LOCUS       NM_001637               2385 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens acyloxyacyl hydrolase (AOAH), transcript variant 1,
            mRNA.
ACCESSION   NM_001637
VERSION     NM_001637.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Wu,Z., Deng,B., Shen,Y., Li,X., Li,J., Li,Y., Ma,S., Pan,Y. and
            Ding,F.
  TITLE     Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition
            of Tubular CD74-Macrophage Crosstalk
  JOURNAL   Int J Biol Sci 20 (8), 3061-3075 (2024)
   PUBMED   38904010
  REMARK    GeneRIF: Acyloxyacyl Hydrolase Protects against Kidney Injury via
            Inhibition of Tubular CD74-Macrophage Crosstalk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Gorelik,A., Illes,K. and Nagar,B.
  TITLE     Crystal structure of the mammalian lipopolysaccharide detoxifier
  JOURNAL   Proc Natl Acad Sci U S A 115 (5), E896-E905 (2018)
   PUBMED   29343645
  REMARK    GeneRIF: analysis of AOAH function through its crystal structure
            and complex with lipopolysaccharide
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Halderman,A. and Lane,A.P.
  TITLE     Genetic and Immune Dysregulation in Chronic Rhinosinusitis
  JOURNAL   Otolaryngol Clin North Am 50 (1), 13-28 (2017)
   PUBMED   27888910
  REMARK    GeneRIF: AOAH - Gene involved in innate immunity that have been
            associated with Chronic Rhinosinusitis.
            Review article
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Wang,L., Beecham,A., Dueker,N., Blanton,S.H., Rundek,T. and
            Sacco,R.L.
  TITLE     Sequencing of candidate genes in Dominican families implicates both
            rare exonic and common non-exonic variants for carotid intima-media
            thickness at bifurcation
  JOURNAL   Hum Genet 134 (10), 1127-1138 (2015)
   PUBMED   26319989
  REMARK    GeneRIF: AOAH rs60023210 variants may be associated with carotid
            intima-media thickness at bifurcation.
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Coulthard,M.G., Swindle,J., Munford,R.S., Gerard,R.D. and
            Meidell,R.S.
  TITLE     Adenovirus-mediated transfer of a gene encoding acyloxyacyl
            hydrolase (AOAH) into mice increases tissue and plasma AOAH
            activity
  JOURNAL   Infect Immun 64 (5), 1510-1515 (1996)
   PUBMED   8613354
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Staab,J.F., Ginkel,D.L., Rosenberg,G.B. and Munford,R.S.
  TITLE     A saposin-like domain influences the intracellular localization,
            stability, and catalytic activity of human acyloxyacyl hydrolase
  JOURNAL   J Biol Chem 269 (38), 23736-23742 (1994)
   PUBMED   8089145
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Whitmore,T.E., Mathewes,S.L., O'Hara,P.J. and Durnam,D.M.
  TITLE     Chromosomal localization of the acyloxyacyl hydrolase (AOAH) gene
            to 7p14-p12 using fluorescence in situ hybridization
  JOURNAL   Genomics 21 (2), 457-458 (1994)
   PUBMED   8088847
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Hagen,F.S., Grant,F.J., Kuijper,J.L., Slaughter,C.A., Moomaw,C.R.,
            Orth,K., O'Hara,P.J. and Munford,R.S.
  TITLE     Expression and characterization of recombinant human acyloxyacyl
            hydrolase, a leukocyte enzyme that deacylates bacterial
            lipopolysaccharides
  JOURNAL   Biochemistry 30 (34), 8415-8423 (1991)
   PUBMED   1883828
REFERENCE   10 (bases 1 to 2385)
  AUTHORS   McDermott,C.M., Cullor,J.S. and Fenwick,B.W.
  TITLE     Intracellular and extracellular enzymatic deacylation of bacterial
            endotoxin during localized inflammation induced by Escherichia coli
  JOURNAL   Infect Immun 59 (2), 478-485 (1991)
   PUBMED   1987068
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP310596.1, BC025698.1 and
            CR748867.1.
            
            On May 17, 2019 this sequence version replaced NM_001637.3.
