LOCUS       NM_018229              11675 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens adaptor related protein complex 5 subunit mu 1
            (AP5M1), transcript variant 1, mRNA.
ACCESSION   NM_018229
VERSION     NM_018229.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11675)
  AUTHORS   Muthu,M., Chun,S., Gopal,J., Park,G.S., Nile,A., Shin,J., Shin,J.,
            Kim,T.H. and Oh,J.W.
  TITLE     The MUDENG Augmentation: A Genesis in Anti-Cancer Therapy?
  JOURNAL   Int J Mol Sci 21 (15), 5583 (2020)
   PUBMED   32759789
  REMARK    GeneRIF: The MUDENG Augmentation: A Genesis in Anti-Cancer Therapy?
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11675)
  AUTHORS   Won,M., Luo,Y., Lee,D.H., Shin,E., Suh,D.S., Kim,T.H., Jin,H. and
            Bae,J.
  TITLE     BAX is an essential key mediator of AP5M1-induced apoptosis in
            cervical carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 518 (2), 368-373 (2019)
   PUBMED   31427081
  REMARK    GeneRIF: The AP5M1 upregulated the level of BAX protein, a key
            pro-apoptotic B cell lymphoma (BCL)-2 family member regulating
            mitochondrial apoptotic cell death pathway.
REFERENCE   3  (bases 1 to 11675)
  AUTHORS   Shin,J.N., Han,J.H., Kim,J.Y., Moon,A.R., Kim,J.E., Chang,J.H.,
            Bae,J., Oh,J.W. and Kim,T.H.
  TITLE     MUDENG is cleaved by caspase-3 during TRAIL-induced cell death
  JOURNAL   Biochem Biophys Res Commun 435 (2), 234-238 (2013)
   PUBMED   23665015
  REMARK    GeneRIF: These results suggest that the adaptin domain plays a key
            role in MUDENG-mediated cell death.
REFERENCE   4  (bases 1 to 11675)
  AUTHORS   Hirst,J., Barlow,L.D., Francisco,G.C., Sahlender,D.A., Seaman,M.N.,
            Dacks,J.B. and Robinson,M.S.
  TITLE     The fifth adaptor protein complex
  JOURNAL   PLoS Biol 9 (10), e1001170 (2011)
   PUBMED   22022230
  REMARK    Erratum:[PLoS Biol. 2012 Mar;10(3). doi:
            10.1371/annotation/89dff893-c156-44bb-a731-bfcc91843583]
REFERENCE   5  (bases 1 to 11675)
  AUTHORS   Lee,M.R., Shin,J.N., Moon,A.R., Park,S.Y., Hong,G., Lee,M.J.,
            Yun,C.W., Seol,D.W., Piya,S., Bae,J., Oh,J.W. and Kim,T.H.
  TITLE     A novel protein, MUDENG, induces cell death in cytotoxic T cells
  JOURNAL   Biochem Biophys Res Commun 370 (3), 504-508 (2008)
   PUBMED   18395520
  REMARK    GeneRIF: The gene encoding the protein MUDENG (Mu-2 related
            death-inducing gene) was cloned and characterized.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN352262.1, AK001675.1, BQ000414.1 and AL355834.4.
