LOCUS       NM_001091               2609 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens amine oxidase copper containing 1 (AOC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001091
VERSION     NM_001091.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Hu,C., Song,S., Zhao,S., Xue,Z. and Zhu,X.
  TITLE     METTL14 contributes to the progression of nasopharyngeal carcinoma
            through regulating the stability of AOC1 mRNA
  JOURNAL   Hereditas 161 (1), 20 (2024)
   PUBMED   38956710
  REMARK    GeneRIF: METTL14 contributes to the progression of nasopharyngeal
            carcinoma through regulating the stability of AOC1 mRNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Zheng,W.H., Long,Z.Q., Zheng,Z.Q., Zhang,L.L., Liang,Y.L., Li,Z.X.,
            Lv,J.W., Kou,J., Hong,X.H., He,S.W., Xu,R., Zhou,G.Q., Liu,N.,
            Ma,J., Sun,Y., Lin,L. and Wei,D.
  TITLE     m6A-enriched lncRNA LINC00839 promotes tumor progression by
            enhancing TAF15-mediated transcription of amine oxidase AOC1 in
            nasopharyngeal carcinoma
  JOURNAL   J Biol Chem 299 (7), 104873 (2023)
   PUBMED   37257820
  REMARK    GeneRIF: m6A-enriched lncRNA LINC00839 promotes tumor progression
            by enhancing TAF15-mediated transcription of amine oxidase AOC1 in
            nasopharyngeal carcinoma.
REFERENCE   3  (bases 1 to 2609)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2609)
  AUTHORS   Zhang,X., Kim,J. and McIntire,W.S.
  TITLE     cDNA sequences of variant forms of human placenta diamine oxidase
  JOURNAL   Biochem Genet 33 (7-8), 261-268 (1995)
   PUBMED   8595053
REFERENCE   5  (bases 1 to 2609)
  AUTHORS   Befani,O., Shiozaki,T.S., Turini,P., Gerosa,P. and Mondovi,B.
  TITLE     Inhibition of diamine oxidase activity by metronidazole
  JOURNAL   Biochem Biophys Res Commun 212 (2), 589-594 (1995)
   PUBMED   7626074
REFERENCE   6  (bases 1 to 2609)
  AUTHORS   Chassande,O., Renard,S., Barbry,P. and Lazdunski,M.
  TITLE     The human gene for diamine oxidase, an amiloride binding protein.
            Molecular cloning, sequencing, and characterization of the promoter
  JOURNAL   J Biol Chem 269 (20), 14484-14489 (1994)
   PUBMED   8182053
REFERENCE   7  (bases 1 to 2609)
  AUTHORS   Novotny,W.F., Chassande,O., Baker,M., Lazdunski,M. and Barbry,P.
  TITLE     Diamine oxidase is the amiloride-binding protein and is inhibited
            by amiloride analogues
  JOURNAL   J Biol Chem 269 (13), 9921-9925 (1994)
   PUBMED   8144586
REFERENCE   8  (bases 1 to 2609)
  AUTHORS   D'Agostino,L., Contegiacomo,A., Pignata,S., Zilembo,N., Daniele,B.,
            Ferraro,C., D'Adamo,G., Petrelli,G., Bianco,A.R. and Mazzacca,G.
  TITLE     Plasma postheparin diamine oxidase in patients with small
            intestinal lymphoma
  JOURNAL   Cancer 67 (2), 511-515 (1991)
   PUBMED   1898707
REFERENCE   9  (bases 1 to 2609)
  AUTHORS   Barbry,P., Simon-Bouy,B., Mattei,M.G., Le Guern,E., Jaume-Roig,B.,
            Chassande,O., Ullrich,A. and Lazdunski,M.
  TITLE     Localization of the gene for amiloride binding protein on
            chromosome 7 and RFLP analysis in cystic fibrosis families
  JOURNAL   Hum Genet 85 (6), 587-589 (1990)
   PUBMED   2227949
REFERENCE   10 (bases 1 to 2609)
  AUTHORS   Barbry,P., Champe,M., Chassande,O., Munemitsu,S., Champigny,G.,
            Lingueglia,E., Maes,P., Frelin,C., Tartar,A., Ullrich,A. et al.
  TITLE     Human kidney amiloride-binding protein: cDNA structure and
            functional expression
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7347-7351 (1990)
   PUBMED   2217167
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U11862.1, AC006343.3 and
            BC014093.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001091.3.
