LOCUS       NM_003664               3980 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens adaptor related protein complex 3 subunit beta 1
            (AP3B1), transcript variant 1, mRNA.
ACCESSION   NM_003664
VERSION     NM_003664.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3980)
  AUTHORS   Kjeldsen,E.W., Thomassen,J.Q. and Frikke-Schmidt,R.
  TITLE     HDL cholesterol concentrations and risk of atherosclerotic
            cardiovascular disease - Insights from randomized clinical trials
            and human genetics
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (1), 159063 (2022)
   PUBMED   34637926
  REMARK    GeneRIF: HDL cholesterol concentrations and risk of atherosclerotic
            cardiovascular disease - Insights from randomized clinical trials
            and human genetics.
            Review article
REFERENCE   2  (bases 1 to 3980)
  AUTHORS   Luo,H., Liu,D., Liu,W., Wang,G., Chen,L., Cao,Y., Wei,J., Xiao,M.,
            Liu,X., Huang,G., Wang,W., Zhou,J. and Wang,Q.F.
  TITLE     Germline variants in UNC13D and AP3B1 are enriched in COVID-19
            patients experiencing severe cytokine storms
  JOURNAL   Eur J Hum Genet 29 (8), 1312-1315 (2021)
   PUBMED   33867526
  REMARK    GeneRIF: Germline variants in UNC13D and AP3B1 are enriched in
            COVID-19 patients experiencing severe cytokine storms.
REFERENCE   3  (bases 1 to 3980)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3980)
  AUTHORS   Karampini,E., Schillemans,M., Hofman,M., van Alphen,F., de Boer,M.,
            Kuijpers,T.W., van den Biggelaar,M., Voorberg,J. and Bierings,R.
  TITLE     Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade
            body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth
            endothelial cells
  JOURNAL   Haematologica 104 (10), 2091-2099 (2019)
   PUBMED   30630984
  REMARK    GeneRIF: data show that defects in adaptor protein complex
            3-dependent maturation of Weibel-Palade bodies impairs exocytosis
            by affecting the recruitment of VAMP8.
REFERENCE   5  (bases 1 to 3980)
  AUTHORS   de Boer,M., van Leeuwen,K., Geissler,J., van Alphen,F., de
            Vries,E., van der Kuip,M., Terheggen,S.W.J., Janssen,H., van den
            Berg,T.K., Meijer,A.B., Roos,D. and Kuijpers,T.W.
  TITLE     Hermansky-Pudlak syndrome type 2: Aberrant pre-mRNA splicing and
            mislocalization of granule proteins in neutrophils
  JOURNAL   Hum Mutat 38 (10), 1402-1411 (2017)
   PUBMED   28585318
  REMARK    GeneRIF: point mutation c.2702C>G in exon 23 of the AP3B1 gene
            caused deletion of 112 bp in the mRNA in two siblings. This
            mutation activates a cryptic donor splice site that overrules the
            wild-type donor splice site of this exon. Three other novel
            mutations in AP3B1 were identified, that is, a nonsense mutation
            c.716G>A (p.Trp239Ter), a 1-bp and a 4-bp deletion c.177delA and
            c.1839_1842delTAGA, respectively
REFERENCE   6  (bases 1 to 3980)
  AUTHORS   Dell'Angelica,E.C., Klumperman,J., Stoorvogel,W. and
            Bonifacino,J.S.
  TITLE     Association of the AP-3 adaptor complex with clathrin
  JOURNAL   Science 280 (5362), 431-434 (1998)
   PUBMED   9545220
REFERENCE   7  (bases 1 to 3980)
  AUTHORS   Dell'Angelica,E.C., Ooi,C.E. and Bonifacino,J.S.
  TITLE     Beta3A-adaptin, a subunit of the adaptor-like complex AP-3
  JOURNAL   J Biol Chem 272 (24), 15078-15084 (1997)
   PUBMED   9182526
REFERENCE   8  (bases 1 to 3980)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J Cell Biol 137 (4), 835-845 (1997)
   PUBMED   9151686
REFERENCE   9  (bases 1 to 3980)
  AUTHORS   MacNeill,S.A. and Nurse,P.
  TITLE     Genetic analysis of human p34CDC2 function in fission yeast
  JOURNAL   Mol Gen Genet 240 (3), 315-322 (1993)
   PUBMED   8413179
REFERENCE   10 (bases 1 to 3980)
  AUTHORS   Introne,W.J., Huizing,M., Malicdan,M.C.V., O'Brien,K.J. and
            Gahl,W.A.
  TITLE     Hermansky-Pudlak Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA889915.1, BC038444.2 and
            KU178426.1.
            
            On Nov 21, 2019 this sequence version replaced NM_003664.4.
