LOCUS       NM_005503               3653 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family A member
            2 (APBA2), transcript variant 1, mRNA.
ACCESSION   NM_005503
VERSION     NM_005503.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Zhou,Z., Blandino,P., Yuan,Q., Shen,P.H., Hodgkinson,C.A.,
            Virkkunen,M., Watson,S.J., Akil,H. and Goldman,D.
  TITLE     Exploratory locomotion, a predictor of addiction vulnerability, is
            oligogenic in rats selected for this phenotype
  JOURNAL   Proc Natl Acad Sci U S A 116 (26), 13107-13115 (2019)
   PUBMED   31182603
  REMARK    GeneRIF: Using exome sequencing and QTL analysis, study identified
            seven genome-wide significant loci accounting for approximately
            one-third of total variance and two-thirds of genetic variance in
            exploratory locomotion (EL), a behavioral phenotype correlated with
            vulnerability to addiction, and found convergent evidence for a
            role of APBA2 in humans.
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Miller,C.C., McLoughlin,D.M., Lau,K.F., Tennant,M.E. and Rogelj,B.
  TITLE     The X11 proteins, Abeta production and Alzheimer's disease
  JOURNAL   Trends Neurosci 29 (5), 280-285 (2006)
   PUBMED   16545469
  REMARK    Review article
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Borg,J.P., Yang,Y., De Taddeo-Borg,M., Margolis,B. and Turner,R.S.
  TITLE     The X11alpha protein slows cellular amyloid precursor protein
            processing and reduces Abeta40 and Abeta42 secretion
  JOURNAL   J Biol Chem 273 (24), 14761-14766 (1998)
   PUBMED   9614075
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Blanco,G., Irving,N.G., Brown,S.D., Miller,C.C. and McLoughlin,D.M.
  TITLE     Mapping of the human and murine X11-like genes (APBA2 and apba2),
            the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2):
            genes encoding phosphotyrosine-binding domain proteins that
            interact with the Alzheimer's disease amyloid precursor protein
  JOURNAL   Mamm Genome 9 (6), 473-475 (1998)
   PUBMED   9585438
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Okamoto,M. and Sudhof,T.C.
  TITLE     Mints, Munc18-interacting proteins in synaptic vesicle exocytosis
  JOURNAL   J Biol Chem 272 (50), 31459-31464 (1997)
   PUBMED   9395480
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   McLoughlin,D.M. and Miller,C.C.
  TITLE     The intracellular cytoplasmic domain of the Alzheimer's disease
            amyloid precursor protein interacts with phosphotyrosine-binding
            domain proteins in the yeast two-hybrid system
  JOURNAL   FEBS Lett 397 (2-3), 197-200 (1996)
   PUBMED   8955346
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   van der Geer,P. and Pawson,T.
  TITLE     The PTB domain: a new protein module implicated in signal
            transduction
  JOURNAL   Trends Biochem Sci 20 (7), 277-280 (1995)
   PUBMED   7545337
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX332225.2, AK310413.1,
            AB209281.1, AB014719.1, BC082986.1, AC024474.8 and BM665057.1.
            
            On Jul 22, 2008 this sequence version replaced NM_005503.2.
