LOCUS       NM_003734               4011 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens amine oxidase copper containing 3 (AOC3), transcript
            variant 1, mRNA.
ACCESSION   NM_003734
VERSION     NM_003734.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4011)
  AUTHORS   Xu,H., Cui,H., Weng,S., Zhang,Y., Wang,L., Xing,Z., Han,X. and
            Liu,Z.
  TITLE     Crosstalk of cell death pathways unveils an autophagy-related gene
            AOC3 as a critical prognostic marker in colorectal cancer
  JOURNAL   Commun Biol 7 (1), 296 (2024)
   PUBMED   38461356
  REMARK    GeneRIF: Crosstalk of cell death pathways unveils an
            autophagy-related gene AOC3 as a critical prognostic marker in
            colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4011)
  AUTHORS   Danielli,M., Thomas,R.C., Gillies,C.L., Lambert,D.G., Khunti,K. and
            Tan,B.K.
  TITLE     Soluble Vascular Adhesion Protein 1 (sVAP-1) as a biomarker for
            pregnancy complications: A pilot study
  JOURNAL   PLoS One 18 (5), e0284412 (2023)
   PUBMED   37253043
  REMARK    GeneRIF: Soluble Vascular Adhesion Protein 1 (sVAP-1) as a
            biomarker for pregnancy complications: A pilot study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4011)
  AUTHORS   Xu,Q., Chen,X., Yu,T., Tang,Q., Zhou,Z., Wang,H., Huang,W.,
            Huang,T. and Liang,F.
  TITLE     Downregulation of VAP-1 in OSCC suppresses tumor growth and
            metastasis via NF-kappaB/IL-8 signaling and reduces neutrophil
            infiltration
  JOURNAL   J Oral Pathol Med 51 (4), 332-341 (2022)
   PUBMED   35174543
  REMARK    GeneRIF: Downregulation of VAP-1 in OSCC suppresses tumor growth
            and metastasis via NF-kappaB/IL-8 signaling and reduces neutrophil
            infiltration.
REFERENCE   4  (bases 1 to 4011)
  AUTHORS   Unzeta,M., Hernandez-Guillamon,M., Sun,P. and Sole,M.
  TITLE     SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic
            Target for Stroke and Alzheimer's Disease
  JOURNAL   Int J Mol Sci 22 (7), 3365 (2021)
   PUBMED   33805974
  REMARK    GeneRIF: SSAO/VAP-1 in Cerebrovascular Disorders: A Potential
            Therapeutic Target for Stroke and Alzheimer's Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4011)
  AUTHORS   Rippe,C., Moren,B., Liu,L., Stenkula,K.G., Mustaniemi,J.,
            Wennstrom,M. and Sward,K.
  TITLE     NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by
            myocardin-related transcription factors in smooth muscle cells
  JOURNAL   Sci Rep 11 (1), 5955 (2021)
   PUBMED   33727640
  REMARK    GeneRIF: NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by
            myocardin-related transcription factors in smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4011)
  AUTHORS   Kaitaniemi,S., Gron,K., Elovaara,H., Salmi,M., Jalkanen,S. and
            Elima,K.
  TITLE     Functional modulation of vascular adhesion protein-1 by a novel
            splice variant
  JOURNAL   PLoS One 8 (1), e54151 (2013)
   PUBMED   23349812
  REMARK    GeneRIF: Data suggest that the down-regulation of both the
            expression and enzymatic activity of VAP-1 may result from a
            dominant-negative effect caused by heterodimerization between VAP-1
            and alternatively spliced VAP-1Delta3.
REFERENCE   7  (bases 1 to 4011)
  AUTHORS   Lalor,P.F., Edwards,S., McNab,G., Salmi,M., Jalkanen,S. and
            Adams,D.H.
  TITLE     Vascular adhesion protein-1 mediates adhesion and transmigration of
            lymphocytes on human hepatic endothelial cells
  JOURNAL   J Immunol 169 (2), 983-992 (2002)
   PUBMED   12097405
  REMARK    GeneRIF: VAP-1 is expressed on hepatic sinusoidal endothelial cells
            in vitro and supports adhesion and transmigration of lymphocytes
            across these cells under physiological shear stress.
REFERENCE   8  (bases 1 to 4011)
  AUTHORS   Smith,D.J., Salmi,M., Bono,P., Hellman,J., Leu,T. and Jalkanen,S.
  TITLE     Cloning of vascular adhesion protein 1 reveals a novel
            multifunctional adhesion molecule
  JOURNAL   J Exp Med 188 (1), 17-27 (1998)
   PUBMED   9653080
REFERENCE   9  (bases 1 to 4011)
  AUTHORS   Zhang,X. and McIntire,W.S.
  TITLE     Cloning and sequencing of a copper-containing, topa
            quinone-containing monoamine oxidase from human placenta
  JOURNAL   Gene 179 (2), 279-286 (1996)
   PUBMED   8972912
REFERENCE   10 (bases 1 to 4011)
  AUTHORS   Bustelo,X.R. and Barbacid,M.
