LOCUS       NM_001261826            5065 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens adaptor related protein complex 3 subunit delta 1
            (AP3D1), transcript variant 3, mRNA.
ACCESSION   NM_001261826
VERSION     NM_001261826.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5065)
  AUTHORS   Frohne,A., Koenighofer,M., Cetin,H., Nieratschker,M., Liu,D.T.,
            Laccone,F., Neesen,J., Nemec,S.F., Schwarz-Nemec,U., Schoefer,C.,
            Avraham,K.B., Frei,K., Grabmeier-Pfistershammer,K., Kratzer,B.,
            Schmetterer,K., Pickl,W.F. and Parzefall,T.
  TITLE     A homozygous AP3D1 missense variant in patients with sensorineural
            hearing loss as the leading manifestation
  JOURNAL   Hum Genet 142 (8), 1077-1089 (2023)
   PUBMED   36445457
  REMARK    GeneRIF: A homozygous AP3D1 missense variant in patients with
            sensorineural hearing loss as the leading manifestation.
REFERENCE   2  (bases 1 to 5065)
  AUTHORS   Gong,L., Bates,S., Li,J., Qiao,D., Glass,K., Wei,W., Hsu,V.W.,
            Zhou,X. and Silverman,E.K.
  TITLE     Connecting COPD GWAS Genes: FAM13A Controls TGFbeta2 Secretion by
            Modulating AP-3 Transport
  JOURNAL   Am J Respir Cell Mol Biol 65 (5), 532-543 (2021)
   PUBMED   34166600
  REMARK    GeneRIF: Connecting COPD GWAS Genes: FAM13A Controls TGFbeta2
            Secretion by Modulating AP-3 Transport.
REFERENCE   3  (bases 1 to 5065)
  AUTHORS   Bowman,S.L., Le,L., Zhu,Y., Harper,D.C., Sitaram,A., Theos,A.C.,
            Sviderskaya,E.V., Bennett,D.C., Raposo-Benedetti,G., Owen,D.J.,
            Dennis,M.K. and Marks,M.S.
  TITLE     A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into
            endosome-derived tubular transport carriers
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   33886957
  REMARK    GeneRIF: A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into
            endosome-derived tubular transport carriers.
REFERENCE   4  (bases 1 to 5065)
  AUTHORS   Mohammed,M., Al-Hashmi,N., Al-Rashdi,S., Al-Sukaiti,N.,
            Al-Adawi,K., Al-Riyami,M. and Al-Maawali,A.
  TITLE     Biallelic mutations in AP3D1 cause Hermansky-Pudlak syndrome type
            10 associated with immunodeficiency and seizure disorder
  JOURNAL   Eur J Med Genet 62 (11), 103583 (2019)
   PUBMED   30472485
  REMARK    GeneRIF: We further demonstrated an abnormal storage pathway in the
            platelets. The current study represents a second confirmation
            report and implicates AP3D1 mutations as a cause of
            Hermansky-Pudlak Syndrome type 10.
REFERENCE   5  (bases 1 to 5065)
  AUTHORS   Montoliu,L. and Marks,M.S.
  TITLE     A new type of syndromic albinism associated with mutations in AP3D1
  JOURNAL   Pigment Cell Melanoma Res 30 (1), 5-7 (2017)
   PUBMED   27900855
REFERENCE   6  (bases 1 to 5065)
  AUTHORS   Honing,S., Sandoval,I.V. and von Figura,K.
  TITLE     A di-leucine-based motif in the cytoplasmic tail of LIMP-II and
            tyrosinase mediates selective binding of AP-3
  JOURNAL   EMBO J 17 (5), 1304-1314 (1998)
   PUBMED   9482728
REFERENCE   7  (bases 1 to 5065)
  AUTHORS   Dell'Angelica,E.C., Klumperman,J., Stoorvogel,W. and
            Bonifacino,J.S.
  TITLE     Association of the AP-3 adaptor complex with clathrin
  JOURNAL   Science 280 (5362), 431-434 (1998)
   PUBMED   9545220
REFERENCE   8  (bases 1 to 5065)
  AUTHORS   Ooi,C.E., Moreira,J.E., Dell'Angelica,E.C., Poy,G., Wassarman,D.A.
            and Bonifacino,J.S.
