LOCUS       NM_001386071            3989 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens aminopeptidase O (putative) (AOPEP), transcript
            variant 13, mRNA.
ACCESSION   NM_001386071
VERSION     NM_001386071.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3989)
  AUTHORS   Lin,J., Li,C., Cui,Y., Hou,Y., Zhang,L., Ou,R., Wei,Q., Liu,K.,
            Huang,R., Yang,T., Xiao,Y., Jiang,Q., Yang,J., Chen,X. and Shang,H.
  TITLE     Mutation screening of AOPEP variants in a large dystonia cohort
  JOURNAL   J Neurol 270 (6), 3225-3233 (2023)
   PUBMED   36933031
  REMARK    GeneRIF: Mutation screening of AOPEP variants in a large dystonia
            cohort.
REFERENCE   2  (bases 1 to 3989)
  AUTHORS   Garavaglia,B., Vallian,S., Romito,L.M., Straccia,G., Capecci,M.,
            Invernizzi,F., Andrenelli,E., Kazemi,A., Boesch,S., Kopajtich,R.,
            Olfati,N., Shariati,M., Shoeibi,A., Sadr-Nabavi,A., Prokisch,H.,
            Winkelmann,J. and Zech,M.
  TITLE     AOPEP variants as a novel cause of recessive dystonia: Generalized
            dystonia and dystonia-parkinsonism
  JOURNAL   Parkinsonism Relat Disord 97, 52-56 (2022)
   PUBMED   35306330
  REMARK    GeneRIF: AOPEP variants as a novel cause of recessive dystonia:
            Generalized dystonia and dystonia-parkinsonism.
REFERENCE   3  (bases 1 to 3989)
  AUTHORS   Zech,M., Kumar,K.R., Reining,S., Reunert,J., Tchan,M., Riley,L.G.,
            Drew,A.P., Adam,R.J., Berutti,R., Biskup,S., Derive,N.,
            Bakhtiari,S., Jin,S.C., Kruer,M.C., Bardakjian,T.,
            Gonzalez-Alegre,P., Keller Sarmiento,I.J., Mencacci,N.E.,
            Lubbe,S.J., Kurian,M.A., Clot,F., Meneret,A., de Sainte
            Agathe,J.M., Fung,V.S.C., Vidailhet,M., Baumann,M., Marquardt,T.,
            Winkelmann,J. and Boesch,S.
  TITLE     Biallelic AOPEP Loss-of-Function Variants Cause Progressive
            Dystonia with Prominent Limb Involvement
  JOURNAL   Mov Disord 37 (1), 137-147 (2022)
   PUBMED   34596301
  REMARK    GeneRIF: Biallelic AOPEP Loss-of-Function Variants Cause
            Progressive Dystonia with Prominent Limb Involvement.
REFERENCE   4  (bases 1 to 3989)
  AUTHORS   Lybech,L.K.M., Calabro,M., Briuglia,S., Drago,A. and Crisafulli,C.
  TITLE     Suicide Related Phenotypes in a Bipolar Sample: Genetic
            Underpinnings
  JOURNAL   Genes (Basel) 12 (10), 1482 (2021)
   PUBMED   34680877
  REMARK    GeneRIF: Suicide Related Phenotypes in a Bipolar Sample: Genetic
            Underpinnings.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3989)
  AUTHORS   Ichikawa,M., Konoshita,T., Makino,Y., Suzuki,J., Ishizuka,T. and
            Nakamura,H.
  TITLE     An association study of C9orf3, a novel component of the
            renin-angiotensin system, and hypertension in diabetes
  JOURNAL   Sci Rep 10 (1), 16111 (2020)
   PUBMED   32999396
  REMARK    GeneRIF: An association study of C9orf3, a novel component of the
            renin-angiotensin system, and hypertension in diabetes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3989)
  AUTHORS   Shi,Y., Zhao,H., Shi,Y., Cao,Y., Yang,D., Li,Z., Zhang,B.,
            Liang,X., Li,T., Chen,J., Shen,J., Zhao,J., You,L., Gao,X., Zhu,D.,
            Zhao,X., Yan,Y., Qin,Y., Li,W., Yan,J., Wang,Q., Zhao,J., Geng,L.,
            Ma,J., Zhao,Y., He,G., Zhang,A., Zou,S., Yang,A., Liu,J., Li,W.,
            Li,B., Wan,C., Qin,Y., Shi,J., Yang,J., Jiang,H., Xu,J.E., Qi,X.,
            Sun,Y., Zhang,Y., Hao,C., Ju,X., Zhao,D., Ren,C.E., Li,X.,
            Zhang,W., Zhang,Y., Zhang,J., Wu,D., Zhang,C., He,L. and Chen,Z.J.
