LOCUS       NM_004886               2176 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family A member
            3 (APBA3), mRNA.
ACCESSION   NM_004886
VERSION     NM_004886.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Tanaka,N., Okada,H., Yamaguchi,K., Seki,M., Matsubara,D., Gotoh,N.,
            Suzuki,Y., Furukawa,Y., Yamashita,T., Inoue,J.I., Kaneko,S. and
            Sakamoto,T.
  TITLE     Mint3-depletion-induced energy stress sensitizes triple-negative
            breast cancer to chemotherapy via HSF1 inactivation
  JOURNAL   Cell Death Dis 14 (12), 815 (2023)
   PUBMED   38081808
  REMARK    GeneRIF: Mint3-depletion-induced energy stress sensitizes
            triple-negative breast cancer to chemotherapy via HSF1
            inactivation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Ten,T., Nagatoishi,S., Maeda,R., Hoshino,M., Nakayama,Y., Seiki,M.,
            Sakamoto,T. and Tsumoto,K.
  TITLE     Structural and thermodynamical insights into the binding and
            inhibition of FIH-1 by the N-terminal disordered region of Mint3
  JOURNAL   J Biol Chem 297 (5), 101304 (2021)
   PUBMED   34655613
  REMARK    GeneRIF: Structural and thermodynamical insights into the binding
            and inhibition of FIH-1 by the N-terminal disordered region of
            Mint3.
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Kanamori,A., Matsubara,D., Saitoh,Y., Fukui,Y., Gotoh,N.,
            Kaneko,S., Seiki,M., Murakami,Y., Inoue,J.I. and Sakamoto,T.
  TITLE     Mint3 depletion restricts tumor malignancy of pancreatic cancer
            cells by decreasing SKP2 expression via HIF-1
  JOURNAL   Oncogene 39 (39), 6218-6230 (2020)
   PUBMED   32826949
  REMARK    GeneRIF: Mint3 depletion restricts tumor malignancy of pancreatic
            cancer cells by decreasing SKP2 expression via HIF-1.
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Morishima-Kawashima,M. and Ihara,Y.
  TITLE     [Recent advances in Alzheimer's disease]
  JOURNAL   Seikagaku 73 (11), 1297-1307 (2001)
   PUBMED   11831025
  REMARK    GeneRIF: Associated with etilogical mechanism of Alzheimer's
            disease.
            Review article
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   Okamoto,M., Nakajima,Y., Matsuyama,T. and Sugita,M.
  TITLE     Amyloid precursor protein associates independently and
            collaboratively with PTB and PDZ domains of mint on vesicles and at
            cell membrane
  JOURNAL   Neuroscience 104 (3), 653-665 (2001)
   PUBMED   11440799
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     Genomic organization of the human X11L2 gene (APBA3), a third
            member of the X11 protein family interacting with Alzheimer's
            beta-amyloid precursor protein
  JOURNAL   Neuroreport 10 (12), 2575-2578 (1999)
   PUBMED   10574372
REFERENCE   9  (bases 1 to 2176)
  AUTHORS   Tanahashi,H. and Tabira,T.
  TITLE     X11L2, a new member of the X11 protein family, interacts with
            Alzheimer's beta-amyloid precursor protein
  JOURNAL   Biochem Biophys Res Commun 255 (3), 663-667 (1999)
   PUBMED   10049767
REFERENCE   10 (bases 1 to 2176)
  AUTHORS   Okamoto,M. and Sudhof,T.C.
  TITLE     Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or
            -2
  JOURNAL   Eur J Cell Biol 77 (3), 161-165 (1998)
   PUBMED   9860131
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005954.1, BI910038.1,
            AB021638.1, BM977984.1, BG938716.1 and BQ707748.1.
            
            On Nov 24, 2018 this sequence version replaced NM_004886.3.
