LOCUS       NM_001039569            3986 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens adaptor related protein complex 1 subunit sigma 3
            (AP1S3), transcript variant 1, mRNA.
ACCESSION   NM_001039569
VERSION     NM_001039569.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3986)
  AUTHORS   Ye,T., Cheng,Y. and Li,C.
  TITLE     Adaptor Protein Complex 1 Sigma 3 Is Highly Expressed in Glioma and
            Could Enhance Its Progression
  JOURNAL   Comput Math Methods Med 2021, 5086236 (2021)
   PUBMED   34367317
  REMARK    GeneRIF: Adaptor Protein Complex 1 Sigma 3 Is Highly Expressed in
            Glioma and Could Enhance Its Progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3986)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3986)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3986)
  AUTHORS   Mahil,S.K., Twelves,S., Farkas,K., Setta-Kaffetzi,N., Burden,A.D.,
            Gach,J.E., Irvine,A.D., Kepiro,L., Mockenhaupt,M., Oon,H.H.,
            Pinner,J., Ranki,A., Seyger,M.M.B., Soler-Palacin,P., Storan,E.R.,
            Tan,E.S., Valeyrie-Allanore,L., Young,H.S., Trembath,R.C.,
            Choon,S.E., Szell,M., Bata-Csorgo,Z., Smith,C.H., Di Meglio,P.,
            Barker,J.N. and Capon,F.
  TITLE     AP1S3 Mutations Cause Skin Autoinflammation by Disrupting
            Keratinocyte Autophagy and Up-Regulating IL-36 Production
  JOURNAL   J Invest Dermatol 136 (11), 2251-2259 (2016)
   PUBMED   27388993
REFERENCE   5  (bases 1 to 3986)
  AUTHORS   Li,X., Niu,Y., Cheng,M., Chi,X., Liu,X. and Yang,W.
  TITLE     AP1S3 is required for hepatitis C virus infection by stabilizing E2
            protein
  JOURNAL   Antiviral Res 131, 26-34 (2016)
   PUBMED   27079945
  REMARK    GeneRIF: study demonstrated that AP1S3 interacts with hepatitis C
            virus E2 and protects it from proteasome-dependent degradation
REFERENCE   6  (bases 1 to 3986)
  AUTHORS   Hirst,J., Lindsay,M.R. and Robinson,M.S.
  TITLE     GGAs: roles of the different domains and comparison with AP-1 and
            clathrin
  JOURNAL   Mol Biol Cell 12 (11), 3573-3588 (2001)
   PUBMED   11694590
REFERENCE   7  (bases 1 to 3986)
  AUTHORS   Boehm,M. and Bonifacino,J.S.
  TITLE     Adaptins: the final recount
  JOURNAL   Mol Biol Cell 12 (10), 2907-2920 (2001)
   PUBMED   11598180
REFERENCE   8  (bases 1 to 3986)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   9  (bases 1 to 3986)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   10 (bases 1 to 3986)
  AUTHORS   Kirchhausen,T., Davis,A.C., Frucht,S., Greco,B.O., Payne,G.S. and
            Tubb,B.
  TITLE     AP17 and AP19, the mammalian small chains of the
            clathrin-associated protein complexes show homology to Yap17p,
            their putative homolog in yeast
  JOURNAL   J Biol Chem 266 (17), 11153-11157 (1991)
   PUBMED   2040623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG177582.1, BG340480.1,
            AC093884.4 and BE856458.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001039569.1.
            
            SUMMARY: This gene encodes a member of the adaptor-related protein
            complex 1, sigma subunit genes. The encoded protein is a component
            of adaptor protein complex 1 (AP-1), one of the AP complexes
            involved in claathrin-mediated vesicular transport from the Golgi
            or endosomes. Disruption of the pathway for display of HIV-1
            antigens, which prevents recognition of the virus by cytotoxic T
            cells, has been shown to involve the AP-1 complex (PMID: 15569716).
