LOCUS       NM_138368               6980 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens adaptor related protein complex 5 subunit beta 1
            (AP5B1), mRNA.
ACCESSION   NM_138368
VERSION     NM_138368.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6980)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6980)
  AUTHORS   Alford,J.E., Marongiu,M., Watkins,G.L. and Anderson,E.C.
  TITLE     Human Immunodeficiency Virus Type 2 (HIV-2) Gag Is Trafficked in an
            AP-3 and AP-5 Dependent Manner
  JOURNAL   PLoS One 11 (7), e0158941 (2016)
   PUBMED   27392064
  REMARK    GeneRIF: HIV-2 particle release was dependent on the adaptor
            protein complex AP-3 and the newly identified AP-5 complex, but
            much less so on AP-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6980)
  AUTHORS   Hirst,J., Borner,G.H., Edgar,J., Hein,M.Y., Mann,M., Buchholz,F.,
            Antrobus,R. and Robinson,M.S.
  TITLE     Interaction between AP-5 and the hereditary spastic paraplegia
            proteins SPG11 and SPG15
  JOURNAL   Mol Biol Cell 24 (16), 2558-2569 (2013)
   PUBMED   23825025
  REMARK    GeneRIF: We propose AP-5, SPG15, SPG11 form a coat-like complex,
            with AP-5 involved in protein sorting, SPG15 facilitating docking
            of the coat onto membranes by interacting with PI3P via its FYVE
            domain, and SPG11 (possibly together with SPG15) forming a
            scaffold.
REFERENCE   4  (bases 1 to 6980)
  AUTHORS   Hirst,J., Barlow,L.D., Francisco,G.C., Sahlender,D.A., Seaman,M.N.,
            Dacks,J.B. and Robinson,M.S.
  TITLE     The fifth adaptor protein complex
  JOURNAL   PLoS Biol 9 (10), e1001170 (2011)
   PUBMED   22022230
  REMARK    GeneRIF: AP-5 is an evolutionarily ancient complex, which is
            involved in endosomal sorting, and which has links with hereditary
            spastic paraplegia.
            Erratum:[PLoS Biol. 2012 Mar;10(3). doi:
            10.1371/annotation/89dff893-c156-44bb-a731-bfcc91843583]
REFERENCE   5  (bases 1 to 6980)
  AUTHORS   Slabicki,M., Theis,M., Krastev,D.B., Samsonov,S., Mundwiller,E.,
            Junqueira,M., Paszkowski-Rogacz,M., Teyra,J., Heninger,A.K.,
            Poser,I., Prieur,F., Truchetto,J., Confavreux,C., Marelli,C.,
            Durr,A., Camdessanche,J.P., Brice,A., Shevchenko,A.,
            Pisabarro,M.T., Stevanin,G. and Buchholz,F.
  TITLE     A genome-scale DNA repair RNAi screen identifies SPG48 as a novel
            gene associated with hereditary spastic paraplegia
  JOURNAL   PLoS Biol 8 (6), e1000408 (2010)
   PUBMED   20613862
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6980)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001266.4, JQ313135.1 and BC109109.1.