            
            On Nov 22, 2018 this sequence version replaced NM_018229.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.36637.1,
                                           SRR1660803.248604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261558.8/ ENSP00000261558.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                CN352262.1         272-343
            73-2866             AK001675.1         1-2794
            2867-3012           BQ000414.1         16-161              c
            3013-11675          AL355834.4         19425-28087
FEATURES             Location/Qualifiers
     source          1..11675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..11675
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /note="adaptor related protein complex 5 subunit mu 1"
                     /db_xref="GeneID:55745"
                     /db_xref="HGNC:HGNC:20192"
                     /db_xref="MIM:614368"
     exon            1..418
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1817
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /note="MHD domain-containing death-inducing protein; Mu-2
                     related death-inducing; putative HIV-1 infection-related
                     protein; mu-2-related death-inducing protein; AP-5 complex
                     subunit mu; adapter-related protein complex 5 mu subunit;
                     MU-2/AP1M2 domain containing, death-inducing;
                     adapter-related protein complex 5 subunit mu-1; adaptor
                     related protein complex 5 mu 1 subunit"
                     /codon_start=1
                     /product="AP-5 complex subunit mu-1"
                     /protein_id="NP_060699.3"
                     /db_xref="CCDS:CCDS9729.1"
                     /db_xref="GeneID:55745"
                     /db_xref="HGNC:HGNC:20192"
                     /db_xref="MIM:614368"
                     /translation="MAQRAVWLISHEPGTPLCGTVRFSRRYPTVEKRARVFNGASYVP
                     VPEDGPFLKALLFELRLLDDDKDFVESRDSCSRINKTSIYGLLIGGEELWPVVAFLKN
                     DMIYACVPLVEQTLSPRPPLISVSGVSQGFEFLFGIQDFLYSGQKNDSELNTKLSQLP
                     DLLLQACPFGTLLDANLQNSLDNTNFASVTQPQKQPAWKTGTYKGKPQVSISITEKVK
                     SMQYDKQGIADTWQVVGTVTCKCDLEGIMPNVTISLSLPTNGSPLQDILVHPCVTSLD
                     SAILTSSSIDAMDDSAFSGPYKFPFTPPLESFNLCFYTSQVPVPPILGFYQMKEEEVQ
                     LRITINLKLHESVKNNFEFCEAHIPFYNRGPITHLEYKTSFGQLEVFREKSLLIWIIG
                     QKFPKSMEISLSGTVTFGAKSHEKQPFDPICTGETAYLKLHFRILDYTLTGCYADQHS
                     VQVFASGKPKISAHRKLISSDYYIWNSKAPAPVTYGSLLL"
     exon            419..1064
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1292
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1432
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1518
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1637
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1734
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..11675
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /note="hexamer: AATAAA"
