LOCUS       NM_001353788            3941 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens amyloid beta precursor protein binding family A member
            2 (APBA2), transcript variant 3, mRNA.
ACCESSION   NM_001353788
VERSION     NM_001353788.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3941)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3941)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3941)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3941)
  AUTHORS   Zhou,Z., Blandino,P., Yuan,Q., Shen,P.H., Hodgkinson,C.A.,
            Virkkunen,M., Watson,S.J., Akil,H. and Goldman,D.
  TITLE     Exploratory locomotion, a predictor of addiction vulnerability, is
            oligogenic in rats selected for this phenotype
  JOURNAL   Proc Natl Acad Sci U S A 116 (26), 13107-13115 (2019)
   PUBMED   31182603
  REMARK    GeneRIF: Using exome sequencing and QTL analysis, study identified
            seven genome-wide significant loci accounting for approximately
            one-third of total variance and two-thirds of genetic variance in
            exploratory locomotion (EL), a behavioral phenotype correlated with
            vulnerability to addiction, and found convergent evidence for a
            role of APBA2 in humans.
REFERENCE   5  (bases 1 to 3941)
  AUTHORS   Miller,C.C., McLoughlin,D.M., Lau,K.F., Tennant,M.E. and Rogelj,B.
  TITLE     The X11 proteins, Abeta production and Alzheimer's disease
  JOURNAL   Trends Neurosci 29 (5), 280-285 (2006)
   PUBMED   16545469
  REMARK    Review article
REFERENCE   6  (bases 1 to 3941)
  AUTHORS   Borg,J.P., Yang,Y., De Taddeo-Borg,M., Margolis,B. and Turner,R.S.
  TITLE     The X11alpha protein slows cellular amyloid precursor protein
            processing and reduces Abeta40 and Abeta42 secretion
  JOURNAL   J Biol Chem 273 (24), 14761-14766 (1998)
   PUBMED   9614075
REFERENCE   7  (bases 1 to 3941)
  AUTHORS   Blanco,G., Irving,N.G., Brown,S.D., Miller,C.C. and McLoughlin,D.M.
  TITLE     Mapping of the human and murine X11-like genes (APBA2 and apba2),
            the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2):
            genes encoding phosphotyrosine-binding domain proteins that
            interact with the Alzheimer's disease amyloid precursor protein
  JOURNAL   Mamm Genome 9 (6), 473-475 (1998)
   PUBMED   9585438
REFERENCE   8  (bases 1 to 3941)
  AUTHORS   Okamoto,M. and Sudhof,T.C.
  TITLE     Mints, Munc18-interacting proteins in synaptic vesicle exocytosis
  JOURNAL   J Biol Chem 272 (50), 31459-31464 (1997)
   PUBMED   9395480
REFERENCE   9  (bases 1 to 3941)
  AUTHORS   McLoughlin,D.M. and Miller,C.C.
  TITLE     The intracellular cytoplasmic domain of the Alzheimer's disease
            amyloid precursor protein interacts with phosphotyrosine-binding
            domain proteins in the yeast two-hybrid system
  JOURNAL   FEBS Lett 397 (2-3), 197-200 (1996)
   PUBMED   8955346
REFERENCE   10 (bases 1 to 3941)
  AUTHORS   van der Geer,P. and Pawson,T.
  TITLE     The PTB domain: a new protein module implicated in signal
            transduction
  JOURNAL   Trends Biochem Sci 20 (7), 277-280 (1995)
   PUBMED   7545337
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC174469.1, AC127522.7,
            AC024474.8 and AF047348.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001353788.1.
