LOCUS       NM_001040084            2020 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens annexin A8 (ANXA8), transcript variant 2, mRNA.
ACCESSION   NM_001040084 XM_926508 XM_931329 XM_931336 XM_931342 XM_931353
            XM_931361 XM_931369 XM_931374 XM_931375 XM_931378 XM_931383
            XM_931388 XM_931391 XM_931399 XM_931404 XM_931411
VERSION     NM_001040084.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Wang,L.H., Cao,B., Li,Y.L. and Qiao,B.P.
  TITLE     Potential prognostic and therapeutic value of ANXA8 in renal cell
            carcinoma: based on the comprehensive analysis of annexins family
  JOURNAL   BMC Cancer 23 (1), 674 (2023)
   PUBMED   37464398
  REMARK    GeneRIF: Potential prognostic and therapeutic value of ANXA8 in
            renal cell carcinoma: based on the comprehensive analysis of
            annexins family.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Zhou,G.Z., Sun,Y.H., Shi,Y.Y., Zhang,Q., Zhang,L., Cui,L.Q. and
            Sun,G.C.
  TITLE     [ANXA8 Regulates Proliferation of Human Non-Small Lung Cancer Cells
            A549 via EGFR-AKT-mTOR Signaling Pathway]
  JOURNAL   Mol Biol (Mosk) 55 (5), 870-880 (2021)
   PUBMED   34671007
  REMARK    GeneRIF: [ANXA8 Regulates Proliferation of Human Non-Small Lung
            Cancer Cells A549 via EGFR-AKT-mTOR Signaling Pathway].
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Gou,R., Zhu,L., Zheng,M., Guo,Q., Hu,Y., Li,X., Liu,J. and Lin,B.
  TITLE     Annexin A8 can serve as potential prognostic biomarker and
            therapeutic target for ovarian cancer: based on the comprehensive
            analysis of Annexins
  JOURNAL   J Transl Med 17 (1), 275 (2019)
   PUBMED   31474227
  REMARK    GeneRIF: ANXA8 was significantly highly expressed in ovarian
            cancer, and high ANXA8 expression was significantly correlated with
            poor prognosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Gerke,V. and Moss,S.E.
  TITLE     Annexins: from structure to function
  JOURNAL   Physiol Rev 82 (2), 331-371 (2002)
   PUBMED   11917092
  REMARK    Review article
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Chambers,J.A., Gardner,E., Hauptmann,R., Ponder,B.A. and
            Mulligan,L.M.
  TITLE     TaqI polymorphisms at the annexin VIII locus (ANX8)
  JOURNAL   Hum Mol Genet 1 (7), 550 (1992)
   PUBMED   1364010
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Chang,K.S., Wang,G., Freireich,E.J., Daly,M., Naylor,S.L.,
            Trujillo,J.M. and Stass,S.A.
  TITLE     Specific expression of the annexin VIII gene in acute promyelocytic
            leukemia
  JOURNAL   Blood 79 (7), 1802-1810 (1992)
   PUBMED   1313714
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Hauptmann,R., Maurer-Fogy,I., Krystek,E., Bodo,G., Andree,H. and
            Reutelingsperger,C.P.
  TITLE     Vascular anticoagulant beta: a novel human Ca2+/phospholipid
            binding protein that inhibits coagulation and phospholipase A2
            activity. Its molecular cloning, expression and comparison with
            VAC-alpha
  JOURNAL   Eur J Biochem 185 (1), 63-71 (1989)
   PUBMED   2530088
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC339657.1, BC004376.1 and
            DR980366.1.
            
            On Jun 3, 2019 this sequence version replaced NM_001040084.2.
            
            Summary: This gene encodes a member of the annexin family of
            evolutionarily conserved Ca2+ and phospholipid binding proteins.
            The encoded protein may function as an an anticoagulant that
            indirectly inhibits the thromboplastin-specific complex.