            
            Summary: This gene encodes a protein that may play a role in
            organelle biogenesis associated with melanosomes, platelet dense
            granules, and lysosomes. The encoded protein is part of the
            heterotetrameric AP-3 protein complex which interacts with the
            scaffolding protein clathrin. Mutations in this gene are associated
            with Hermansky-Pudlak syndrome type 2. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038444.2, SRR11853562.25965.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255194.11/ ENSP00000255194.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA889915.1         58-64
            8-1872              BC038444.2         1-1865
            1873-1956           KU178426.1         1754-1837
            1957-3980           BC038444.2         1950-3973
FEATURES             Location/Qualifiers
     source          1..3980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..3980
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /note="adaptor related protein complex 3 subunit beta 1"
                     /db_xref="GeneID:8546"
                     /db_xref="HGNC:HGNC:566"
                     /db_xref="MIM:603401"
     exon            1..247
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..3404
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /note="isoform 1 is encoded by transcript variant 1; AP-3
                     complex beta-3A subunit; beta-3A-adaptin; adaptor protein
                     complex AP-3 subunit beta-1; clathrin assembly protein
                     complex 3 beta-1 large chain; adaptor related protein
                     complex 3 beta 1 subunit"
                     /codon_start=1
                     /product="AP-3 complex subunit beta-1 isoform 1"
                     /protein_id="NP_003655.3"
                     /db_xref="CCDS:CCDS4041.1"
                     /db_xref="GeneID:8546"
                     /db_xref="HGNC:HGNC:566"
                     /db_xref="MIM:603401"
                     /translation="MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKN
                     EDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYL
                     VRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASA
                     DLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDR
                     IDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYES
                     DDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGI
                     ISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEI
                     LTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLL
                     SNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCE
                     RVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQ
                     NYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSH
                     TLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEE
                     EDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTA
                     KRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVT
                     KEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSS
                     VISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKI
                     ENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFN
                     VNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSVIFQKVVNVA
                     NVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELK
                     PVLSQG"
     exon            248..323
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            324..398
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            399..494
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            495..655
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            656..722
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            723..905
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1061
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1159
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1214
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1286
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1349
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1482
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1592
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1769
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1956
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2087
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2196
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2368
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2516
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2589
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2696
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2928
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3013
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3111
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3250
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3980
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3958..3963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /note="hexamer: AATAAA"
