LOCUS       NM_005829               5543 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens adaptor related protein complex 3 subunit sigma 2
            (AP3S2), transcript variant 1, mRNA.
ACCESSION   NM_005829
VERSION     NM_005829.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5543)
  AUTHORS   Mahajan,A., Go,M.J., Zhang,W., Below,J.E., Gaulton,K.J.,
            Ferreira,T., Horikoshi,M., Johnson,A.D., Ng,M.C., Prokopenko,I.,
            Saleheen,D., Wang,X., Zeggini,E., Abecasis,G.R., Adair,L.S.,
            Almgren,P., Atalay,M., Aung,T., Baldassarre,D., Balkau,B., Bao,Y.,
            Barnett,A.H., Barroso,I., Basit,A., Been,L.F., Beilby,J.,
            Bell,G.I., Benediktsson,R., Bergman,R.N., Boehm,B.O.,
            Boerwinkle,E., Bonnycastle,L.L., Burtt,N., Cai,Q., Campbell,H.,
            Carey,J., Cauchi,S., Caulfield,M., Chan,J.C., Chang,L.C.,
            Chang,T.J., Chang,Y.C., Charpentier,G., Chen,C.H., Chen,H.,
            Chen,Y.T., Chia,K.S., Chidambaram,M., Chines,P.S., Cho,N.H.,
            Cho,Y.M., Chuang,L.M., Collins,F.S., Cornelis,M.C., Couper,D.J.,
            Crenshaw,A.T., van Dam,R.M., Danesh,J., Das,D., de Faire,U.,
            Dedoussis,G., Deloukas,P., Dimas,A.S., Dina,C., Doney,A.S.,
            Donnelly,P.J., Dorkhan,M., van Duijn,C., Dupuis,J., Edkins,S.,
            Elliott,P., Emilsson,V., Erbel,R., Eriksson,J.G., Escobedo,J.,
            Esko,T., Eury,E., Florez,J.C., Fontanillas,P., Forouhi,N.G.,
            Forsen,T., Fox,C., Fraser,R.M., Frayling,T.M., Froguel,P.,
            Frossard,P., Gao,Y., Gertow,K., Gieger,C., Gigante,B., Grallert,H.,
            Grant,G.B., Grrop,L.C., Groves,C.J., Grundberg,E., Guiducci,C.,
            Hamsten,A., Han,B.G., Hara,K., Hassanali,N., Hattersley,A.T.,
            Hayward,C., Hedman,A.K., Herder,C., Hofman,A., Holmen,O.L.,
            Hovingh,K., Hreidarsson,A.B., Hu,C., Hu,F.B., Hui,J.,
            Humphries,S.E., Hunt,S.E., Hunter,D.J., Hveem,K., Hydrie,Z.I.,
            Ikegami,H., Illig,T., Ingelsson,E., Islam,M., Isomaa,B.,
            Jackson,A.U., Jafar,T., James,A., Jia,W., Jockel,K.H., Jonsson,A.,
            Jowett,J.B., Kadowaki,T., Kang,H.M., Kanoni,S., Kao,W.H.,
            Kathiresan,S., Kato,N., Katulanda,P., Keinanen-Kiukaanniemi,K.M.,
            Kelly,A.M., Khan,H., Khaw,K.T., Khor,C.C., Kim,H.L., Kim,S.,
            Kim,Y.J., Kinnunen,L., Klopp,N., Kong,A., Korpi-Hyovalti,E.,
            Kowlessur,S., Kraft,P., Kravic,J., Kristensen,M.M., Krithika,S.,
            Kumar,A., Kumate,J., Kuusisto,J., Kwak,S.H., Laakso,M., Lagou,V.,
            Lakka,T.A., Langenberg,C., Langford,C., Lawrence,R., Leander,K.,
            Lee,J.M., Lee,N.R., Li,M., Li,X., Li,Y., Liang,J., Liju,S.,
            Lim,W.Y., Lind,L., Lindgren,C.M., Lindholm,E., Liu,C.T., Liu,J.J.,
            Lobbens,S., Long,J., Loos,R.J., Lu,W., Luan,J., Lyssenko,V.,
            Ma,R.C., Maeda,S., Magi,R., Mannisto,S., Matthews,D.R., Meigs,J.B.,
            Melander,O., Metspalu,A., Meyer,J., Mirza,G., Mihailov,E.,
            Moebus,S., Mohan,V., Mohlke,K.L., Morris,A.D., Muhleisen,T.W.,
