LOCUS       NM_001098845            1908 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens annexin A8 like 1 (ANXA8L1), transcript variant 1,
            mRNA.
ACCESSION   NM_001098845 XM_001127358
VERSION     NM_001098845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Karanjawala,Z.E., Illei,P.B., Ashfaq,R., Infante,J.R., Murphy,K.,
            Pandey,A., Schulick,R., Winter,J., Sharma,R., Maitra,A., Goggins,M.
            and Hruban,R.H.
  TITLE     New markers of pancreatic cancer identified through differential
            gene expression analyses: claudin 18 and annexin A8
  JOURNAL   Am J Surg Pathol 32 (2), 188-196 (2008)
   PUBMED   18223320
  REMARK    GeneRIF: Claudin 18 and annexin A8 are frequently highly
            overexpressed in infiltrating ductal adenocarcinomas.
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Gerke,V., Creutz,C.E. and Moss,S.E.
  TITLE     Annexins: linking Ca2+ signalling to membrane dynamics
  JOURNAL   Nat Rev Mol Cell Biol 6 (6), 449-461 (2005)
   PUBMED   15928709
  REMARK    Review article
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Gerke,V. and Moss,S.E.
  TITLE     Annexins: from structure to function
  JOURNAL   Physiol Rev 82 (2), 331-371 (2002)
   PUBMED   11917092
  REMARK    Review article
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Reutelingsperger,C.P., van Heerde,W., Hauptmann,R., Maassen,C., van
            Gool,R.G., de Leeuw,P. and Tiebosch,A.
  TITLE     Differential tissue expression of Annexin VIII in human
  JOURNAL   FEBS Lett 349 (1), 120-124 (1994)
   PUBMED   8045287
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Sarkar,A., Yang,P., Fan,Y.H., Mu,Z.M., Hauptmann,R., Adolf,G.R.,
            Stass,S.A. and Chang,K.S.
  TITLE     Regulation of the expression of annexin VIII in acute promyelocytic
            leukemia
  JOURNAL   Blood 84 (1), 279-286 (1994)
   PUBMED   8018923
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Chambers,J.A., Gardner,E., Hauptmann,R., Ponder,B.A. and
            Mulligan,L.M.
  TITLE     TaqI polymorphisms at the annexin VIII locus (ANX8)
  JOURNAL   Hum Mol Genet 1 (7), 550 (1992)
   PUBMED   1364010
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Hauptmann,R., Maurer-Fogy,I., Krystek,E., Bodo,G., Andree,H. and
            Reutelingsperger,C.P.
  TITLE     Vascular anticoagulant beta: a novel human Ca2+/phospholipid
            binding protein that inhibits coagulation and phospholipase A2
            activity. Its molecular cloning, expression and comparison with
            VAC-alpha
  JOURNAL   Eur J Biochem 185 (1), 63-71 (1989)
   PUBMED   2530088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313626.1 and AC244230.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001098845.2.
            
            Summary: This gene encodes a member of the annexin family of
            evolutionarily conserved Ca2+ and phospholipid binding proteins.
            The encoded protein may function as an an anticoagulant that
            indirectly inhibits the thromboplastin-specific complex.
            Overexpression of this gene has been associated with acute
            myelocytic leukemia. A highly similar duplicated copy of this gene
            is found in close proximity on the long arm of chromosome 10.
