LOCUS       NM_001386074            4707 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens aminopeptidase O (putative) (AOPEP), transcript
            variant 16, mRNA.
ACCESSION   NM_001386074
VERSION     NM_001386074.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4707)
  AUTHORS   Lin,J., Li,C., Cui,Y., Hou,Y., Zhang,L., Ou,R., Wei,Q., Liu,K.,
            Huang,R., Yang,T., Xiao,Y., Jiang,Q., Yang,J., Chen,X. and Shang,H.
  TITLE     Mutation screening of AOPEP variants in a large dystonia cohort
  JOURNAL   J Neurol 270 (6), 3225-3233 (2023)
   PUBMED   36933031
  REMARK    GeneRIF: Mutation screening of AOPEP variants in a large dystonia
            cohort.
REFERENCE   2  (bases 1 to 4707)
  AUTHORS   Garavaglia,B., Vallian,S., Romito,L.M., Straccia,G., Capecci,M.,
            Invernizzi,F., Andrenelli,E., Kazemi,A., Boesch,S., Kopajtich,R.,
            Olfati,N., Shariati,M., Shoeibi,A., Sadr-Nabavi,A., Prokisch,H.,
            Winkelmann,J. and Zech,M.
  TITLE     AOPEP variants as a novel cause of recessive dystonia: Generalized
            dystonia and dystonia-parkinsonism
  JOURNAL   Parkinsonism Relat Disord 97, 52-56 (2022)
   PUBMED   35306330
  REMARK    GeneRIF: AOPEP variants as a novel cause of recessive dystonia:
            Generalized dystonia and dystonia-parkinsonism.
REFERENCE   3  (bases 1 to 4707)
  AUTHORS   Zech,M., Kumar,K.R., Reining,S., Reunert,J., Tchan,M., Riley,L.G.,
            Drew,A.P., Adam,R.J., Berutti,R., Biskup,S., Derive,N.,
            Bakhtiari,S., Jin,S.C., Kruer,M.C., Bardakjian,T.,
            Gonzalez-Alegre,P., Keller Sarmiento,I.J., Mencacci,N.E.,
            Lubbe,S.J., Kurian,M.A., Clot,F., Meneret,A., de Sainte
            Agathe,J.M., Fung,V.S.C., Vidailhet,M., Baumann,M., Marquardt,T.,
            Winkelmann,J. and Boesch,S.
  TITLE     Biallelic AOPEP Loss-of-Function Variants Cause Progressive
            Dystonia with Prominent Limb Involvement
  JOURNAL   Mov Disord 37 (1), 137-147 (2022)
   PUBMED   34596301
  REMARK    GeneRIF: Biallelic AOPEP Loss-of-Function Variants Cause
            Progressive Dystonia with Prominent Limb Involvement.
REFERENCE   4  (bases 1 to 4707)
  AUTHORS   Lybech,L.K.M., Calabro,M., Briuglia,S., Drago,A. and Crisafulli,C.
  TITLE     Suicide Related Phenotypes in a Bipolar Sample: Genetic
            Underpinnings
  JOURNAL   Genes (Basel) 12 (10), 1482 (2021)
   PUBMED   34680877
  REMARK    GeneRIF: Suicide Related Phenotypes in a Bipolar Sample: Genetic
            Underpinnings.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4707)
  AUTHORS   Ichikawa,M., Konoshita,T., Makino,Y., Suzuki,J., Ishizuka,T. and
            Nakamura,H.
  TITLE     An association study of C9orf3, a novel component of the
            renin-angiotensin system, and hypertension in diabetes
  JOURNAL   Sci Rep 10 (1), 16111 (2020)
   PUBMED   32999396
  REMARK    GeneRIF: An association study of C9orf3, a novel component of the
            renin-angiotensin system, and hypertension in diabetes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4707)
  AUTHORS   Shi,Y., Zhao,H., Shi,Y., Cao,Y., Yang,D., Li,Z., Zhang,B.,
            Liang,X., Li,T., Chen,J., Shen,J., Zhao,J., You,L., Gao,X., Zhu,D.,
            Zhao,X., Yan,Y., Qin,Y., Li,W., Yan,J., Wang,Q., Zhao,J., Geng,L.,
            Ma,J., Zhao,Y., He,G., Zhang,A., Zou,S., Yang,A., Liu,J., Li,W.,
            Li,B., Wan,C., Qin,Y., Shi,J., Yang,J., Jiang,H., Xu,J.E., Qi,X.,
            Sun,Y., Zhang,Y., Hao,C., Ju,X., Zhao,D., Ren,C.E., Li,X.,
            Zhang,W., Zhang,Y., Zhang,J., Wu,D., Zhang,C., He,L. and Chen,Z.J.