            
            On May 17, 2019 this sequence version replaced NM_138368.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JQ313135.1, DRR138518.188221.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000532090.3/ ENSP00000454303.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AP001266.4         80284-80668         c
            386-1491            JQ313135.1         1-1106
            1492-3624           BC109109.1         640-2772
            3625-6980           AP001266.4         73590-76945         c
FEATURES             Location/Qualifiers
     source          1..6980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..6980
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /note="adaptor related protein complex 5 subunit beta 1"
                     /db_xref="GeneID:91056"
                     /db_xref="HGNC:HGNC:25104"
                     /db_xref="MIM:614367"
     exon            1..535
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..3022
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /note="AP-5 complex subunit beta; beta5; adaptor-related
                     protein complex 5 beta subunit; adaptor related protein
                     complex 5 beta 1 subunit"
                     /codon_start=1
                     /product="AP-5 complex subunit beta-1"
                     /protein_id="NP_612377.4"
                     /db_xref="CCDS:CCDS58146.1"
                     /db_xref="GeneID:91056"
                     /db_xref="HGNC:HGNC:25104"
                     /db_xref="MIM:614367"
                     /translation="MGPLSRDAWAQRLGAFRASPSAFMAGPEGEDLGRDLLSDLRSEK
                     LSEQTKVSLLALSMEYPAQLWPDASAAEVAATSLLDTLVLLPPRPSALRRPLLLAATT
                     ALAAGGALGPTSGASCRLLPLLLGLAAGSDLGRGFVPASEQRPLQATACECLRELESC
                     KPGLLGGSLGLLRGLLGQEGPVQPLSLLLALALRNTLVLQSRVGAGLGGLLTDKVSPT
                     GGGPWDWTLVEEGDGRLQPQAPSWPAAEEGEGERSLTAREHSPEEARELRAAVIQLLD
                     TSYLLTPVAQAQLLWLLGWALRGLQGQPPALFKPQLVRLLGTAQLTLLHAMLALKAAF
                     GEALFTAQDEALLLRRLTLAAQHPALPPPTHLFYLHCVLSFPENWPLGPEGEEAAPLL
                     LGPQLCRGLLPSLLHDPMALLARLHLLCLLCAEEEEEEKGQLPSPRHYLEELLAGLRQ
                     RAALDGGPRALATLCFQASYLVACCLAGQPTVLTPLIHGLAQLYQARPMLAPHFVDLL
                     DQVDSELREPLKVVLRQVVVSRPGRDEALCWHLQMLAKVADGDAQSATLNFLQAAAAH
                     CTNWDLQQGLLRVCRALLRAGVRGGLVDLLQVLARQLEDPDGRDHARLYYILLAHLAA
                     PKLGVALGPSLAAPALASSLVAENQGFVAALMVQEAPALVRLSLGSHRVKGPLPVLKL
                     QPEALEPIYSLELRFRVEGQLYAPLEAVHVPCLCPGRPARPLLLPLQPRCPAPARLDV
                     HALYTTSTGLTCHAHLPPLFVNFADLFLPFPQPPEGAGLGFFEELWDSCLPEGAESRV
                     WCPLGPQGLEGLVSRHLEPFVVVAQPPTSYCVAIHLPPDSKLLLRLEAALADGVPVAL
                     RTDDWAVLPLAGDYLRGLAAAV"
     exon            536..6980
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /note="hexamer: AATAAA"
     polyA_site      3258
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /note="major polyA site"
