LOCUS       NM_001159               4928 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens aldehyde oxidase 1 (AOX1), mRNA.
ACCESSION   NM_001159
VERSION     NM_001159.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4928)
  AUTHORS   Sun,S. and Iwata,T.
  TITLE     Role of AOX1 on RXR signaling regulates osteoblastogenesis in
            hPDLMSCs
  JOURNAL   Sci Rep 14 (1), 16767 (2024)
   PUBMED   39034354
  REMARK    GeneRIF: Role of AOX1 on RXR signaling regulates osteoblastogenesis
            in hPDLMSCs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4928)
  AUTHORS   Yuan,Z., Yi,G., Ma,R., Wang,Z., Hu,J., Zhao,W. and Hu,Y.
  TITLE     Aldehyde oxidase 1 promotes gallbladder carcinogenesis through
            ROS-mediated activation of the Wnt/beta-catenin pathway
  JOURNAL   Cell Signal 116, 111042 (2024)
   PUBMED   38199597
  REMARK    GeneRIF: Aldehyde oxidase 1 promotes gallbladder carcinogenesis
            through ROS-mediated activation of the Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 4928)
  AUTHORS   Hammid,A., Fallon,J.K., Vellonen,K.S., Lassila,T., Reinisalo,M.,
            Urtti,A., Gonzalez,F., Tolonen,A., Smith,P.C. and Honkakoski,P.
  TITLE     Aldehyde oxidase 1 activity and protein expression in human,
            rabbit, and pig ocular tissues
  JOURNAL   Eur J Pharm Sci 191, 106603 (2023)
   PUBMED   37827455
  REMARK    GeneRIF: Aldehyde oxidase 1 activity and protein expression in
            human, rabbit, and pig ocular tissues.
REFERENCE   4  (bases 1 to 4928)
  AUTHORS   Wu,J., Wei,Y., Li,T., Lin,L., Yang,Z. and Ye,L.
  TITLE     DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell
            Migration and Invasion of Prostate Cancer
  JOURNAL   Urol Int 107 (5), 517-525 (2023)
   PUBMED   35354150
  REMARK    GeneRIF: DNA Methylation-Mediated Lowly Expressed AOX1 Promotes
            Cell Migration and Invasion of Prostate Cancer.
REFERENCE   5  (bases 1 to 4928)
  AUTHORS   Zhang,W., Chai,W., Zhu,Z. and Li,X.
  TITLE     Aldehyde oxidase 1 promoted the occurrence and development of
            colorectal cancer by up-regulation of expression of CD133
  JOURNAL   Int Immunopharmacol 85, 106618 (2020)
   PUBMED   32470878
  REMARK    GeneRIF: Aldehyde oxidase 1 promoted the occurrence and development
            of colorectal cancer by up-regulation of expression of CD133.
REFERENCE   6  (bases 1 to 4928)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 4928)
  AUTHORS   Ichida,K., Matsumura,T., Sakuma,R., Hosoya,T. and Nishino,T.
  TITLE     Mutation of human molybdenum cofactor sulfurase gene is responsible
            for classical xanthinuria type II
  JOURNAL   Biochem Biophys Res Commun 282 (5), 1194-1200 (2001)
   PUBMED   11302742
REFERENCE   8  (bases 1 to 4928)
  AUTHORS   Berger,R., Mezey,E., Clancy,K.P., Harta,G., Wright,R.M.,
            Repine,J.E., Brown,R.H., Brownstein,M. and Patterson,D.
  TITLE     Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as
            possible candidate genes for autosomal recessive familial
            amyotrophic lateral sclerosis
  JOURNAL   Somat Cell Mol Genet 21 (2), 121-131 (1995)
   PUBMED   7570184
REFERENCE   9  (bases 1 to 4928)
  AUTHORS   Rodrigues,A.D.
  TITLE     Comparison of levels of aldehyde oxidase with cytochrome P450
            activities in human liver in vitro
  JOURNAL   Biochem Pharmacol 48 (1), 197-200 (1994)
   PUBMED   8043023
REFERENCE   10 (bases 1 to 4928)
  AUTHORS   Wright,R.M., Vaitaitis,G.M., Wilson,C.M., Repine,T.B., Terada,L.S.
            and Repine,J.E.
  TITLE     cDNA cloning, characterization, and tissue-specific expression of
            human xanthine dehydrogenase/xanthine oxidase
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10690-10694 (1993)
   PUBMED   8248161
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080164.6 and AC007163.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001159.3.
            
            Summary: Aldehyde oxidase produces hydrogen peroxide and, under
            certain conditions, can catalyze the formation of superoxide.
