LOCUS       NM_001127               4165 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens adaptor related protein complex 1 subunit beta 1
            (AP1B1), transcript variant 1, mRNA.
ACCESSION   NM_001127
VERSION     NM_001127.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4165)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   2  (bases 1 to 4165)
  AUTHORS   Ito,Y., Takeichi,T., Igari,S., Mori,T., Ono,A., Suyama,K.,
            Takeuchi,S., Muro,Y., Ogi,T., Hosoya,M., Yamamoto,T. and Akiyama,M.
  TITLE     MEDNIK-like syndrome due to compound heterozygous mutations in
            AP1B1
  JOURNAL   J Eur Acad Dermatol Venereol 35 (5), e345-e347 (2021)
   PUBMED   33349978
  REMARK    GeneRIF: MEDNIK-like syndrome due to compound heterozygous
            mutations in AP1B1.
REFERENCE   3  (bases 1 to 4165)
  AUTHORS   Kell,M.J., Ang,S.F., Pigati,L., Halpern,A. and Folsch,H.
  TITLE     Novel function for AP-1B during cell migration
  JOURNAL   Mol Biol Cell 31 (22), 2475-2493 (2020)
   PUBMED   32816642
  REMARK    GeneRIF: Novel function for AP-1B during cell migration.
REFERENCE   4  (bases 1 to 4165)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4165)
  AUTHORS   Alsaif,H.S., Al-Owain,M., Barrios-Llerena,M.E., Gosadi,G.,
            Binamer,Y., Devadason,D., Ravenscroft,J., Suri,M. and Alkuraya,F.S.
  TITLE     Homozygous Loss-of-Function Mutations in AP1B1, Encoding Beta-1
            Subunit of Adaptor-Related Protein Complex 1, Cause MEDNIK-like
            Syndrome
  JOURNAL   Am J Hum Genet 105 (5), 1016-1022 (2019)
   PUBMED   31630791
  REMARK    GeneRIF: Three individuals from two unrelated families in whom a
            MEDNIK-like phenotype segregates with two homozygous null variants
            in AP1B1.
REFERENCE   6  (bases 1 to 4165)
  AUTHORS   Lim,D.S., Kirsch,D.G., Canman,C.E., Ahn,J.H., Ziv,Y., Newman,L.S.,
            Darnell,R.B., Shiloh,Y. and Kastan,M.B.
  TITLE     ATM binds to beta-adaptin in cytoplasmic vesicles
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 10146-10151 (1998)
   PUBMED   9707615
REFERENCE   7  (bases 1 to 4165)
  AUTHORS   Zucman-Rossi,J., Legoix,P. and Thomas,G.
  TITLE     Identification of new members of the Gas2 and Ras families in the
            22q12 chromosome region
  JOURNAL   Genomics 38 (3), 247-254 (1996)
   PUBMED   8975699
REFERENCE   8  (bases 1 to 4165)
  AUTHORS   Peyrard,M., Pan,H.Q., Kedra,D., Fransson,I., Swahn,S., Hartman,K.,
            Clifton,S.W., Roe,B.A. and Dumanski,J.P.
  TITLE     Structure of the promoter and genomic organization of the human
            beta'-adaptin gene (BAM22) from chromosome 22q12
  JOURNAL   Genomics 36 (1), 112-117 (1996)
   PUBMED   8812422
REFERENCE   9  (bases 1 to 4165)
  AUTHORS   Peyrard,M., Fransson,I., Xie,Y.G., Han,F.Y., Ruttledge,M.H.,
            Swahn,S., Collins,J.E., Dunham,I., Collins,V.P. and Dumanski,J.P.
  TITLE     Characterization of a new member of the human beta-adaptin gene
            family from chromosome 22q12, a candidate meningioma gene
  JOURNAL   Hum Mol Genet 3 (8), 1393-1399 (1994)
   PUBMED   7987321
REFERENCE   10 (bases 1 to 4165)
  AUTHORS   Alsaif,H.S. and Alkuraya,F.S.
  TITLE     IDEDNIK Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39541497
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002059.3 and KF457400.1.