     regulatory      6959..6964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /note="hexamer: AATAAA"
     polyA_site      6980
                     /gene="AP5B1"
                     /gene_synonym="AP-5; PP1030"
                     /note="major polyA site"
ORIGIN      
        1 agcccggaag gagccggccg gcctgagtgc ccgcggcggc tgagtcaggc ggcgagcgcg
       61 gcccgttacc gccggcgccg ggggccgggg tggcgctgtg gtttcggtgc gggccgcggg
      121 cgggagggag gcggcctaac gagctctcgg cacgcaccct cccccgccct gctcctgtcc
      181 tgtcccgcga gggccccggc gcccagctct ggcgtcggcc ccgagagccc tggtctcacc
      241 gtgggagccg ggcgcgggtc ccgccggcat ctgcgcggcg tctgggggtg accgcagccc
      301 ctcggggtcg gcagcgggcc ccgcgctccc ggtggctgcg gcctgagggt ccctcttccc
      361 tgcgcagggg cccgcgcgcc tcaccatggg gcccctgagc cgggacgcct gggcccagcg
      421 cttgggggcc ttccgggcca gcccgtctgc cttcatggca ggtcccgagg gggaggattt
      481 gggtcgcgac ctgctgagcg acctgagaag tgagaagctg agcgaacaga ccaaggtttc
      541 cctgctggcc ctgagcatgg agtaccctgc gcagctgtgg cccgacgcct ctgcggccga
      601 agtggccgcc acctccctgt tggacacctt ggtcctccta cccccgcggc cctcagctct
      661 ccgtcggcca ctgctgctgg cggccaccac tgccctggcg gcgggcggcg cgctgggccc
      721 cacctcgggc gcctcctgcc ggctcctgcc cctactgctc ggcctggccg cgggtagcga
      781 tctggggcga ggctttgtcc ccgcctcgga acagcgcccc ttgcaggcca cggcctgcga
      841 gtgcctgcga gagctagaga gctgcaagcc cgggctgctg gggggctccc tggggttgct
      901 gcggggcctg ctggggcagg aaggccctgt ccagccactc agcctgttgc tggccctcgc
      961 tttgcgcaac accttggtgc tccagtcccg ggttggggct ggcctggggg gactgctcac
     1021 ggataaggtc tccccaactg ggggtggtcc ctgggattgg acactagtgg aggagggcga
     1081 tggacgcctt cagccccagg cacccagctg gccggcagct gaggagggag agggggagcg
     1141 tagccttaca gcacgagagc acagccctga ggaggcgcgg gagctgcggg ctgcggtgat
     1201 ccagcttctg gacacctcct atctgctcac tcctgtggcc caggcccagc tcctgtggct
     1261 gctgggctgg gccctgcggg gtctgcaggg acagccaccg gcactcttca agccgcagct
     1321 ggtacggctg ctaggcacag cacagctgac actgttgcac gccatgcttg cgctcaaggc
     1381 ggcctttggt gaggccttgt tcacagccca ggatgaagcg ttgctgctcc gccggctcac
     1441 cttggctgcc cagcaccctg ctctgcctcc gcccacccat ctcttttacc ttcactgcgt
     1501 cctgagcttc cctgagaact ggccgctggg ccctgaaggt gaggaggctg ccccactgct
     1561 gctagggccc cagctatgcc gtggtctcct gcccagtctc ctgcatgacc caatggccct
     1621 cctggcccgc ctgcatttac tgtgcctgct ctgtgccgag gaggaagaag aggagaaagg
     1681 ccagcttcca agcccacggc actacctgga agagctgctg gctggcttgc ggcagcgggc
     1741 agccctggat gggggccccc gggccttggc cactctctgc ttccaggcct cgtatctggt
     1801 ggcctgctgc ctggctgggc aacctacggt gctgaccccc ttgatccacg gactggccca
     1861 gctgtaccaa gcccggccca tgctggctcc ccactttgtg gacctcttgg atcaggtgga
     1921 ctctgagctg agggagcccc tgaaggtggt gttgcggcag gtggtggtgt ccaggccggg
     1981 cagggatgaa gctctttgct ggcacctgca aatgctggca aaggtggcag atggagatgc
     2041 ccagagtgct accctcaact ttctacaggc cgcggctgcc cactgcacga actgggacct
     2101 acagcagggc ctgctgcggg tctgccgggc gctgctgcgg gcaggggtga ggggcggcct
     2161 ggtcgacttg ctgcaggtgc tggccaggca gctggaggac cctgatgggc gtgaccacgc