  TITLE     Genome-wide association study identifies eight new risk loci for
            polycystic ovary syndrome
  JOURNAL   Nat Genet 44 (9), 1020-1025 (2012)
   PUBMED   22885925
REFERENCE   7  (bases 1 to 3989)
  AUTHORS   Ellinor,P.T., Lunetta,K.L., Albert,C.M., Glazer,N.L., Ritchie,M.D.,
            Smith,A.V., Arking,D.E., Muller-Nurasyid,M., Krijthe,B.P.,
            Lubitz,S.A., Bis,J.C., Chung,M.K., Dorr,M., Ozaki,K., Roberts,J.D.,
            Smith,J.G., Pfeufer,A., Sinner,M.F., Lohman,K., Ding,J.,
            Smith,N.L., Smith,J.D., Rienstra,M., Rice,K.M., Van Wagoner,D.R.,
            Magnani,J.W., Wakili,R., Clauss,S., Rotter,J.I., Steinbeck,G.,
            Launer,L.J., Davies,R.W., Borkovich,M., Harris,T.B., Lin,H.,
            Volker,U., Volzke,H., Milan,D.J., Hofman,A., Boerwinkle,E.,
            Chen,L.Y., Soliman,E.Z., Voight,B.F., Li,G., Chakravarti,A.,
            Kubo,M., Tedrow,U.B., Rose,L.M., Ridker,P.M., Conen,D., Tsunoda,T.,
            Furukawa,T., Sotoodehnia,N., Xu,S., Kamatani,N., Levy,D.,
            Nakamura,Y., Parvez,B., Mahida,S., Furie,K.L., Rosand,J.,
            Muhammad,R., Psaty,B.M., Meitinger,T., Perz,S., Wichmann,H.E.,
            Witteman,J.C., Kao,W.H., Kathiresan,S., Roden,D.M.,
            Uitterlinden,A.G., Rivadeneira,F., McKnight,B., Sjogren,M.,
            Newman,A.B., Liu,Y., Gollob,M.H., Melander,O., Tanaka,T.,
            Stricker,B.H., Felix,S.B., Alonso,A., Darbar,D., Barnard,J.,
            Chasman,D.I., Heckbert,S.R., Benjamin,E.J., Gudnason,V. and Kaab,S.
  TITLE     Meta-analysis identifies six new susceptibility loci for atrial
            fibrillation
  JOURNAL   Nat Genet 44 (6), 670-675 (2012)
   PUBMED   22544366
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3989)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   9  (bases 1 to 3989)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   10 (bases 1 to 3989)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157936.12 and AL353768.28.
