LOCUS       XM_047428759            3148 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens apoptotic peptidase activating factor 1
            (APAF1), transcript variant X2, mRNA.
ACCESSION   XM_047428759
VERSION     XM_047428759.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     gene            1..3148
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /note="apoptotic peptidase activating factor 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 7 ESTs, 81 long SRA reads, 1 Protein, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:317"
                     /db_xref="HGNC:HGNC:576"
                     /db_xref="MIM:602233"
     CDS             588..3032
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /codon_start=1
                     /product="apoptotic protease-activating factor 1 isoform
                     X2"
                     /protein_id="XP_047284715.1"
                     /db_xref="GeneID:317"
                     /db_xref="HGNC:HGNC:576"
                     /db_xref="MIM:602233"
                     /translation="MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVR
                     NEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDS
                     VSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGK
                     SVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPL
                     NIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGP
                     KYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDF
                     PNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKD
                     VKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNC
                     SQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLD
                     WIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQL
                     GLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFS
                     EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK
                     IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF
                     GHTNSVNHCRFSPDDKLLASCSADGTLKLFLQHLTLATTSITALPSQFIQSHGFNSSF
                     FSFGMRHQQMRGKALM"
     polyA_site      3148
                     /gene="APAF1"
                     /gene_synonym="APAF-1; CED4"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 agaggcggag aagaagaggt agcgagtgga cgtgactgct ctatcccggg caaaagggat
       61 agaaccagag gtggggagtc tgggcagtcg gcgacccgcg aagacttgag gtgccgcagc
      121 ggcatccgga gtagcgccgg gctccctccg gggtgcagcc gccgtcgggg gaagggcgcc
      181 acaggccggg aagacctcct ccctttgtgt ccagtagtgg ggtccaccgg agggcggccc
      241 gtgggccggg cctcaccgcg gcgctccggg actgtggggt caggctgcgt tgggtggacg
      301 cccacctcgc caaccttcgg aggtccctgg gggtcttcgt gcgccccggg gctgcagaga
      361 tccaggggag gcgcctgtga ggcccggacc tgccccgggg cgaagggtat gtggcgagac
      421 agagccctgc acccctaatt cccggtggaa aactcctgtt gccgtttccc tccaccggcc
      481 tggagtctcc cagtcttgtc ccggcagtgc cgccctcccc actaagacct aggcgcaaag
      541 gcttggctca tggttgacag ctcagagaga gaaagatctg agggaagatg gatgcaaaag
      601 ctcgaaattg tttgcttcaa catagagaag ctctggaaaa ggacatcaag acatcctaca
      661 tcatggatca catgattagt gatggatttt taacaatatc agaagaggaa aaagtaagaa
      721 atgagcccac tcaacagcaa agagcagcta tgctgattaa aatgatactt aaaaaagata
      781 atgattccta cgtatcattc tacaatgctc tactacatga aggatataaa gatcttgctg
      841 cccttctcca tgatggcatt cctgttgtct cttcttccag tggtaaagat tcagttagtg
      901 gaataacttc gtatgtaagg acagtcctgt gtgaaggtgg agtaccacag aggccagttg
      961 tttttgtcac aaggaagaag ctggtgaatg caattcagca gaagctctcc aaattgaaag
     1021 gtgaaccagg atgggtcacc atacatggaa tggcaggctg tgggaagtct gtattagctg
     1081 cagaagctgt tagagatcat tcccttttag aaggttgttt cccaggggga gtgcattggg
     1141 tttcagttgg gaaacaagac aaatctgggc ttctgatgaa actgcagaat ctttgcacac
     1201 ggttggatca ggatgagagt ttttcccaga ggcttccact taatattgaa gaggctaaag
     1261 accgtctccg cattctgatg cttcgcaaac acccaaggtc tctcttgatc ttggatgatg
     1321 tttgggactc ttgggtgttg aaagcttttg acagtcagtg tcagattctt cttacaacca
     1381 gagacaagag tgttacagat tcagtaatgg gtcctaaata tgtagtccct gtggagagtt
     1441 ccttaggaaa ggaaaaagga cttgaaattt tatccctttt tgttaatatg aagaaggcag
     1501 atttgccaga acaagctcat agtattataa aagaatgtaa aggctctccc cttgtagtat
     1561 ctttaattgg tgcactttta cgtgattttc ccaatcgctg ggagtactac ctcaaacagc
     1621 ttcagaataa gcagtttaag agaataagga aatcttcgtc ttatgattat gaggctctag
     1681 atgaagccat gtctataagt gttgaaatgc tcagagaaga catcaaagat tattacacag
     1741 atctttccat ccttcagaag gacgttaagg tgcctacaaa ggtgttatgt attctctggg
     1801 acatggaaac tgaagaagtt gaagacatac tgcaggagtt tgtaaataag tctcttttat
     1861 tctgtgatcg gaatggaaag tcgtttcgtt attatttaca tgatcttcaa gtagattttc
     1921 ttacagagaa gaattgcagc cagcttcagg atctacataa gaagataatc actcagtttc
     1981 agagatatca ccagccgcat actctttcac cagatcagga agactgtatg tattggtaca
     2041 actttctggc ctatcacatg gccagtgcca agatgcacaa ggaactttgt gctttaatgt
     2101 tttccctgga ttggattaaa gcaaaaacag aacttgtagg ccctgctcat ctgattcatg
     2161 aatttgtgga atacagacat atactagatg aaaaggattg tgcagtcagt gagaattttc
     2221 aggagttttt atctttaaat ggacaccttc ttggacgaca gccatttcct aatattgtac
     2281 aactgggtct ctgtgagccg gaaacttcag aagtttatca gcaagctaag ctgcaggcca
     2341 agcaggaggt cgataatgga atgctttacc tggaatggat aaacaaaaaa aacatcacga
     2401 atctttcccg cttagttgtc cgcccccaca cagatgctgt ttaccatgcc tgcttttctg
     2461 aggatggtca gagaatagct tcttgtggag ctgataaaac cttacaggtg ttcaaagctg
     2521 aaacaggaga gaaacttcta gaaatcaagg ctcatgagga tgaagtgctt tgttgtgcat
     2581 tctctacaga tgacagattt atagcaacct gctcagtgga taaaaaagtg aagatttgga
     2641 attctatgac tggggaacta gtacacacct atgatgagca ctcagagcaa gtcaattgct
     2701 gccatttcac caacagtagt catcatcttc tcttagccac tgggtcaagt gactgcttcc
     2761 tcaaactttg ggatttgaat caaaaagaat gtcgaaatac catgtttggt catacaaatt
     2821 cagtcaatca ctgcagattt tcaccagatg ataagctttt ggctagttgt tcagctgatg
     2881 gaaccttaaa gctattcctg cagcatctaa ccttggctac cacctctatc accgctcttc
     2941 catcccagtt cattcagtct catggcttca actcatcttt tttcagcttt gggatgcgac
     3001 atcagcaaat gagaggaaaa gcattaatgt gaaacagttc ttcctaaatt tggaggaccc
     3061 tcaagaggat atggaagtga tagtgaagtg ttgttcgtgg tctgctgatg gtgcaaggat
     3121 aatggtggca gcaaaaaata aaatcttt
//