            Overexpression of this gene has been associated with acute
            myelocytic leukemia. A highly similar duplicated copy of this gene
            is found in close proximity on the long arm of chromosome 10.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. It
            encodes isoform 2, which has a shorter N-terminus compared to
            isoform 1. An in-frame AUG is located 66 codons upstream of the
            annotated translation start site but was not annotated as a start
            site since it is not conserved and is in a weak Kozak sequence
            context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073755.1, M81844.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585281.6/ ENSP00000462880.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                DC339657.1         44-103
            61-2014             BC004376.1         1-1954
            2015-2020           DR980366.1         85-90
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..2020
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /note="annexin A8"
                     /db_xref="GeneID:653145"
                     /db_xref="HGNC:HGNC:546"
                     /db_xref="MIM:602396"
     exon            1..203
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1166
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     VAC-beta; annexin-8; annexin VIII; vascular
                     anticoagulant-beta"
                     /codon_start=1
                     /product="annexin A8 isoform 2"
                     /protein_id="NP_001035173.1"
                     /db_xref="CCDS:CCDS73122.1"
                     /db_xref="GeneID:653145"
                     /db_xref="HGNC:HGNC:546"
                     /db_xref="MIM:602396"
                     /translation="MAWWKSWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAI
                     IDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKEL
                     HDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILV
                     CLLQGSRDDVSSFVDPGLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFE
                     EYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTL
                     IRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP"
     exon            204..294
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..389
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..503
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..594
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..674
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..734
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..828
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..924
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..983
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1106
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..2020
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /note="major polyA site"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /note="hexamer: AATAAA"
     polyA_site      2020
                     /gene="ANXA8"
                     /gene_synonym="ANX8; CH17-360D5.2"
                     /note="major polyA site"
ORIGIN      
        1 agagcccggg ggcgagggga cggcaggcag gtgtggcgct gccctgggcg ggcttgcacc
       61 cccacaccca agtgagcggc ctgctcactc ctcagctgca ggagccagac gtgtggagtc
      121 ccagcagagg ccaacctgtg tctcttcatc tccctgggaa aggtgccccc gaggtgaaag
      181 agatggcctg gtggaaatcc tggattgaac aggagggtgt cacagtgaag agcagctccc
      241 acttcaaccc agaccctgat gcagagaccc tctacaaagc catgaagggg atcgggacca
      301 acgagcaggc tatcatcgat gtgctcacca agagaagcaa cacgcagcgg cagcagatcg
      361 ccaagtcctt caaggctcag ttcggcaagg acctcactga gaccttgaag tctgagctca
      421 gtggcaagtt tgagaggctc attgtggccc ttatgtaccc gccatacaga tacgaagcca
      481 aggagctgca tgacgccatg aagggcttag gaaccaagga gggtgtcatc attgagatcc
      541 tggcctctcg gaccaagaac cagctgcggg agataatgaa ggcgtatgag gaagactatg
      601 ggtccagcct ggaggaggac atccaagcag acacaagtgg ctacctggag aggatcctgg
      661 tgtgcctcct gcagggcagc agggatgatg tgagcagctt tgtggaccca ggactggccc
      721 tccaagacgc acaggatctg tatgcggcag gcgagaagat tcgtgggact gatgagatga
      781 aattcatcac catcctgtgc acgcgcagtg ccactcacct gctgagagtg tttgaagagt
      841 atgagaaaat tgccaacaag agcattgagg acagcatcaa gagtgagacc catggctcac
      901 tggaggaggc catgctcact gtggtgaaat gcacccaaaa cctccacagc tactttgcag
      961 agagactcta ctatgccatg aagggagcag ggacgcgtga tgggaccctg ataagaaaca
     1021 tcgtttcaag gagcgagatt gacttaaatc ttatcaaatg tcacttcaag aagatgtacg
     1081 gcaagaccct cagcagcatg atcatggaag acaccagcgg tgactacaag aacgccctgc
     1141 tgagcctggt gggcagcgac ccctgaggca cagaagaaca agagcaaaga ccatgaagcc
     1201 agagtctcca ggactcctca ctcaacctcg gccatggacg caggttgggt gtgagggggg
     1261 tcccagcctt tcggtcttct atttccctat ttccagtgct ttccagccgg gtttctgacc
     1321 cagagggtgg aaccggcctg gactcctctt cccaacttcc tccaggtcat ttcccagtgt
     1381 gagcacaatg ccaaccttag tgtttctcca gccagacaga tgcctcagca tgaagggctt
     1441 ggggacttgt ggatcattcc ttcctccctg caggagcttc ccaagctggt cacagagtct
     1501 cctgggcaca ggttatacag accccagccc cattcccatc tactgaaaca gggtctccac
     1561 aagaggggcc agggaatatg ggtttttaac aagcgtctta caaaacactt ctctatcatg
     1621 cagccggaga gctggctggg agcccttttg ttttagaaca cacatccttc agcagctgag
     1681 aaacgaacac gaatccatcc caaccgagat gccattaaca ttcatctaaa aatgttaggc
     1741 tctaaatgga cgaaaaattc tctcgccatc ttaataacaa aataaactac aaattcctga
     1801 cccaaggaca ctgtgttata agaggcgtgg gctcccctgg tggctgacca ggtcagctgc
     1861 cctggccttg cacccctctg catgcagcac agaagggtgt gaccatgccc tcagcaccac
     1921 tcttgtcccc actgaacggc aactgagact gggtacctgg agattctgaa gtgcctttgc
     1981 tgtggttttc aaaataataa agatttgtat tcaactcaaa
//