            
            Summary: The protein encoded by this gene is a member of the X11
            protein family. It is an adapter protein that interacts with the
            Alzheimer's disease amyloid precursor protein. This gene product is
            believed to be involved in signal transduction processes. This gene
            is a candidate gene for Alzheimer's disease. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.235058.1,
                                           SRR1163657.278287.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316757.4/ ENSP00000315136.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC005954.1         33661-33677         c
            18-27               BI910038.1         1-10
            28-2052             AB021638.1         1-2025
            2053-2059           BM977984.1         137-143             c
            2060-2151           BG938716.1         6-97                c
            2152-2175           BQ707748.1         127-150
            2176-2176           AC005954.1         22757-22757         c
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2176
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /note="amyloid beta precursor protein binding family A
                     member 3"
                     /db_xref="GeneID:9546"
                     /db_xref="HGNC:HGNC:580"
                     /db_xref="MIM:604262"
     exon            1..157
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            158..770
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1922
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /note="amyloid beta (A4) precursor protein-binding, family
                     A, member 3 (X11-like 2);
                     phosphotyrosine-binding/-interacting domain (PTB)-bearing
                     protein; neuron-specific X11L2 protein; adapter protein
                     X11gamma; neuronal munc18-1-interacting protein 3;
                     X11-like 2 protein; mint-3"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 3"
                     /protein_id="NP_004877.1"
                     /db_xref="CCDS:CCDS12110.1"
                     /db_xref="GeneID:9546"
                     /db_xref="HGNC:HGNC:580"
                     /db_xref="MIM:604262"
                     /translation="MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGP
                     GSLSRMELDESSLQELVQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGL
                     LSAEAGRDDLLGLLHCEECPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASA
                     EQEGSRSSSSSPEPWLETVPLVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDG
                     VIFGARYLGSTQLVSERNPPTSTRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIK
                     VLTADSQEAMMDHALHTISYTADIGCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFY
                     AEDAQLIAQAIGQAFAAAYSQFLRESGIDPSQVGVHPSPGACHLHNGDLDHFSNSDNC
                     REVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGT
                     SLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICS
                     LLRGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLL
                     TGQEQPVYL"
     exon            771..810
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..956
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1043
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1205
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1376
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1589
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1709
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1850
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2176
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /note="hexamer: AGTAAA"
     polyA_site      2072
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /note="major polyA site"
     polyA_site      2129
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
                     /note="hexamer: ATTAAA"
     polyA_site      2176
                     /gene="APBA3"
                     /gene_synonym="MGC:15815; mint3; X11L2"
ORIGIN      
        1 aatgggccag ggctctgcgc ggatagagga gcgggcgccg ggaccgggaa tccccgagct
       61 gcgccttctg gggacgcggc ccgggctacg tcggggccgt ccgtggggag cggggtcctg
      121 gaggctgcgc ggggctgagg cggcctcgat ttgggaactg cctgaagatg ccggcctaag
      181 cctggagtcc aggcatggac ttccccacaa tttcccgatc cccttcgggg cctccagcca
      241 tggacttgga ggggcccagg gacattcttg tgccttcgga ggacctcacc cctgacagcc
      301 agtgggaccc tatgccagga ggccccggca gcctcagtcg gatggaactt gatgagtcaa
      361 gccttcagga gctggtgcag cagtttgaag ctctgccagg cgatctggtg ggcccatccc
      421 caggtggagc cccctgtccc ctacacattg ccacaggcca tggcctggcc tcccaggaga
      481 ttgctgatgc ccacgggctc ctgtctgccg aagctggccg ggatgacctg ctgggcctct
      541 tgcactgcga ggaatgcccg ccttcccaga ctggtcctga agagcctcta gagcctgccc
      601 cccgactgtt gcagccccct gaggacccag atgaggattc tgactcccca gaatgggtgg
      661 agggggcctc tgctgagcag gagggcagca ggagctcaag cagttccccg gaaccctggc
      721 tggagacggt gcctctagtc acacctgaag agccacccgc tggtgcccag agccccgaga
      781 ccctggcttc ctaccctgcc ccccaggagg tgcctggtcc ctgtgaccat gaagacctcc
      841 tggacggtgt catatttggg gccaggtacc tggggtccac ccagctggtg tcggaacgga
      901 acccgcccac cagcacgcgc atggcccagg cccgggaggc catggaccgc gtcaaggccc
      961 ccgatgggga gacccagccc atgacggagg tggacctgtt cgtctccacc aagaggatca
     1021 aggtcttgac agcggactcc caggaggcca tgatggacca cgccctgcat accatctcct
     1081 acacagccga catcggctgc gtgctggtgc tgatggcgcg gcggcggctg gcacggaggc
     1141 cggcacccca ggaccacggc cgccgcctct acaagatgct ctgccacgta ttctacgcgg
     1201 aggacgccca gctcatcgcc caggccattg gccaggcctt cgccgccgcc tacagccagt
     1261 tcctacggga aagcggtatt gaccccagcc aggtgggcgt gcacccgagc ccaggcgcct
     1321 gccacctcca taatggggac ctggaccact tctccaacag tgacaactgc cgggaggtgc
     1381 acctcgagaa gcggcgaggg gagggcctgg gcgtggccct ggtggagtcg ggctggggct
     1441 ccctgctgcc cacagccgtc atcgccaacc tgctgcacgg ggggcctgct gagcgctcgg
     1501 gggccctcag catcggggac cgcctgaccg ccatcaacgg gaccagcctg gtggggctgc
     1561 ccctggctgc gtgccaggcc gctgtccgcg agacgaagtc gcagacgtcg gtgacactca
     1621 gcatcgtcca ctgccctccc gtcaccaccg ccatcatcca ccggccccac gcccgcgagc
     1681 agctgggctt ctgcgtggag gacggcatca tctgcagcct cctccgtggt ggcatcgccg
     1741 agcgtggggg catccgcgtc ggccaccgca tcattgagat caatgggcag agtgtggtgg
     1801 ccacgccaca cgcccgcatc atcgagctgc tcaccgaggc ctatggcgag gtgcatatca
     1861 agacgatgcc agctgccaca tatcgcctcc ttacaggcca ggagcagccc gtgtacctgt
     1921 gaccacctca tcccttgcct gccactgtgc cttcgcctcc atggccccgg agccccatcc
     1981 tgggcctgcc ctggctggcc aggaccccag cggttcttgg tcctgtatga tttcctaata
     2041 taaaaacagt aaaagcttat gcatttggca aagtctcgga tcagggtcta cgggaccgag
     2101 gaccttgtcc ttcctggaag ccactagaag ccggtgctgt gaaaatactc tgtttattaa
     2161 agaccaggcg gaggga
//
