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2162
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
     exon            1..285
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            286..325
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            326..501
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1737
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="isoform d is encoded by transcript variant 4;
                     stat-like protein; adaptor protein FE65a2; amyloid beta
                     (A4) precursor protein-binding, family B, member 1 (Fe65)"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform d"
                     /protein_id="NP_001244250.1"
                     /db_xref="CCDS:CCDS66015.1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
                     /translation="MRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWT
                     GFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPR
                     NTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEG
                     KDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQML
                     KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP
                     KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTIL
                     HQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQ
                     AACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHT
                     P"
     exon            502..558
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            559..644
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            645..708
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            709..858
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            859..986
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            987..992
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1107
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1192
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1276
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1392
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1569
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..2147
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="major polyA site"
ORIGIN      
        1 gagacgctgc agcctagctg ggccctggca ggtgaggggt ggggggtggt gctgggaagc
       61 cccaagccca gcctcaagct tgctggggct caggacctca aagcccaccc ttgggttcaa
      121 actgctgtgc aggtcctgga caggggcggg atccctgaag gccttgaaac cacaccctat
      181 ttatgctgac agctataggc tctgcagggc cccaggcagc tggggtattc cttaggggct
      241 gagtctcctg gtatccctaa gactgggctt ggcttaggca ctgaggactt tttcctggcc
      301 attatcctgc aggacagcag cgcagattcc ttctggaacc ccaacgcctt cgagacggat
      361 tccgacctgc cggctggatg gatgagggtc caggacacct cagggaccta ttactggcac
      421 atcccaacag ggaccaccca gtgggaaccc cccggccggg cctccccctc acaggggagc
      481 agcccccaag aggagtccca gctcacctgg acaggttttg ctcatggaga aggctttgag
      541 gatggagaat tttggaagga tgaacccagt gatgaggccc caatggagct gggactgaag
      601 gaacctgagg aggggacgtt gaccttccca gctcagagcc tcagcccaga gccgttgccc
      661 caagaggagg agaagcttcc cccacggaat accaacccag ggatcaagtg tttcgccgtg
      721 cgctccctag gctgggtaga gatgaccgag gaggagctgg cccctggacg cagcagtgtg
      781 gcagtcaaca attgcatccg tcagctctct taccacaaaa acaacctgca tgaccccatg
      841 tctgggggct ggggggaagg aaaggatctg ctactgcagc tggaggatga gacactaaag
      901 ctagtggagc cacagagcca ggcactgctg cacgcccaac ccatcatcag catccgcgtg
      961 tggggcgtcg ggcgggacag tggaagagag agggactttg cctacgtagc tcgtgataag
     1021 ctgacccaga tgctcaagtg ccacgtgttt cgctgtgagg cacctgccaa gaacatcgcc
     1081 accagcctgc atgagatctg ctctaagatc atggccgaac ggcgtaatgc ccgctgcttg
     1141 gtaaatggac tctccctgga ccactctaaa cttgtggatg tccctttcca agtggaattc
     1201 ccagcgccta agaatgagtt ggtccagaag ttccaagtct attacctggg gaatgtacct
     1261 gttgctaaac ctgttggggt agatgtgatt aatggggccc tcgagtcagt cctgtcctcc
     1321 agcagccgtg aacaatggac cccaagtcat gtcagtgtgg cccctgctac cctcaccatc
     1381 ttgcaccagc agacagaggc agtgctggga gagtgtcggg tgcgtttcct ctccttcctg
     1441 gccgtgggca gagatgtcca cacgtttgca ttcatcatgg ctgccggccc agcctccttc
     1501 tgctgccaca tgttctggtg cgagcccaat gctgccagcc tctcagaggc tgtgcaggct
     1561 gcgtgcatgc ttcgctacca gaagtgtctg gatgcccgtt cccaggcctc cacctcctgc
     1621 ctcccagcac cccctgctga gtctgtggca cggcgtgtag ggtggactgt ccgcaggggt
     1681 gttcagtcgc tgtggggctc cctgaagccc aaacggctgg gggcccatac cccatgaaga
     1741 agcccccacc ttccctccac ctgcttgtgt tgggccccag ggaactaaag ggtgtgggtc
     1801 agggaggggt ctagaggcta ttcctaggcc tcaggcctcc caaatatgcc cctccccagt
     1861 agctacggtt ccctgcctag gagctgggga gggagagatc taatcccttc aaggaagtga
     1921 taacactgga gtggtaacaa gaggagcagg aagcaaggcc agccctggtt ctccatcccc
     1981 atgtgtttca ggtggaacag gaggaactgg tccaggccag gcctcatcct cctggaccca
     2041 gcaggggcag aaggaggaag ggactggtcc aggcatgggt cccttccccc tgctccatgg
     2101 gcacctctgc tgtattgata tcactaataa agtctgtctg cactgctaaa aaaaaaaaaa
     2161 aa
//