  TITLE     Genome-wide association study identifies eight new risk loci for
            polycystic ovary syndrome
  JOURNAL   Nat Genet 44 (9), 1020-1025 (2012)
   PUBMED   22885925
REFERENCE   7  (bases 1 to 4707)
  AUTHORS   Ellinor,P.T., Lunetta,K.L., Albert,C.M., Glazer,N.L., Ritchie,M.D.,
            Smith,A.V., Arking,D.E., Muller-Nurasyid,M., Krijthe,B.P.,
            Lubitz,S.A., Bis,J.C., Chung,M.K., Dorr,M., Ozaki,K., Roberts,J.D.,
            Smith,J.G., Pfeufer,A., Sinner,M.F., Lohman,K., Ding,J.,
            Smith,N.L., Smith,J.D., Rienstra,M., Rice,K.M., Van Wagoner,D.R.,
            Magnani,J.W., Wakili,R., Clauss,S., Rotter,J.I., Steinbeck,G.,
            Launer,L.J., Davies,R.W., Borkovich,M., Harris,T.B., Lin,H.,
            Volker,U., Volzke,H., Milan,D.J., Hofman,A., Boerwinkle,E.,
            Chen,L.Y., Soliman,E.Z., Voight,B.F., Li,G., Chakravarti,A.,
            Kubo,M., Tedrow,U.B., Rose,L.M., Ridker,P.M., Conen,D., Tsunoda,T.,
            Furukawa,T., Sotoodehnia,N., Xu,S., Kamatani,N., Levy,D.,
            Nakamura,Y., Parvez,B., Mahida,S., Furie,K.L., Rosand,J.,
            Muhammad,R., Psaty,B.M., Meitinger,T., Perz,S., Wichmann,H.E.,
            Witteman,J.C., Kao,W.H., Kathiresan,S., Roden,D.M.,
            Uitterlinden,A.G., Rivadeneira,F., McKnight,B., Sjogren,M.,
            Newman,A.B., Liu,Y., Gollob,M.H., Melander,O., Tanaka,T.,
            Stricker,B.H., Felix,S.B., Alonso,A., Darbar,D., Barnard,J.,
            Chasman,D.I., Heckbert,S.R., Benjamin,E.J., Gudnason,V. and Kaab,S.
  TITLE     Meta-analysis identifies six new susceptibility loci for atrial
            fibrillation
  JOURNAL   Nat Genet 44 (6), 670-675 (2012)
   PUBMED   22544366
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4707)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   9  (bases 1 to 4707)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   10 (bases 1 to 4707)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157936.12, AL353768.28 and
            AL354893.14.
            
            Summary: This gene encodes a member of the M1 zinc aminopeptidase
            family. The encoded protein is a zinc-dependent metallopeptidase
            that catalyzes the removal of an amino acid from the amino terminus
            of a protein or peptide. This protein may play a role in the
            generation of angiotensin IV. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.246957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL157936.12        87173-87225         c
            54-985              AL157936.12        53344-54275         c
            986-1152            AL157936.12        40756-40922         c
            1153-1306           AL157936.12        21006-21159         c
            1307-1552           AL157936.12        12922-13167         c
            1553-1742           AL353768.28        20784-20973
            1743-1849           AL353768.28        25223-25329
            1850-1952           AL353768.28        51975-52077
            1953-2060           AL353768.28        52706-52813
            2061-2104           AL353768.28        64556-64599
            2105-2165           AL353768.28        76165-76225
            2166-2228           AL353768.28        101956-102018
            2229-2303           AL353768.28        102340-102414
            2304-2420           AL353768.28        157492-157608
            2421-2507           AL354893.14        92465-92551         c
            2508-4707           AL354893.14        88910-91109         c
FEATURES             Location/Qualifiers
     source          1..4707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..4707
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="aminopeptidase O (putative)"
                     /db_xref="GeneID:84909"
                     /db_xref="HGNC:HGNC:1361"
                     /db_xref="MIM:619600"
     exon            1..53
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            54..985
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2585
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="isoform 13 is encoded by transcript variant 16"
                     /codon_start=1