            
            Summary: This locus encodes both the light and heavy subunits of
            acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis
            of acyloxylacyl-linked fatty acyl chains from bacterial
            lipopolysaccharides, effectively detoxifying these molecules. The
            encoded protein may play a role in modulating host inflammatory
            response to gram-negative bacteria. Alternatively spliced
            transcript variants have been described.[provided by RefSeq, Apr
            2010].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.198040.1, BC025698.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617537.5/ ENSP00000483783.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               BP310596.1         12-423
            413-2327            BC025698.1         373-2287
            2328-2385           CR748867.1         414-471
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.2"
     gene            1..2385
                     /gene="AOAH"
                     /note="acyloxyacyl hydrolase"
                     /db_xref="GeneID:313"
                     /db_xref="HGNC:HGNC:548"
                     /db_xref="MIM:102593"
     exon            1..473
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..2074
                     /gene="AOAH"
                     /EC_number="3.1.1.77"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; acyloxyacyl hydrolase (neutrophil)"
                     /codon_start=1
                     /product="acyloxyacyl hydrolase isoform 1 preproprotein"
                     /protein_id="NP_001628.1"
                     /db_xref="CCDS:CCDS5448.1"
                     /db_xref="GeneID:313"
                     /db_xref="HGNC:HGNC:548"
                     /db_xref="MIM:102593"
                     /translation="MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGC
                     VLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADM
                     NADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDIC
                     SLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRR
                     PNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWIT
                     ASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDY
                     QNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKL
                     YSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSF
                     LNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEI
                     IQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILGKENPFNPQIK
                     QVFGDQGGH"
     exon            474..569
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            570..636
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            637..736
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            737..796
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            797..867
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            868..928
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            929..999
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1048
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1097
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1192
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1284
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1367
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1404
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1479
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1652
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1711
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1771
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1868
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1945
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2385
                     /gene="AOAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2300..2305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AOAH"
                     /note="hexamer: CATAAA"
     polyA_site      2327
                     /gene="AOAH"
                     /note="major polyA site"
ORIGIN      
        1 actgagccag ggagcacgga agttgtgcca ctgtgcaact tgggttttct ttatcctgca
       61 gtctttacct cagcagaacc gcacaccaca gactccctcc agctctttgt gtgtggctct
      121 ctcagggtcc aacaagagca agctgtgggt ctgtgagtgt ttatgtgtgc ttttattcac
      181 ttcacactta ttgaaaagtg tgtatgtgag agggtggggt gtgtgtgtca aagagagtga
      241 ggaagagaag gagagagaga tcaattgatt ctgcagcctc agctccagca tccctcagtt
      301 gggagcttcc aaagccgggt gatcacttgg ggtgcatagc tcggagatgc agtccccctg
      361 gaaaatcctt acggtggcgc ctctattctt gctcctgtct cttcagtcct cggcctctcc
      421 agccaacgat gaccagtcca ggcccagcct ctcgaatggg cacacctgtg tagggtgtgt
      481 gctggtggtg tctgtaatag aacagcttgc tcaagttcac aactcgacgg tccaggcctc
      541 gatggagaga ctgtgcagct acctgcctga aaaactgttc ttgaaaacca cctgctattt
      601 agtcattgac aagtttggat cagacatcat aaaactgctt agcgcagata tgaatgctga
      661 tgtggtatgt cacactctgg agttttgtaa acagaacact ggccaaccat tgtgtcatct
      721 ctaccctctt cccaaggaga catggaaatt tacactacag aaggcaagac aaattgtcaa
      781 gaagtccccg attctgaaat attctagaag tggttctgac atttgttcac tcccggtttt
      841 ggccaagatc tgccagaaaa ttaaattagc tatggaacag tctgtgccat tcaaagatgt
      901 ggattcagac aaatacagcg ttttcccaac actgcggggc tatcactggc gggggagaga
      961 ctgtaatgac agcgacgagt cagtgtaccc aggtagaagg ccgaacaact gggatgtcca
     1021 tcaggattca aactgtaatg gcatttgggg tgtcgatcca aaagatggag ttccatatga
     1081 gaagaaattc tgtgaaggtt cacagcccag gggaatcatt ttgctgggag actcagctgg
     1141 ggctcatttt cacatctctc ctgaatggat cacagcgtcg cagatgtctt tgaactcttt
     1201 catcaatcta ccaacagccc ttaccaacga gcttgactgg ccccaactct ctggtgctac
     1261 aggatttctg gactccactg ttggaattaa agaaaaatct atttaccttc gcttatggaa
     1321 aagaaaccac tgtaatcaca gggactacca gaatatttca agaaatggtg catcttcccg
     1381 aaacctgaag aaatttatag aaagcttgtc tagaaacaag gtgttggact atcccgccat
     1441 cgttatatat gccatgattg gaaatgatgt ctgcagtggg aagagtgacc cagtcccagc
     1501 catgaccact cctgagaaac tctactccaa cgtcatgcag actctgaagc atctaaattc
     1561 ccacctgccc aatggcagcc atgttatttt gtatggctta ccagatggaa cctttctctg
     1621 ggataatttg cacaacagat atcatcctct cggccagcta aataaagaca tgacctatgc
     1681 gcagttgtac tccttcctga actgcctcca ggtcagcccc tgccacggct ggatgtcttc
     1741 caacaagacg ttgcggactc tcacttcaga gagagcagag caactctcca acacactgaa
     1801 aaaaattgca gccagtgaga aatttacaaa cttcaatctt ttctacatgg attttgcctt
     1861 ccatgaaatc atacaggagt ggcagaagag aggcggacag ccctggcagc tcatcgagcc
     1921 cgtggatgga ttccacccca acgaggtggc tttgctgttg ttggcggatc atttctggaa
     1981 aaaggtgcag ctccagtggc cccaaatcct gggaaaggag aatccgttca acccccagat
     2041 taaacaggtg tttggagacc aaggcgggca ctgagcctct caggagcatg cacccctggg
     2101 gagcacaggg aggcagaggc ttgggtaaac tcattccaca aaccctatgg gggctgccac
     2161 gtcacaggcc caaaggactc ttcttcagca gcatctttgc aaaatgtctt tctctcaatg
     2221 aagagcatat ctggacgact gtgcaatgct gtgtgctccc gggatcagta acccttccgc
     2281 tgttcctgaa ataacctttc ataaagtgct ttgggtgcca ttccaaacaa gagagtatct
     2341 gtgcccttta cagctaattg ttctaaaagg agtttctaaa aacac
//
