LOCUS       NM_001155               2889 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens annexin A6 (ANXA6), transcript variant 1, mRNA.
ACCESSION   NM_001155
VERSION     NM_001155.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2889)
  AUTHORS   Yang,Y., Huang,L., Zhang,N., Deng,Y.N., Cao,X., Liang,Y., Hou,H.,
            Luo,Y., Yang,Y., Li,Q. and Liang,S.
  TITLE     SUMOylation of annexin A6 retards cell migration and tumor growth
            by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma
  JOURNAL   Cell Commun Signal 22 (1), 206 (2024)
   PUBMED   38566133
  REMARK    GeneRIF: SUMOylation of annexin A6 retards cell migration and tumor
            growth by suppressing RHOU/AKT1-involved EMT in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2889)
  AUTHORS   Wang,Y., Yang,Z., Wang,R., Zheng,Y., Han,Z., Fan,J., Yan,F., Liu,P.
            and Luo,Y.
  TITLE     Annexin A6 mitigates neurological deficit in ischemia/reperfusion
            injury by promoting synaptic plasticity
  JOURNAL   CNS Neurosci Ther 30 (2), e14639 (2024)
   PUBMED   38380783
  REMARK    GeneRIF: Annexin A6 mitigates neurological deficit in
            ischemia/reperfusion injury by promoting synaptic plasticity.
REFERENCE   3  (bases 1 to 2889)
  AUTHORS   Huang,B. and Yang,K.
  TITLE     Comprehensive analysis the diagnosis, malignant progression and
            immune infiltrate of ANXA6 in prostate cancer
  JOURNAL   Genes Genomics 45 (9), 1197-1209 (2023)
   PUBMED   37311953
  REMARK    GeneRIF: Comprehensive analysis the diagnosis, malignant
            progression and immune infiltrate of ANXA6 in prostate cancer.
            Erratum:[Genes Genomics. 2023 Jul 13. doi:
            10.1007/s13258-023-01425-2.. PMID: 37450236]
REFERENCE   4  (bases 1 to 2889)
  AUTHORS   Gounou,C., Bouvet,F., Liet,B., Prouzet-Mauleon,V., d'Agata,L.,
            Harte,E., Argoul,F., Siegfried,G., Iggo,R., Khatib,A.M. and
            Bouter,A.
  TITLE     Annexin-A5 and annexin-A6 silencing prevents metastasis of breast
            cancer cells in zebrafish
  JOURNAL   Biol Cell 115 (6), e202200110 (2023)
   PUBMED   36958013
  REMARK    GeneRIF: Annexin-A5 and annexin-A6 silencing prevents metastasis of
            breast cancer cells in zebrafish.
REFERENCE   5  (bases 1 to 2889)
  AUTHORS   Williams,J.K., Ngo,J.M., Lehman,I.M. and Schekman,R.
  TITLE     Annexin A6 mediates calcium-dependent exosome secretion during
            plasma membrane repair
  JOURNAL   Elife 12, e86556 (2023)
   PUBMED   37204294
  REMARK    GeneRIF: Annexin A6 mediates calcium-dependent exosome secretion
            during plasma membrane repair.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2889)
  AUTHORS   Moss,S.E., Jacob,S.M., Davies,A.A. and Crumpton,M.J.
  TITLE     A growth-dependent post-translational modification of annexin VI
  JOURNAL   Biochim Biophys Acta 1160 (1), 120-126 (1992)
   PUBMED   1420329
REFERENCE   7  (bases 1 to 2889)
  AUTHORS   Barel,M., Gauffre,A., Lyamani,F., Fiandino,A., Hermann,J. and
            Frade,R.
  TITLE     Intracellular interaction of EBV/C3d receptor (CR2) with p68, a
            calcium-binding protein present in normal but not in transformed B
            lymphocytes
  JOURNAL   J Immunol 147 (4), 1286-1291 (1991)
   PUBMED   1831222
REFERENCE   8  (bases 1 to 2889)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
REFERENCE   9  (bases 1 to 2889)
  AUTHORS   Yoshizaki,H., Mizoguchi,T., Arai,K., Shiratsuchi,M., Shidara,Y. and
            Maki,M.
  TITLE     Structure and properties of calphobindin II, an anticoagulant
            protein from human placenta
  JOURNAL   J Biochem 107 (1), 43-50 (1990)
   PUBMED   2139657
REFERENCE   10 (bases 1 to 2889)
  AUTHORS   Iwasaki,A., Suda,M., Watanabe,M., Nakao,H., Hattori,Y., Nagoya,T.,
            Saino,Y., Shidara,Y. and Maki,M.