            Muller-Nurasyid,M., Musk,B., Nakamura,J., Nakashima,E., Navarro,P.,
            Ng,P.K., Nica,A.C., Nilsson,P.M., Njolstad,I., Nothen,M.M.,
            Ohnaka,K., Ong,T.H., Owen,K.R., Palmer,C.N., Pankow,J.S.,
            Park,K.S., Parkin,M., Pechlivanis,S., Pedersen,N.L., Peltonen,L.,
            Perry,J.R., Peters,A., Pinidiyapathirage,J.M., Platou,C.G.,
            Potter,S., Price,J.F., Qi,L., Radha,V., Rallidis,L., Rasheed,A.,
            Rathman,W., Rauramaa,R., Raychaudhuri,S., Rayner,N.W., Rees,S.D.,
            Rehnberg,E., Ripatti,S., Robertson,N., Roden,M., Rossin,E.J.,
            Rudan,I., Rybin,D., Saaristo,T.E., Salomaa,V., Saltevo,J.,
            Samuel,M., Sanghera,D.K., Saramies,J., Scott,J., Scott,L.J.,
            Scott,R.A., Segre,A.V., Sehmi,J., Sennblad,B., Shah,N., Shah,S.,
            Shera,A.S., Shu,X.O., Shuldiner,A.R., Sigurdsson,G., Sijbrands,E.,
            Silveira,A., Sim,X., Sivapalaratnam,S., Small,K.S., So,W.Y.,
            Stancakova,A., Stefansson,K., Steinbach,G., Steinthorsdottir,V.,
            Stirrups,K., Strawbridge,R.J., Stringham,H.M., Sun,Q., Suo,C.,
            Syvanen,A.C., Takayanagi,R., Takeuchi,F., Tay,W.T., Teslovich,T.M.,
            Thorand,B., Thorleifsson,G., Thorsteinsdottir,U., Tikkanen,E.,
            Trakalo,J., Tremoli,E., Trip,M.D., Tsai,F.J., Tuomi,T.,
            Tuomilehto,J., Uitterlinden,A.G., Valladares-Salgado,A.,
            Vedantam,S., Veglia,F., Voight,B.F., Wang,C., Wareham,N.J.,
            Wennauer,R., Wickremasinghe,A.R., Wilsgaard,T., Wilson,J.F.,
            Wiltshire,S., Winckler,W., Wong,T.Y., Wood,A.R., Wu,J.Y., Wu,Y.,
            Yamamoto,K., Yamauchi,T., Yang,M., Yengo,L., Yokota,M., Young,R.,
            Zabaneh,D., Zhang,F., Zhang,R., Zheng,W., Zimmet,P.Z.,
            Altshuler,D., Bowden,D.W., Cho,Y.S., Cox,N.J., Cruz,M., Hanis,C.L.,
            Kooner,J., Lee,J.Y., Seielstad,M., Teo,Y.Y., Boehnke,M.,
            Parra,E.J., Chambers,J.C., Tai,E.S., McCarthy,M.I. and Morris,A.P.
  CONSRTM   DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
            Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes
            (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D)
            Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium;
            Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in
            muylti-Ethnic Samples (T2D-GENES) Consortium
  TITLE     Genome-wide trans-ancestry meta-analysis provides insight into the
            genetic architecture of type 2 diabetes susceptibility
  JOURNAL   Nat Genet 46 (3), 234-244 (2014)
   PUBMED   24509480
REFERENCE   2  (bases 1 to 5543)
  AUTHORS   Hara,K., Fujita,H., Johnson,T.A., Yamauchi,T., Yasuda,K.,
            Horikoshi,M., Peng,C., Hu,C., Ma,R.C., Imamura,M., Iwata,M.,
            Tsunoda,T., Morizono,T., Shojima,N., So,W.Y., Leung,T.F., Kwan,P.,
            Zhang,R., Wang,J., Yu,W., Maegawa,H., Hirose,H., Kaku,K., Ito,C.,
            Watada,H., Tanaka,Y., Tobe,K., Kashiwagi,A., Kawamori,R., Jia,W.,
            Chan,J.C., Teo,Y.Y., Shyong,T.E., Kamatani,N., Kubo,M., Maeda,S.
            and Kadowaki,T.