                     /product="aminopeptidase O isoform 13"
                     /protein_id="NP_001373003.1"
                     /db_xref="GeneID:84909"
                     /db_xref="HGNC:HGNC:1361"
                     /db_xref="MIM:619600"
                     /translation="MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIV
                     LFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTFSSEMEYNDFAIC
                     SKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVD
                     VAAVPGLEKFTRSPELTVVSEEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGEL
                     LFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPI
                     NNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPM
                     PASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASA
                     TTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
                     LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHL
                     EDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKTGHTSDS
                     GASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQ
                     DFLQMLLENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVT
                     KWIGVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLEQKTLSPRTLQSLQRTYHLQD
                     QDAEVRHRWCELIVKHKFTKAYKSVERFLQEDQVKDFPDELRPATPRDTLCGAGVPCL
                     "
     exon            986..1152
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1306
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1552
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1742
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1849
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1952
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2060
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2104
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2165
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2228
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2303
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2420
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2507
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..4707
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4689..4694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="hexamer: AATAAA"
     polyA_site      4707
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="major polyA site"
ORIGIN      
        1 gtagtaaccc cgagtctgcg gaagtggtga cccgtgggac gcggctgaga caggagactg
       61 aaaggaacca taatttgtga catcagttgt tttctttgat aagcagctat ttatgattct
      121 ggaagattaa ggcagatagg aaaccccatc tgagatttta ataaatccct caaacaataa
      181 accacatcat ggacatacag ctggaccctg ccagagatga cctgcctctc atggccaaca
      241 ccagccacat acttgtgaag cactatgtac tggatttgga tgtggatttt gaaagtcaag
      301 tcattgaggg gaccatagtg cttttcctcg aggatggaaa cagattcaag aaacagaata
      361 gctctattga ggaagcctgc caatcagaat caaacaaagc ctgcaaattt gggatgcctg
      421 aaccctgcca tattcccgtg acaaatgcaa ggaccttctc atctgaaatg gaatataatg
      481 attttgcaat ctgtagtaaa ggtgaaaaag atacttctga taaagatggt aaccatgaca
      541 accaggaaca tgcttctggg atttctagct caaagtactg ctgtgacaca gggaatcatg
      601 ggagtgagga ttttttgcta gtgttggact gctgtgattt atctgtgtta aaagtcgagg
      661 aggtggatgt tgctgctgtg ccaggtctgg aaaaatttac aaggtctcct gagctcacgg
      721 ttgtttctga ggagttcagg aatcagattg tacgtgaact tgtgactttg cctgcaaatc
      781 gttggaggga gcagttagac tattacgctc gctgcagcca ggctcctggc tgtggggaac
      841 tcctctttga cactgacact tggagcttgc agataaggaa gacaggggct cagacagcta
      901 ctgactttcc tcatgctatc aggatatggt acaaaactaa acctgaaggg cgatcggtta
      961 catggacctc agaccagagt ggcaggccat gtgtttatac tgtgggatct cccataaaca
     1021 acagggccct ttttccatgc caggagccac ccgttgccat gtcaacatgg caggctacag
     1081 ttcgagcagc tgcatctttt gttgttttaa tgagtgggga aaattctgcc aaaccaacgc
     1141 agctttggga agagtgctca agctggtatt actatgtaac tatgccaatg ccagcctcca
     1201 ccttcacaat tgcagtggga tgctggacag aaatgaagat ggagacatgg tcatcaaatg
     1261 atttggcaac agagagaccc ttctcacctt ctgaggccaa cttcaggcat gttggtgttt
     1321 gcagtcacat ggaatacccc tgccgcttcc agaatgcttc tgccaccacc caggagatca