  TITLE     Tyrosine phosphorylation of the vav proto-oncogene product in
            activated B cells
  JOURNAL   Science 256 (5060), 1196-1199 (1992)
   PUBMED   1375396
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U39447.1 and AF054985.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003734.3.
            
            Summary: This gene encodes a member of the semicarbazide-sensitive
            amine oxidase family. Copper amine oxidases catalyze the oxidative
            conversion of amines to aldehydes in the presence of copper and
            quinone cofactor. The encoded protein is localized to the cell
            surface, has adhesive properties as well as monoamine oxidase
            activity, and may be involved in leukocyte trafficking. Alterations
            in levels of the encoded protein may be associated with many
            diseases, including diabetes mellitus. A pseudogene of this gene
            has been described and is located approximately 9-kb downstream on
            the same chromosome. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            VAP-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39447.1, SRR1803615.161306.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308423.7/ ENSP00000312326.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3782              U39447.1           16-3797
            3783-4011           AF054985.1         1542-1770
FEATURES             Location/Qualifiers
     source          1..4011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4011
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /note="amine oxidase copper containing 3"
                     /db_xref="GeneID:8639"
                     /db_xref="HGNC:HGNC:550"
                     /db_xref="MIM:603735"
     exon            1..1745
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2437
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /EC_number="1.4.3.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     semicarbazide-sensitive amine oxidase; copper amine
                     oxidase; membrane primary amine oxidase; placenta copper
                     monamine oxidase; amine oxidase, copper containing 3
                     (vascular adhesion protein 1); amine oxidase
                     [copper-containing] 3"
                     /codon_start=1
                     /product="amine oxidase [copper-containing] 3 isoform 1"
                     /protein_id="NP_003725.1"
                     /db_xref="CCDS:CCDS11444.1"
                     /db_xref="GeneID:8639"
                     /db_xref="HGNC:HGNC:550"
                     /db_xref="MIM:603735"
                     /translation="MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSV
                     SPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQ
                     LPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERH
                     GGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGL
                     QSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQ
                     LEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSL
                     WTFSFGLGAFSGPRIFDVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMG
                     KYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFCVFEQNQGLPLRRHHSDLYSH
                     YFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYG
                     NQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTR
                     KLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARG
                     FSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGF
                     LHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLA
                     CLPQAAACAPDLPAFSHGGFSHN"
     exon            1746..2031
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2161
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..4011
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3989..3994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /note="hexamer: AATAAA"
     polyA_site      4011
                     /gene="AOC3"
                     /gene_synonym="HPAO; SSAO; VAP-1; VAP1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccaggc atctgactac cgggaacctc agccagagtc cgggagcccc ccaccccgtc
       61 caggagccaa cagagccccc gtcttgctgg cgtgagaata cattgctctc ctttggttga
      121 atcagctgtc cctcttcgtg ggaaaatgaa ccagaagaca atcctcgtgc tcctcattct
      181 ggccgtcatc accatctttg ccttggtttg tgtcctgctg gtgggcaggg gtggagatgg
      241 gggtgaaccc agccagcttc cccattgccc ctctgtatct cccagtgccc agccttggac
      301 acaccctggc cagagccagc tgtttgcaga cctgagccga gaggagctga cggctgtgat