  CONSRTM   DIAGRAM consortium
  TITLE     Genome-wide association study identifies three novel loci for type
            2 diabetes
  JOURNAL   Hum Mol Genet 23 (1), 239-246 (2014)
   PUBMED   23945395
REFERENCE   3  (bases 1 to 5543)
  AUTHORS   Bultema,J.J. and Di Pietro,S.M.
  TITLE     Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous
            lysosome biogenesis machinery to synthesize specialized
            lysosome-related organelles
  JOURNAL   Small GTPases 4 (1), 16-21 (2013)
   PUBMED   23247405
  REMARK    Review article
REFERENCE   4  (bases 1 to 5543)
  AUTHORS   Kooner,J.S., Saleheen,D., Sim,X., Sehmi,J., Zhang,W., Frossard,P.,
            Been,L.F., Chia,K.S., Dimas,A.S., Hassanali,N., Jafar,T.,
            Jowett,J.B., Li,X., Radha,V., Rees,S.D., Takeuchi,F., Young,R.,
            Aung,T., Basit,A., Chidambaram,M., Das,D., Grundberg,E.,
            Hedman,A.K., Hydrie,Z.I., Islam,M., Khor,C.C., Kowlessur,S.,
            Kristensen,M.M., Liju,S., Lim,W.Y., Matthews,D.R., Liu,J.,
            Morris,A.P., Nica,A.C., Pinidiyapathirage,J.M., Prokopenko,I.,
            Rasheed,A., Samuel,M., Shah,N., Shera,A.S., Small,K.S., Suo,C.,
            Wickremasinghe,A.R., Wong,T.Y., Yang,M., Zhang,F., Abecasis,G.R.,
            Barnett,A.H., Caulfield,M., Deloukas,P., Frayling,T.M., Froguel,P.,
            Kato,N., Katulanda,P., Kelly,M.A., Liang,J., Mohan,V.,
            Sanghera,D.K., Scott,J., Seielstad,M., Zimmet,P.Z., Elliott,P.,
            Teo,Y.Y., McCarthy,M.I., Danesh,J., Tai,E.S. and Chambers,J.C.
  CONSRTM   DIAGRAM; MuTHER
  TITLE     Genome-wide association study in individuals of South Asian
            ancestry identifies six new type 2 diabetes susceptibility loci
  JOURNAL   Nat Genet 43 (10), 984-989 (2011)
   PUBMED   21874001
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5543)
  AUTHORS   Dong,C., Beecham,A., Slifer,S., Wang,L., Blanton,S.H., Wright,C.B.,
            Rundek,T. and Sacco,R.L.
  TITLE     Genomewide linkage and peakwide association analyses of carotid
            plaque in Caribbean Hispanics
  JOURNAL   Stroke 41 (12), 2750-2756 (2010)
   PUBMED   20966410
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5543)
  AUTHORS   Rous,B.A., Reaves,B.J., Ihrke,G., Briggs,J.A., Gray,S.R.,
            Stephens,D.J., Banting,G. and Luzio,J.P.
  TITLE     Role of adaptor complex AP-3 in targeting wild-type and mutated
            CD63 to lysosomes
  JOURNAL   Mol Biol Cell 13 (3), 1071-1082 (2002)
   PUBMED   11907283
REFERENCE   7  (bases 1 to 5543)
  AUTHORS   Dell'Angelica,E.C., Klumperman,J., Stoorvogel,W. and
            Bonifacino,J.S.
  TITLE     Association of the AP-3 adaptor complex with clathrin
  JOURNAL   Science 280 (5362), 431-434 (1998)
   PUBMED   9545220
REFERENCE   8  (bases 1 to 5543)
  AUTHORS   Dell'Angelica,E.C., Ooi,C.E. and Bonifacino,J.S.
  TITLE     Beta3A-adaptin, a subunit of the adaptor-like complex AP-3
  JOURNAL   J Biol Chem 272 (24), 15078-15084 (1997)
   PUBMED   9182526
REFERENCE   9  (bases 1 to 5543)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J Cell Biol 137 (4), 835-845 (1997)
   PUBMED   9151686
REFERENCE   10 (bases 1 to 5543)
  AUTHORS   Dell'Angelica,E.C., Ohno,H., Ooi,C.E., Rabinovich,E., Roche,K.W.
            and Bonifacino,J.S.