            
            Summary: This gene encodes a metal-binding membrane glycoprotein
            that oxidatively deaminates putrescine, histamine, and related
            compounds. The encoded protein is inhibited by amiloride, a
            diuretic that acts by closing epithelial sodium ion channels.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Jan
            2013].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site, compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014093.2, U11862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360937.9/ ENSP00000354193.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1052              U11862.1           41-1092
            1053-1053           AC006343.3         109145-109145       c
            1054-1832           U11862.1           1094-1872
            1833-1834           AC006343.3         107642-107643       c
            1835-2394           U11862.1           1875-2434
            2395-2396           BC014093.2         2388-2389
            2397-2609           AC006343.3         105106-105318       c
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2609
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /note="amine oxidase copper containing 1"
                     /db_xref="GeneID:26"
                     /db_xref="HGNC:HGNC:80"
                     /db_xref="MIM:104610"
     exon            1..42
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /inference="alignment:Splign:2.1.0"
     exon            43..1628
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2314
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /EC_number="1.4.3.22"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; diamine oxidase; histaminase; kidney amine
                     oxidase; amiloride-sensitive amine oxidase; amiloride
                     binding protein 1 (amine oxidase (copper-containing));
                     amiloride-binding protein 1; amine oxidase copper
                     domain-containing protein 1"
                     /codon_start=1
                     /product="diamine oxidase [copper-containing] isoform 2
                     precursor"
                     /protein_id="NP_001082.2"
                     /db_xref="CCDS:CCDS43679.1"
                     /db_xref="GeneID:26"
                     /db_xref="HGNC:HGNC:80"
                     /db_xref="MIM:104610"
                     /translation="MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAV
                     HSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIF
                     FGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATK
                     PLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLE
                     LLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDST
                     EEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGL
                     QVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCP
                     ETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVL
                     VLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGN
                     IHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAA
                     FRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAV
                     TKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDI
                     PNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPP
                     PFSYNGTYRPV"
     exon            1629..1914
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2047
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2609
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /note="hexamer: AATAAA"
     polyA_site      2394
                     /gene="AOC1"
                     /gene_synonym="ABP; ABP1; DAO; DAO1; KAO; KDAO"
                     /note="major polyA site"
ORIGIN      
        1 gcaaaggctg gaagcagagc gaactgggag cagagcacac agagccgtgg agcgagagat
       61 gccggccctg ggctgggccg tggctgccat cctgatgctg cagacggcca tggcggagcc
      121 ctccccgggg actctgccca ggaaggcagg ggtgttttca gacctaagca accaagagct
      181 gaaggcagtg cacagcttcc tctggtccaa gaaggagctg aggctgcagc cctccagtac
      241 caccaccatg gccaagaaca ccgtgtttct catcgagatg ctgctgccca agaagtacca
      301 tgtgctgagg tttctggata aaggtgaaag gcatcctgtg cgggaagccc gtgccgtcat
      361 cttctttggt gaccaggagc atcccaatgt caccgagttt gctgtggggc ccctgccagg
      421 gccctgctac atgcgagcac tgtcccccag gcctgggtac cagtcctcct gggcatcgag
      481 gcccatctcc acagcagagt atgccctcct ctaccacacc ctgcaggaag ccaccaagcc
      541 cctgcatcag ttcttcctca ataccacagg cttctcattc caagactgcc atgacagatg
      601 cctggccttc accgatgtgg ccccccgggg tgtggcttct ggccagcgcc gcagttggct
      661 tatcatacag cgctatgtag aaggctactt tctgcacccc actgggctgg agctcctcgt
      721 ggatcatggg agcacagatg ctgggcactg ggccgtggag caggtgtggt acaacgggaa
      781 gttctatggg agcccagagg aactggctcg gaagtatgca gatggagagg tggacgtggt
      841 ggtcctggag gacccgctgc ctgggggcaa ggggcatgac agcacagagg agccgcccct
      901 cttctcctcc cacaagcccc gcggggactt ccccagcccc atccatgtga gcggcccccg
      961 cttggtccag ccccacggcc ctcgcttcag gctggagggc aacgctgtgc tctacggcgg
     1021 ctggagcttt gccttccggc tgcgctcctc ctccgggctg caggtcctga acgtgcactt
     1081 cggcggagag cgcattgcct atgaggtcag cgtgcaagag gcagtggcgc tgtatggagg
     1141 acacacacct gcaggcatgc agaccaagta cctcgatgtc ggctggggcc tgggcagcgt
     1201 cactcatgag ttagcccccg gcatcgactg cccggagacc gccaccttcc tggacacttt
     1261 ccactactat gatgccgatg acccggtcca ttatccccga gccctctgcc tctttgaaat
     1321 gcccacaggg gtgccccttc ggcggcactt taattccaac tttaaaggtg gcttcaactt
     1381 ctatgcgggg ctgaagggcc aggtgctggt gctgcggaca acttcaactg tctacaatta
     1441 tgattacatt tgggacttta tcttctaccc caacggggtg atggaggcca agatgcatgc
     1501 cactggctac gtccacgcca ccttctacac ccccgagggg ctgcgccacg gcactcgcct
     1561 gcacacccac ctgattggca acatacacac tcacttggtg cactaccgcg tagacctgga
     1621 tgtggcaggc accaagaaca gcttccagac actgcagatg aagctagaaa acatcaccaa
     1681 cccctggagc ccaagacacc gcgtggtcca gccaactctg gagcagacgc agtactcctg
     1741 ggagcgccag gcggccttcc gcttcaaaag gaagctgcct aagtacctgc tctttaccag
     1801 cccccaggag aacccctggg gccacaagcg cacgtaccgc ctgcagatcc actccatggc
     1861 cgaccaggtg ctgcccccag gctggcagga ggagcaggcc atcacctggg caaggtaccc
     1921 cctggcagtg accaagtacc gggagtcgga gctgtgcagc agcagcatct accaccagaa
     1981 cgacccctgg cacccgcccg tggtctttga gcagtttctt cacaacaacg agaacattga
     2041 aaatgaggac ctggtggcct gggtgacggt gggcttcctg cacatccccc actcagagga
     2101 cattcccaac acagccacac ctgggaactc cgtgggcttc ctgctccggc cattcaactt
     2161 cttcccagag gacccctccc tggcatccag agacactgtg atcgtgtggc ctcgggacaa
     2221 cggccccaac tacgtccagc gctggatccc tgaggacagg gactgctcga tgcctccccc
     2281 ttttagctac aatgggacct atagacctgt gtgaccagcc cccagttcct cccccagttc
     2341 ctcccaggaa gcccaggagc ctcactgggg cagacaataa accctcagag cctcgctctg
     2401 tgtgctgctt cttgcgggga ggcacagggc catgtgtgta ggaaacacac gaacagacgt
     2461 gcacacacac agacgtgcac acacacacag acatgcacac acacacagac gtgcacacac
     2521 acagacgtgc acgcactcac acggacatgc acacacatgg catgtacttt attcacactg
     2581 gtctactgca gtccagaaaa gccaccatt
//
