LOCUS       NM_003568               1551 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens annexin A9 (ANXA9), mRNA.
ACCESSION   NM_003568
VERSION     NM_003568.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1551)
  AUTHORS   Gao,H., Xia,M. and Ruan,H.
  TITLE     Knockdown of sulfotransferase 2B1 suppresses cell migration,
            invasion and promotes apoptosis in ovarian carcinoma cells via
            targeting annexin A9
  JOURNAL   J Obstet Gynaecol Res 50 (8), 1334-1344 (2024)
   PUBMED   38777329
  REMARK    GeneRIF: Knockdown of sulfotransferase 2B1 suppresses cell
            migration, invasion and promotes apoptosis in ovarian carcinoma
            cells via targeting annexin A9.
REFERENCE   2  (bases 1 to 1551)
  AUTHORS   Zhou,X., Zhao,J., Yan,T., Ye,D., Wang,Y., Zhou,B., Liu,D., Wang,X.,
            Zheng,W., Zheng,B., Qian,F., Li,Y., Li,D. and Fang,L.
  TITLE     ANXA9 facilitates S100A4 and promotes breast cancer progression
            through modulating STAT3 pathway
  JOURNAL   Cell Death Dis 15 (4), 260 (2024)
   PUBMED   38609357
  REMARK    GeneRIF: ANXA9 facilitates S100A4 and promotes breast cancer
            progression through modulating STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1551)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1551)
  AUTHORS   Kou,X., Ding,H., Li,L. and Chao,H.
  TITLE     Hsa-miR-105-1 Regulates Cisplatin-Resistance in Ovarian Carcinoma
            Cells by Targeting ANXA9
  JOURNAL   Anal Cell Pathol (Amst) 2021, 6662486 (2021)
   PUBMED   33680718
  REMARK    GeneRIF: Hsa-miR-105-1 Regulates Cisplatin-Resistance in Ovarian
            Carcinoma Cells by Targeting ANXA9.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1551)
  AUTHORS   Zhou,Y., Qiu,C., Wang,T., Tao,L., Zhang,Z. and Yao,J.
  TITLE     High Expression of Annexin A9 Promotes Cell Proliferation and
            Migration in Gastric Cancer via the TGF-beta Signaling Pathway
  JOURNAL   J Environ Pathol Toxicol Oncol 40 (3), 87-94 (2021)
   PUBMED   34587407
  REMARK    GeneRIF: High Expression of Annexin A9 Promotes Cell Proliferation
            and Migration in Gastric Cancer via the TGF-beta Signaling Pathway.
REFERENCE   6  (bases 1 to 1551)
  AUTHORS   Goebeler,V., Ruhe,D., Gerke,V. and Rescher,U.
  TITLE     Atypical properties displayed by annexin A9, a novel member of the
            annexin family of Ca(2+) and lipid binding proteins
  JOURNAL   FEBS Lett 546 (2-3), 359-364 (2003)
   PUBMED   12832069
  REMARK    GeneRIF: examination of atypical properties
REFERENCE   7  (bases 1 to 1551)
  AUTHORS   Nguyen,V.T., Ndoye,A. and Grando,S.A.
  TITLE     Pemphigus vulgaris antibody identifies pemphaxin. A novel
            keratinocyte annexin-like molecule binding acetylcholine
  JOURNAL   J Biol Chem 275 (38), 29466-29476 (2000)
   PUBMED   10899159
REFERENCE   8  (bases 1 to 1551)
  AUTHORS   Morgan,R.O., Bell,D.W., Testa,J.R. and Fernandez,M.P.
  TITLE     Human annexin 31 genetic mapping and origin
  JOURNAL   Gene 227 (1), 33-38 (1999)
   PUBMED   9931420
REFERENCE   9  (bases 1 to 1551)
  AUTHORS   Morgan,R.O. and Fernandez,M.P.
  TITLE     Expression profile and structural divergence of novel human annexin
            31
  JOURNAL   FEBS Lett 434 (3), 300-304 (1998)
   PUBMED   9742942
REFERENCE   10 (bases 1 to 1551)
  AUTHORS   Benz,J. and Hofmann,A.
  TITLE     Annexins: from structure to function
  JOURNAL   Biol Chem 378 (3-4), 177-183 (1997)
   PUBMED   9165068
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BJ993162.1, BC005830.2 and AJ009985.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003568.2.