     2221 ccgcctctac tacatcctgc tggcacacct ggcagcaccc aagttggggg tggccctggg
     2281 cccctcgctt gccgcacctg cactggcctc ttcactggtg gccgagaacc agggctttgt
     2341 ggcagcactg atggtgcagg aggcaccggc cctggtacgg ctgagcctgg ggtcccatcg
     2401 ggtcaagggc ccactcccag tgttgaagct ccagccggag gcgctggagc ccatctactc
     2461 tctggagctg cgcttccgtg tggaaggaca gctgtatgca cccctggagg ctgtccatgt
     2521 gccctgcctg tgtcctggcc gccctgcccg ccctctgctc ctgcctctgc agccccgatg
     2581 cccggccccc gcacggctgg atgtccatgc cctttacacc acatccactg gtctcacgtg
     2641 ccatgcccac ttgccacccc tgttcgtgaa ctttgccgac ctctttctgc ctttcccgca
     2701 gcctccagag ggggccgggc tgggcttctt tgaggagctc tgggattcct gcctgccaga
     2761 gggtgctgag agtcgtgtgt ggtgtccact tgggccacag ggcctggagg gcttggtgtc
     2821 ccgccacctg gagccttttg tggtggtggc ccagcctcct accagctact gtgtagcaat
     2881 ccacctgccc ccggactcaa agctgctgct gcggctggag gcggccctgg cagatggagt
     2941 gcctgtggcc ctgcggaccg atgactgggc cgtgctgccc ctggcggggg actacctccg
     3001 tgggctggcg gctgctgtct gagccccggg agaccaggtg ggggcaggac tgtggccctt
     3061 gtgggggcca aggcacactc ctgtagctct gtcgccaaaa ccctgcattc cgcagtgccc
     3121 tcgctggctt gttttctttt gggccccggt tgggagcagg ctcctggggg tgagggtctg
     3181 tctgagtctg tttttgctgc tctagcaaga tccctgagac ggggtaagtt ataataaaca
     3241 gaaatgtatt ggctcagagc tctggaggct gggaagtcca tagtggaggg cccagagccc
     3301 agtgaggacc cttctgcatc ttcccatgac agaggacaga gtgacaggag tgaggggaga
     3361 gagcgaaccc actcccaaga taacggcctg agtccacgca ggagggcaga gccctcgtgg
     3421 cctgaccacc tcttagggtc taatcttata ctgttacagt ggcaatcgca tttcaacgtg
     3481 agcgtgggag gggacaaaca ttcaaaccat agcagggtca taggccccaa gaaggcttcc
     3541 agacagaacc cggcactgta gagctacaga gttccttctc acccagacac actagtgctc
     3601 tccagaatct ctgcccagga ggcaggggaa aaatctcctt tctgcttccc agagagggtc
     3661 tggccttgcc caaggccact cagtgattta ggaagaaggc tgaagctaga gtgtggacct
     3721 gacctgttgg acagtacttt tctttctttt tttttcgggg aggggttaaa gacaggatct
     3781 cactctggcg ctctggagtg cagtggtgtg attagggatc attgcagact ctgcctctca
     3841 ggctcaggtg atcctcccat ctcagcctgc ctccgagtag ctgggactac aggtgtgagt
     3901 caccactgta ttttttgcag acaggatctc cctgtttcct aggctggtct cgaactcctg
     3961 ggcttaaatg actcttctgc ctcagcctca ccaaagtgtt gggattactg gtgtgagccc
     4021 ccacacctgg ccgagccagc gcttctcaac tcccaaggtt tgcaagctcc ctgccccagg
     4081 gagctcacgc caggcaggcc agtgggccta agccagaaac agaaagacag cagtggccag
     4141 gtggagagct tcccaagctg tgccgattag agccagctct aggaagggcc tgctaataag
     4201 gtctagggtc tgagaccaag ttttttctaa tctcagcccc taagaaacct aatttgtgct
     4261 taggaatctt cccaggtaag aagaactagt tcctctagtt gttgtttttt tttcccaaac
     4321 atgcaaacac tgaggattga gctgtgtggg gtcagctgtg ctgccaggca catgtacgtt
     4381 gcctcatttc atccttgcaa cagctctgca gggccccgca gatgaggaaa tccgtaggca
     4441 ggagcggttg agtgattttc ctaaggtcac ccagctgttt ggtaatagtg ttttgtcatc
     4501 tggtagcagg tttccattac catgccatca gagcagacct cagccagggc cacagaggtc
     4561 ccaaccgtct ctgccctctt ctgctgcccc tgcctcatgg gctcccagcc acaggttccc