  TITLE     AP-3: an adaptor-like protein complex with ubiquitous expression
  JOURNAL   EMBO J 16 (5), 917-928 (1997)
   PUBMED   9118953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010020.2, X99459.1, BC002785.2, DA464242.1, DA268327.1,
            DA752479.1 and AC018988.12.
            
            On Nov 22, 2018 this sequence version replaced NM_005829.4.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript but encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3688336.1, BC002785.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336418.9/ ENSP00000338777.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BC010020.2         4-18
            16-1844             X99459.1           1-1829
            1845-2586           BC002785.2         1820-2561
            2587-2914           DA464242.1         91-418
            2915-3344           DA268327.1         117-546
            3345-3440           DA752479.1         145-240
            3441-5543           AC018988.12        83666-85768         c
FEATURES             Location/Qualifiers
     source          1..5543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..5543
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /note="adaptor related protein complex 3 subunit sigma 2"
                     /db_xref="GeneID:10239"
                     /db_xref="HGNC:HGNC:571"
                     /db_xref="MIM:602416"
     exon            1..114
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..627
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /note="adaptor complex sigma3B;
                     clathrin-associated/assembly/adaptor protein, small 4,
                     22-kD; sigma-3B-adaptin; sigma-adaptin 3b; AP-3 complex
                     subunit sigma-3B; adapter-related protein complex 3
                     subunit sigma-2; adaptor related protein complex 3 sigma 2
                     subunit"
                     /codon_start=1
                     /product="AP-3 complex subunit sigma-2"
                     /protein_id="NP_005820.1"
                     /db_xref="CCDS:CCDS10357.1"
                     /db_xref="GeneID:10239"
                     /db_xref="HGNC:HGNC:571"
                     /db_xref="MIM:602416"
                     /translation="MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDD
                     NICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFE
                     NVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPAR
                     AVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV"
     exon            115..206
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /inference="alignment:Splign:2.1.0"
     exon            207..318
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /inference="alignment:Splign:2.1.0"
     exon            319..390
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /inference="alignment:Splign:2.1.0"
     exon            391..498
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /inference="alignment:Splign:2.1.0"
     exon            499..5543
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1815..1820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /note="hexamer: AATACA"
     polyA_site      1837
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /note="major polyA site"
     regulatory      2559..2564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /note="hexamer: AATAAA"
     polyA_site      2586
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
     regulatory      5519..5524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /note="hexamer: AATAAA"