            Aldehyde oxidase is a candidate gene for amyotrophic lateral
            sclerosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L11005.1, SRR1660803.14342.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374700.7/ ENSP00000363832.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC080164.6         18895-19034
            141-198             AC080164.6         26027-26084
            199-295             AC080164.6         28153-28249
            296-404             AC080164.6         30278-30386
            405-531             AC080164.6         32501-32627
            532-593             AC080164.6         35165-35226
            594-683             AC080164.6         36148-36237
            684-764             AC080164.6         36898-36978
            765-909             AC080164.6         37577-37721
            910-1002            AC080164.6         38417-38509
            1003-1154           AC080164.6         41865-42016
            1155-1248           AC080164.6         42202-42295
            1249-1358           AC080164.6         44265-44374
            1359-1543           AC080164.6         45490-45674
            1544-1706           AC080164.6         46685-46847
            1707-1799           AC080164.6         48852-48944
            1800-1969           AC080164.6         53531-53700
            1970-2096           AC080164.6         54001-54127
            2097-2219           AC080164.6         56742-56864
            2220-2316           AC080164.6         60234-60330
            2317-2441           AC080164.6         67672-67796
            2442-2575           AC080164.6         69792-69925
            2576-2663           AC080164.6         71096-71183
            2664-2750           AC080164.6         73979-74065
            2751-2942           AC080164.6         75491-75682
            2943-3170           AC007163.3         172977-173204       c
            3171-3266           AC007163.3         167241-167336       c
            3267-3395           AC007163.3         164885-165013       c
            3396-3470           AC007163.3         164109-164183       c
            3471-3523           AC007163.3         162547-162599       c
            3524-3638           AC007163.3         161209-161323       c
            3639-3704           AC007163.3         157426-157491       c
            3705-3893           AC007163.3         155375-155563       c
            3894-4061           AC007163.3         154436-154603       c
            4062-4928           AC007163.3         152683-153549       c
FEATURES             Location/Qualifiers
     source          1..4928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..4928
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /note="aldehyde oxidase 1"
                     /db_xref="GeneID:316"
                     /db_xref="HGNC:HGNC:553"
                     /db_xref="MIM:602841"
     exon            1..140
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..4112
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /EC_number="1.2.3.1"
                     /note="azaheterocycle hydroxylase"
                     /codon_start=1
                     /product="aldehyde oxidase"
                     /protein_id="NP_001150.3"
                     /db_xref="CCDS:CCDS33360.1"
                     /db_xref="GeneID:316"
                     /db_xref="HGNC:HGNC:553"
                     /db_xref="MIM:602841"
                     /translation="MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGC
                     GGGGCGACTVMISRYNPITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPV
                     QERIAKCHGTQCGFCTPGMVMSIYTLLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDA
                     CKTFCKTSGCCQSKENGVCCLDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIF
                     PPELMIMAEKQSQRTRVFGSERMMWFSPVTLKELLEFKFKYPQAPVIMGNTSVGPEVK
                     FKGVFHPVIISPDRIEELSVVNHAYNGLTLGAGLSLAQVKDILADVVQKLPEEKTQMY
                     HALLKHLGTLAGSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGKRQIPL
                     NEQFLSKCPNADLKPQEILVSVNIPYSRKWEFVSAFRQAQRQENALAIVNSGMRVFFG
                     EGDGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQMLDIACRLILNEVSLLGSAP
                     GGKVEFKRTLIISFLFKFYLEVSQILKKMDPVHYPSLADKYESALEDLHSKHHCSTLK
                     YQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFVTSSRAHAKI
                     VSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAEKFLATDKVFCVGQLVCAVLADS
                     EVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPERKLEYGNVDEAFKVVDQILE
                     GEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLKLPANKVMC
                     HVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYK
                     AGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKFPNLRCRGWACRTNL
                     PSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYKQEINAKN
                     LIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAAGQAAALV
                     HIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETVPNANISGG
                     SVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFRGYE
                     SDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQI
                     EGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSNTL
                     YSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFT
                     KMIPRDEPGSYVPWNVPI"
     exon            141..198
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..295
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..404
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..531
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..593
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..683
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..764
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..909
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1002
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1154
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1248
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1358
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1543
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1706
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1799
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1969
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2096
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2219
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2316
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2441
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2575
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2663
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2750
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2942
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3170
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3266
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3395
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3470
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3523
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3638
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3704
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3893
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4061
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4928
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4906..4911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /note="hexamer: AATAAA"
     polyA_site      4928
                     /gene="AOX1"
                     /gene_synonym="AO; AOH1"
                     /note="major polyA site"
ORIGIN      
        1 actcggcggg tcggtgccgc cgggtcccag gtgcccgcta cttcccagaa cctccgcctc
       61 ccgctccggg ccctcgaacc agcgcggaca ccacaatgga ccgggcgtcc gagctgctct
      121 tctacgtgaa cggccgcaag gtgatagaaa aaaatgtcga tcctgaaaca atgctgttgc
      181 cttatttgag gaagaagctt cgactcacag gaactaagta tggctgtgga ggaggaggct
      241 gtggtgcttg tacagtgatg atatcacgat acaaccccat caccaagagg ataaggcatc
      301 acccagccaa tgcctgtctg attcccatct gttctctgta tggtgctgcc gtcaccacag
      361 tagaaggcat aggaagcacc cacaccagaa ttcatcctgt tcaggagagg attgccaagt
      421 gtcatggcac ccagtgtggc ttctgcacac ctgggatggt gatgtccatc tacacgctgc
      481 tcaggaacca cccagagccc actctggatc agttaactga tgcccttggt ggtaacctgt
      541 gccgttgcac tggatacagg cccataattg atgcatgcaa gactttctgt aaaacttcgg
      601 gctgctgtca aagtaaagaa aatggggttt gctgtttgga tcaaggaatc aatggattgc
      661 cagaatttga ggaaggaagt aagacaagtc caaaactctt cgcagaagag gagtttctgc
      721 cattggatcc aacccaggaa ctgatatttc ctcctgagct aatgataatg gctgagaaac
      781 agtcgcaaag gaccagggtg tttggcagtg agagaatgat gtggttttcc cccgtgaccc
      841 tgaaggaact gctggaattt aaattcaagt atccccaggc tcctgttatc atgggaaaca
      901 cctctgtggg gcctgaagtg aaatttaaag gcgtctttca cccagttata atttctcctg
      961 atagaattga agaactgagt gttgtaaacc atgcatataa tggactcacc cttggtgctg
     1021 gtctcagcct agcccaggtg aaggacattt tggctgatgt agtccagaag cttccagagg
     1081 agaagacaca gatgtaccat gctctcctga agcatttggg aactctggct gggtcccaga
     1141 tcaggaacat ggcttcttta gggggacaca tcattagcag gcatccagat tcagatctga
     1201 atcccatcct ggctgtgggt aactgtaccc tcaacttgct atcaaaagaa ggaaaacgac