  TITLE     Structure and expression of cDNA for calphobindin II, a human
            placental coagulation inhibitor
  JOURNAL   J Biochem 106 (1), 43-49 (1989)
   PUBMED   2528541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC411634.1, BC017046.1,
            AI566871.1 and AC008641.7.
            
            On Nov 23, 2018 this sequence version replaced NM_001155.4.
            
            Summary: Annexin VI belongs to a family of calcium-dependent
            membrane and phospholipid binding proteins. Several members of the
            annexin family have been implicated in membrane-related events
            along exocytotic and endocytotic pathways. The annexin VI gene is
            approximately 60 kbp long and contains 26 exons. It encodes a
            protein of about 68 kDa that consists of eight 68-amino acid
            repeats separated by linking sequences of variable lengths. It is
            highly similar to human annexins I and II sequences, each of which
            contain four such repeats. Annexin VI has been implicated in
            mediating the endosome aggregation and vesicle fusion in secreting
            epithelia during exocytosis. Alternatively spliced transcript
            variants have been described. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.179629.1, HM005611.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354546.10/ ENSP00000346550.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DC411634.1         104-179
            77-2490             BC017046.1         1-2414
            2491-2568           AI566871.1         332-409             c
            2569-2570           AC008641.7         95001-95002         c
            2571-2889           AI566871.1         11-329              c
FEATURES             Location/Qualifiers
     source          1..2889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2889
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /note="annexin A6"
                     /db_xref="GeneID:309"
                     /db_xref="HGNC:HGNC:544"
                     /db_xref="MIM:114070"
     exon            1..100
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            101..143
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2147
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /note="isoform 1 is encoded by transcript variant 1;
                     annexin VI (p68); calcium-binding protein p68;
                     calphobindin II; calelectrin; annexin-6; lipocortin VI;
                     chromobindin-20; 67 kDa calelectrin; testis secretory
                     sperm-binding protein Li 198a"
                     /codon_start=1
                     /product="annexin A6 isoform 1"
                     /protein_id="NP_001146.2"
                     /db_xref="CCDS:CCDS47315.1"
                     /db_xref="GeneID:309"
                     /db_xref="HGNC:HGNC:544"
                     /db_xref="MIM:114070"
                     /translation="MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAIL
                     DIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIK
                     DAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVV
                     LLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEY
                     LKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIR
                     IMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPE
                     AAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITH
                     RSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEG
                     AGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH
                     REEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEF
                     IKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTR
                     IMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCGGED"
     exon            144..234
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            235..329
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            330..443
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            444..534
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            535..614
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            615..671
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            672..765
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            766..861
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            862..920
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1043
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1102
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1181
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1263