     polyA_site      5543
                     /gene="AP3S2"
                     /gene_synonym="AP3S3; sigma3b"
                     /note="major polyA site"
ORIGIN      
        1 gctttctggg agtagccggt gctgagagaa ccgtggctgg caaagatgat tcaggcgatt
       61 ctggttttca acaaccatgg gaagccacgg ctagtccgct tctaccagcg tttcccagaa
      121 gaaattcaac agcagattgt tcgagagact ttccatctag tcctcaagcg ggatgacaac
      181 atctgtaact tcttggaggg tggaagtttg attggtggct ctgactacaa actgatctac
      241 cggcactatg ctaccctcta ctttgtattt tgtgtggatt cctcagagag tgaacttgga
      301 atcttggacc tcatccaggt ttttgtggaa actctggata agtgtttcga aaatgtgtgt
      361 gaattggatt tgatcttcca tatggataag gtgcactaca tcctccagga ggtggtgatg
      421 ggtgggatgg tgttggaaac aaacatgaat gaaatcgtgg ctcagattga ggctcaaaac
      481 aggctggaga aatccgaggg tggcctttca gcagcccctg cgcgggctgt gtctgctgtg
      541 aaaaacatca acctgccaga gattcctcgg aacatcaaca ttggcgatct caacatcaaa
      601 gttcccaacc tgtcccagtt tgtctgagga tcaagtattg gcctgaaata gagtccttaa
      661 gacaagcaaa gacaagcaag gcaagcacgt ctggaaacag aacccatttt gagccttaga
      721 agagtcaagc ctcaggacct ggaaactttg tgtctgggga agactgtttg gcatggaata
      781 gggaagggat tcctattgac actgctcggg tgcacccagt tctcacatgt gcagtcatgc
      841 cgttctctga tgcatacggc cactgcagat gtgaggggcc ctgccttcct cagtagggag
      901 tcaacatgcc caagtcattt gcacctttac ctctcacatg gatgctccca agggttaggg
      961 actgcattga gcaggcccac ctgcttccca gaacctcctc actagggctg agcaccttct
     1021 ctgagtagag tcttcatcct tagcaccaca gacttctgag gtcctgtgcc ctttacttgc
     1081 tggtgaggtg tcataggtag aaaagggctg gcccttcaga tctgggggtg tggtgagtgg
     1141 caagtaaggg cagaatttta ggagaaccag agtcacccgc tggctctact gagattgtta
     1201 cacccagaat ccttttgtgt ttttttgtgg tttttttttt ttgaggtgga gtcttgctct
     1261 gtcacccagg ctggagtgct gtggtgcaat ctcggctcac tgcaacctct gcttcccggg
     1321 ttcaagcatt tctcctgtct cagcctcccc agtagctggg attacaggca cccaccacca
     1381 tgcccagcta attgttgtat gtttagtaga gacagggttt caccatgttg gccaggctgg
     1441 gctcgaactc ctggacctca agtgatctac ccgccttggc ctcccaaagt gctggcatta
     1501 caggtgtgag ccaccgtgcc cggccaccag aatcctttgg tatagccaag ccttttggtt
     1561 accgcctcat gaagaatatg cttcccgcat tgtcctagtc ccagttgtat tctcacaggt
     1621 gttatgtgca ggacacaatc caaatcataa acctggctca tgcccaacac atttctgcta
     1681 atagggagag ggacccacca cacacccaca catgccagag gtccctcctc acagaggaga
     1741 gggcctgtgt ctgtagaagg ttaaagctga caacatgtga aacatcccag aattatgact
     1801 cttcccaagt ttaaaataca ttctcctcat gagagcagaa ggtttgttgc tgtgttgtga
     1861 atgatgagct gcctccatag ggaacccact gccacctggg ccagcttctg gagcatgaga
     1921 acctgagcca gggtcaccct tgtggggcct ggacatgacg cacgctggct gcgactagga
     1981 gcagggctgc ctcttctccc tccccaaggt ctgcttgtgg gcacgctctg ttccctcagg
     2041 tgccattctc ccagggctta ggcgcccata aatgttcttt ctgtggtgga gtagggcctc
     2101 ctgcttccat actgtcgcat gggctagatc tcaggtgtgg tgttgagcca ccttaagatg
     2161 agggctgctt cgcagtaaag tttccagcct gggcccctct tgggccttct ggctggggac
     2221 cctcagcctc ctgatgctgt tgcagggcag gtctgagagg gtgcccagca gcacccggtg
     2281 tcagggccac cttgttttcc atttttgaac agcgctccct gtggtttgtg cccactgctc
     2341 aatacagcct ccgatcctca ctcttgaaag ctccatgata agcacagaga tgggcagtgt
     2401 gggtcagaag gtgggccgct tcctgtggaa gagggaagtg taggtgaata gatatcaaaa
     2461 cccctgatgt cattcttttg aggggttgga ttttcttttt tctggcagac atttcagtac
     2521 attcacattt ctctcacatt tgctgaatgt gagatcagaa taaaggagat cggcgtttat
     2581 ttcgtacctt ctgtaagttg gcatgagcaa gatcattcaa ctgtccttac aacaggcatt
     2641 cttatcccca ttttgcagat gacgaaagta gacccagctc cagtaacctt cccttagatt