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299026.1, SRR1163657.8576.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396654.7/ ENSP00000379891.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               BG177582.1         154-629
            477-812             BG340480.1         259-594
            813-3848            AC093884.4         3556-6591           c
            3849-3982           BE856458.1         4-137               c
            3983-3986           AC093884.4         3418-3421           c
FEATURES             Location/Qualifiers
     source          1..3986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..3986
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /note="adaptor related protein complex 1 subunit sigma 3"
                     /db_xref="GeneID:130340"
                     /db_xref="HGNC:HGNC:18971"
                     /db_xref="MIM:615781"
     exon            1..135
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..597
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /note="sigma 1C subunit of AP-1 clathrin; adaptor protein
                     complex AP-1 sigma-1C subunit; golgi adaptor HA1/AP1
                     adaptin sigma-1C subunit; clathrin assembly protein
                     complex 1 sigma-1C small chain; adaptor related protein
                     complex 1 sigma 3 subunit; adapter-related protein complex
                     1 subunit sigma-1C; adaptor-related protein complex 1
                     subunit sigma-1C"
                     /codon_start=1
                     /product="AP-1 complex subunit sigma-3"
                     /protein_id="NP_001034658.1"
                     /db_xref="CCDS:CCDS42827.1"
                     /db_xref="GeneID:130340"
                     /db_xref="HGNC:HGNC:18971"
                     /db_xref="MIM:615781"
                     /translation="MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGH
                     RTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELD
                     IIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQETMEEYMNKPTF"
     exon            136..314
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /inference="alignment:Splign:2.1.0"
     exon            315..423
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /inference="alignment:Splign:2.1.0"
     exon            424..561
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /inference="alignment:Splign:2.1.0"
     exon            562..3986
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3955..3960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /note="hexamer: AATAAA"
     polyA_site      3986
                     /gene="AP1S3"
                     /gene_synonym="PSORS15; sigma1C"
                     /note="major polyA site"
ORIGIN      
        1 attgtgggaa gcagccatgg tctaagccgg gcgcctcacc tgtcagccgc accggctcca
       61 gcgctcgcct ctcgccctcg cttctccagc gctccttgct cgcaaggcgg gggaggcggc
      121 ggcccagcca cgatgataca tttcatattg ctcttcagtc gacaagggaa attacggcta
      181 cagaaatggt acatcactct ccctgataaa gagaggaaga agatcacccg ggaaattgtt
      241 cagattattc tctcccgtgg tcacaggaca agcagttttg ttgactggaa ggagctaaaa
      301 cttgtttata aaaggtatgc tagtttatat ttttgctgtg caatagaaaa tcaggacaat
      361 gagctcttga cgctagagat tgtgcatcgt tacgtggagc tgctggacaa atattttgga
      421 aatgtctgtg agctggatat tatctttaat tttgaaaagg cttatttcat cctggacgag
      481 tttataatag gtggggaaat tcaggaaaca tccaagaaaa ttgctgtcaa agccattgaa
      541 gactctgata tgttacagga gacaatggaa gaatacatga acaagcctac attttaactg
      601 gaaatctact tgaagactcc agcactacat gttatgaagc tgtaaataag caacgcctcc
      661 catccggttt tttgatggag cctcaggcac catgccaaaa ataatttaaa gggattcttt
      721 gttaactaac aaagttaaag ttgtttaaca tatttataat tactatgtgt ctgtattatt
      781 aaaaaaaatt atgtgtctgt gttatactgt ataggtactt gtagctctaa atgtttaaag
      841 taactaccac ctaacccaac agacaatatt tgtaatgtat taactccatg ttatgttttt