     1381 ttcctcatcg ggtctttgcc cctgtgtgcc tcacgggtgc ctgccaagag acccttctgc
     1441 ggctgatccc tccttgcctc tcagcagcac attctgttct gggagcacac ccgttctctc
     1501 ggctggatgt tctcatcgtc cctgccaact ttccaagtct ggggatggcc agcccacaca
     1561 tcatgttcct ctctcagagc atcttgacag gagggaacca tctctgtggg acccgcctct
     1621 gccatgaaat tgcccatgcc tggtttggcc tagccatcgg ggcccgagac tggacggagg
     1681 agtggctgag tgaaggcttc gccactcact tggaggatgt gttttgggcc acagcacagc
     1741 agctggcccc ctatgaggcc cgggagcagc aggagctgag ggcttgtctg cgctggcgtc
     1801 gcctccagga cgagatgcaa tgctcccccg aggagatgca ggtgttaaga cccagtaaag
     1861 acaaaactgg ccacacaagt gactcgggag catctgttat caagcatgga cttaatccgg
     1921 agaagatctt catgcaggtg cattatttaa agggctactt ccttcttcgg tttcttgcca
     1981 aaagacttgg agatgaaacc tatttttcat ttttaagaaa atttgtgcac acatttcatg
     2041 gacagctgat tctttcccag gatttccttc aaatgctact ggagaacatt ccagaagaaa
     2101 aaaggcttga gctgtctgtt gaaaacatct accaagactg gcttgagagt tccggaatac
     2161 caaagccgct gcagagggag cgtcgcgccg gggcggagtg cgggcttgcg cggcaagtgc
     2221 gcgccgaggt cacgaaatgg attggagtga accggagacc ccgaaaacgg aagcgcaggg
     2281 agaaggaaga ggtgtttgaa aagcttcttc cagaccagct ggtcttgctt ctggagcatc
     2341 tcttggagca gaagactctg agcccccgaa ctctgcaaag cctccagagg acataccacc
     2401 tccaggatca ggatgcagag gttcgccatc ggtggtgtga actcattgtt aagcacaagt
     2461 tcacgaaagc ctacaaaagt gtggagaggt tccttcagga ggatcaggtg aaggacttcc
     2521 cggatgagct cagaccagct actcctaggg acacactttg cggggcagga gtcccgtgtc
     2581 tgtaatgcca cacaggctct ccgcgtggta attctgggaa ccatctctgt ctgttcagag
     2641 cgttcctgac acggccatca tggtgggaat gcctgctcat cgttctgtca ccagtgaaat
     2701 cgtcagagtc tgtgtagaga attgggagct gaggattcct tggggttttg agtacaagga
     2761 ggagacaggg attgcagact gcagcttcca aaagcacagt cagcccacgg cctctgtctt
     2821 ctctggggtc tttgcaattt ctagaccagc aagtgtgtgt ggaacaagca cagactgagc
     2881 tcatgtgtgc gtgtgtgtgg gtacccacac cttcgcctga tgccctttgg cctctgtgcc
     2941 ctgcaggcca tgggtgtgta cctctacggg gagctgatgg tgagtgagga cgccagacag
     3001 cagcagctcg cccgtaggtg cttcgagcgg accaaggagc agatggatag gtcctcagcc
     3061 caggtggtgg ccgaaatgtt attttaacga ggtgattctc tccctttcct ttctgtcatt
     3121 tagttctaac cagatactcc ttttaggagc caactaaatc agtaagccga atagttagcc
     3181 aagactaccc gcagcatcaa tagtcggctc cctggcccag ggcctggaga gtaactggcc
     3241 aagtgggtgc tgggctggta tgggagcccc gggtccctgg agcaccttgc ctggctgtgg
     3301 cagtcaccgg gaagcagagg ctgtccacct ggaggcacag cggcactcct tggcactatt
     3361 ttggccactt caggttttat aatctgttga aacaaaaatt gtgggggaac atcttgagta
     3421 ggtttagaga tggaatggga agcctggcag aagcgctggt ccagtcttca gggtcacggc
     3481 tgatacagga gtttaagcgg ccgtgtgact ccaaagccta gcttctgcaa gcagatgttt
     3541 tcttctagcc atgtgtgaat tggaggttcc ttgggctgtc cacgcctggt catcggctgg
     3601 caggaggctc tccaggcaca cgcagcacac acagcacatg caccacacgt agcacacaca
     3661 ctgcatgcag cacacacaca ccagaggacg caccacacag agcacgcaca gcacacacca
     3721 cacagcgcac gcaccacaca gagcacacgc ggcacacaca gcacacacag cgcacgcacc
     3781 acgcagagca cacacggcac atgcagcata cacaccaaac agcgcacgca ccacacagag
     3841 cacacgcggc acacgcagca cacacaccac acagagcacc tggagcaccc acagcacaca
     3901 caccacgcag agtacacgcg gcacacacac cacacacagc gcatgcacaa cacagagcac
     3961 acacagcaca tgcaccacac gtagcgcgca cactgcatgc agcacacaca ccacacacag
     4021 cgcgtgcacc acacagagca cctgcggcac acacagcaca caccgcacgc accacacaga
     4081 gcacatgtgg cacacacagt gcacgcacca cacagcaccc gcggcgcaca cagcacacgt
     4141 ggcatatggc ctccatgacc ctgtgtcttg agggcaggtc ctactttttg ctttgttgtg
     4201 ttggagcgga atttctcccc tggcttctat tggagtccta gattatttaa atcacttcct
     4261 ctgttaattg tgcctggaat taacctgtta gatttacttc ctagcagtta gttgctcagt
     4321 atgggtttct acactattaa agcaacctag cggtagtaca caaggttttg ttaggatagc
     4381 tgtgagattt tttttctcta acaatcatca ttatttctgt gtctgctccg tttttcttca
     4441 gtgttttata tgatattaat aggggatgtc taattttgta tctttaaaaa aactttatca
     4501 aatctgaagc atttttcgtg ttatagcttc tctataattt ttcatggata ttgaatattt
     4561 ggtgttgata ttcttcactc agttttgaac attgagtttt cttctaatgt tttgtgctta
     4621 tgaaaaccat ttctgtgtaa cgtgtttaag tagcttattt atctgaaaga actctaataa
     4681 tgaaaagaaa taaaaagttt ttcagaa
//