     2701 acacggggct gagatctgag actgttcact tgactccact gtccttttct ttcctcgctg
     2761 cttaagatgg cttctcccaa tgttatcatc ttctttttta tagataagga aactgagcct
     2821 cagagagtct gacttctcac aaaccgtggt ctaaataggc ttgattttct aaggtggcca
     2881 gtgatcatgt catagagtat aagagccaaa gagtcgtctg tgtccctcca tttaactgat
     2941 gttgaagccg aagcccaagg tggtaaatgt tatgttgagg gtcacaaatc cagagccaca
     3001 tccctcttct tgagttcgtt tgttacgtgg tttaatgcat tactgcagga cagcccttat
     3061 gctagatttc ctgggatagc ctagattttg aatgttttgc ctgccagaaa ccaatggttt
     3121 taaaaaatca ttgagtggtc ctacagattc aaagcgagca tccaaacatc cctcacatgg
     3181 cctcttacaa tgacataaaa ctgaagccca cttttttatt tggaaaactc aatccctttg
     3241 gacaagccac aataattttt cattaactac ttgaggttgc ctgcaaattc agctagcttt
     3301 ccagcctgct atcagcaaag ccataaacat cttttttaaa aataggttaa ggttggccag
     3361 gtgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cagatcacga
     3421 ggtcaggaga tcgagaccat cctagctaac acagtgaaaa cccatctcta ctaaaaatac
     3481 aaaaaattgg ccagccgtgg tagtggacac ctgtagtccc agctactcag gaggctgcgg
     3541 caggagaatg gcatgaaccc gggaggcaga gcttgcagtg agccaagatc gcaccactac
     3601 actccagcct gggcaacaca gcaagactcc gtctcaaaaa aaaaaaaaaa aaaaataggt
     3661 taaggttgta tagaatacta ggctttcctt tttttgtgag atgggggtct cacactgtgg
     3721 ctcaggctgg agtgcagtgg tgtgatcatg gctcactgca gcctcgaagc cccggggtca
     3781 agtgatcctc tcacctcagc ctcctaggta gctggaacca caggcacgca accaccactc
     3841 ctggctagtt ttattttttt agtagaataa ggtctcacta tgttgcacag gctggtctct
     3901 aactccttac ctcaagccat cctcccgcct tggcctccca aacatgttgg gattacaggt
     3961 gtgagccact ggacctggcc aaatactggg ttttcagtgc tcactgccac taataaaaat
     4021 ctgaaattct ttcattatgc aatttctaag tgcctggtga gggccaagct cagttctagg
     4081 ctctgaagat taagagagaa acaaggctct gtctgctcct gttgtctctg tgagcatctt
     4141 tgacagagtg ctcagattgt tgggatatag tgcatcggac tggcagcctg aatttgtgga
     4201 gaccgcagtc agtaactttg tgatatatgg aatatttaga ggacagtaac ccatttccct
     4261 acgccctacc tgatcacatc gtgccctgct gggccatacc ccaaacagcc caccttcctc
     4321 taggcctggc catggccctg tgcctgccac attgaggatt aagtcaggat atcttgagcc
     4381 ctctcaaatc cctgtttatt caggcctctg ccacatatag agccagcctt ctgtccccac
     4441 cacttccact accatggagc ccacttagta aaacgctctc tgggcccagc ttcgccagaa
     4501 aagacaccag gggagcaagg ctcaaaccag gggcagctaa atctgatctt gtggaccagt
     4561 ctctagtaag ggctttcagc gtggctgtct gtccattgct ttccaaatag gatgcagcaa
     4621 tgattggtac atgggtatta agatcggtag taggggctag tccaagttta gcaatagcca
     4681 aactggagag cctctgaagt atgagagtcc cagagggatt tgtcagctcc tggcagacat
     4741 cctgattttc accttcctga gtctacccta ccccagaggg tgccagtctc actgtggtga
     4801 tggttagccc agtgtgtgct gcactcacac accagcacgg ggtccgtgct tgcaggctgg
     4861 tggatgctgt cctctgggtt aagactgtct cccttctcgg gagcactgga gggttctcca
     4921 tctgcgtgtt tcagtggaag ttggcagata cgaaaacagg cccctatagg gaagcagttc
     4981 catgaaaatg attaattctt tccaaaagac ttaaaatttt ttcctatttc aattttcctt
     5041 tcaaaaaagg aaatacattc atgtagttca aaacttaaga aaacaaaagt ctgttcagca
     5101 aaagactccc actccggttc cccaaacgct gagccccacc ccccatccct ggtagcaaga
     5161 agtgtttcca attttaaggt taagaaacaa agtccctgga tttgtgttag ggatgtcttc
     5221 ctgagagtgg gttgtgttcc gtttgaccct ggcggttgac ctcggcccac taggatcatg
     5281 ccgccctctc cagggaggag ggcctcccca tcaccctgta cagtggcacc ccagccctgg
     5341 cactgcccgc ccttgctcag cgtacctttc ccatggcact ctgacgtact ggatgtttgg
     5401 tttctgaagt tactggctgt ttaccctgcc gggatgtaag cccctccagg gcaggggctt
     5461 gtctcgtgtt cagtgctgca tcccagctgc tgggcacggt acctggtcca tggcgttcaa
     5521 taaataactg ttggatgagt gaa
//
