LOCUS       NM_001163               6597 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens amyloid beta precursor protein binding family A member
            1 (APBA1), mRNA.
ACCESSION   NM_001163
VERSION     NM_001163.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6597)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6597)
  AUTHORS   Roundhill,E.A., Chicon-Bosch,M., Jeys,L., Parry,M., Rankin,K.S.,
            Droop,A. and Burchill,S.A.
  TITLE     RNA sequencing and functional studies of patient-derived cells
            reveal that neurexin-1 and regulators of this pathway are
            associated with poor outcomes in Ewing sarcoma
  JOURNAL   Cell Oncol (Dordr) 44 (5), 1065-1085 (2021)
   PUBMED   34403115
  REMARK    GeneRIF: RNA sequencing and functional studies of patient-derived
            cells reveal that neurexin-1 and regulators of this pathway are
            associated with poor outcomes in Ewing sarcoma.
REFERENCE   3  (bases 1 to 6597)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6597)
  AUTHORS   Liu,C., Yuan,Z.Y., Yuan,H., Wu,K.X., Cao,B., Ren,K.Y., Cui,M.J.,
            Liu,J.H., Chen,H.X. and Pang,Y.W.
  TITLE     Status of Gene Methylation and Polymorphism in Different Courses of
            Ulcerative Colitis and Their Comparison with Sporadic Colorectal
            Cancer
  JOURNAL   Inflamm Bowel Dis 27 (4), 522-529 (2021)
   PUBMED   32793962
  REMARK    GeneRIF: Status of Gene Methylation and Polymorphism in Different
            Courses of Ulcerative Colitis and Their Comparison with Sporadic
            Colorectal Cancer.
REFERENCE   5  (bases 1 to 6597)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6597)
  AUTHORS   Borg,J.P., Ooi,J., Levy,E. and Margolis,B.
  TITLE     The phosphotyrosine interaction domains of X11 and FE65 bind to
            distinct sites on the YENPTY motif of amyloid precursor protein
  JOURNAL   Mol Cell Biol 16 (11), 6229-6241 (1996)
   PUBMED   8887653
REFERENCE   7  (bases 1 to 6597)
  AUTHORS   van der Geer,P. and Pawson,T.
  TITLE     The PTB domain: a new protein module implicated in signal
            transduction
  JOURNAL   Trends Biochem Sci 20 (7), 277-280 (1995)
   PUBMED   7545337
  REMARK    Review article
REFERENCE   8  (bases 1 to 6597)
  AUTHORS   Duclos,F. and Koenig,M.
  TITLE     Comparison of primary structure of a neuron-specific protein, X11,
            between human and mouse
  JOURNAL   Mamm Genome 6 (1), 57-58 (1995)
   PUBMED   7719031
REFERENCE   9  (bases 1 to 6597)
  AUTHORS   Duclos,F., Boschert,U., Sirugo,G., Mandel,J.L., Hen,R. and
            Koenig,M.
  TITLE     Gene in the region of the Friedreich ataxia locus encodes a
            putative transmembrane protein expressed in the nervous system
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 109-113 (1993)
   PUBMED   7678331
REFERENCE   10 (bases 1 to 6597)
  AUTHORS   Chen,W.J., Goldstein,J.L. and Brown,M.S.
  TITLE     NPXY, a sequence often found in cytoplasmic tails, is required for
            coated pit-mediated internalization of the low density lipoprotein
            receptor
  JOURNAL   J Biol Chem 265 (6), 3116-3123 (1990)
   PUBMED   1968060
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162412.11, BQ269294.1,
            AF047347.1, BF435835.1, DA313538.1, AL355140.25, DA179202.1 and
            AL713639.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001163.3.