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1358
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1472
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1563
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1643
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1697
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1715
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1809
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1905
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1964
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2087
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2889
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2490
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /note="major polyA site"
     regulatory      2570..2575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /note="hexamer: AGTAAA"
     polyA_site      2593
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
                     /note="hexamer: AATAAA"
     polyA_site      2889
                     /gene="ANXA6"
                     /gene_synonym="ANX6; CBP68; CPB-II; p68; p70"
ORIGIN      
        1 gcggttgctg ctgggctaac gggctccgat ccagcgagcg ctgcgtcctc gagtccctgc
       61 gcccgtgcgt ccgtctgcga cccgaggcct ccgctgcgcg tggattctgc tgcgaaccgg
      121 agaccatggc caaaccagca cagggtgcca agtaccgggg ctccatccat gacttcccag
      181 gctttgaccc caaccaggat gccgaggctc tgtacactgc catgaagggc tttggcagtg
      241 acaaggaggc catactggac ataatcacct cacggagcaa caggcagagg caggaggtct
      301 gccagagcta caagtccctc tacggcaagg acctcattgc tgatttaaag tatgaattga
      361 cgggcaagtt tgaacggttg attgtgggcc tgatgaggcc acctgcctat tgtgatgcca
      421 aagaaattaa agatgccatc tcgggcattg gcactgatga gaagtgcctc attgagatct
      481 tggcttcccg gaccaatgag cagatgcacc agctggtggc agcatacaaa gatgcctacg
      541 agcgggacct ggaggctgac atcatcggcg acacctctgg ccacttccag aagatgcttg
      601 tggtcctgct ccagggaacc agggaggagg atgacgtagt gagcgaggac ctggtacaac
      661 aggatgtcca ggacctatac gaggcagggg aactgaaatg gggaacagat gaagcccagt
      721 tcatttacat cttgggaaat cgcagcaagc agcatcttcg gttggtgttc gatgagtatc
      781 tgaagaccac agggaagccg attgaagcca gcatccgagg ggagctgtct ggggactttg
      841 agaagctaat gctggccgta gtgaagtgta tccggagcac cccggaatat tttgctgaaa
      901 ggctcttcaa ggctatgaag ggcctgggga ctcgggacaa caccctgatc cgcatcatgg
      961 tctcccgtag tgagttggac atgctcgaca ttcgggagat cttccggacc aagtatgaga
     1021 agtccctcta cagcatgatc aagaatgaca cctctggcga gtacaagaag actctgctga
     1081 agctgtctgg gggagatgat gatgctgctg gccagttctt cccggaggca gcgcaggtgg
     1141 cctatcagat gtgggaactt agtgcagtgg cccgagtaga gctgaaggga actgtgcgcc
     1201 cagccaatga cttcaaccct gacgcagatg ccaaagcgct gcggaaagcc atgaagggac
     1261 tcgggactga cgaagacaca atcatcgata tcatcacgca ccgcagcaat gtccagcggc
     1321 agcagatccg gcagaccttc aagtctcact ttggccggga cttaatgact gacctgaagt
     1381 ctgagatctc tggagacctg gcaaggctga ttctggggct catgatgcca ccggcccatt
     1441 acgatgccaa gcagttgaag aaggccatgg agggagccgg cacagatgaa aaggctctta
     1501 ttgaaatcct ggccactcgg accaatgctg aaatccgggc catcaatgag gcctataagg
     1561 aggactatca caagtccctg gaggatgctc tgagctcaga cacatctggc cacttcagga
     1621 ggatcctcat ttctctggcc acggggcatc gtgaggaggg aggagaaaac ctggaccagg
     1681 cacgggaaga tgcccaggtg gctgctgaga tcttggaaat agcagacaca cctagtggag
     1741 acaaaacttc cttggagaca cgtttcatga cgatcctgtg tacccggagc tatccgcacc
     1801 tccggagagt cttccaggag ttcatcaaga tgaccaacta tgacgtggag cacaccatca
     1861 agaaggagat gtctggggat gtcagggatg catttgtggc cattgttcaa agtgtcaaga
     1921 acaagcctct cttctttgcc gacaaacttt acaaatccat gaagggtgct ggcacagatg
     1981 agaagactct gaccaggatc atggtatccc gcagtgagat tgacctgctc aacatccgga
     2041 gggaattcat tgagaaatat gacaagtctc tccaccaagc cattgagggt gacacctccg
     2101 gagacttcct gaaggccttg ctggctctct gtggtggtga ggactagggc cacagctttg
     2161 gcgggcactt ctgccaagaa atggttatca gcaccagccg ccatggccaa gcctgattgt
     2221 tccagctcca gagactaagg aaggggcagg ggtgggggga ggggttgggt tgggctctta
     2281 tcttcagtgg agcttaggaa acgctcccac tcccacgggc catcgagggc ccagcacggc
     2341 tgagcggctg aaaaaccgta gccatagatc ctgtccacct ccactcccct ctgaccctca
     2401 ggctttccca gcttcctccc cttgctacag cctctgccct ggtttgggct atgtcagatc
     2461 caaaaacatc ctgaacctct gtctgtaaaa tgagtagtgt ctgtactttg aatgaggggg
     2521 ttggtggcag gggccagttg aatgtgctgg gcggggtggt gggaaggata gtaaatgtgc
     2581 tggggcaaac tgacaaatct tcccatccat ttcaccaccc atctccatcc aggccgcgct
     2641 agagtactgg accaggaatt tggatgcctg ggttcaaatc tgcatctgcc atgcacttgt
     2701 ttctgacctt aggccagccc ctttccctcc ctgagtctct attttcttat ctacaatgag
     2761 acagttggac aaaaaaatct tggcttccct tctaacatta acttcctaaa gtatgcctcc
     2821 gattcattcc cttgacactt tttatttcta aggaagaaat aaaaagagat acacaaacac
     2881 ataaacaca
//