            [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.179629.1, X16662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619162.5/ ENSP00000480221.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AK313626.1         50-525
            477-477             AC244230.3         96528-96528
            478-1060            AK313626.1         527-1109
            1061-1908           AC244230.3         103924-104771
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..1908
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /note="annexin A8 like 1"
                     /db_xref="GeneID:728113"
                     /db_xref="HGNC:HGNC:23334"
     exon            1..97
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1060
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     annexin A8-like protein 1; annexin-8; annexin VIII;
                     vascular anticoagulant-beta; annexin A8L2; annexin A8-like
                     protein 2"
                     /codon_start=1
                     /product="annexin A8-like protein 1 isoform 1"
                     /protein_id="NP_001092315.2"
                     /db_xref="CCDS:CCDS73098.1"
                     /db_xref="GeneID:728113"
                     /db_xref="HGNC:HGNC:23334"
                     /translation="MAWWKAWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAI
                     IDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKEL
                     HDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILV
                     CLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFE
                     EYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTL
                     IRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP"
     exon            98..188
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            189..283
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            284..397
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            398..488
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            489..568
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            569..628
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            629..722
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            723..818
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            819..877
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1000
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1908
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /note="hexamer: AATAAA"
     polyA_site      1908
                     /gene="ANXA8L1"
                     /gene_synonym="ANXA8; ANXA8L2; bA145E20.2; VAC-beta"
                     /note="major polyA site"
ORIGIN      
        1 agacgtgtgg agtcccagca gaggccaacc tgtgtctctt catctccgtg agaaaggtgc
       61 ccccgaagtg aaagagatgg cctggtggaa agcctggatt gaacaggagg gtgtcacagt
      121 gaagagcagc tcccacttca acccagaccc tgatgcagag accctctaca aagccatgaa
      181 ggggatcggg accaacgagc aggctatcat cgatgtgctc accaagagaa gcaacacgca
      241 gcggcagcag atcgccaagt ccttcaaggc tcagttcggc aaggacctca ctgagacctt
      301 gaagtctgag ctcagtggca agtttgagag gctcattgtg gcccttatgt atccgccata
      361 cagatacgaa gccaaggagc tgcatgacgc catgaagggc ttaggaacca aggagggtgt
      421 catcattgag atcctggcct ctcggaccaa gaaccagctg cgggagataa tgaaggcgta
      481 tgaggaagac tatgggtcca gcctggagga ggacatccaa gcagacacaa gtggctacct
      541 ggagaggatc ctggtgtgcc tcctgcaggg cagcagggat gatgtgagca gctttgtgga
      601 cccggcactg gccctccaag acgcacagga tctgtatgcg gcaggcgaga agattcgtgg
      661 gactgatgag atgaaattca tcaccatcct gtgcacgcgc agtgccactc acctgctgag
      721 agtgtttgaa gagtatgaga aaattgccaa caagagcatt gaggacagca tcaagagtga
      781 gacccatggc tcactggagg aggccatgct cactgtggtg aaatgcaccc aaaacctcca
      841 cagctacttt gcagagagac tctactatgc catgaaggga gcagggacgc gtgatgggac
      901 cctgataaga aacatcgttt caaggagcga gattgactta aatcttatca aatgtcactt
      961 caagaagatg tacggcaaga ccctcagcag catgatcatg gaagacacca gcggcgacta
     1021 caagaacgcc ctgctgagcc tggtgggcag cgacccctga ggcacagaag aacaagagca
     1081 aagaccatga agccagagtc tccaggactc ctcactcaac ctcggccatg gacgcaggtt
     1141 gggtgtgagg ggggtcccag cctttcggtc ttctatttcc ctatttccag tgctttccag
     1201 ccgggtttct gacccagagg gtggaaccgg cctggactcc tcttcccaac ttcctccagg
     1261 tcatttccca gtgtgagcac aatgccaacc ttagtgtttc tccagccaga cagatgcctc
     1321 agcatgaagg gcttggggac ttgtggatca ttccttcctc cctgcaggag cttcccaagc
     1381 tggtcacaga gtctcctggg cacaggttat acagacccca gccccattcc catctactga
     1441 aacagggtct ccacaagagg ggccagggaa tatgggtttt taacaagcgt cttacaaaac
     1501 acttctctat catgcagccg gagagctggc tgggagccct tttgttttag aacacacatc
     1561 cttcagcagc tgagaaatga acacgaatcc atcccaaccg agatgccatt aacattcatc
     1621 taaaaatgtt aggctctaaa tggacgaaaa attctctcgc catcttaata acaaaataaa
     1681 ctacaaattc ctgacccaag gacactgtgt tataagaggc gtgggctccc ctggtggctg
     1741 accaggtcag ctgccctggc cttgcacccc tctgcatgca gcacagaagg gtgtgaccat
     1801 gccctcagca ccactcttgt ccccactgaa cggcaactga gactgggtac ctggagattc
     1861 tgaagtgcct ttgctgtggt tttcaaaata ataaagattt gtattcaa
//