     1261 agattccttt aaatgagcaa ttcctcagca agtgccctaa tgcagatctt aagcctcaag
     1321 aaatcttggt ctcagtgaac atcccctact caaggaagtg ggaatttgtg tcagccttcc
     1381 gacaagccca gcgacaggag aatgcgctag cgatagtcaa ttcaggaatg agagtctttt
     1441 ttggagaagg ggatggcatt attagagagt tatgcatctc atatggaggc gttggtccag
     1501 ccaccatctg tgccaagaat tcctgccaga aactcattgg aaggcactgg aacgaacaga
     1561 tgctggatat agcctgcagg cttattctga atgaagtctc ccttttgggc tcggcgccag
     1621 gtgggaaagt ggagttcaag aggactctca tcatcagctt cctcttcaag ttctacctgg
     1681 aagtgtcaca gattttgaaa aagatggatc cagttcacta tcctagcctt gcagacaagt
     1741 atgaaagtgc tttagaagat cttcattcca aacatcactg cagtacatta aagtaccaga
     1801 atataggccc aaagcagcat cctgaagacc caattggcca ccccatcatg catctgtctg
     1861 gtgtgaagca tgccacgggg gaggccatct actgtgatga catgcctctg gtggaccagg
     1921 aacttttctt gacttttgtg actagttcaa gagctcatgc taagattgtg tctattgatc
     1981 tgtcagaagc tctcagcatg cccggtgtgg tggacatcat gacagcagaa catcttagtg
     2041 acgtcaactc cttctgcttt tttactgaag ctgagaaatt tctggcgaca gataaggtgt
     2101 tctgtgtggg tcagcttgtc tgtgctgtgc ttgccgattc tgaggttcag gcaaagcgag
     2161 ctgctaagcg agtgaagatt gtctatcaag acttggagcc gctgatacta acaattgagg
     2221 aaagtataca acacaactcc tccttcaagc cagaaaggaa actggaatat ggaaatgttg
     2281 acgaagcatt taaagtggtt gatcaaattc ttgaaggtga aatacatatg ggaggtcaag
     2341 aacattttta tatggaaacc caaagcatgc ttgtcgttcc caagggagag gatcaagaaa
     2401 tggatgtcta cgtgtccaca cagtttccca aatatataca ggacattgtt gcctcaacct
     2461 tgaagctccc agctaacaag gtcatgtgcc atgtaaggcg tgttggtgga gcgtttggag
     2521 ggaaggtgtt aaaaaccgga atcattgcag ccgtcactgc atttgccgca aacaaacatg
     2581 gccgtgcagt tcgctgtgtt ctggaacgag gagaagacat gttaataact ggaggccgcc
     2641 atccttacct tggaaagtac aaagctggat tcatgaacga tggcagaatc ttggccctgg
     2701 acatggagca ttacagcaat gcaggcgcct ccttggatga atcattattc gtgatagaaa
     2761 tgggacttct gaaaatggac aatgcttaca agtttcccaa tctccgctgc cggggttggg
     2821 catgcagaac caaccttcca tccaacacag cttttcgtgg gtttggcttt cctcaggcag
     2881 cgctgatcac cgaatcttgt atcacggaag ttgcagccaa atgtggacta tcccctgaga
     2941 aggtgcgaat cataaacatg tacaaggaaa ttgatcaaac accctacaaa caagagatca
     3001 atgccaagaa cctaatccag tgttggagag aatgtatggc catgtcttcc tactccttga
     3061 ggaaagttgc tgtggaaaag ttcaatgcag agaattattg gaagaagaaa ggactggcca
     3121 tggtccccct gaagtttcct gttggccttg gctcacgtgc tgctggtcag gctgctgcct
     3181 tggttcacat ttatcttgat ggctctgtgc tggtcactca cggtggaatt gaaatggggc
     3241 agggggtcca cactaaaatg attcaggtgg tcagccgtga attaagaatg ccaatgtcga
     3301 atgtccacct gcgtggaaca agcacagaaa ctgtccctaa tgcaaatatc tctggaggtt
     3361 ctgtggtggc agatctcaac ggtttggcag taaaggatgc ctgtcaaact cttctaaaac
     3421 gcctcgaacc catcatcagc aagaatccta aaggaacttg gaaagactgg gcacagactg
     3481 cttttgatga aagcattaac ctttcagctg ttggatactt cagaggttat gagtcagaca
     3541 tgaactggga gaaaggcgaa ggccagccct tcgaatactt tgtttatgga gctgcctgtt
     3601 ccgaggttga aatagactgc ctgacggggg atcataagaa catcagaaca gacattgtca
     3661 tggatgttgg ctgcagtata aatccagcca ttgacatagg ccagattgaa ggtgcattta
     3721 ttcaaggcat gggactttat acaatagagg aactgaatta ttctccccag ggcattctgc
     3781 acactcgtgg tccagaccaa tataaaatcc ctgccatctg tgacatgccc acggagttgc
     3841 acattgcttt gttgcctcct tctcaaaact caaatactct ttattcatct aagggtctgg
     3901 gagagtcggg ggtgttcctg gggtgttccg tgtttttcgc tatccatgac gcagtgagtg
     3961 cagcacgaca ggagagaggc ctgcatggac ccttgaccct taatagtcca ctgaccccgg
     4021 agaagattag gatggcctgt gaagacaagt tcacaaaaat gattccgaga gatgaacctg
     4081 gatcctacgt tccttggaat gtacccatct gaatcaaatg caaacttctg gagaaaacag
     4141 agtgcctctt cccagatggc aatctgtcct atctctgtgc tggaagatgc tagatctgaa
     4201 agacagagtt tccacagttc agaaatcatc ccacagtgtt gcttttctat ggagctgatt
     4261 taaagtattc catttagatt tgatagatat gcttaagcaa tctataaatc attttcaatg
     4321 ttataaacac taattggttt cctctagggt gatatccgtc attactctgt ctcttcaatc
     4381 catccagcta aatggaatag gtgatgactt gcatgtgact cctacttggc ttctatccac
     4441 caacagaaat tataccatat agtgaaaggc aattttctaa ataatttcat tactaatatg
     4501 aactgtgaag ttgtcatttt ttcatttgtc cttttctgct atcaccttcc tcttgtcaga
     4561 atgaatatag acactgtatc taagtgggac caaagaaaaa atagcgaact ttcaccaaag
     4621 ttttcatgaa aacccaaaag ctttaaaagt tactatcaag aaattgaaag gaaacccaca
     4681 gaataggata aaatatttgt aaatcatata tttgataaaa gtcttgtaac cagatacata
     4741 aagagctctt acaactcaat aaaaggcaag taatttaaaa ataggcaaaa gaattgctgg
     4801 atggtatggt agttctattt ttagttttta ccctaactac tctgacttga tcatttaaca
     4861 ttctgtgtat gtaacaaaat atcacatgca taaatattat gtatcaataa aattttttaa
     4921 tgggcaaa
//