      901 aagctggttt agatacatta gctgcaattt tttttgcatt tgacacaata ttgtaataat
      961 ccatgatttt gaatgtaaag tatatatgat gtcattaata ctttttctaa atgtttagtt
     1021 ttctaaattg tataataatt caaaattatg ttaatagtgc agagtttata tgtaatgcta
     1081 gacatttttc atacacttaa tagtactgta actgcaattc acatacaaaa tgtctgattt
     1141 taatgtgctg aattcattta ttttttttag aattgggatt atgaaaataa ccaaagagta
     1201 tagaacttaa taagtgtttt tgatgcctta gaagctgcta tcttgactga ggttttaatt
     1261 tatcttttaa ttgaatataa gggacattcc aataaggttt tctatgaact atatatttat
     1321 taaggtttat agagacctag agatacagca tctatgactt cctttattat tctaaaatag
     1381 tatgataaga attaatagca ataataatta ttgctactat tttttaaaat tcacgttcca
     1441 agcactctta gatgctggaa atttcatttc aaatatgttt taatgtatct ctaatgcatt
     1501 tgaagactta ttacatggct tacttagagc atttaagatt atcacagcct atatggtaga
     1561 ttcctttcct tcttttttct tttcttaccc tttcctcccc aaagaaaaga tttgctgctg
     1621 accattatta ctgtaagtat atcacatttg tgcttcctgg aatgaaaatt ctgtataacc
     1681 aggtcctaac agtgatcaga catattacag ggaaatagct tgtaggccgg gagtggtggc
     1741 ttacacctgt aatcccagca ctttgggagg ccgaggcagg tggatcactt gaggtcagga
     1801 gttcgagagc agcctggcca atatgatgaa accccatctc tactaaaaat acaaaaatta
     1861 ggccgggtac agtggctcat gcctataatt ccagcacttt gggaggcaga ggtgggcgga
     1921 tcacaaggtc aagagatcaa gaccatcctc gccaacaagg tgaaacccca cctctattaa
     1981 aaatacaaaa attagccggg agtggtggtg cgtgcctgta gtcccagcta cttgggaggc
     2041 tgaggcagga gaatcgcttg aacctgggag gcagaagttg cagtgagctg agattgtgcc
     2101 actgcactcc agcctgggcg acagagcgag acttcgtctc aaacaaacaa aaaaattagc
     2161 cgggcatggt ggcaggtgcc tgtaatccca gctactcagg gggctgaggc aggggaatgg
     2221 cttgaaccca ggaggcagag gttgcagtga gccaaggtca taccagtgca ctccaggcgg
     2281 gtgacagagc aagactgcgt ctcaagaaaa aaaaaaaaaa aaagaaaaag taaaagcttg
     2341 tagtattctg tcttgctgcc tgctatttga tgttttacct gtgcattttc aatgttagct
     2401 ttgaggtctg gtatcattca tattagagtg gtttgggacc tccagtgatt tcctagaaga
     2461 gtgtgtttcc tgttggattc tttaggagat cccatctggt agatttttag agaactcgat
     2521 ggaaaaatgt tctctttagt tcatctcagc agacatattt agggaaaaca gcaaagcaag
     2581 caggagaaca aagggaaaaa ttcaccaatt cctcaatata accattgttc aaaggaaata
     2641 actcagatta gcatataaaa taatcattag gcttttacta tccaatattt cttcaggtta
     2701 ccatgtaatt acaattatgg catcagcttg aagtttatca tgtatgattg accactgtgt
     2761 ttactttagc taaccttcag ttttgtggtt taacttttta atgtgttaga attttttctt
     2821 tctttttttc tttctttctt tcttttcttt ctttctttct tttccttcct ttcttccttc
     2881 cttcttctct ctctctcctt ccctcccttc cttccttccc ttcctccctc cctcctttct
     2941 ttctttcttt ttctcttttc ttttcttttc tttcttttct ttcctcgctt cttgtcaccc
     3001 aggccagagt gcaatggtgt gatctcaggt cactgcagcc tccgtctcct gggttcaaac
     3061 gattctcctg cctcagcctc ccgagtagct gggattatag gcatgcgcca ccacgcctgg
     3121 ctaattttgt atttttggta gagttgggat ttctccatgt tggtcaggct ggtcttgaac
     3181 gccgacctca ggtgatccgc ccgccttggc cttccaaagt gctggaatta caggcatgag
     3241 ccgctgcacc cggccaaatt ctttattttt caatacaatt ttgtaaagat ggacctcatg
     3301 taaatccatc atagtttttc cggttctttt gaaatttgtc accatatttg gataaaggta
     3361 tctcttgaac ctcattcaaa tatactacac atgttctgga taattccata ttagacactt
     3421 tagttatgga cagggcttct cagacttcaa tcagtgtcac acatagaaag taaatatatc
     3481 tcttctgggc aaggtggctc acgcctgtaa tcccagcact ttgggaggtc aaggcggcag
     3541 atcacctgag gtcaggagtt cgagaccagc ctggccaaca tggtgaaacc ctgtctctac
     3601 taaaaattca aaaattagcc aagtgtggtg gcacatgctt gtagtgccag ctactcagga
     3661 ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcagtgag ctgagatcac
     3721 gccactgtac tccagcccgg gtgacagagt gagaccctgt ctcaaaaaaa aaaaaaaaaa
     3781 aatgaaagta agtaaacata tctatatggc acagtggggt aaatttgagg gattttaggg
     3841 acatcttcca tgggcctagg ctaaaatagt cattgtgttt tctttatatt atataattac
     3901 tataaaacta ccaagagaaa gacagtaaat gttaaatttc tataaaactt ccaaaataaa
     3961 atgttttaac atgttttaat gaggaa
//
