LOCUS       NM_001156               2443 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens annexin A7 (ANXA7), transcript variant 1, mRNA.
ACCESSION   NM_001156
VERSION     NM_001156.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Ling,F., Zhang,H., Sun,Y., Meng,J., Sanches,J.G.P., Huang,H.,
            Zhang,Q., Yu,X., Wang,B., Hou,L. and Zhang,J.
  TITLE     AnnexinA7 promotes epithelial-mesenchymal transition by interacting
            with Sorcin and contributes to aggressiveness in hepatocellular
            carcinoma
  JOURNAL   Cell Death Dis 12 (11), 1018 (2021)
   PUBMED   34716295
  REMARK    GeneRIF: AnnexinA7 promotes epithelial-mesenchymal transition by
            interacting with Sorcin and contributes to aggressiveness in
            hepatocellular carcinoma.
            Erratum:[Cell Death Dis. 2024 Nov 29;15(11):866. doi:
            10.1038/s41419-024-07184-6.. PMID: 39614081]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Liu,H., Guo,D., Sha,Y., Zhang,C., Jiang,Y., Hong,L., Zhang,J.,
            Jiang,Y., Lu,L. and Huang,H.
  TITLE     ANXA7 promotes the cell cycle, proliferation and cell
            adhesion-mediated drug resistance of multiple myeloma cells by
            up-regulating CDC5L
  JOURNAL   Aging (Albany NY) 12 (11), 11100-11115 (2020)
   PUBMED   32526706
  REMARK    GeneRIF: ANXA7 promotes the cell cycle, proliferation and cell
            adhesion-mediated drug resistance of multiple myeloma cells by
            up-regulating CDC5L.
REFERENCE   3  (bases 1 to 2443)
  AUTHORS   Gui,S.J., Ding,R.L., Wan,Y.P., Zhou,L., Chen,X.J., Zeng,G.Q. and
            He,C.Z.
  TITLE     Knockdown of annexin VII enhances nasopharyngeal carcinoma cell
            radiosensitivity in vivo and in vitro
  JOURNAL   Cancer Biomark 28 (2), 129-139 (2020)
   PUBMED   31958076
  REMARK    GeneRIF: Knockdown of annexin VII enhances nasopharyngeal carcinoma
            cell radiosensitivity in vivo and in vitro.
REFERENCE   4  (bases 1 to 2443)
  AUTHORS   Mo,H.Q., Tian,F.J., Li,X., Zhang,J., Ma,X.L., Zeng,W.H., Lin,Y. and
            Zhang,Y.
  TITLE     ANXA7 regulates trophoblast proliferation and apoptosis in
            preeclampsia
  JOURNAL   Am J Reprod Immunol 82 (6), e13183 (2019)
   PUBMED   31446642
  REMARK    GeneRIF: ANXA7 regulates trophoblast proliferation and apoptosis in
            preeclampsia.
REFERENCE   5  (bases 1 to 2443)
  AUTHORS   Sonder,S.L., Boye,T.L., Tolle,R., Dengjel,J., Maeda,K.,
            Jaattela,M., Simonsen,A.C., Jaiswal,J.K. and Nylandsted,J.
  TITLE     Annexin A7 is required for ESCRT III-mediated plasma membrane
            repair
  JOURNAL   Sci Rep 9 (1), 6726 (2019)
   PUBMED   31040365
  REMARK    GeneRIF: Annexin A7 is required for ESCRT III-mediated plasma
            membrane repair.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2443)
  AUTHORS   Selbert,S., Fischer,P., Pongratz,D., Stewart,M. and Noegel,A.A.
  TITLE     Expression and localization of annexin VII (synexin) in muscle
            cells
  JOURNAL   J Cell Sci 108 (Pt 1), 85-95 (1995)
   PUBMED   7738119
REFERENCE   7  (bases 1 to 2443)
  AUTHORS   Shirvan,A., Srivastava,M., Wang,M.G., Cultraro,C., Magendzo,K.,
            McBride,O.W., Pollard,H.B. and Burns,A.L.
  TITLE     Divergent structure of the human synexin (annexin VII) gene and
            assignment to chromosome 10
  JOURNAL   Biochemistry 33 (22), 6888-6901 (1994)
   PUBMED   7515686
REFERENCE   8  (bases 1 to 2443)
  AUTHORS   Creutz,C.E., Moss,S., Edwardson,J.M., Hide,I. and Gomperts,B.
  TITLE     Differential recognition of secretory vesicles by annexins.
