LOCUS       NM_001164               2666 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens amyloid beta precursor protein binding family B member
            1 (APBB1), transcript variant 1, mRNA.
ACCESSION   NM_001164
VERSION     NM_001164.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2666)
  AUTHORS   Revol,R.S., Koistinen,N.A., Menon,P.K., Chicote-Gonzalez,A.,
            Iverfeldt,K. and Strom,A.L.
  TITLE     Alpha-secretase dependent nuclear localization of the amyloid-beta
            precursor protein-binding protein Fe65 promotes DNA repair
  JOURNAL   Mol Cell Neurosci 127, 103903 (2023)
   PUBMED   37918552
  REMARK    GeneRIF: Alpha-secretase dependent nuclear localization of the
            amyloid-beta precursor protein-binding protein Fe65 promotes DNA
            repair.
REFERENCE   2  (bases 1 to 2666)
  AUTHORS   Chau,D.D., Li,W., Chan,W.W.R., Sun,J.K., Zhai,Y., Chow,H.M. and
            Lau,K.F.
  TITLE     Insulin stimulates atypical protein kinase C-mediated
            phosphorylation of the neuronal adaptor FE65 to potentiate neurite
            outgrowth by activating ARF6-Rac1 signaling
  JOURNAL   FASEB J 36 (11), e22594 (2022)
   PUBMED   36250347
REFERENCE   3  (bases 1 to 2666)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2666)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2666)
  AUTHORS   Hu,Q., Hearn,M.G., Jin,L.W., Bressler,S.L. and Martin,G.M.
  TITLE     Alternatively spliced isoforms of FE65 serve as neuron-specific and
            non-neuronal markers
  JOURNAL   J Neurosci Res 58 (5), 632-640 (1999)
   PUBMED   10561691
REFERENCE   6  (bases 1 to 2666)
  AUTHORS   Ermekova,K.S., Zambrano,N., Linn,H., Minopoli,G., Gertler,F.,
            Russo,T. and Sudol,M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (bases 1 to 2666)
  AUTHORS   Zambrano,N., Buxbaum,J.D., Minopoli,G., Fiore,F., De Candia,P., De
            Renzis,S., Faraonio,R., Sabo,S., Cheetham,J., Sudol,M. and Russo,T.
  TITLE     Interaction of the phosphotyrosine interaction/phosphotyrosine
            binding-related domains of Fe65 with wild-type and mutant
            Alzheimer's beta-amyloid precursor proteins
  JOURNAL   J Biol Chem 272 (10), 6399-6405 (1997)
   PUBMED   9045663
REFERENCE   8  (bases 1 to 2666)
  AUTHORS   McLoughlin,D.M. and Miller,C.C.
  TITLE     The intracellular cytoplasmic domain of the Alzheimer's disease
            amyloid precursor protein interacts with phosphotyrosine-binding
            domain proteins in the yeast two-hybrid system
  JOURNAL   FEBS Lett 397 (2-3), 197-200 (1996)
   PUBMED   8955346
REFERENCE   9  (bases 1 to 2666)
  AUTHORS   Borg,J.P., Ooi,J., Levy,E. and Margolis,B.
  TITLE     The phosphotyrosine interaction domains of X11 and FE65 bind to
            distinct sites on the YENPTY motif of amyloid precursor protein
  JOURNAL   Mol Cell Biol 16 (11), 6229-6241 (1996)
   PUBMED   8887653
REFERENCE   10 (bases 1 to 2666)
  AUTHORS   Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G.,
            Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A.,
            Disteche,C.M. and Martin,G.M.
  TITLE     cDNA cloning and chromosome mapping of the human Fe65 gene:
            interaction of the conserved cytoplasmic domains of the human
            beta-amyloid precursor protein and its homologues with the mouse
            Fe65 protein
  JOURNAL   Hum Mol Genet 5 (10), 1589-1598 (1996)
   PUBMED   8894693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY145957.1, L77864.1 and
            BC010854.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001164.4.
            
            Summary: The protein encoded by this gene is a member of the Fe65
            protein family. It is an adaptor protein localized in the nucleus.
            It interacts with the Alzheimer's disease amyloid precursor protein
            (APP), transcription factor CP2/LSF/LBP1 and the low-density
            lipoprotein receptor-related protein. APP functions as a cytosolic
            anchoring site that can prevent the gene product's nuclear
            translocation. This encoded protein could play an important role in
            the pathogenesis of Alzheimer's disease. It is thought to regulate
            transcription. Also it is observed to block cell cycle progression
            by downregulating thymidylate synthase expression. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Mar 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as E9).