     polyA_site      2450
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /note="major polyA site"
     regulatory      2984..2989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /note="hexamer: ATTAAA"
     polyA_site      3007
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
     regulatory      11654..11659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /note="hexamer: AATAAA"
     polyA_site      11675
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /note="major polyA site"
ORIGIN      
        1 aggctcgacg ctaccgtgta tgaggaactt tgatccttgc gggccaccat tccggaagta
       61 gaatttagag gaagaaaata ccggagttgc agggtatagg taaatttctc aaggttatag
      121 gttggggttc ttagaacttt ttgtggtgtg tgttggccta gagcgactca gaagcgttag
      181 tgacttcacc taaaaaagct aacctctctg ctgagcgcga ccggtatgcg gcgcaggatg
      241 agcctcaggg cttctgttaa gagtctgtct gagaaagccg gtctgcgctg ttcctcggtg
      301 gcgaccttaa ttatgagatg agctaatgct ttactgactt aaccatggcg cagcgggcag
      361 tgtggctcat aagccacgaa ccgggaactc cactttgtgg caccgtgaga ttctccagac
      421 ggtatccaac tgttgaaaaa cgagccagag tcttcaatgg agcaagttat gtgcctgttc
      481 ctgaagatgg tccctttctt aaagcactgc tctttgaact tagattattg gatgatgata
      541 aagacttcgt tgagagtcgt gatagctgtt cacgcatcaa taaaacatcc atttatggac
      601 tcctgatagg aggtgaagaa ctctggccag ttgttgcttt tctgaagaat gacatgatat
      661 atgcttgtgt tccactagtt gaacaaactc tgtcccctcg tccgccacta attagtgtca
      721 gtggagtttc acaaggcttt gaatttcttt ttgggataca ggattttctt tattcaggtc
      781 aaaaaaatga ctctgagctg aatacaaaat tgagccagtt gcctgacttg cttctgcagg
      841 cttgtccatt tggtacttta ttagatgcca acttacagaa ttcattagat aataccaatt
      901 ttgcatctgt gactcagcca cagaaacagc cagcttggaa aactgggacg tacaaaggaa
      961 aaccacaagt ttctatttct atcactgaaa aggtaaaatc catgcaatat gataaacagg
     1021 gtatagcaga tacatggcaa gttgttggaa cagtgacttg caagtgtgat ttggaaggaa
     1081 tcatgccaaa tgttaccatc agcttgagtc tccccaccaa tggatctcca cttcaggata
     1141 ttctagttca cccttgtgta acttctcttg actctgcaat tctgacttct agtagtattg
     1201 atgcaatgga tgactctgca tttagtgggc cttacaaatt tccattcact ccacctttag
     1261 agtcattcaa cttatgcttc tacacttccc aggtccctgt cccaccaatt ttgggttttt
     1321 atcaaatgaa ggaggaagaa gtacaactaa gaataaccat taatttaaaa cttcatgaaa
     1381 gtgtgaaaaa taattttgaa ttctgtgaag cccatatacc tttttacaat agaggtccaa
     1441 ttacacattt ggaatacaaa actagttttg gccagcttga agtatttcga gagaaaagct
     1501 tattgatctg gattattggc cagaagttcc caaaatcaat ggaaattagt ctttctggaa
     1561 ctgtaacttt tggagccaag agccatgaga agcagccatt tgacccaatt tgtactggag
     1621 aaacagcata tttaaagctt cattttagga tcttagatta cacacttact ggatgttatg
     1681 cagatcagca ttcagttcaa gtttttgcat caggaaaacc aaaaataagt gcacaccgga
     1741 aactaatttc ttctgattat tacatctgga attctaaagc ccctgctcca gtaacatatg
     1801 gatcattatt attgtaatag tctcatgttt aaatgggatt atataatgat aacagtttaa
     1861 agaaaatcat aatcttatat ttttaatgtg gatgcatata acctgtgagt gaaaaatcac
     1921 tgaatgattt aattgtaaaa gtagtcttat gtggtgtttg tagtctgata gagcttgaaa