            European Molecular Biology Organization Course 'Advanced Techniques
            for Studying Secretion'
  JOURNAL   Biochem Biophys Res Commun 184 (1), 347-352 (1992)
   PUBMED   1533123
REFERENCE   9  (bases 1 to 2443)
  AUTHORS   Magendzo,K., Shirvan,A., Cultraro,C., Srivastava,M., Pollard,H.B.
            and Burns,A.L.
  TITLE     Alternative splicing of human synexin mRNA in brain, cardiac, and
            skeletal muscle alters the unique N-terminal domain
  JOURNAL   J Biol Chem 266 (5), 3228-3232 (1991)
   PUBMED   1825209
REFERENCE   10 (bases 1 to 2443)
  AUTHORS   Burns,A.L., Magendzo,K., Shirvan,A., Srivastava,M., Rojas,E.,
            Alijani,M.R. and Pollard,H.B.
  TITLE     Calcium channel activity of purified human synexin and structure of
            the human synexin gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (10), 3798-3802 (1989)
   PUBMED   2542947
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY002854.1, J04543.1,
            AL512656.16 and BQ017137.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001156.4.
            
            Summary: Annexin VII is a member of the annexin family of
            calcium-dependent phospholipid binding proteins.The Annexin VII
            gene contains 14 exons and spans approximately 34 kb of DNA. An
            alternatively spliced cassette exon results in two mRNA transcripts
            of 2.0 and 2.4 kb which are predicted to generate two protein
            isoforms differing in their N-terminal domain. The alternative
            splicing event is tissue specific and the mRNA containing the
            cassette exon is prevalent in brain, heart and skeletal muscle. The
            transcripts also differ in their 3'-non coding regions by the use
            of two alternative poly(A) signals. Annexin VII encodes a protein
            with a molecular weight of approximately 51 kDa with a unique,
            highly hydrophobic N-terminal domain of 167 amino acids and a
            conserved C-terminal region of 299 amino acids. The latter domain
            is composed of alternating hydrophobic and hydrophilic segments.
            Structural analysis of the protein suggests that Annexin VII is a
            membrane binding protein with diverse properties, including
            voltage-sensitive calcium channel activity, ion selectivity and
            membrane fusion. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon, compared to variant 2, resulting in a shorter protein
            (isoform 1) that lacks an internal segment, compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.13214.1,
                                           SRR1660803.111243.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372921.10/ ENSP00000362012.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY002854.1         28-40
            14-1480             J04543.1           26-1492
            1481-1856           AL512656.16        147717-148092       c
            1857-2443           BQ017137.1         15-601              c
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..2443
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /note="annexin A7"
                     /db_xref="GeneID:310"
                     /db_xref="HGNC:HGNC:545"
                     /db_xref="MIM:186360"
     exon            1..47
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            48..102
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1449
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     annexin VII; annexin-7"
                     /codon_start=1
                     /product="annexin A7 isoform 1"
                     /protein_id="NP_001147.1"
                     /db_xref="CCDS:CCDS7325.1"
                     /db_xref="GeneID:310"
                     /db_xref="HGNC:HGNC:545"
                     /db_xref="MIM:186360"
                     /translation="MSYPGYPPTGYPPFPGYPPAGQESSFPPSGQYPYPSGFPPMGGG
                     AYPQVPSSGYPGAGGYPAPGGYPAPGGYPGAPQPGGAPSYPGVPPGQGFGVPPGGAGF
                     SGYPQPPSQSYGGGPAQVPLPGGFPGGQMPSQYPGGQPTYPSQPATVTQVTQGTIRPA
                     ANFDAIRDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLK
                     SELSGNMEELILALFMPPTYYDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRC
                     YQSEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQSINHQMAQEDAQRLYQAGEGR
                     LGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTILQCA
                     LNRPAFFAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAG
                     DTSGDYRRLLLAIVGQ"
     exon            103..307
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            308..418
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            419..483
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            484..586
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            587..681
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            682..795
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            796..966
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1137
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1213
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1326
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..2443
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /note="hexamer: AATAAA"
     polyA_site      1763
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /note="major polyA site"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /note="hexamer: AATAAA"
     polyA_site      2099
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /note="major polyA site"
     regulatory      2426..2431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
                     /note="hexamer: TATAAA"
     polyA_site      2443
                     /gene="ANXA7"
                     /gene_synonym="ANX7; SNX; SYNEXIN"
ORIGIN      
        1 atcttgcggg agaccgggtt gggctgtgac gctgctgctg gggtcagaat gtcataccca
       61 ggctatcccc caacaggcta cccacctttc cctggatatc ctcctgcagg tcaggagtca
      121 tcttttcccc cttctggtca gtatccttat cctagtggct ttcctccaat gggaggaggt
      181 gcctacccac aagtgccaag tagtggctac ccaggagctg gaggctaccc tgcgcctgga
      241 ggttatccag cccctggagg ctatcctggt gccccacagc cagggggagc tccatcctat
      301 cccggagttc ctccaggcca aggatttgga gtcccaccag gtggagcagg cttttctggg
      361 tatccacagc caccttcaca gtcttatgga ggtggtccag cacaggttcc actacctggt
      421 ggctttcctg gaggacagat gccttctcag tatcctggag gacaacctac ttaccctagt
      481 cagcctgcca cagtgactca ggtcactcaa ggaactatcc gaccagctgc caacttcgat
      541 gctataagag atgcagaaat tcttcgtaag gcaatgaagg gttttgggac agatgagcag
      601 gcaattgtgg atgtggtggc caaccgttcc aatgatcaga ggcaaaaaat taaagcagca
      661 tttaagacct cctatggcaa ggatttaatc aaagatctca aatcagagtt aagtggaaat
      721 atggaagaac tgatcctggc cctcttcatg cctcctacgt attacgatgc ctggagctta
      781 cggaaagcaa tgcagggagc aggaactcag gaacgtgtat tgattgagat tttgtgcaca
      841 agaacaaatc aggaaatccg agaaattgtc agatgttatc agtcagaatt tggacgagac
      901 cttgaaaagg acattaggtc agatacatca ggacattttg aacgtttact tgtgtccatg
      961 tgccagggaa atcgtgatga gaaccagagt ataaaccacc aaatggctca ggaagatgct
     1021 cagcgtctct atcaagctgg tgaggggaga ctagggaccg atgaatcttg ctttaacatg
     1081 atccttgcca caagaagctt tcctcagctg agagctacca tggaggctta ttctaggatg
     1141 gctaatcgag acttgttaag cagtgtgagc cgtgagtttt ccggatatgt agaaagtggt
     1201 ttgaagacca tcttgcagtg tgccctgaac cgccctgcct tctttgctga gaggctctac
     1261 tatgctatga aaggtgctgg cacagatgac tccaccctgg tccggattgt ggtcactcga
     1321 agtgagattg accttgtaca aataaaacag atgttcgctc agatgtatca gaagactctg
     1381 ggcacaatga ttgcaggtga cacgagtgga gattaccgaa gacttcttct ggctattgtg
     1441 ggccagtagg agggattttt ttttttttaa tgaaaaaaaa tttctattca tagcttatcc
     1501 ttcagagcaa tgacctgcat gcagcaatat caaacatcag ctaaccgaaa gagctttctg
     1561 tcaaggaccg tatcagggta atgtgcttgg tttgcacatg ttgttattgc cttaattcta
     1621 attttatttt gttctctaca tacaatcaat gtaaagccat atcacaatga tacagtaata
     1681 ttgcaatgtt tgtaaacctt cattcttact agtttcattc taatcaagat gtcaaattga
     1741 ataaaaatca cagcaatctc tgattctgtg taataatatt gaataatttt ttagaaggtt
     1801 actgaaagct ctgccttccg gaatccctct aagtctgctt gatagagtgg atagtgtgtt
     1861 aaaactgtgt actttaaaaa aaaattcaac ctttacatct agaataattt gcatctcatt
     1921 ttgcctaaat tggttctgta ttcataaaca ctttccacat agaaaataga ttagtattac
     1981 ctgtggcacc ttttaagaaa gggtcaaatg tttatatgct taagatacat agcctacttt
     2041 tttttcgcag ttgttttctt tttttaaatt gagttatgac aaataaaaaa ttgcatatat
     2101 ttaaggtgta caatatggtg ttttgatatc agcattcctt gtgtaatgat tccacaatta
     2161 aggtcaggct aattacgtat ctgtcacctt gacatagtta ccattttttc atgtgtggtg
     2221 aaaacactta agatctacta ccttagcaaa ttttaagtgt tcagtacatt attaactata
     2281 gatactgtgc tctacattaa acctctagca tttattcgtt ttataactga aagtttatac
     2341 cctttgacca acatctcccc attttcccca cctctcacct ggacaaccac cactgtgttt
     2401 aagttcagct attttagatt ccacgtataa atggtataca ata
//