            
            On Feb 21, 2020 this sequence version replaced NM_001127.3.
            
            Summary: Adaptor protein complex 1 is found at the cytoplasmic face
            of coated vesicles located at the Golgi complex, where it mediates
            both the recruitment of clathrin to the membrane and the
            recognition of sorting signals within the cytosolic tails of
            transmembrane receptors. This complex is a heterotetramer composed
            of two large, one medium, and one small adaptin subunit. The
            protein encoded by this gene serves as one of the large subunits of
            this complex and is a member of the adaptin protein family. This
            gene is a candidate meningioma gene. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357586.7/ ENSP00000350199.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC002059.3         106356-106502       c
            148-211             AC002059.3         85139-85202         c
            212-317             AC002059.3         80933-81038         c
            318-453             AC002059.3         77756-77891         c
            454-699             AC002059.3         76658-76903         c
            700-890             AC002059.3         74358-74548         c
            891-1112            AC002059.3         72582-72803         c
            1113-1233           AC002059.3         69637-69757         c
            1234-1329           AC002059.3         69103-69198         c
            1330-1445           AC002059.3         67967-68082         c
            1446-1611           AC002059.3         67150-67315         c
            1612-1710           AC002059.3         60217-60315         c
            1711-1970           AC002059.3         59433-59692         c
            1971-2172           AC002059.3         58588-58789         c
            2173-2193           AC002059.3         57686-57706         c
            2194-2337           AC002059.3         56922-57065         c
            2338-2483           AC002059.3         52197-52342         c
            2484-2613           KF457400.1         54-183              c
            2614-2698           AC002059.3         49381-49465         c
            2699-2785           AC002059.3         48555-48641         c
            2786-2940           AC002059.3         48310-48464         c
            2941-2949           AC002059.3         47644-47652         c
            2950-4165           AC002059.3         45612-46827         c
FEATURES             Location/Qualifiers
     source          1..4165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..4165
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /note="adaptor related protein complex 1 subunit beta 1"
                     /db_xref="GeneID:162"
                     /db_xref="HGNC:HGNC:554"
                     /db_xref="MIM:600157"
     exon            1..147
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            148..211
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3024
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /note="isoform a is encoded by transcript variant 1;
                     clathrin assembly protein complex 1 beta large chain;
                     Golgi adaptor HA1/AP1 adaptin beta subunit; plasma
                     membrane adaptor HA2/AP2 adaptor beta subunit;
                     beta-prime-adaptin; beta-adaptin 1; AP-1 complex subunit
                     beta-1; adaptor protein complex AP-1 subunit beta-1;
                     beta1-adaptin; beta-1-adaptin; adapter-related protein
                     complex 1 subunit beta-1; ADTB1, CLAPB2; adaptor related
                     protein complex 1 beta 1 subunit"
                     /codon_start=1
                     /product="AP-1 complex subunit beta-1 isoform a"
                     /protein_id="NP_001118.3"
                     /db_xref="CCDS:CCDS13855.1"
                     /db_xref="GeneID:162"
                     /db_xref="HGNC:HGNC:554"
                     /db_xref="MIM:600157"
                     /translation="MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVG
                     KDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLI
                     RALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQG
                     FLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWG
                     QIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDY
                     YGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYV
                     KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV
                     STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIW
                     IVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLS
                     LATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICY
                     IGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPA
                     QGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAP
                     PTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTR
                     QVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPNQTVEISLPLS
                     TVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNE
                     NEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRI
                     QPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN"
     exon            212..317
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            318..453
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            454..699
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            700..890
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1112
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1233
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1329
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1445
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1611
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1710
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1970
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2172
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2193
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2337
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2483
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2613
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2698
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2785
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2940
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..2949
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..4165
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3967..3972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /note="hexamer: AAGAAA"
     polyA_site      3989
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /note="major polyA site"
     regulatory      4146..4151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
                     /note="hexamer: AATAAA"
     polyA_site      4165
                     /gene="AP1B1"
                     /gene_synonym="ADTB1; AP105A; BAM22; CLAPB2; KIDAR"
ORIGIN      
        1 agctcacttc cgcccggcag gtgacagccg cggggctccg agccgccggc agcccggacg
       61 caccgggaga gcgagaggtg gaggccgcgg acattttggt gccaagccga accgagccgg
      121 ggcgccggga gctattggga cctgcggaag cctggctaca gataagggac caaaatgact
      181 gactcaaaat atttcaccac gaccaagaaa ggggagatct tcgagctgaa ggcagagctc
      241 aacagtgaca agaaggagaa gaagaaggag gcagtgaaga aagtgattgc atcgatgacc
      301 gtgggcaaag atgtcagtgc cctcttcccc gatgtggtca actgcatgca gacggacaac
      361 ctggagctga agaagctagt atacctctac ttgatgaatt acgccaagag tcagcctgac
      421 atggccatta tggccgtcaa cacctttgtg aaggactgtg aggaccccaa ccccctcatc
      481 cgagccctgg cagtgcggac catgggctgc atccgcgttg acaagatcac agagtacctg
      541 tgcgagccac tccggaagtg cctgaaggac gaggatccat atgtgcgcaa gacagcagct
      601 gtgtgcgtgg ccaagctcca cgacatcaac gcccagctgg tggaggacca gggcttcctg
      661 gacaccctta aagacctcat ctccgactct aaccccatgg tggtggccaa tgcagtggca
      721 gcgctctcag aaattgccga gtctcacccc agcagcaacc tgctcgatct gaacccacag
      781 tccatcaaca agctgctgac agccctcaat gagtgcaccg agtggggcca gatcttcatc
      841 ctggactgcc tcgccaacta tatgcccaag gacgaccgcg aggcccagag catctgtgag