            
            Summary: The protein encoded by this gene is a member of the X11
            protein family. It is a neuronal adapter protein that interacts
            with the Alzheimer's disease amyloid precursor protein (APP). It
            stabilizes APP and inhibits production of proteolytic APP fragments
            including the A beta peptide that is deposited in the brains of
            Alzheimer's disease patients. This gene product is believed to be
            involved in signal transduction processes. It is also regarded as a
            putative vesicular trafficking protein in the brain that can form a
            complex with the potential to couple synaptic vesicle exocytosis to
            neuronal cell adhesion. [provided by RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047348.1, SRR1803611.143151.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               BX332225.2         1-531
            532-1401            AK310413.1         648-1517
            1402-2526           AB209281.1         1273-2397
            2527-3010           AB014719.1         2341-2824
            3011-3035           BC082986.1         2954-2978
            3036-3194           AC024474.8         15968-16126         c
            3195-3653           BM665057.1         1-459               c
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.1"
     gene            1..3653
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="amyloid beta precursor protein binding family A
                     member 2"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
     exon            1..113
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            114..167
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            168..1158
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2457
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="isoform a is encoded by transcript variant 1;
                     amyloid beta (A4) precursor protein-binding, family A,
                     member 2 (X11-like); phosphotyrosine-binding/-interacting
                     domain (PTB)-bearing protein; X11-like protein;
                     neuron-specific X11L protein; adapter protein X11beta;
                     neuronal munc18-1-interacting protein 2; mint-2"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform a"
                     /protein_id="NP_005494.2"
                     /db_xref="CCDS:CCDS10022.1"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
                     /translation="MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPE
                     GLELAALRPESPAPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIR
                     YCPEDDSYLEGMDCNGEEYLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDY
                     PDGQLPIPEDEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGD
                     LEDQEEDIDQIVAEIKMSLSMTSITSASEASPEHGPEPGPEDSVEACPPIKASCSPSR
                     HEARPKSLNLLPEAKHPGDPQRGFKPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLN
                     GPVDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNI
                     RMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMM
                     DHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESED
                     AQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENC
                     KELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGT
                     SLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICS
                     LMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLL
                     TGQETPLYI"
     exon            1159..1239
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1276
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1422
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1458
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1545
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1731
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1911
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2124
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2244
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2385
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..3639
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3615..3620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="hexamer: AATAAA"
     polyA_site      3639
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="major polyA site"
ORIGIN      
        1 cagtctcctg aatatttacg cgttgctgaa tctcctgtgg acaaaccacc aataggccag