     4621 catgggccag ctttacgcct cctgatcctt ccgattgggg cagactagga gaggaaagac
     4681 gggcctgggc tgggtgcggt ggctcatgcc tgtaatccca gcactttgag aggctgcggc
     4741 gggtggatca cctgaggcca ggtgtttgag atcagcctgg ccagcatggc gaaaccctgt
     4801 gtctaataaa aatacaaaaa ttagccgggc gtggtggcgg gcgcctgtaa tcccagctac
     4861 ttgggaggct gaggcaggag aattacttga acctgggagg cagaagttgc agtgagccga
     4921 gatcacgcca ctgcactcca gcctgggcga cagagcaagg ctctgtctca aaaaaagaaa
     4981 aaaaagaaag ggcctgggac agtggtactg ttaataggtg gagtcaggag gcctgtctca
     5041 aacttgagat gtggcaataa cttgctttgt cacctcggca agtcatttcc aaatcaggaa
     5101 ggggtcagtt tcaggaaaca gaaacttctc cagctgtttt tggcagaagg ggatttaagg
     5161 gaatcagggt acttaaagta catgggaagg ctggagaagt cgcctccagg aagctcccac
     5221 tggagctggg atcagaacgt actgtcctgc ctgccatccc ctgtaagcac ccaggaagct
     5281 gggcttgggc cctgggacat ggggtgggac tgccactcct gcctcctgac acccacaaag
     5341 ccagaagcgt ggtgctgctg cagaaggact gaacatctcc aaggctgggc ccgcagagca
     5401 aacttccttg gccctgtgtc ctccatccat atccttcaaa ggacacctca ttagtggact
     5461 ccatttctct cttccacgga actccagtgg caagggaatc cagaaacgtt ttctttttgc
     5521 ctggagatgc taatccttag cctaagaata aggaaactgg tccatgtaag gactgaccat
     5581 cctttcaccc atctgtctgc ccacttgtgc atccatccca ttttatccat ccattcctcc
     5641 agttgtggac accagatgac tttcagctcc ccctacccca accagaactt tgctgcaatg
     5701 gccattctta tatgccccta tggacccatg ggacaattct ctgggataca tgctaggagc
     5761 agaattgctg aatcataggg aatgcatgtg cttagcttgg ctaagcaatg ttggagtaaa
     5821 agcttttggt tttgcatctt ctcagcactt ctagggaggc accaaaaggg aggatggcac
     5881 tgactgagcc cacctgagat agctcctaga ccccagccct ctgtgtcctc agaatcacac
     5941 actgctgctc atcacttcag cttcccgaag atcatggcaa tagcagcatg cctgtaactg
     6001 tcccaagtac aaccaaaaat tcttcctaaa gagagggaac caaagtcaca cgggtcacct
     6061 tgtccacctg tgtggacgtt gctcatgttc acataccctt ccttgcctcc ttcaaggcag
     6121 gtctggccac aagcccagct ctggctaatg aaatgtgaag ggagtcaagg gccgggggcg
     6181 gtggctcaca cctgtaatcc cagcattttg ggaggccgag gtgggttgat tacctgaggt
     6241 gaagaatttg agaccagcct ggccaacatg gtgaaacccg tctctactaa aaatccaaaa
     6301 attagccggg tgtggtggcg tgctcataat cccagctact caggaggctg aggcaggaga
     6361 atcgcttgaa cccgggaggt ggaggttgca gtgaactgag attgggccac tacactccag
     6421 cctggatgac agagcaggac tccgtctcaa aaaagaaaaa agaaatgtga aggggtcagt
     6481 tttggggcaa aatatgtcat tgccagtgct caattttcca gccctctctt cctctgccat
     6541 gaccgttggg gaagtacatg ttgagatgga ggtgctaaat agttgagtca taatctcacc
     6601 tggatacgct gtaacaaatg ccctggatta tcaaatcagt tatgtaaact aaaaatccta
     6661 aaaccccacc gactgaacag atgccacctc gtggccgagg gaatctcaga aaaaacttaa
     6721 aacaattcct ggccctgatg ggttgggagg tcagatgcaa cttgttatac cccatccctt
     6781 tatggtttag acacagctgc cgagcatgaa tgaacaaaat agggatcatg agatggacag
     6841 aacagacact gtggcaataa gataccaaat tgtaaacagg acctaaggcc atgccaagca
     6901 agggttaagt catgtagagc ccaccttcat gccccgcctc ccctgccccc aacttatgaa
     6961 taaactatgt tctaactgca
//