      361 gcgctttctg acccagcggc tggggccagg gctggtggat gcagcccagg cccggccctc
      421 ggacaactgt gtcttctcag tggagttgca gctgcctccc aaggctgcag ccctggctca
      481 cttggacagg gggagccccc cacctgcccg ggaggcactg gccatcgtct tctttggcag
      541 gcaaccccag cccaacgtga gtgagctggt ggtggggcca ctgcctcacc cctcctacat
      601 gcgggacgtg actgtggagc gtcatggagg ccccctgccc tatcaccgac gccccgtgct
      661 gttccaagag tacctggaca tagaccagat gatcttcaac agagagctgc cccaggcttc
      721 tgggcttctc caccactgtt gcttctacaa gcaccgggga cggaacctgg tgacaatgac
      781 cacggctccc cgtggtctgc aatcagggga ccgggccacc tggtttggcc tctactacaa
      841 catctcgggc gctgggttct tcctgcacca cgtgggcttg gagctgctag tgaaccacaa
      901 ggcccttgac cctgcccgct ggactatcca gaaggtgttc tatcaaggcc gctactacga
      961 cagcctggcc cagctggagg cccagtttga ggccggcctg gtgaatgtgg tgctgatccc
     1021 agacaatggc acaggtgggt cctggtccct gaagtcccct gtgcccccgg gtccagctcc
     1081 ccctctacag ttctatcccc aaggcccccg cttcagtgtc cagggaagtc gagtggcctc
     1141 ctcactgtgg actttctcct ttggcctcgg agcattcagt ggcccaagga tctttgacgt
     1201 tcgcttccaa ggagaaagac tagtttatga gataagcctc caagaggcct tggccatcta
     1261 tggtggaaat tccccagcag caatgacgac ccgctatgtg gatggaggct ttggcatggg
     1321 caagtacacc acgcccctga cccgtggggt ggactgcccc tacttggcca cctacgtgga
     1381 ctggcacttc cttttggagt cccaggcccc caagacaata cgtgatgcct tttgtgtgtt
     1441 tgaacagaac cagggcctcc ccctgcggcg acaccactca gatctctact cgcactactt
     1501 tgggggtctt gcggaaacgg tgctggtcgt cagatctatg tccaccttgc tcaactatga
     1561 ctatgtgtgg gatacggtct tccaccccag tggggccata gaaatacgat tctatgccac
     1621 gggctacatc agctcggcat tcctctttgg tgctactggg aagtacggga accaagtgtc
     1681 agagcacacc ctgggcacgg tccacaccca cagcgcccac ttcaaggtgg atctggatgt
     1741 agcaggactg gagaactggg tctgggccga ggatatggtc tttgtcccca tggctgtgcc
     1801 ctggagccct gagcaccagc tgcagaggct gcaggtgacc cggaagctgc tggagatgga
     1861 ggagcaggcc gccttcctcg tgggaagcgc cacccctcgc tacctgtacc tggccagcaa
     1921 ccacagcaac aagtggggtc acccccgggg ctaccgcatc cagatgctca gctttgctgg
     1981 agagccgctg ccccaaaaca gctccatggc gagaggcttc agctgggaga ggtaccagct
     2041 ggctgtgacc cagcggaagg aggaggagcc cagtagcagc agcgttttca atcagaatga
     2101 cccttgggcc cccactgtgg atttcagtga cttcatcaac aatgagacca ttgctggaaa
     2161 ggatttggtg gcctgggtga cagctggttt tctgcatatc ccacatgcag aggacattcc
     2221 taacacagtg actgtgggga acggcgtggg cttcttcctc cgaccctata acttctttga
     2281 cgaagacccc tccttctact ctgccgactc catctacttc cgaggggacc aggatgctgg
     2341 ggcctgcgag gtcaaccccc tagcttgcct gccccaggct gctgcctgtg cccccgacct
     2401 ccctgccttc tcccacgggg gcttctctca caactaggcg gtcctgggat ggggcatgtg
     2461 gccaagggct ccagggccag ggtgtgaggg atggggagca gctgggcact gggccggcag
     2521 cctggttccc tctttcctgt gccaggactc tctttcttcc actaccctcc ctcgcatccg
     2581 cctctgagcc aggagcctcc tgaccctgtg atgcctgaca caggggacac tgaaccttgt
     2641 tgatgccagc tgtactgagt tctcatccac agaggccagg catggcccag cctggagccg
     2701 tggccgaggg cttccctaga tggttccctt tgttgctgtc tggctttccc gaatcttttt
     2761 aggccacctc caaggactct aaaagggggc tattccctgg agaccccaga gtagggttgc
     2821 cagtcctgca agtccatagc tgagctggaa aggatgcttc tgctcacatt ccctctcatc
     2881 caggtccttt ccttctcgtc ttcctctctc tcacctactt cctcctcctc ctcctgttcc
     2941 tgccttctct tctatcctgc aatttctccc gaatcctgag gggatatccc tatgtcccag
     3001 cccctggtac tcccccagcc ctcagttttc agtcaagttc cgtctcctct ccagccctat
     3061 ggaagtctca aggtcacggg acccctaatc agagtggcca atccctgtgt gtcgttccct
     3121 tgtgtctgtt gcttattggg agtaggagtt gctcctaccc ctgtcctggg gctgggtgtg
     3181 tttcaggaca gctgcttctg tgcatttgtg tctgcctgcc tcatgctctc tatagaggag
     3241 gatggtcatc gtgacagcag cagctcaagt tagcatttca agtgatttgg gggtgcaatg
     3301 ataatgaaga atggccattt tgtaccaggg ctctgtattc tgcaacagcc tgtttgggag
     3361 gctggagtgg aaacaaaggg tgggcatcaa agatgagaag ccaaagcccc tacaactcca
     3421 gccacccagc caggaggggc tgtccaatca cattcaggca tgcgaatgag ctgggccctg
     3481 ggtgaggtgg gggtctggcc tagtggggag gggcctggcc tgggtggggc agggcctggc
     3541 ctggtccagg cttgggctcc attcccatca ctgctgtccc tcctgaggtc tggattgggg
     3601 atggggacaa agaaatagca agagatgaga aacaacagaa acttttttct ctaaaggact
     3661 ggttaaatca attctgatac agccttacaa tacaatagta tgcagctaaa aaataattgt
     3721 atgtctttat atactaatat gtaataatct tcaggtgaaa aaggcaagcc acagaaatgt
     3781 gtatagcgca cttcccattt gtgtttcaga aaggagtaga atataaacac ataattgctt
     3841 atgtatgcct attcagaata aatgggtaac actgattact tttgggaggg gaaccagtag
     3901 gttgaggaca ggagagggaa gggtcttaac acttacaccc ttttgtacat tttgaatttt
     3961 gaaccatgtg actgtattac ctattcaaaa taaacaataa atgggcccaa a
//