            
            Summary: This gene encodes a member of the M1 zinc aminopeptidase
            family. The encoded protein is a zinc-dependent metallopeptidase
            that catalyzes the removal of an amino acid from the amino terminus
            of a protein or peptide. This protein may play a role in the
            generation of angiotensin IV. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1433691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL157936.12        87173-87225         c
            54-234              AL157936.12        54834-55014         c
            235-1166            AL157936.12        53344-54275         c
            1167-1333           AL157936.12        40756-40922         c
            1334-1487           AL157936.12        21006-21159         c
            1488-1733           AL157936.12        12922-13167         c
            1734-1923           AL353768.28        20784-20973
            1924-2030           AL353768.28        25223-25329
            2031-3989           AL353768.28        28513-30471
FEATURES             Location/Qualifiers
     source          1..3989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..3989
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="aminopeptidase O (putative)"
                     /db_xref="GeneID:84909"
                     /db_xref="HGNC:HGNC:1361"
                     /db_xref="MIM:619600"
     exon            1..53
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            54..234
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            235..1166
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..2070
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="isoform 4 is encoded by transcript variant 13"
                     /codon_start=1
                     /product="aminopeptidase O isoform 4"
                     /protein_id="NP_001373000.1"
                     /db_xref="CCDS:CCDS55327.1"
                     /db_xref="GeneID:84909"
                     /db_xref="HGNC:HGNC:1361"
                     /db_xref="MIM:619600"
                     /translation="MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIV
                     LFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTFSSEMEYNDFAIC
                     SKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVD
                     VAAVPGLEKFTRSPELTVVSEEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGEL
                     LFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPI
                     NNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPM
                     PASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASA
                     TTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
                     LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHL
                     EDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRFPHVGGCSGSFS
                     "
     exon            1167..1333
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1487
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1733
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1923
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2030
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..3989
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="hexamer: AATAAA"
     polyA_site      3989
                     /gene="AOPEP"
                     /gene_synonym="AP-O; APO; C90RF3; C9orf3; DYT31; ONPEP"
                     /note="major polyA site"
ORIGIN      
        1 gtagtaaccc cgagtctgcg gaagtggtga cccgtgggac gcggctgaga caggtatttg
       61 cctgcctttt ttttttcaag tgagaagacc ttttgtttgc cacaagaagg ctattatcca
      121 gaatgttaat gggttttcag ctattaagat gtaatgatat accttgagta tttaactata
      181 aatttgaaaa atctccgtga acaatctcaa aggaatactt agaatgcact cctggagact
      241 gaaaggaacc ataatttgtg acatcagttg ttttctttga taagcagcta tttatgattc
      301 tggaagatta aggcagatag gaaaccccat ctgagatttt aataaatccc tcaaacaata
      361 aaccacatca tggacataca gctggaccct gccagagatg acctgcctct catggccaac
      421 accagccaca tacttgtgaa gcactatgta ctggatttgg atgtggattt tgaaagtcaa
      481 gtcattgagg ggaccatagt gcttttcctc gaggatggaa acagattcaa gaaacagaat
      541 agctctattg aggaagcctg ccaatcagaa tcaaacaaag cctgcaaatt tgggatgcct