            This isoform is exclusively expressed in neurons.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.236835.1,
                                           SRR1803612.229885.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609360.6/ ENSP00000477213.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                HY145957.1         18-41
            25-690              L77864.1           1-666
            691-1506            BC010854.2         662-1477
            1507-2276           L77864.1           1483-2252
            2277-2666           BC010854.2         2242-2631
FEATURES             Location/Qualifiers
     source          1..2666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2666
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="amyloid beta precursor protein binding family B
                     member 1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
     exon            1..110
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            111..845
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2257
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="isoform a is encoded by transcript variant 1;
                     stat-like protein; adaptor protein FE65a2; amyloid beta
                     (A4) precursor protein-binding, family B, member 1 (Fe65)"
                     /codon_start=1
                     /product="amyloid beta precursor protein binding family B
                     member 1 isoform a"
                     /protein_id="NP_001155.1"
                     /db_xref="CCDS:CCDS66018.1"
                     /db_xref="GeneID:322"
                     /db_xref="HGNC:HGNC:581"
                     /db_xref="MIM:602709"
                     /translation="MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATA
                     VGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQE
                     PEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEE
                     EEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAAS
                     DEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTG
                     TTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEP
                     EEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSV
                     AVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
                     RVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRN
                     ARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGAL
                     ESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFI
                     MAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVA
                     RRVGWTVRRGVQSLWGSLKPKRLGAHTP"
     exon            846..1021
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1078
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1164
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1228
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1378
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1506
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1512
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1627
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1712
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1796
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1912
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2089
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2666
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2646..2651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="hexamer: AATAAA"
     polyA_site      2666
                     /gene="APBB1"
                     /gene_synonym="FE65; MGC:9072; RIR"
                     /note="major polyA site"
ORIGIN      
        1 ggcccgcgcg ctcctgggcg ggggatgttg tgatggagaa gccgcggcgg agcccgaacc
       61 ccgcagcctg agccacctcc gtcatctggg cccggggcct caccgcgcag gagctgccaa
      121 ggccatgtct gttccatcat cactgagcca gtcggccatt aatgccaaca gccacggagg
      181 ccccgcactg agcctacccc tgcctctgca cgctgcccac aaccagctgc tcaacgccaa
      241 gctgcaggcc acagctgtgg gacccaagga cctgcgcagc gccatggggg agggtggtgg
      301 gcctgagcca ggccctgcca atgccaagtg gctaaaagag ggccagaacc agctccggcg
      361 ggccgccacg gcccaccgtg accagaatcg caatgtgacc ttgaccttgg cggaggaggc
      421 cagccaggag cctgagatgg cacccttggg ccccaaaggc ctgatacacc tgtactctga
      481 gctggagctc tcagctcaca acgcagccaa ccgaggccta cgaggacctg gcctgatcat
      541 cagcactcaa gagcaggggc cagatgaggg agaggagaag gcggccgggg aggccgagga
      601 ggaggaggag gatgatgatg atgaagagga ggaggaggac ttatcttctc ccccagggct
      661 gcctgagccc ctggagagtg tggaggcccc tcccaggccc caagccctta cagatggccc
      721 ccgggaacac agcaagagtg ccagcctcct gtttggcatg cggaacagtg cagccagtga
      781 tgaggactca agctgggcta ccttatccca gggcagcccc tcctatggct ccccagagga
      841 cacagattcc ttctggaacc ccaacgcctt cgagacggat tccgacctgc cggctggatg
      901 gatgagggtc caggacacct cagggaccta ttactggcac atcccaacag ggaccaccca
      961 gtgggaaccc cccggccggg cctccccctc acaggggagc agcccccaag aggagtccca
     1021 gctcacctgg acaggttttg ctcatggaga aggctttgag gatggagaat tttggaagga
     1081 tgaacccagt gatgaggccc caatggagct gggactgaag gaacctgagg aggggacgtt
     1141 gaccttccca gctcagagcc tcagcccaga gccgttgccc caagaggagg agaagcttcc
     1201 cccacggaat accaacccag ggatcaagtg tttcgccgtg cgctccctag gctgggtaga
     1261 gatgaccgag gaggagctgg cccctggacg cagcagtgtg gcagtcaaca attgcatccg
     1321 tcagctctct taccacaaaa acaacctgca tgaccccatg tctgggggct ggggggaagg
     1381 aaaggatctg ctactgcagc tggaggatga gacactaaag ctagtggagc cacagagcca
     1441 ggcactgctg cacgcccaac ccatcatcag catccgcgtg tggggcgtcg ggcgggacag
     1501 tggaagagag agggactttg cctacgtagc tcgtgataag ctgacccaga tgctcaagtg
     1561 ccacgtgttt cgctgtgagg cacctgccaa gaacatcgcc accagcctgc atgagatctg
     1621 ctctaagatc atggccgaac ggcgtaatgc ccgctgcttg gtaaatggac tctccctgga
     1681 ccactctaaa cttgtggatg tccctttcca agtggaattc ccagcgccta agaatgagtt
     1741 ggtccagaag ttccaagtct attacctggg gaatgtacct gttgctaaac ctgttggggt
     1801 agatgtgatt aatggggccc tcgagtcagt cctgtcctcc agcagccgtg aacaatggac
     1861 cccaagtcat gtcagtgtgg cccctgctac cctcaccatc ttgcaccagc agacagaggc
     1921 agtgctggga gagtgtcggg tgcgtttcct ctccttcctg gccgtgggca gagatgtcca
     1981 cacgtttgca ttcatcatgg ctgccggccc agcctccttc tgctgccaca tgttctggtg
     2041 cgagcccaat gctgccagcc tctcagaggc tgtgcaggct gcgtgcatgc ttcgctacca
     2101 gaagtgtctg gatgcccgtt cccaggcctc cacctcctgc ctcccagcac cccctgctga
     2161 gtctgtggca cggcgtgtag ggtggactgt ccgcaggggt gttcagtcgc tgtggggctc
     2221 cctgaagccc aaacggctgg gggcccatac cccatgaaga agcccccacc ttccctccac
     2281 ctgcttgtgt tgggccccag ggaactaaag ggtgtgggtc agggaggggt ctagaggcta
     2341 ttcctaggcc tcaggcctcc caaatatgcc cctccccagt agctacggtt ccctgcctag
     2401 gagctgggga gggagagatc taatcccttc aaggaagtga taacactgga gtggtaacaa
     2461 gaggagcagg aagcaaggcc agccctggtt ctccatcccc atgtgtttca ggtggaacag
     2521 gaggaactgg tccaggccag gcctcatcct cctggaccca gcaggggcag aaggaggaag
     2581 ggactggtcc aggcatgggt cccttccccc tgctccatgg gcacctctgc tgtattgata
     2641 tcactaataa agtctgtctg cactgc
//