            
            Summary: The protein encoded by this gene is a member of the X11
            protein family. It is a neuronal adapter protein that interacts
            with the Alzheimer's disease amyloid precursor protein (APP). It
            stabilizes APP and inhibits production of proteolytic APP fragments
            including the A beta peptide that is deposited in the brains of
            Alzheimer's disease patients. This gene product is believed to be
            involved in signal transduction processes. It is also regarded as a
            putative vesicular trafficking protein in the brain that can form a
            complex with the potential to couple synaptic vesicle exocytosis to
            neuronal cell adhesion. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047347.1, AF029106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265381.7/ ENSP00000265381.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL162412.11        29530-29541         c
            13-65               BQ269294.1         9-61
            66-2986             AF047347.1         17-2937
            2987-3440           BF435835.1         6-459
            3441-3585           DA313538.1         198-342
            3586-4038           AL355140.25        138090-138542       c
            4039-4596           DA179202.1         1-558
            4597-6596           AL713639.1         305-2304
            6597-6597           AL355140.25        135531-135531       c
FEATURES             Location/Qualifiers
     source          1..6597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.12"
     gene            1..6597
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /note="amyloid beta precursor protein binding family A
                     member 1"
                     /db_xref="GeneID:320"
                     /db_xref="HGNC:HGNC:578"
                     /db_xref="MIM:602414"
     exon            1..219
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            220..1488
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2802
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /note="amyloid beta (A4) precursor protein-binding, family
                     A, member 1 (X11); phosphotyrosine-binding/-interacting
                     domain (PTB)-bearing protein; neuronal
                     munc18-1-interacting protein 1; neuron-specific X11
                     protein; adaptor protein X11alpha; mint-1; adapter protein
                     X11alpha"
                     /codon_start=1
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 1"
                     /protein_id="NP_001154.2"
                     /db_xref="CCDS:CCDS6630.1"
                     /db_xref="GeneID:320"
                     /db_xref="HGNC:HGNC:578"
                     /db_xref="MIM:602414"
                     /translation="MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQ
                     QHYVGRHQRGRALEDLRAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARD
                     GYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEA
                     MNAAYSGYVYTHRLFHRGEDEPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQ
                     ERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAE
                     VKQSMSSQSLDKAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEA
                     GQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCD
                     DQRPMDGDSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYVEVPGPC
                     DPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRKKAPE
                     GESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMPRS
                     NSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPE
                     DLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPT
                     VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV
                     RCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVA
                     TPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI"
     exon            1489..1584
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1624
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1770
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1803
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1890
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2076
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2256