      601 gaaccctgcc atattcccgt gacaaatgca aggaccttct catctgaaat ggaatataat
      661 gattttgcaa tctgtagtaa aggtgaaaaa gatacttctg ataaagatgg taaccatgac
      721 aaccaggaac atgcttctgg gatttctagc tcaaagtact gctgtgacac agggaatcat
      781 gggagtgagg attttttgct agtgttggac tgctgtgatt tatctgtgtt aaaagtcgag
      841 gaggtggatg ttgctgctgt gccaggtctg gaaaaattta caaggtctcc tgagctcacg
      901 gttgtttctg aggagttcag gaatcagatt gtacgtgaac ttgtgacttt gcctgcaaat
      961 cgttggaggg agcagttaga ctattacgct cgctgcagcc aggctcctgg ctgtggggaa
     1021 ctcctctttg acactgacac ttggagcttg cagataagga agacaggggc tcagacagct
     1081 actgactttc ctcatgctat caggatatgg tacaaaacta aacctgaagg gcgatcggtt
     1141 acatggacct cagaccagag tggcaggcca tgtgtttata ctgtgggatc tcccataaac
     1201 aacagggccc tttttccatg ccaggagcca cccgttgcca tgtcaacatg gcaggctaca
     1261 gttcgagcag ctgcatcttt tgttgtttta atgagtgggg aaaattctgc caaaccaacg
     1321 cagctttggg aagagtgctc aagctggtat tactatgtaa ctatgccaat gccagcctcc
     1381 accttcacaa ttgcagtggg atgctggaca gaaatgaaga tggagacatg gtcatcaaat
     1441 gatttggcaa cagagagacc cttctcacct tctgaggcca acttcaggca tgttggtgtt
     1501 tgcagtcaca tggaataccc ctgccgcttc cagaatgctt ctgccaccac ccaggagatc
     1561 attcctcatc gggtctttgc ccctgtgtgc ctcacgggtg cctgccaaga gacccttctg
     1621 cggctgatcc ctccttgcct ctcagcagca cattctgttc tgggagcaca cccgttctct
     1681 cggctggatg ttctcatcgt ccctgccaac tttccaagtc tggggatggc cagcccacac
     1741 atcatgttcc tctctcagag catcttgaca ggagggaacc atctctgtgg gacccgcctc
     1801 tgccatgaaa ttgcccatgc ctggtttggc ctagccatcg gggcccgaga ctggacggag
     1861 gagtggctga gtgaaggctt cgccactcac ttggaggatg tgttttgggc cacagcacag
     1921 cagctggccc cctatgaggc ccgggagcag caggagctga gggcttgtct gcgctggcgt
     1981 cgcctccagg acgagatgca atgctccccc gaggagatgc aggtgttaag gtttccacat
     2041 gttggcggat gcagtggaag cttctcttga gatctttgcc acactgttca acatgtttga
     2101 ccactctgtc ctaaaaacgc tttcttctta aagcactttc tcctcctggc ttctgtgtgt
     2161 cttactctcc ttgagttccc tctgcctctg tggccagtcc ttcctcacct ctcttgctgg
     2221 caggttaaca gtctccactt caatagccca aggctcagaa agactgagta atgcgtctaa
     2281 cctcctctag ctgataaaga accaaggctc agaaagactg aataacgtgt ctaacctcct
     2341 ctagctgata aagaagagaa cagggattta aacccaggga cggaaactct tctcggttcc
     2401 ctataccata ttcctgtctt cagggaactg agagcattta gttgcattaa aacaaataaa
     2461 aaaacaaaca aacaaaaaac ctgcaggtat cttgggctct ggaaggacat acaggtcagg
     2521 gtgaaaagta tgcttggtcc aagcatcttt tttcttttaa cacatgaagt atgtgtctta
     2581 ttattttaaa agacattgag aaaaaggaac attcaacatt ctcttggtta tagatactgg
     2641 agtattaaca aagtgaaaag agaaaaacta aaattttgtt tggctctgac ttactagttt
     2701 tagtaattta taagaacagc tttccatttg tgcctttcat acatccactg agtcatgagg
     2761 tttcatcaaa tgtttctttt tttcttttct ttctttcttt cttttttttt tttttttaag
     2821 acagagtctt gctctgtcgc ccaggctgga gtgcagtggc atgatctctg ctcactgcaa
     2881 cctctgcctc ctggattcaa gtgattctcc cacctcagtc tcccaagtag ctggaactgt
     2941 aggcatgtgc cactatgccc ggctaatttt tgtattttta gtagagacag ggtttcacca
     3001 tgttggccag gctggtctca aactcctaac ctcaagtgat ctgcctgctt cggcctccca
     3061 aagtgctggg attataggcg tgaaccactg cgcccagccc agatgtttct tagattgact
     3121 ttgctgtgtt tcctttgtat ccgatgtgtc tgagattgac ttccttgtaa gtcattcgtt
     3181 aacaggtttc ttgtattttc ctagccttct cagccttcat tggctggaga gcctgtaatg
     3241 tggctacagg cttctgaggc aagacgattt gctcagtttc aaaatgttag gggtcacatg
     3301 ccatttttca tttgttaatt attgaagatg tctttcccac agataagacc ccaaggactc
     3361 tcccagactc ttcatctcct ctctggccct gggcagaact cttccccagg caaagtctga
     3421 tttcagtgtt cctttctgtc ctgccactgt tcagctctct cctgtcatct atcccctgcc
     3481 tacaaggtcc cctcctgact cgtgcagcag tggtggctct tgcctgagat gcatggcagc
     3541 ttccgaaagg ctcgccatgc ctcctgtctc cagggtgcag ctggattccg gcagcttctg
     3601 cctaagtgct ttcagttagc acactctgac aggccccagg gatggaagag ctaaggtggc
     3661 agggtcagaa gaaatctgtt gtttttttat tgtttgtgat ttattatgac ttctcttttt
     3721 ttctggattc attgttaaat tcaagctcct gctgaggaaa acgttaaaat gtatcgcttt
     3781 aaggaggtgc aacaggcagg agtctatgga actcttaatc ttagctgctg cctccacttt
     3841 gatacaatgc tagataaatg cgagcatctt tccctaacct tcctcctgaa tgcctcatcc
     3901 cttgatcaca aaaacatccc ttaataatag ggggaaaacc ccaagtatgt aaccctatcc
     3961 atagccaaaa taaagtctgc atgccacaa
//