     1981 ggacatttta aaagctaatg tctccaattt tgttaacctt cgattttatg ccagtataat
     2041 tcagaacata gaaaagtaat gattcacttg ggctcatttt agactggtcc tgggtcaccc
     2101 tgccacactt gtttcctagt gtttctgtgg cagacattgc taatcaatta cagccctttt
     2161 ctgtactgag ccttggataa agggtcaggc tcctttttag ttcagagatt caggcagcca
     2221 ctcccagtgg gttgtagata atgtgcaaga taaaaactat tttctcttcc aaatctaagt
     2281 actaagctcc tagtataagg tgttgttaca gaataccaga gaccatgtta gagacaacta
     2341 catctcttca aaaaacagcc aacagagaca aaggaaaagt gtttaaatag taagctgttc
     2401 ttcttaatca gaactatcct attgactaat aaataatctg cataattcta cttaaggtgt
     2461 gtaatctctg ttctagagtt agtttttaag taagcttgtt aatctgccac tttgacattt
     2521 tgcttaggat gtcagtagcc atattaagat gtgtagaata ccttcagaag atgatcatag
     2581 tgttttgtaa tcatttaatg tctgcagcca aatttttaaa ggtaatttag acctaatact
     2641 gctcttgctg tgtcttatta agttaaaatt aatgaatgaa ttctggtaaa aattcaaaag
     2701 gcactctgtg agtagagagt atcatttaag cttattttag tcacatgtag tatatatctc
     2761 cttaaagctg tcactctcac tttcttacca ttctcttgat ttcttcagaa accatctagt
     2821 catcatcttt atactctacc tgcttctgca attatatatc atattatgtt ttcagagcag
     2881 ttcattgtca agttggactt taagtgacca ttcaagaaaa gatgaaatct cacgaacctc
     2941 aaaacttcat tcatgtcttt ttacaaatga gaaaaaaaaa tgcattaaag attaatactc
     3001 aatttgatta tatcttgggt tctgtttttt aatgagtgtt ctaaggaaaa gcttagaaaa
     3061 gctgctaact cctcagaaga aagcatgata gtttaaaggt atagggcata taaatttagg
     3121 atttgaaata tgatttttta attaaggtca gtcctactca taaactcatt ttctgcaaag
     3181 cattatcatg gcataaggtt ctatgttcaa aattatccca agtaacaaag aaaaaaagaa
     3241 taactgcctg accaggattt taacttgtta ttctagctta atcatagata atcagcagtg
     3301 aaaactttcc ttttgaaaga agaaaatatc attccctata agttatttga tctctcttaa
     3361 actcaaagct taacatttca cttatgttga taagttaatg gtaatggagc catttggaat
     3421 cttgattgta taaatgttta ccaaatacac taaggtaagc aagaggcatt tatctagtga
     3481 gtaggcaaag atttaatata ataatcccct aggcaaaagt ttataagcag ttagaaaaat
     3541 cagtgaatct tctatttgac atttctagaa accggaggaa aatctagggt gtcctggaaa
     3601 agtgatgagg tgttggggaa cctgatgcca tctgttgcca ttccattcta acatagtgct
     3661 acagaactga accaacttag gttttcatcc cattgagatc agctgggcac actgtgatgc
     3721 ttttgatttt gtctagaaac ctgtcacttc aggataattt ctgaagacaa agtctgtttc
     3781 ccgtttggta ggtgacctgt ttaatgtttt ccctgtgtct gggaactcct tagtgtaatt
     3841 agcgaccttt gaactccaca actaatcctg agctattttg tattccttac tcatctttaa
     3901 ggctggacct ttcctttctt cagagtccgt tgccacaatt aaagaagaaa cagctgcatt
     3961 tcaaagggat tccgattcca gaagcttaat cgtgattgac atgttcttat tctaagctat
     4021 aagacactct aagagtcctt tcttgggtta aaacttcaat cattttctaa aaaattatct
     4081 cactatggat tttattcatt ttctttgata actattcttt gcatttttta acttgaaaga
     4141 tgctttgcgt ttgcagtgaa tatgagcaac tacttccagt gaaagatttg gatagtgtca
     4201 gaccttctct agatgcaaaa ttgctaaatt cccttttagt gccaaaatat gattatgaaa
     4261 tctgatgtct atcacatagg taattattct tcaataaact cgaaaggtta aaaaaaaaag
     4321 tgttaatttt ttagaatgaa ctccagaaaa gatcgttcat gattttgtaa acgcttcttt
     4381 tctccatttt ttactaaaca atattttaaa aactttttag agccagcaat atagtactta