            
            Summary: The protein encoded by this gene is a member of the X11
            protein family. It is a neuronal adapter protein that interacts
            with the Alzheimer's disease amyloid precursor protein (APP). It
            stabilizes APP and inhibits production of proteolytic APP fragments
            including the A beta peptide that is deposited in the brains of
            Alzheimer's disease patients. This gene product is believed to be
            involved in signal transduction processes. It is also regarded as a
            putative vesicular trafficking protein in the brain that can form a
            complex with the potential to couple synaptic vesicle exocytosis to
            neuronal cell adhesion. [provided by RefSeq, Jul 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.234495.1,
                                           SRR1660805.150633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2152719
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683413.1/ ENSP00000507394.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC174469.1         28020-28324         c
            306-415             AC127522.7         162406-162515       c
            416-469             AC127522.7         88349-88402         c
            470-1460            AC127522.7         29320-30310         c
            1461-1541           AC127522.7         9154-9234           c
            1542-1578           AC127522.7         8064-8100           c
            1579-1724           AC024474.8         40618-40763         c
            1725-1760           AC024474.8         39525-39560         c
            1761-1847           AC024474.8         35262-35348         c
            1848-2033           AC024474.8         32054-32239         c
            2034-2213           AC024474.8         28280-28459         c
            2214-2426           AC024474.8         27019-27231         c
            2427-2546           AC024474.8         25449-25568         c
            2547-2687           AC024474.8         19822-19962         c
            2688-3940           AC024474.8         15524-16776         c
            3941-3941           AF047348.1         3630-3630
FEATURES             Location/Qualifiers
     source          1..3941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.1"
     gene            1..3941
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="amyloid beta precursor protein binding family A
                     member 2"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
     exon            1..305
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            306..415
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            416..469
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1460
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     CDS             510..2759
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="isoform a is encoded by transcript variant 3;
                     amyloid beta (A4) precursor protein-binding, family A,
                     member 2 (X11-like); phosphotyrosine-binding/-interacting
                     domain (PTB)-bearing protein; X11-like protein;
                     neuron-specific X11L protein; adapter protein X11beta;
                     neuronal munc18-1-interacting protein 2; mint-2"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform a"
                     /protein_id="NP_001340717.1"
                     /db_xref="CCDS:CCDS10022.1"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
                     /translation="MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPE
                     GLELAALRPESPAPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIR
                     YCPEDDSYLEGMDCNGEEYLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDY
                     PDGQLPIPEDEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGD
                     LEDQEEDIDQIVAEIKMSLSMTSITSASEASPEHGPEPGPEDSVEACPPIKASCSPSR
                     HEARPKSLNLLPEAKHPGDPQRGFKPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLN
                     GPVDNNNIPETKKVASFPSFVAVPGPCEPEDLIDGIIFAANYLGSTQLLSERNPSKNI
                     RMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTLTEVDLFISTQRIKVLNADTQETMM
                     DHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQEGKKQYKMICHVFESED
                     AQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMYNDDLIHFSNSENC
                     KELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQIMSINGT
                     SLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICS
                     LMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLL
                     TGQETPLYI"
     exon            1461..1541
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1578
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1724
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1760
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1847
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2033
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2213
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2426
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2546
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2687