  TITLE     Altered expression of a novel adaptin leads to defective pigment
            granule biogenesis in the Drosophila eye color mutant garnet
  JOURNAL   EMBO J 16 (15), 4508-4518 (1997)
   PUBMED   9303295
REFERENCE   9  (bases 1 to 5065)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J Cell Biol 137 (4), 835-845 (1997)
   PUBMED   9151686
REFERENCE   10 (bases 1 to 5065)
  AUTHORS   Introne,W.J., Huizing,M., Malicdan,M.C.V., O'Brien,K.J. and
            Gahl,W.A.
  TITLE     Hermansky-Pudlak Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY040370.1, AB208804.1,
            AC005545.1 and BM982261.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 9, 2018 this sequence version replaced NM_001261826.2.
            
            Summary: The protein encoded by this gene is a subunit of the AP3
            adaptor-like complex, which is not clathrin-associated, but is
            associated with the golgi region, as well as more peripheral
            structures. The AP-3 complex facilitates the budding of vesicles
            from the golgi membrane, and may be directly involved in
            trafficking to lysosomes. This subunit is implicated in
            intracellular biogenesis and trafficking of pigment granules, and
            possibly platelet dense granules and neurotransmitter vesicles.
            Defects in this gene are a cause of a new type of Hermansky-Pudlak
            syndrome. [provided by RefSeq, Feb 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB208804.1, SRR14038194.3810535.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643116.3/ ENSP00000495274.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                HY040370.1         62-86
            26-387              AB208804.1         1-362
            388-388             AC005545.1         39778-39778         c
            389-1275            AB208804.1         364-1250
            1276-1276           AC005545.1         22914-22914         c
            1277-5058           AB208804.1         1252-5033
            5059-5065           BM982261.1         18-24               c
FEATURES             Location/Qualifiers
     source          1..5065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..5065
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /note="adaptor related protein complex 3 subunit delta 1"
                     /db_xref="GeneID:8943"
                     /db_xref="HGNC:HGNC:568"
                     /db_xref="MIM:607246"
     exon            1..328
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..3880
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /note="isoform 3 is encoded by transcript variant 3; AP-3
                     complex subunit delta-1; delta adaptin; AP-3 complex delta
                     subunit, partial CDS; subunit of putative vesicle coat
                     adaptor complex AP-3; adapter-related protein complex 3
                     subunit delta-1; adaptor related protein complex 3 delta 1
                     subunit"
                     /codon_start=1
                     /product="AP-3 complex subunit delta-1 isoform 3"
                     /protein_id="NP_001248755.1"
                     /db_xref="CCDS:CCDS58638.1"
                     /db_xref="GeneID:8943"
                     /db_xref="HGNC:HGNC:568"
                     /db_xref="MIM:607246"
                     /translation="MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIK
                     QELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSF
                     HEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKP
                     YIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNY
                     LSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLL
                     YECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTH
                     PKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTY
                     RDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKA
                     IRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLR
                     PRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADL
                     EVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLD
                     AWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFY
                     IKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKD
                     KRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDP
                     YRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKER
                     DKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTGELSVNTVTTPKDECEDAKTE
                     AQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGA
                     PEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSV
                     LDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAK
                     NDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNL
                     LAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNL
                     LEEMKATLAKC"
     exon            329..424
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            425..505
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            506..586
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            587..694
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            695..824
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            825..964
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1038
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1088
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1138
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1187
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1333
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1482
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1713
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1945
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2091
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2233
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2305
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2381
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2581
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2655
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2833
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2911
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3019
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3169
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3217
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3407
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3496
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3582
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3704
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3784
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..5065
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5039..5044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /note="hexamer: AATAAA"
     polyA_site      5059
                     /gene="AP3D1"
                     /gene_synonym="ADTD; hBLVR; HPS10"
                     /note="major polyA site"
ORIGIN      
        1 gccgccatct tgtccgccat ttgcaagggg cccggagcgg gatcgcggca cctgccgagc
       61 gggtcgccgc ctctgccgcg gtccttggac cccgccgccg ccctggcctg ggagcttgcc
      121 ccgccgcagc ggccggcagc gcggcgctcc gcgggcggca ggcacgggcc ccgggccccc
      181 tcacggcgcc cagccgcggg cctcccgagg caaaagcccg tgggccgccg cgatggccct
      241 caagatggtg aagggcagca tcgaccgcat gttcgacaag aatctgcagg acttggtccg
      301 cggcatccgt aaccacaagg aggacgaggc aaaatacata tctcagtgca ttgatgagat
      361 caagcaggag ctgaagcagg acaacatagc ggtgaaggcg aacgcggtct gcaagctgac
      421 gtatttacag atgttgggat acgacatcag ctgggccgcc ttcaacatca tagaagtgat
      481 gagtgcctcc aagttcacct tcaagcgaat tggctacctc gctgcttccc agagctttca
      541 cgaaggcacc gacgtcatca tgctgaccac caatcagatc cgtaaggact tgagcagccc
      601 cagccagtac gacacaggtg ttgcactgac gggtctgtcc tgcttcgtca ccccagacct
      661 tgccagagac ctggcaaatg acatcatgac actgatgtca cacaccaagc cctacatcag
      721 gaagaaggct gtgctgatca tgtacaaggt gttcctgaag taccccgagt cgctgcgccc
      781 tgcctttccc cggctgaagg agaagctgga ggaccccgac cccggggttc agtcggctgc
      841 cgtcaatgtc atctgcgagc tggccagacg caaccctaag aactacctgt ccctggcccc
      901 gctctttttc aagctgatga cgtcctccac caacaactgg gtcctcatca agatcatcaa
      961 gctgttcggt gctcttactc ctttggaacc gcggctgggc aagaagctga tcgagcccct
     1021 caccaatctc atccacagca cgtctgccat gtctctcctc tatgaatgtg tgaacaccgt
     1081 gattgcagtg ctcatctcgc tgtcctccgg catgcccaac cacagcgcca gcatccagct
     1141 ttgtgttcag aaattaagga tattgatcga ggactccgat cagaacttga agtacctggg
     1201 gctgctggca atgtccaaga tcctgaagac ccaccccaag tccgtgcagt cccacaagga
     1261 cctcatcctg cagtgcctgg acgacaagga cgagtccatc cggctgcggg ccctggacct
     1321 gctctatggg atggtgtcca agaagaacct gatggagatc gtgaagaagc tgatgaccca
     1381 cgtagacaag gcagagggta ccacctaccg tgacgagctg ctcaccaaga tcattgacat