     4441 ggcaataccc ttacggtggt ggcaattttt ttttaacttt ttaagtaatt gattcaaatg
     4501 tcaagtttga agcagtcttg tcaggaattc tgatgacaat tatttgttta aaaaattttt
     4561 tttattaaac attagtctgt cccataaaat cgttttcatt tttttcacac caattcagta
     4621 tttctactag gttaaaatta tggtgttttt atacattgta tgatttaaga tctttcaagg
     4681 cagacattta tacttggtaa caattgccaa tttttttttc tggtttttgt tgtagtattt
     4741 caaaatactt cgtagacatt gatagactcc tacactaccc ctgggagcta ggtaggtgga
     4801 attatcatcc aggccttctg tagggactgc tgccacaaca gagtggttgt tcctaagaca
     4861 aaggtcaaaa aaaggggtgt taataaacag tcctcaggtt taagggactt ttttaggatt
     4921 acatcttaaa ttccaacaaa tcagatttag gagttactga aagtgaaatt gatccatccc
     4981 tcatccaaac tttgcaatac tttcctgttc tgacatcatt tagatagtta gctgtattat
     5041 cagattagaa accattgtac caggctgctg aaaggaaaag gaggcaaaaa gctaaacatg
     5101 ggatgaattc tgaacctttt aacctggctg aagtacgttg gtccctgtta tgcaaatacc
     5161 ttcaatcctc tgctaagttc agtggaaata attttcttga atgacaggtt tattcagcaa
     5221 ggattcagtt ggtgattaat ccccctttga tctagggtat ttcacttaac taccagttac
     5281 ctcgttctga caaagtgcaa ctgagattag ggagatcact agaacactac cagggtgtgc
     5341 gtttattctc tataaccttt taaagcaagg gccaagaatg caatttattt tcagtatttg
     5401 aagatgtaaa gtcctgtctg ctaagttaga aagtcaattg aataccaaat gaagtttatt
     5461 tcttacgtaa tagaacaaac atttcttttt gcttcgccta acaatgatat taggaaacat
     5521 aggctttgaa gaaagaagaa acaaagacta cattctaagt attgcttcta gttttgtttc
     5581 atgcactagg gtatacttaa ctggccttga cataaccaaa aatcaaagca gtggctacaa
     5641 cttagactga gaaaatgctt ctgttttatt aagctgcatg gtttcttctc acctttcccc
     5701 ctaccaccac caccaccatt agaaaatgtc atactgtgtg gtaaagaaat ccagttgagg
     5761 aaaatgtgtt gcagtacaca gttatccacc ttaagactaa tgatttcgaa gctttgttaa
     5821 ctatttcttt tcttgaggca aaggagcttc ttgtgtttcc attataagaa taattgcatt
     5881 cattttcaga atgctttttt aaaaaaaaaa agtgacagca ttaccaaaat agccgagtaa
     5941 ttaaattttt tctgcctgcc tttttctcag ttatctgagt acctcttctt ccataatttt
     6001 aaattttgaa atattatatg gaattttgca cagtattttg agaaagaaaa ggtaatgttt
     6061 catggtaggt ttctcaattt gctgtttaaa actgtttcaa tagcaatgtc agtctttatc
     6121 ttgtaagatg tcaaatcggg atttattcct ccagtatatt ttaagacctt taaaaaaaaa
     6181 gtatagtgat ttgttacaaa atatgttttt aaagattaga ttttgattaa tgatttagtt
     6241 atatacagca ttttaatgct tagtaattac tgttctagta gcattttgca atacaaggga
     6301 tgtatttaga ttattatact ttttttggct cagacttttt gtgatctaat ttataaattg
     6361 aaacaatgac tcaaagaagt gcatacctaa cttacgtttg tgccaagcca gcctcctcta
     6421 gtttcaattt aataactagt ttcaaaatat attttgatag caagttccta aaccacagca
     6481 gaattgcgga tcaggaaaaa tacaagataa cggcattcta taaagataga gggcaggttc
     6541 ccatggctat gttgctaaga aactagtgtt tttaatcatt acactccgtg cagtcatatt
     6601 taatcaataa aacaggatat attttgaaat tcaccatcac agaatatata tatatataca
     6661 cacaacatat atatacaagt atatgaattt acgtaaatgt gtacaacact agtgtgtctg
     6721 acttggtggg tttccctgtg aaacatgtca gtatcatgta agatgaagaa tattttaagg
     6781 gcaaatattc aaatatcttt cctccaaaca cagtattagt taatagtaat gaaatgattc