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..3941
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3917..3922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="hexamer: AATAAA"
     polyA_site      3941
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcccg gcgcgggtga ggcggaagcg gccggggcgg gggcgcaggc ccggcagccg
       61 caggccggtg cgggatgcgc cccgcagccg cgccgcgtgc gcccggcaga ggcggccctg
      121 cgtgccgtac gctgcgtccg gggcgcgccc gccgctattc gggaagctat tcagcttccc
      181 gggctcatta gcagtcgcgg tgtgcggctc ggcgcgggct cacaaagagc tcggcctcgc
      241 ggactgagcc ggcggcagcg gggcggggac ggcggcgtac ccgggcagcc cagcgccctg
      301 gccagtctcc tgaatattta cgcgttgctg aatctcctgt ggacaaacca ccaataggcc
      361 aggactgtcc tgtggacaga cggggtgagc ctcttcttgt gtctggagat tctgaaaaga
      421 tttgatcacc aggagatttt tcgggacatt accaaaccac tcattttagt ggctgcctcc
      481 gggtgatgat ggctgtgtga acgactgcca tggcccaccg gaagcttgag agcgtgggga
      541 gcggcatgtt ggaccatagg gtgagaccag gtcctgtccc tcacagccag gagcccgaga
      601 gcgaggacat ggagctgccc ttggagggct atgtgcccga gggcctggag ctggctgccc
      661 tgcggccaga gagccccgcg ccagaggaac aggagtgcca caaccacagc cccgatgggg
      721 actccagctc tgactacgtg aacaacacct ctgaggagga ggactatgac gagggcctcc
      781 ctgaggagga ggagggcatc acctactaca tccgctactg ccctgaggac gacagctacc
      841 tagagggcat ggactgcaac ggggaggagt acctggccca cagtgcacac cctgtggaca
      901 ctgatgagtg ccaggaggcg gtggaggagt ggacggactc ggcgggcccg cacccccacg
      961 gccacgaggc tgaaggcagc caggactacc cagacggcca actgcccatt ccggaggatg
     1021 agccctccgt ccttgaggcc catgaccagg aagaagatgg tcactactgt gccagcaaag
     1081 agggctacca ggactactac cccgaggagg ccaacgggaa caccggcgcc tccccctacc
     1141 gcctgaggcg tggggatggg gacctggagg accaggagga ggacattgac cagatcgtgg
     1201 cagagatcaa gatgagtctg agcatgacca gcatcaccag cgccagtgag gccagccccg
     1261 agcatgggcc tgagccaggg cctgaggact ctgtagaggc ctgcccaccc atcaaggcca
     1321 gctgcagccc cagcaggcac gaggcgaggc ccaagtcgct gaacctcctt cccgaggcca
     1381 agcaccccgg agacccccag agaggcttca agcccaagac caggacccca gaagagaggc
     1441 tgaagtggcc ccacgagcag gtttgcaatg gtctggagca gccaaggaag cagcagcgct
     1501 ctgatctcaa tggacctgtt gacaataaca acattccaga gacaaagaag gtggcatcat
     1561 ttccaagttt tgtggctgtt ccagggccct gcgaaccaga agacctcatc gacgggatca
     1621 tctttgctgc caattacctg gggtccaccc agctgctatc agaacggaac ccttccaaaa
     1681 acatcagaat gatgcaagcg caggaggccg tcagccgggt caagaggatg caaaaggctg
     1741 ctaagatcaa gaaaaaagcg aattctgagg gggatgccca gacgctgacg gaagtggacc
     1801 tcttcatttc cacccagagg atcaaggttt taaatgcaga cacgcaggaa accatgatgg
     1861 accacgcctt gcgtaccatc tcctacatcg ccgacattgg gaacattgta gtgctgatgg
     1921 ccagacgccg catgccccgg tcagcctctc aggactgcat cgagaccacg cccggggccc
     1981 aggaaggcaa gaagcagtat aagatgatct gccatgtgtt cgagtcggag gatgcccagc
     2041 tcatcgccca gtctatcggc caggccttca gcgtggccta ccaggagttc ctgcgagcca
     2101 atggcatcaa ccccgaagac ttgagccaga aggaatacag cgacatcatc aacacccagg
     2161 agatgtacaa cgacgacctc atccacttct caaactcgga gaactgcaag gagctgcagc
     2221 tggagaagca caagggcgag atcctgggcg tggtggtggt ggagtcgggc tggggctcca
     2281 tcctgcccac ggtgatcctg gccaacatga tgaatggcgg cccggctgcc cgctcgggga
     2341 agctgagcat cggggaccag atcatgtcca tcaatggcac cagcctggtg gggctgcccc
     2401 tcgccacctg ccaaggcatc atcaagggcc tgaagaacca gacacaggtg aagctcaaca
     2461 ttgtcagctg tcccccggtc accacggtcc ttatcaagcg gccagacctc aagtaccagc
     2521 tgggcttcag cgtgcagaat ggaattatct gcagcctcat gagagggggc attgctgagc
     2581 gagggggcgt ccgtgtgggc caccgcatca tcgagatcaa cgggcagagc gtggtggcca
     2641 cagcccacga gaagatagtc caagctctgt ccaactcggt cggagagatc cacatgaaga
     2701 ccatgcccgc cgccatgttc aggctcctca cgggtcagga gaccccgctg tacatctagg
     2761 ccaccccagc ctggccacgc agccaggaca ccgggcaggg ccgcccgggc ccagaggagc
     2821 tgggagccgg gccgcagact tgaccccgac gccacagccc agccacggac gctggctccc
     2881 caaagggtgt gccctcacca cccacttgat ttttttcatt ttgccaaaaa ggggtatgtc
     2941 tttatcaaag gagagtcaca gaacaaatgt ttgtttgtaa agcgttccaa gtattttgcc
     3001 acgttctgga ctgtcttctc cctgcacaag ccagggtgtg tctcggtagc tgtgcgtggt
     3061 gtggagtgtg tgtctttcct ccctgaagct gtgcggagcg aactggcgcc tccgagggac
     3121 gcggctcccg gggcagggca gccgtcaccc ctgcctcccg cccccttggc tgggacgtct
     3181 ggggtcctgt ggggccccca caatggtccc aaacagctgc ctctgccact gactgcaggg
     3241 acacgggcag cctggctccc aggacacgac ttgtaatgaa agtttgggga catgtgattg
     3301 attgattgat tgtaaataaa ggatgatggc cacaacatga aaactccata tttatttaga
     3361 tgctattatt actgtttgga cttttatttt ggcaggcttt tttccagact ctagggtttt
     3421 ccaatgtgac taatgaccac acctgcctct cccgtcgtct cttctgggca ccctcccacc
     3481 cggctgcata cccgggcagg gctcccacag agacaaggag ggcacaggtg tctgccccct
     3541 ctttaaaatc gatctacaca catccacgca catgcgaccc cgaggaaacg aaacccactc
     3601 tagaaaacgc gaccttggcc gcacctaaag cagccagccg tgagtgcaga ccccttggcc
     3661 agcgtggcgc agtggccctg agcagtagtg gcatgtgtgt agatcaagtc ggatctagtc
     3721 cagctcggtt cattagcgat ccatgtaatc tgacgtcatc ttgtctcgaa gtctcttttt
     3781 ttggcccagg ccttgaagaa tacactgtga cttaagaagc cttaccacgc agtaactaaa
     3841 gctttaggat gactgtattc gaggagtgcc gtgtgttgca tgcagctacc cgtaggaaga
     3901 cttcgcgcat atcactaata aacctgaagt cgtgatgaaa a
//