       61 gactgtcctg tggacagacg gggtgagcct cttcttgtgt ctggagattc tgaaaagatt
      121 tgatcaccag gagatttttc gggacattac caaaccactc attttagtgg ctgcctccgg
      181 gtgatgatgg ctgtgtgaac gactgccatg gcccaccgga agcttgagag cgtggggagc
      241 ggcatgttgg accatagggt gagaccaggt cctgtccctc acagccagga gcccgagagc
      301 gaggacatgg agctgccctt ggagggctat gtgcccgagg gcctggagct ggctgccctg
      361 cggccagaga gccccgcgcc agaggaacag gagtgccaca accacagccc cgatggggac
      421 tccagctctg actacgtgaa caacacctct gaggaggagg actatgacga gggcctccct
      481 gaggaggagg agggcatcac ctactacatc cgctactgcc ctgaggacga cagctaccta
      541 gagggcatgg actgcaacgg ggaggagtac ctggcccaca gtgcacaccc tgtggacact
      601 gatgagtgcc aggaggcggt ggaggagtgg acggactcgg cgggcccgca cccccacggc
      661 cacgaggctg aaggcagcca ggactaccca gacggccaac tgcccattcc ggaggatgag
      721 ccctccgtcc ttgaggccca tgaccaggaa gaagatggtc actactgtgc cagcaaagag
      781 ggctaccagg actactaccc cgaggaggcc aacgggaaca ccggcgcctc cccctaccgc
      841 ctgaggcgtg gggatgggga cctggaggac caggaggagg acattgacca gatcgtggca
      901 gagatcaaga tgagtctgag catgaccagc atcaccagcg ccagtgaggc cagccccgag
      961 catgggcctg agccagggcc tgaggactct gtagaggcct gcccacccat caaggccagc
     1021 tgcagcccca gcaggcacga ggcgaggccc aagtcgctga acctccttcc cgaggccaag
     1081 caccccggag acccccagag aggcttcaag cccaagacca ggaccccaga agagaggctg
     1141 aagtggcccc acgagcaggt ttgcaatggt ctggagcagc caaggaagca gcagcgctct
     1201 gatctcaatg gacctgttga caataacaac attccagaga caaagaaggt ggcatcattt
     1261 ccaagttttg tggctgttcc agggccctgc gaaccagaag acctcatcga cgggatcatc
     1321 tttgctgcca attacctggg gtccacccag ctgctatcag aacggaaccc ttccaaaaac
     1381 atcagaatga tgcaagcgca ggaggccgtc agccgggtca agaggatgca aaaggctgct
     1441 aagatcaaga aaaaagcgaa ttctgagggg gatgcccaga cgctgacgga agtggacctc
     1501 ttcatttcca cccagaggat caaggtttta aatgcagaca cgcaggaaac catgatggac
     1561 cacgccttgc gtaccatctc ctacatcgcc gacattggga acattgtagt gctgatggcc
     1621 agacgccgca tgccccggtc agcctctcag gactgcatcg agaccacgcc cggggcccag
     1681 gaaggcaaga agcagtataa gatgatctgc catgtgttcg agtcggagga tgcccagctc
     1741 atcgcccagt ctatcggcca ggccttcagc gtggcctacc aggagttcct gcgagccaat
     1801 ggcatcaacc ccgaagactt gagccagaag gaatacagcg acatcatcaa cacccaggag
     1861 atgtacaacg acgacctcat ccacttctca aactcggaga actgcaagga gctgcagctg
     1921 gagaagcaca agggcgagat cctgggcgtg gtggtggtgg agtcgggctg gggctccatc
     1981 ctgcccacgg tgatcctggc caacatgatg aatggcggcc cggctgcccg ctcggggaag
     2041 ctgagcatcg gggaccagat catgtccatc aatggcacca gcctggtggg gctgcccctc
     2101 gccacctgcc aaggcatcat caagggcctg aagaaccaga cacaggtgaa gctcaacatt
     2161 gtcagctgtc ccccggtcac cacggtcctt atcaagcggc cagacctcaa gtaccagctg
     2221 ggcttcagcg tgcagaatgg aattatctgc agcctcatga gagggggcat tgctgagcga
     2281 gggggcgtcc gtgtgggcca ccgcatcatc gagatcaacg ggcagagcgt ggtggccaca
     2341 gcccacgaga agatagtcca agctctgtcc aactcggtcg gagagatcca catgaagacc
     2401 atgcccgccg ccatgttcag gctcctcacg ggtcaggaga ccccgctgta catctaggcc
     2461 accccagcct ggccacgcag ccaggacacc gggcagggcc gcccgggccc agaggagctg
     2521 ggagccgggc cgcagacttg accccgacgc cacagcccag ccacggacgc tggctcccca
     2581 aagggtgtgc cctcaccacc cacttgattt ttttcatttt gccaaaaagg ggtatgtctt
     2641 tatcaaagga gagtcacaga acaaatgttt gtttgtaaag cgttccaagt attttgccac
     2701 gttctggact gtcttctccc tgcacaagcc agggtgtgtc tcggtagctg tgcgtggtgt
     2761 ggagtgtgtg tctttcctcc ctgaagctgt gcggagcgaa ctggcgcctc cgagggacgc
     2821 ggctcccggg gcagggcagc cgtcacccct gcctcccgcc cccttggctg ggacgtctgg
     2881 ggtcctgtgg ggcccccaca atggtcccaa acagctgcct ctgccactga ctgcagggac
     2941 acgggcagcc tggctcccag gacacgactt gtaatgaaag tttggggaca tgtgattgat
     3001 tgattgattg taaataaagg atgatggcca caacatgaaa actccatatt tatttagatg
     3061 ctattattac tgtttggact tttattttgg caggcttttt tccagactct agggttttcc
     3121 aatgtgacta atgaccacac ctgcctctcc cgtcgtctct tctgggcacc ctcccacccg
     3181 gctgcatacc cgggcagggc tcccacagag acaaggaggg cacaggtgtc tgccccctct
     3241 ttaaaatcga tctacacaca tccacgcaca tgcgaccccg aggaaacgaa acccactcta
     3301 gaaaacgcga ccttggccgc acctaaagca gccagccgtg agtgcagacc ccttggccag
     3361 cgtggcgcag tggccctgag cagtagtggc atgtgtgtag atcaagtcgg atctagtcca
     3421 gctcggttca ttagcgatcc atgtaatctg acgtcatctt gtctcgaagt ctcttttttt
     3481 ggcccaggcc ttgaagaata cactgtgact taagaagcct taccacgcag taactaaagc
     3541 tttaggatga ctgtattcga ggagtgccgt gtgttgcatg cagctacccg taggaagact
     3601 tcgcgcatat cactaataaa cctgaagtcg tgatgaaaaa aaaaaaaaaa aaa
//