     6841 attaaactga aaattgcaaa ggaactcatg agttcctttg tgattgaaac aaagtgatta
     6901 aaactcttat gacctgaagg ctttccaact agcctccaac tgtccgcacc agctgtttca
     6961 tggatataac attagtgttt gtgtatagcc tggaacaata caaggctgta tctgtatcac
     7021 tagcttcttg ccttataagc aggatactgc aaggtctggt tgatttctct aatgccctag
     7081 ctaatctgcc taattgacat cagtgtcatg ttaatgtatg atgcacaagc atttacagat
     7141 ggacaaatgc tccacactaa aaaccacctg ctgaattttt tttccagtag gatgtgaaat
     7201 tttgcacttc taatctgttg aacatttaaa gtcaaaacta catgtttcct ttaaatggcc
     7261 tctttaaatg atattttatg tttataaatt ttgttatgaa aaatttaaaa attagttatt
     7321 cctcttaaat ttttactttt tccttcaaag gacttgggtg ccctctgcag gttataaaga
     7381 gataattagt gactatatct attttaaaac cctgtgattt ttctctttca tacacatagc
     7441 ctgcttacac ccaatttcaa agaaagtgtg agctaattta tttatattaa ctcttattaa
     7501 tttgccagtg gttgaagttg gagtttcttt tctccactgg ttttataggt gtgtttagtg
     7561 tgaagaatgt gataccattg aacttccaga ctacttagct ggggctcttt aaatgttgga
     7621 actatagtaa cacacattcc ctcacagaaa ggagattggg aaaatagcta ttttgaaagt
     7681 tattgcagat gtagggaata gcttgtttcc cattatgttt ctagaatatt acacatttgg
     7741 agtaagcctt gctttttcaa catgcatcat gtaaaattac atgaaagaaa ataatttgaa
     7801 aattacacaa gatttctctt tcttgatctt gttgatgatg attgtgttct agctcaaaaa
     7861 acagaccttc ttagaatttc ttatttttta aaaaagtgag tactcaacag ataatacttt
     7921 ggtactgccc gttgcagaca tgggcctact aaactagaaa gagcatttga agagcaaaag
     7981 gcaaaggttc catcaccatc ctgtggaaat acgtgagttg ttcatttcag tacacccata
     8041 gtttctcaac aggtgtagca gatttgtttc taaaggacat aggagtgcat tttttatatg
     8101 aaaccagaac tggagtggta atggcacttc tgattcaatt aacttacttg gtgaagctgc
     8161 cagggaaact aaatatgatg agaagaagag gaatgactgg atcaaattaa tagaaataga
     8221 tctttttgca agcaacataa tgattctgat catcaacctt gaaaagtaaa ttagaacaag
     8281 caaattgctg ttgaaaaatt ctttcagcac tctgctgttg ctactcagct agtcatagct
     8341 cagccagagg gaaggaaaaa atgcactcgg ttttgcatta acaaaggaaa cattattaaa
     8401 gtgaatgttt acattgtgtt tattgaagtg ttgaaagaat atttgttgca tcttcaagca
     8461 acctgctgct ctccagactg ttacagtgca tgagtgataa taaaaatgag tcagtcactt
     8521 gtacatttta gaaaataaat aacttttaac atagtatttc tcaactatgt tacttcaaaa
     8581 tgtttaagtg ccaaacttaa tgttaccttc tctgctaaag atttttgtct ctaggaaata
     8641 tattccatta aaaaaaaaaa gaaagaaact catttattta tttatttggg tataccttcc
     8701 agttacttcc agatgcttta tgtaactttc ctcccagaag ctgcaataca taagaaataa
     8761 taagctgaaa ataatcaaaa aatgaaaaca attgtgaaat tactgaaatg agtatgtaat
     8821 tgagtatgta atatatgcat tggagaaata ccggttgatt attgtgataa cttttgagag
     8881 ctacagttat tttgaactac ctcgtaaaga ctacattgag aatgaaaaag ccattgaaca
     8941 atagatgtac caatttgacc tttaaaagtt caatctttat tatatgcatt gataaatggg
     9001 aaagttagta attaaaaatt tagaaggaat tttagccttt acctttctaa aatgaacaat
     9061 ttaaatcact cttacacttt agaaattgaa atatagtatt taacagggat taaaatgttt
     9121 tacttggtct cttagtgtta ctgaatacaa gtttagtatt ctgtaatccc ttatggattg
     9181 gctgattttt gaagaactat tttcttagat ttaccaacag gacaagttgt cggccttttc