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2469
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2589
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2730
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..6597
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6574..6579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /note="hexamer: AATAAA"
     polyA_site      6597
                     /gene="APBA1"
                     /gene_synonym="D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA"
                     /note="major polyA site"
ORIGIN      
        1 gcgagaccgg aggggtccga gcagcggctg cggagccgga gctgggcgag ggcggctgcg
       61 gtcccggcgg cggcggcggc ggcggcagct gcggcgggag aagatggtgg cgctggaggc
      121 agcagcggct ggagcggagc tttattccca ggcttggcac cagcgctgtc actagcgccg
      181 cctgctcccg cgggcccgcg gacccagctg tcaggcaagc ccagtggagc aaaatgagag
      241 cgcagtgagc cgggcccagc ttctctccta gccgttccga ctcccaccat gaaccacttg
      301 gaggggtctg cggaggtgga ggtgaccgac gaggcggcag gtggggaggt gaacgagtcg
      361 gtggaggccg acctggagca ccccgaggtg gaagaggaac agcagcagcc gccgcagcag
      421 cagcactatg tgggccgcca ccagcgcggg cgagccctcg aggacctccg cgcccagctc
      481 ggccaggagg aagaggagcg cggggaatgc ctggcgcgct cagccagcac ggagagcggc
      541 ttccacaacc acacggacac cgccgagggc gacgtgatcg ccgcggcccg cgacggctac
      601 gatgcggagc gcgcgcagga ccccgaggac gagagcgcct atgctgtgca gtaccggccc
      661 gaggccgagg agtacacgga gcaggcagag gccgagcacg ccgaggccac gcaccgccgc
      721 gcgctgccca accacctgca cttccactcg ctggagcacg aggaagccat gaatgcggcc
      781 tactcaggct acgtctacac gcaccggctc ttccaccgcg gtgaggacga gccctactcc
      841 gagccctatg ccgactacgg cggcctccag gagcacgtgt acgaggagat aggggacgcg
      901 cccgagctgg acgcacgcga cggcctgcgg ctctacgagc aggagcgcga cgaggcggcc
      961 gcgtaccgcc aggaggccct gggcgcgcgg ctgcaccatt acgacgagcg ctccgacggc
     1021 gagtccgaca gccccgagaa ggaggccgag ttcgcgccct acccgcgcat ggacagctac
     1081 gagcaggagg aggacatcga ccagatagtg gccgaggtga agcagagcat gagctcgcag
     1141 agcctcgaca aggcagccga ggacatgcct gaggccgagc aggacctgga gcgtccccct
     1201 accccggccg ggggtcgccc cgacagcccc gggctgcagg cgccggcggg gcagcagcgg
     1261 gcggtgggcc ccgcgggcgg cggcgaggcg gggcagcggt acagcaagga gaagcgcgat
     1321 gccatctcgc tggccatcaa ggacatcaag gaggccatcg aggaggtgaa aaccaggacc
     1381 atccgttcgc cttacacccc cgacgagccc aaagagccca tctgggtcat gcgccaggac
     1441 attagcccca ccagggactg tgacgaccag aggccgatgg acggagattc tccgtctcct
     1501 ggcagctcct cccccttggg tgcagagtca tcaagcacat ctcttcaccc cagtgaccct
     1561 gtggaagcgt ccactaataa agagtcaaga aaaagcttgg cttcattccc aacctacgtt
     1621 gaagttccgg gaccctgcga ccccgaagac ttgatcgatg gaatcatttt tgccgccaat
     1681 taccttggct ccactcagct gctctcagac aaaactcctt ccaaaaacgt gcgcatgatg
     1741 caggcccagg aagccgtaag caggatcaag atggcccaga aattagccaa aagcaggaag
     1801 aaggctcctg aaggcgaatc tcagccaatg actgaagtgg atctcttcat ttctacccag
     1861 agaatcaaag tgctgaacgc cgacacacag gagacaatga tggaccaccc tctgaggacc
     1921 atttcctaca ttgcggacat tgggaacatc gttgtgctga tggcccgccg gcggatgcct
     1981 cgctccaact cccaggagaa cgtggaagcg tcccacccat cccaggatgg gaaaaggcag
     2041 tacaagatga tctgccacgt cttcgagtct gaggatgctc agctgattgc acagtccatc
     2101 ggacaggcat ttagcgtggc ataccaggaa ttcctcaggg ccaatgggat taaccccgaa
     2161 gatctcagcc agaaggagta tagtgacctg ctcaataccc aggacatgta caacgatgac
     2221 ctgatccact tctccaagtc ggaaaactgt aaagatgttt tcatagagaa gcagaaagga
     2281 gaaatcctag gtgtggtgat tgtggagtct ggctggggat ccatcctccc caccgtgatc
     2341 attgccaaca tgatgcatgg tggccctgcg gagaaatctg ggaagctgaa tatcggtgac
     2401 cagatcatgt ccattaatgg caccagcctg gtgggcctgc ctctgtccac ctgccagagc
     2461 attattaagg gcttaaagaa tcagtcccga gtcaagctga atatcgtgag atgtcctccg
     2521 gtgaccaccg tgttaatcag aagaccagac cttcgctacc agctcggttt cagcgtccag
     2581 aatggaatta tctgcagcct catgcgaggg ggaatagctg agagaggagg cgtccgtgtg
     2641 gggcaccgga tcattgaaat caatggacag agcgtcgtgg ccacccccca cgagaagatc
     2701 gtccacattc tctccaatgc tgttggggag attcatatga agacaatgcc agccgcgatg
     2761 tacaggctgc tgacggccca ggagcagcct gtttacatct gaccgcggcc acacgcggtg
     2821 gcatgcatgg aggactctcc tcttcgtggt tgtgtttctc gtgctgcatc cctgtgtcca
     2881 ctgagacttt cccctctcgc gcccagcatt tggttttaca caggaagaga agaatccaca
     2941 aggacctctt tactctctcc gatttgcttt tttttttttt tttttttcaa taccagggaa
     3001 gtttcgtatg cactcccttg aggatggaga gcagccagca cccacctggt actgacccag