     1441 ctgcagccag tccaactacc agtacatcac caacttcgag tggtacatca gcatcctggt
     1501 ggagctgacc cggctggagg gcacacggca cggccacctc atcgccgccc aaatgctgga
     1561 cgtggccatc cgcgtgaagg ccatccgcaa gttcgccgtg tcccagatgt ctgcgctgct
     1621 tgacagtgca cacctgctgg ccagcagcac ccagcggaac gggatctgtg aggtgctgta
     1681 cgctgccgcc tggatctgcg gggagttctc agagcatctg caggaaccac accacacttt
     1741 ggaggccatg ctgcggccca gagtcaccac gctgccaggc cacatccagg ccgtgtatgt
     1801 gcagaacgtg gtcaagctct acgcctccat cctgcagcag aaggagcagg ccggggaggc
     1861 agagggcgct caggccgtca cccagctcat ggtggaccgg ctgccccagt ttgtgcagag
     1921 cgcagacctg gaggtgcagg agcgggcgtc ctgcatcctg cagctggtca agcacatcca
     1981 gaagcttcag gccaaggacg tgcctgtggc agaggaggtc agcgctctct ttgctgggga
     2041 gctgaaccca gtggccccca aggcccagaa gaaggttcca gtccccgaag gcctggacct
     2101 ggacgcctgg atcaatgagc cactctcgga cagcgagtca gaggacgaga ggcccagggc
     2161 cgtcttccac gaggaggagc agcggcgtcc caagcaccgg ccgtcggagg cggacgagga
     2221 agagctggct cggcgccgag aggcccggaa gcaggagcag gccaacaacc ccttctacat
     2281 caagagctcg ccatcgccac agaagcggta ccaggacacc ccgggcgtgg agcacattcc
     2341 cgtggtgcag attgacctct ccgtcccctt gaaggttcca gggctgccta tgtcagatca
     2401 gtatgtgaag ctggaggagg agcggcggca ccggcagaag ctggagaagg acaagaggag
     2461 gaaaaagagg aaggagaagg agaagaaggg caagcgccgc cacagctcgc tgcccacgga
     2521 gagcgacgag gacatcgccc ctgcccagca ggtggacatc gtcacagagg agatgcctga
     2581 gaatgctctg cccagcgacg aggatgacaa agaccccaac gacccctaca gggctctgga
     2641 tattgacctg gataagccct tagccgacag cgagaaactg cctattcaga aacacagaaa
     2701 caccgagacc tcaaaatccc ctgagaagga cgttcccatg gtagaaaaga agagcaagaa
     2761 acccaagaag aaagagaaaa aacacaaaga gaaagagaga gacaaggaga agaagaagga
     2821 gaaggagaag aaggctgagg acctggactt ctggctgtct accaccccac cgcctgcccc
     2881 cgcccccgcc cccgcccccg ttccatccac gggggagctc agtgtgaaca ctgtcactac
     2941 cccgaaggac gagtgtgagg acgccaagac ggaggcgcag ggcgaggagg acgatgccga
     3001 ggggcaagac caggacaaga aatctcccaa gcctaagaag aagaagcaca ggaaggagaa
     3061 ggaggagcgg accaaaggca agaagaagtc caagaagcag cctccaggca gcgaggaggc
     3121 agcgggggag ccggtgcaga atggcgcgcc agaggaggag cagctcccgc ctgagtccag
     3181 ctactccctc ctcgctgaaa attcctatgt taaaatgacc tgtgacatcc ggggcagtct
     3241 gcaggaggac agccaggtca ctgtggccat cgtgctggag aacaggagca gcagcatcct
     3301 caagggcatg gagctcagcg tgctggactc actcaatgcc aggatggccc ggccgcaggg
     3361 ctcctccgtc cacgatggcg tccccgtgcc tttccagctg cccccaggcg tctccaacga
     3421 agcccagtat gtgttcacca tccagagcat cgtcatggcg cagaagctca aggggaccct
     3481 gtccttcatt gccaagaatg acgagggtgc gacccacgag aagctggact tcaggctgca
     3541 cttcagctgc agctcctact tgatcaccac tccctgctac agtgacgcct ttgctaagtt
     3601 gctggagtct ggggacttga gcatgagctc aatcaaagtc gatggcattc ggatgtcctt
     3661 ccagaatctt ctggcgaaga tctgttttca ccaccatttt tccgttgtgg agcgagtgga
     3721 ctcctgcgcc tccatgtaca gccgctccat ccagggccac catgtctgcc tcctggtgaa
     3781 aaagggtgag aactctgtct cagtcgacgg gaagtgcagt gactccacgc tactgagcaa
     3841 cttgttagaa gagatgaagg cgacgctggc caagtgttga gagctgcctg cgagccccgc
     3901 accaccccgc ggagcacgta cccagggacc gcagccctga cgtgtctcgc ctctcctcag
     3961 tcgtgtgtac tgtacccaag cctgagtgtt aatttaactc tatgttgtcc gccgtgtaga
     4021 catccgaggt catttgttgc gttgaattat ctgaccatcc ttttttactg tgactcttcc
     4081 cattctcttt ggcaagaagt ccccttctcg cccccaaacc agcaagggac tcccccacct
     4141 gggtctgtgc cctgccccgc gctgggggcc gagtccttga atgtggcttc aggggctcct
     4201 gtcctgggcc agggcctgat gggcaccacg tgaggggcac ttggtggaca gggcggggct
     4261 gacgtggcct cctctggggt cgcctgcttt tgacccaaag gtcctgacgg ttgcgtccgg
     4321 gggaggggaa ggaagggccg ctgtcgccaa ggttttctct cccagaaccc acagtgggaa
     4381 agcggtcttg ccaggcgttg tccattgtca gtgtgctcgt gggctggtga ctgggtcttg
     4441 ggatcccagg ccacgcgcca gccaggctgt gggcagggcg gggccaggga cgccaaagag
     4501 aggttgcagt cagaaccgtg gacggggtgg gttgaggcct ctctgccacc cgtcttcctg
     4561 gtcagcagaa gtgcatctcg gcttgggttt ggggtggtcc gcatcccctg cttgccacta
     4621 tgcgcaccaa ggtttcccca catccttccc agcaccctta ggaaggccca ggcagggcct
     4681 ggaagcagcg gacctgggct gttctgtgtt gaaggagtgt gcccagtgcc cttgggcagg
     4741 acctgtgaga gccacctcac aggcagagcc cccaccaggc agggcaagga gactccgctc
     4801 actccccacg gccagcgtgg gcacaggact gacccttctt cagagataat gacattttat
     4861 cttctccttt tgatgaaaac tgtcacttta gcatgtaatc cattacagaa tcccatgcag
     4921 tgattccagg atttgaaatt gtatgatgtg ttacataaga atttatttgc tatcgacatt
     4981 cccgtataaa gagagagaca tatcacgctg ctgtcatgat tttgtgtcaa gatgatccaa
     5041 taaagttgta aaacaggcat ttcca
//