     9241 ccacatttca acctaaaaat ggtatctatc acagttatca aagattaccc cttgctaaag
     9301 gctcttaaga aactgttagc ctgttacttt attacttacc atttctataa catgtacatt
     9361 tatagagcat catatattta ttttaagtct agaatcagta aaaagttatg tgtttgtcaa
     9421 taatcaaaaa atgtttaatc taaaataaag tagatgccac gcttctaatt ctgcttttgc
     9481 taaggcaata atcagtagaa gtggttagta atatttgtag cttgttaacc aactggagca
     9541 aaaggacttt ttaatatgaa taacagtggt ctcgtgccat aagtatttct ctcatacata
     9601 ttaaaatagc atgttatttt atttaatatt gaaggcctaa acacaattga acataaggta
     9661 tggcttggaa tttagaactg ctgagcaata tggttgagag ggagacctta atttagtcaa
     9721 taaaaattca taattaatgt taagctttgt gctcatatta tatgccactc tgggattaga
     9781 caaaagacaa aaaacagttc catattttga acgatatatt ctacctcctg cagtgtatta
     9841 gcattgtagc gtaggagact atttctgtat gttattagta cagaaactgc ccaaaaaggt
     9901 gatggttgaa gttccccagc cagttaaagg gcacaccgtg ggggcagcat atctccatgg
     9961 gtctatctct agcaaacaga atcccagaaa cttgagcacc tgatatagca gaaggaaata
    10021 aagattatag taagtatatt catgagagag aatttttttt gcctccagat gtttggggtt
    10081 tggatatgta gggtaaatat aaatgtctaa tgaaagtaat tactattata tttgatttga
    10141 tatttaattt attatactga aatactaaat taaatacaaa aaaactccta catactaact
    10201 atatgtttct cccactgatt cccctcctgc ctccttcact gattttgaat gtgtgctcaa
    10261 tttgctagta tgagatttac ctctgcctta tcagtgaaga aaatatgatg tctatataga
    10321 attataagga aaatatatat gtgaagaaat gttaggtaat ctaacatttg tatgctaatg
    10381 tgtcttagat ttaccaacta tcctaatgtg tagtcaattg ataaactaaa tttttcttta
    10441 ggatagttca catccagtag aacttctacc ttggaaaaca ttcttagcct tgtttatttt
    10501 gaatgtatgt gtgtgtgtgt gcatgtgtgg aaaacaagaa aaatacaagc tctagagtag
    10561 tggcctcaca ttgatttata ttagtgtgcc agtctttccc ctacctccct aatatttcaa
    10621 acttcttgtg gacaatgaca ttcattttca tacctttata tttccagtgc caccagaaac
    10681 acaaaagcag cttagtgttg atttaatgaa gtagcaaaat gttaaataca taacaaaaca
    10741 gattgtcctg tcacctaaaa caaattagtg atgtttgagt aattagggtt ttgcatgtgt
    10801 atatagaaag gctattttgc aaacagtggt tcagtctgta ttgggcacag gtgaattctg
    10861 ccctgcgatt gccatcttta gcacttttca gagaatttgt tgccatttat gacactgatc
    10921 ttcagacaca ctgtgtagtg ccttggctta aactgtcaga ctggcaacag ctgaggctgc
    10981 ccatcatagg acacgttcct tgcagttatg cttcagtgaa ctttaaaaca tttggcactc
    11041 gtatcttaga aatgtccttc cgaaactcac tctacaacag ctttgtgggc tccctactat
    11101 ttactagagt caatcctgat tttgtttggc ataatgagac ctgatatgct atgactctcc
    11161 ctatcctata aagccacagc tttcagcggt ccccgtatac taatgaaatg gagtcgccag
    11221 tatccaaaag ttccaagtga ttatttagaa catttccatt aaccataaag gcaaagtggt
    11281 atagagaaaa taatacagtc tttgaagtca cacaggcctg atttcaaatc ccagctctgt
    11341 catttacaaa ctgggtggtc ctggataaat tacttaacct ctgtggtctt cagtttcctc
    11401 ccaactttgt agggttattg tgagcattga atgataccaa gttataagtg cataggtatt
    11461 caatcagtgt tcattccctt ctgtatcaaa gacttataat ggccttttca tggaattgtc
    11521 tctacctata attatgtgac tgtgccttca gattatcaaa attatatgaa ttgtccatgt
    11581 gcccttggtt ttgaatgttc aattctgtat tgcaggaatg cctactcagt tgcttgaatg
    11641 ggtgtttgga gttaataaaa tggctgtaca attga
//