            
            Summary: The annexins are a family of calcium-dependent
            phospholipid-binding proteins. Members of the annexin family
            contain 4 internal repeat domains, each of which includes a type II
            calcium-binding site. The calcium-binding sites are required for
            annexins to aggregate and cooperatively bind anionic phospholipids
            and extracellular matrix proteins. This gene encodes a divergent
            member of the annexin protein family in which all four homologous
            type II calcium-binding sites in the conserved tetrad core contain
            amino acid substitutions that ablate their function. However,
            structural analysis suggests that the conserved putative ion
            channel formed by the tetrad core is intact. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ009985.1, BC005830.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368947.9/ ENSP00000357943.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BJ993162.1         270-344
            76-815              BC005830.2         1-740
            816-1551            AJ009985.1         1030-1765
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1551
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /note="annexin A9"
                     /db_xref="GeneID:8416"
                     /db_xref="HGNC:HGNC:547"
                     /db_xref="MIM:603319"
     exon            1..88
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            89..185
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            186..276
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1239
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /note="annexin 31; annexin XXXI; annexin-9; pemphaxin"
                     /codon_start=1
                     /product="annexin A9"
                     /protein_id="NP_003559.2"
                     /db_xref="CCDS:CCDS975.2"
                     /db_xref="GeneID:8416"
                     /db_xref="HGNC:HGNC:547"
                     /db_xref="MIM:603319"
                     /translation="MSVTGGKMAPSLTQEILSHLGLASKTAAWGTLGTLRTFLNFSVD
                     KDAQRLLRAITGQGVDRSAIVDVLTNRSREQRQLISRNFQERTQQDLMKSLQAALSGN
                     LERIVMALLQPTAQFDAQELRTALKASDSAVDVAIEILATRTPPQLQECLAVYKHNFQ
                     VEAVDDITSETSGILQDLLLALAKGGRDSYSGIIDYNLAEQDVQALQRAEGPSREETW
                     VPVFTQRNPEHLIRVFDQYQRSTGQELEEAVQNRFHGDAQVALLGLASVIKNTPLYFA
                     DKLHQALQETEPNYQVLIRILISRCETDLLSIRAEFRKKFGKSLYSSLQDAVKGDCQS
                     ALLALCRAEDM"
     exon            277..373
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            374..468
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            469..582
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            583..673
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            674..753
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            754..813
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            814..898
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            899..994
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1053
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1176
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1551
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1551
                     /gene="ANXA9"
                     /gene_synonym="ANX31"
                     /note="major polyA site"
ORIGIN      
        1 ctctaccagg ccacaccgga ggcagtgctc acacaggcaa gctaccaggc cacaacaacg
       61 acacccacct cacctctggc acctctgagc atccacgtac ttgcaagaac tcttgctcac
      121 atcagctaag agattgcacc tgctgaccta gagattccgg cctgtgctcc tgtgctgctg
      181 agcagggcaa ccagtagcac catgtctgtg actggcggga agatggcacc gtccctcacc
      241 caggagatcc tcagccacct gggcctggcc agcaagactg cagcgtgggg gaccctgggc
      301 accctcagga ccttcttgaa cttcagcgtg gacaaggatg cgcagaggct actgagggcc
      361 attactggcc aaggcgtgga ccgcagtgcc attgtggacg tgctgaccaa ccggagcaga
      421 gagcaaaggc agctcatctc acgaaacttc caggagcgca cccaacagga cctgatgaag
      481 tctctacagg cagcactttc cggcaacctg gagaggattg tgatggctct gctgcagccc
      541 acagcccagt ttgacgccca ggaattgagg acagctctga aggcctcaga ttctgctgtg
      601 gacgtggcca ttgaaattct tgccactcga accccacccc agctgcagga gtgcctggca
      661 gtctacaaac acaatttcca ggtggaggct gtggatgaca tcacatctga gaccagtggc
      721 atcttgcagg acctgctgtt ggccctggcc aaggggggcc gtgacagcta ctctggaatc
      781 attgactata atctggcaga acaagatgtc caggcactgc agcgggcaga aggacctagc
      841 agagaggaaa catgggtccc agtcttcacc cagcgaaatc ctgaacacct catccgagtg
      901 tttgatcagt accagcggag cactgggcaa gagctggagg aggctgtcca gaaccgtttc
      961 catggagatg ctcaggtggc tctgctcggc ctagcttcgg tgatcaagaa cacaccgctg
     1021 tactttgctg acaaacttca tcaagccctc caggaaactg agcccaatta ccaagtcctg
     1081 attcgcatcc ttatctctcg atgtgagact gaccttctga gtatcagagc tgagttcagg
     1141 aagaaatttg ggaagtccct ctactcttct ctccaggatg cagtgaaagg ggattgccag
     1201 tcagccctcc tggccttgtg cagggctgaa gacatgtgag acttccctgc cccaccccac
     1261 atgacatccg aggatctgag atttccgtgt ttggctgaac ctgggagacc agctgggcct
     1321 ccaagtagga taacccctca ctgagcacca cattctctag cttcttgttg aggctggaac
     1381 tgtttcttta aaatccctta attttcccat ctcaaaatta tatctgtacc tgggtcatcc
     1441 agctccttct tgggtgtggg gaaatgagtt ttctttgata gtttctgcct cactcatccc
     1501 tcctgtaccc tggccagaac atctcactga tactcgaatt cttttggcaa a
//