     polyA_site      3980
                     /gene="AP3B1"
                     /gene_synonym="ADTB3; ADTB3A; HPS; HPS2; PE"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcgcct gcgcgcgctc ctccgtacga gaactagttt tgttccgtgc cctctggact
       61 ggaacctttt ggagagaacc cccggcagga ccaaccccgc acccgccagc accgcggcaa
      121 tgtccagcaa tagttttcct tacaatgagc agtccggagg aggggaggcg acggagctgg
      181 gtcaggaggc gacctcaacc atttccccct cgggggcctt cggcctcttt agcagcgatt
      241 tgaagaagaa tgaagatcta aagcaaatgt tagagagcaa caaagattct gctaaactgg
      301 atgctatgaa gcggattgtt gggatgattg caaaagggaa aaatgcatct gaactgtttc
      361 ctgctgttgt gaagaatgtg gccagtaaaa atattgagat caagaagttg gtatatgttt
      421 acctggttcg atatgctgaa gaacagcagg atcttgcact cctgtccata agcacttttc
      481 agcgagctct gaaggaccca aaccaactaa ttcgtgcaag cgctttgaga gttctgtcaa
      541 gtattagagt gccaattatt gtacctatca tgatgcttgc tattaaggaa gcttctgctg
      601 acttatcacc atatgttagg aagaatgcag cccatgcaat acaaaaatta tacagccttg
      661 atccagagca gaaggaaatg ttaattgaag taattgaaaa acttctgaaa gataaaagca
      721 cattggtagc tggcagtgtt gtgatggctt ttgaagaagt atgcccggac agaatagatc
      781 tgattcataa aaattaccgc aagctatgta acttactagt ggatgttgaa gagtgggggc
      841 aggttgtcat aatccacatg ctaactcgat atgctcggac acagtttgtc agcccttgga
      901 aagagggtga tgaattagaa gacaatggaa agaatttcta cgaatctgat gatgatcaga
      961 aggaaaagac tgacaaaaag aagaagccgt atactatgga tccagatcat agactcttaa
     1021 ttagaaatac aaagcctttg cttcagagca ggaatgctgc ggtggttatg gcagttgctc
     1081 agctgtattg gcacatatca ccaaaatctg aagctggcat aatttctaaa tcactagtgc
     1141 gtttacttcg tagcaatagg gaggtgcagt atattgtcct acaaaatata gcaactatgt
     1201 caattcaaag aaaggggatg tttgaacctt atctgaagag tttctatgtt aggtcaactg
     1261 atccaactat gatcaagaca ctgaagcttg aaattttgac aaacttggca aatgaagcca
     1321 acatatcaac tcttcttcga gaatttcaga cctatgtgaa aagccaggat aaacaatttg
     1381 cagcagccac tattcagact ataggcagat gtgcaaccaa catcttggaa gtcactgaca
     1441 cgtgcctcaa tggcttggtc tgtctgctgt ccaacaggga tgaaatagtt gttgctgaaa
     1501 gtgtggttgt tataaagaaa ttactgcaaa tgcaacctgc acaacatggt gaaattatta
     1561 aacatatggc caaactcctg gacagtatca ctgttcctgt tgctagagca agtattcttt
     1621 ggctaattgg agaaaactgt gaacgagttc ctaaaattgc ccctgatgtt ttgaggaaga
     1681 tggctaaaag cttcactagt gaagatgatc tggtaaaact gcagatatta aatctgggag
     1741 caaaattgta tttaaccaac tccaaacaga caaaattgct tacccagtac atattaaatc
     1801 tcggcaagta tgatcaaaac tacgacatca gagaccgtac aagatttatt aggcagctta
     1861 ttgttccgaa tgtaaagagt ggagctttaa gtaaatatgc caaaaaaata ttcctagcac
     1921 aaaagcctgc accactgctt gagtctcctt ttaaagatag agatcatttc cagcttggca
     1981 ccttatctca tactctcaac attaaagcta ctgggtacct ggaattatct aattggccag
     2041 aggtggcgcc cgacccatca gttcgaaatg tagaagtaat agagttggca aaagaatgga
     2101 ccccagcagg aaaagcaaag caagagaatt ctgctaagaa gttttattct gaatctgagg
     2161 aagaggagga ctcttctgat agtagcagtg acagtgagag tgaatctgga agtgaaagtg
     2221 gagaacaagg cgaaagtggg gaggaaggag acagcaatga ggacagcagt gaggactcct
     2281 ccagtgagca ggacagtgag agtggacggg agtcaggcct agaaaacaaa agaacagcca
     2341 agaggaactc aaaagccaaa ggaaaaagtg attctgaaga tggggagaag gaaaatgaaa
     2401 aatctaaaac ttcagattct tcaaatgacg aatctagttc aatagaagac agttcttccg
     2461 attctgaatc agagtcagaa cctgaaagtg aatctgaatc cagaagagtc actaaggaga
     2521 aagaaaagaa aacaaagcaa gatagaactc ctcttaccaa agatgtttca cttctagatc
     2581 tggatgattt taacccagta tccactccag ttgcacttcc cacaccagct ctttctccaa
     2641 gtttgatggc tgatcttgaa ggtttacact tgtcaacttc ctcttcagtc atcagtgtca
     2701 gtactcctgc atttgtacca acgaaaactc acgtgctgct tcatcgaatg agtggaaaag
     2761 gactagctgc ccattatttc tttccaagac agccttgcat ttttggtgat aagatggtct
     2821 ctatacaaat aacactgaat aacactactg atcgaaagat agaaaatatc cacatagggg
     2881 aaaaaaaact tcctataggc atgaaaatgc atgtttttaa tccaatagac tctcttgagc
     2941 ctgagggatc cattacagtt tcaatgggta ttgacttttg tgattctact cagactgcca
     3001 gtttccagtt gtgtaccaag gatgattgct tcaatgttaa tattcagcca cctgttggag
     3061 aactgctttt acctgtggcc atgtcagaga aagattttaa gaaagagcaa ggagtgctaa
     3121 caggaatgaa tgaaacttct gctgtaatca ttgctgcacc acagaatttc actccctctg
     3181 tgatctttca gaaggttgta aatgtagcca atgtaggtgc agtcccttct ggccaggata
     3241 atatacacag gtttgcagct aaaactgtgc acagtgggtc attgatgcta gtcacagtgg
     3301 aactgaagga aggctctaca gcccagctta tcataaacac tgagaaaact gtgattggct
     3361 ctgttctgct gcgggaactg aagcctgtcc tgtctcaggg gtaacctgct tacatctgga
     3421 ctttagaatc tggcacacaa caaaagtgcc tggcatccac tactgctgcc tttcatttat
     3481 aataatagcc cttccatctg gcagtggggg tagaatacac tcttgacatt cttgtctcct
     3541 gctttagaat gctagtgtgt atctatcatg tatgcaatac tttccccctt tttgctttgc
     3601 taaccaaaga gcatatattt tactgtcagt tgtctcaact cttgaatcca tgtggcgttt
     3661 tctctgtcct gctgcttctt ttggcctcct cgttttcctt ctctttttcg acaatggtag
     3721 acatgaatga gatatttaaa gttcattgga aatcttcttc cctacagcag taagcaaaaa
     3781 ttagcaaaga gatagtctaa atggcctctc agcttggtat gtgaaaatga gatcacatac
     3841 tttttaaatc caaatacaaa agcatagtct ctgcaagatt ttgttctttg aatttcttga
     3901 tattgtaatt gattattgat aactgtcatc atgaaattat ctctcaataa taagataaat
     3961 aaactagcat atgaatcata
//