      901 cgggtcaccc ccaggctctc ccatgccaac tccgctgtgg tgctctctgc tgtgaaggtg
      961 ctgatgaagt tcatggagat gttgtctaag gacttggact actacggcac actgctcaag
     1021 aagctggccc cacccctggt cacactgctg tcagccgagc cagagctgca gtatgtggcc
     1081 ctgcgcaaca tcaatctcat cgtgcagaaa aggcctgaga tcctgaagca tgagatgaag
     1141 gtgttcttcg tgaagtacaa cgaccctatc tacgtgaagc tggagaagct ggacatcatg
     1201 atccgcctgg cctctcaggc caacatcgcc caggtgttgg cagagctgaa agagtacgca
     1261 acagaagtgg atgtggactt tgtacggaag gctgtgcgtg ctattggccg ctgcgccatc
     1321 aaggtggagc aatctgcgga gcgctgtgtg agcacgctgc tcgacctcat ccagaccaag
     1381 gtcaactatg tggtccagga ggccatcgtg gtcatcaagg acatcttccg caagtacccc
     1441 aacaagtatg agagtgtgat tgccacactg tgtgagaatc tggactccct ggatgagcct
     1501 gaggcccggg ctgccatgat ctggattgtg ggcgagtacg cggaacggat cgacaacgca
     1561 gatgagctgc tggagagctt cctcgagggc ttccatgacg agagcacaca ggtccagctg
     1621 cagctgctga cagccattgt gaaactcttt ctaaagaagc caacagagac ccaggagctg
     1681 gtgcagcagg tcctcagttt ggccactcag gactcagata acccagacct gcgggaccgt
     1741 ggctacatct actggcgcct gctgtccacg gacccggtgg cagccaagga ggtggtgttg
     1801 gctgagaagc cactcatctc tgaagagacg gacctcatcg agcccacact gttagacgag
     1861 cttatctgct acatcggcac gctggcttcc gtctaccata agcctcccag tgcctttgtg
     1921 gaggggggcc ggggcgtcgt gcacaagagc ctgccacctc gcacggcctc gagtgagagc
     1981 gcagagagcc ctgagacagc ccctactgga gcacctcctg gggagcagcc agatgtcatc
     2041 cccgcccagg gcgacctgct gggtgacctc ctcaacctgg acctcggccc cccagtgagc
     2101 ggcccacccc tggccacctc ctcggtgcag atgggagctg tggaccttct tggcggtggc
     2161 cttgacagcc tgatggggga tgagcctgaa gggattgggg gcaccaactt cgtggcacct
     2221 ccaacagcag cagtaccagc caatcttgga gcacccatcg gcagtggcct gagtgacctc
     2281 tttgacctga ccagtggcgt gggcaccctg tcaggatcat atgtggcccc caaagcagtc
     2341 tggctcccag ccatgaaggc taaggggctg gagatctcag gcaccttcac ccgccaggtg
     2401 ggctccatct ccatggacct gcagctgacc aacaaggcct tgcaggtcat gaccgacttt
     2461 gccatccagt tcaaccgcaa cagctttggc ctggcccccg ccgcccccct ccaggtccac
     2521 gcgccactca gccccaacca gacagtggag atctccctgc ctctcagcac ggtgggctcg
     2581 gtcatgaaga tggagcctct gaacaacctc caggtggccg tgaagaacaa catcgatgtc
     2641 ttctacttca gcaccttgta cccactgcac atcctctttg tggaggacgg gaagatggac
     2701 cggcagatgt tcctggccac atggaaggat attcccaatg agaatgaggc ccagttccag
     2761 atcagagact gccccctcaa tgcagaggct gcgagcagca agctgcagag cagcaacatc
     2821 ttcactgtcg ccaagaggaa cgtggagggc caggacatgc tctaccagtc cctgaagctg
     2881 accaacggca tctgggtgct ggcggagctg cggatccagc cgggcaaccc cagctgcacg
     2941 gacttagagc tgtccctgaa gtgtcgagca ccagaggtgt cccagcacgt gtaccaggcc
     3001 tacgagacca tcctcaagaa ctgagacccc ggccagcgcc caccccagcc ttctgcccgc
     3061 cccatcgagg aggcccctcg ggggcagcac atcttcctcc tcgcaggagg gaccaggcgg
     3121 ggctccaggc cactcagtgg gctccctggt cctgatggca gaacccaccc gatccctggg
     3181 gtagggcacc accccctcct ggggtgagag cgcagtgcac tcccgtgctc tgggacaccc
     3241 ctgctcctgt ggctgtgatg tggggttaag tgaggtgggg accaaaggaa acagagccag
     3301 agcagccaca gaagctgtgc ctgaagggtg agtgtggagc ttgcccctcc ggctcacagc
     3361 cccggcagcc cctggctcct tggtctctcc ggttggtgtt aaagggccct ccactgccac
     3421 ctctcatggg atggaccctg ccaacctggc ctgggtgtgc agggaggggt tccccttggt
     3481 accaggagag ctgctcactt agggcctggg gctcaaggag ctgtaggtgc cggcagaggg
     3541 gcagagctag gctgggagga gcccagggcc tgcaccaccc acttgcaacc accaggctgg
     3601 tgccctgcag ctgtgccagt tgggccacag cctcccgagt gctgacccac atggtcaaga
     3661 ccaggcagaa gctcccagag cccctgtctc gggctcccca ccgactggca gctgcactat
     3721 ccccaactcc ccacttctgc cccaagggtg gtcactgcct gtgatacatt cctcagtgtc
     3781 gcctctgagc ccaggcctcc tgccacaaag actgggccga gagatggggc tgggtaagcg
     3841 ggtgcgcctc ctgtttgggt ttcttcgggg tttctctgta gtgtctgctg ccctcctcct
     3901 ggcctcccag gtttcagttg tgtctgacag agcattaggt tttcctgtta ctgctgtgta
     3961 ataataaaga aagattcggc ttttggcaat cacggacact tttttcccct ccaccgaatg
     4021 tcaggattga aagctgcctc cgagtggttg gggatggttt tctgacccta cggtaactag
     4081 atctaatata tatcatcaga aaatatatat tgtatgttta ctcttatttt cagaaagaga
     4141 aaatgaataa aaatgatgac atcaa
//