     3061 gaccatcctg gagggctttc tgggtgtgtc cagggggtgg gctgtcactg cttgagggag
     3121 aatcctccct tcccaggagg tgcagacttc ttaaaaggag ctcgcggggc agcaaagcag
     3181 ctgattcagc agtgcctaaa acccagttgc tgatccctgc tctctgagtt tatctgtggg
     3241 aatgtggtag tacccagggc cagcccacgt cattaaggtt atgcactgcc tgccatgtag
     3301 ttggggcacc atacattatt tcttcccaga atctctgagc caaccttaaa cctcttctat
     3361 tgctagttct aatttcaacg tatgtgtgtt ttctaatacg agccttctca ccccaggata
     3421 aaaggggaaa taactgcctt gggcaaggac accatagtgt cacagagagc ttggcaattc
     3481 atggggcatc tgaagcttta ccaggttgtc ctcaagttat caaccattag ataaacacag
     3541 gcaggtactg tctgcttctc tctctctcac acacacacac acacacacag tcccatttgc
     3601 atatcaccct tccctgctcc caccaccagt gagacaagct gaagattagg cacacagatc
     3661 ccctggaaac ccacctctct ggaaggcccc ttccctggca ggtggccagg caggcggggg
     3721 ctgctcagcc tcatcctgag agacctgccc tctctgcgct gaggcccagc ccctccagca
     3781 ccactttggc ttaaagcatc ctcctcctgg actcccctcc ctgccgaaca cacatcccag
     3841 gagtctggga aggagggact gttcccaaga aggcaagctg caggtgcaat tgcgtcttgt
     3901 tttctggccc aaggcaagac caactttctt ctctgctcag ggccactagg cggatgtgat
     3961 attggaaagg ccagaatagt acataaacca caaaattaag gagacaatag caacctcaag
     4021 ttatgcctca gaatccccag atgtggtcca taaacaccct cttgctgcct tgtgggcctg
     4081 agagcatttt tggctggtgt ggaattgttc cgtgttttca tcaggtgcct catatttatg
     4141 cttccgtctc agttcagtgt agatgtttta gtaatattat aattctgagc cagttttcac
     4201 ttggtccaaa gagcattttg tgttcatgtg aggtgtgatt tggctttgct tttgttttgt
     4261 ttcattcatg acctcagtag agacagggga agagaaacta ttatattttg taattaatat
     4321 agtccctgtt ctctgcatcc gagatattta tgttgtgtct atggaaatag gaactcagtg
     4381 agcaaatggt gggtagcatg tatttataga gagaatggag ggattctaag gagggagcaa
     4441 agtgactata acaagattag ggacaagaga cttcaaccag agagttctgt gatcaattcc
     4501 ccgagatctc tgcatcttct gagttttctg cttagaatca gggaagctca gtgcttgaca
     4561 ggaacgagca gtggcactct cagtttcact gtgttacaaa ggagccctga ggaagggagg
     4621 ccgctggctg cccaggtgcc ctggggggaa agggacttct gctgctgcag agagtggcac
     4681 ccggtggggc caggggctct gggatggtcc gtaaagctcc ccaggacttc tttgaaggat
     4741 gctttacaga atgtttctgg gagaccagcc tcaaggtcaa cccatcacaa acgtgaggac
     4801 caggaaggaa ccatggccag ggttctccat ttgctgtaga gtatctggtg atacagtgag
     4861 acactaaaga gtcatcagcc agttcatctt tcctctgcca ataagagtgg atagaacagg
     4921 aatgaagtgt tactggtggt atttcaggca tcaggagcct tggaaaatca tcgtaggggc
     4981 ccatgcctgt ctgtccctag gcacctgggc agtgccacag aggcccgccc acgactggcc
     5041 aggggacaga actccagtag tgcatccctg tacaacctgc acataacggt tatgtatgtt
     5101 cacctaaagg agagaatata ctttctattc ctattgcaca aaaaccttgt aaactttgag
     5161 aggtgctgaa aaagccaatt ctgcaagctc tcctagagga ctgacattgt aacattagag
     5221 tgagaagatt tctctgccac attcttttgt gttaatccag gtgtgtcttc acacccagtg
     5281 agtggaagtt gctggagctc ggtacaggtc cacccagctg aagtgggttc tttttcccac
     5341 taccactggg gcaagggagt gagcctaggt atggtcacct cagcagccac agtcttaaaa
     5401 gcaagtcgct agattttttg aaagtcccaa gagaagtggt ggtcttccct tctgtcatcc
     5461 cagtatatat agttatacat gtaaatatct aaatacccca tgtaatggga aggctatgta
     5521 cagggcagcc ttcccaaacg ctgtgagggc acagagctgc tgtggctgct ccaccagggt
     5581 gtgctggtgg ctcagctttg gggttggact cccacgttca cctccccctc ctggtccagg
     5641 cagaggcacc agaacccatc ctgccttttc tccagtgtga gcatttcagg gagccaccat
     5701 cagccttggg ttcatgagag gaagaaaccc ccaaagacca atgcctggag cccacttctc
     5761 cagcgacacc ttccctcgcc agagcaggct cctaggagtg catggcaggg gtgccgggtc
     5821 cctgtgcacg ggtttgcttt ctgaacattg cccatcaaca ccgccttcag ggagtcccag
     5881 agtaacctac tacctccccc atcgctcctc tgcccccctc accctgtggg caccaacacc
     5941 tcccgcacac agatgaaaac catctacaga gcccttcccg ggtccctcga cccagtggtg
     6001 tagccgttac caatgtttac aaccaggggc cgcccctcct tagatgtgtt tactcgcatt
     6061 cacaggccac ctgttggttt gagtttcatg tgtctccttc cctggcctag gttgacttga
     6121 gcacacaact cgatctttct tcccctccat caaggcagtg tgtgaggact gtgtgggaat
     6181 gacatttctt gtacatactt agcacagcac ctagagtatg aacttgtact attgttctgt
     6241 aaagagggtg aaatagagct tattgtaaag tgtcgggaga agtatagtat tgtatttgta
     6301 acaatatcgt tctttgtata cacaaaactc aatgatctat atataaatat aaataaatat
     6361 ataaataaaa tatatctaca cgtgagcctg gaatgtggac accgcacacc cactgaatgt
     6421 acttccttga cagtctggtc actggtccct ccctccctcc ctcctccgtc ccgtggccac
     6481 agtcatccag tttggggttg tgatgtattt actgtgctat ctatcttcct ttatttaact
     6541 gaacgctaat gtctgtataa gagttgctgc aacaataaac aagaacttca cctcttg
//
