LOCUS       NM_001154               1638 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens annexin A5 (ANXA5), mRNA.
ACCESSION   NM_001154
VERSION     NM_001154.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Wang,W., Liu,D., Yao,J., Yuan,Z., Yan,L. and Cao,B.
  TITLE     ANXA5: A Key Regulator of Immune Cell Infiltration in
            Hepatocellular Carcinoma
  JOURNAL   Med Sci Monit 30, e943523 (2024)
   PUBMED   38824386
  REMARK    GeneRIF: ANXA5: A Key Regulator of Immune Cell Infiltration in
            Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1638)
  AUTHORS   Jing,J.
  TITLE     The Relevance, Predictability, and Utility of Annexin A5 for Human
            Physiopathology
  JOURNAL   Int J Mol Sci 25 (5), 2865 (2024)
   PUBMED   38474114
  REMARK    GeneRIF: The Relevance, Predictability, and Utility of Annexin A5
            for Human Physiopathology.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1638)
  AUTHORS   Abe,T., Marutani,Y., Deng,L., Matsui,C., Fukasawa,M., Suzuki,R.,
            Wakita,T., Matsuura,Y. and Shoji,I.
  TITLE     Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin Integrity
            through Downregulation of Protein Kinase Calpha (PKCalpha) and
            PKCeta Expression, Thereby Promoting Viral Propagation
  JOURNAL   J Virol 97 (6), e0065523 (2023)
   PUBMED   37272842
  REMARK    GeneRIF: Hepatitis C Virus Disrupts Annexin 5-Mediated Occludin
            Integrity through Downregulation of Protein Kinase Calpha
            (PKCalpha) and PKCeta Expression, Thereby Promoting Viral
            Propagation.
REFERENCE   4  (bases 1 to 1638)
  AUTHORS   Gounou,C., Bouvet,F., Liet,B., Prouzet-Mauleon,V., d'Agata,L.,
            Harte,E., Argoul,F., Siegfried,G., Iggo,R., Khatib,A.M. and
            Bouter,A.
  TITLE     Annexin-A5 and annexin-A6 silencing prevents metastasis of breast
            cancer cells in zebrafish
  JOURNAL   Biol Cell 115 (6), e202200110 (2023)
   PUBMED   36958013
  REMARK    GeneRIF: Annexin-A5 and annexin-A6 silencing prevents metastasis of
            breast cancer cells in zebrafish.
REFERENCE   5  (bases 1 to 1638)
  AUTHORS   Woodward,A., Faria,G.N.F. and Harrison,R.G.
  TITLE     Annexin A5 as a targeting agent for cancer treatment
  JOURNAL   Cancer Lett 547, 215857 (2022)
   PUBMED   35940392
  REMARK    GeneRIF: Annexin A5 as a targeting agent for cancer treatment.
            Review article
REFERENCE   6  (bases 1 to 1638)
  AUTHORS   Kirsch,T. and Pfaffle,M.
  TITLE     Selective binding of anchorin CII (annexin V) to type II and X
            collagen and to chondrocalcin (C-propeptide of type II collagen).
            Implications for anchoring function between matrix vesicles and
            matrix proteins
  JOURNAL   FEBS Lett 310 (2), 143-147 (1992)
   PUBMED   1397263
REFERENCE   7  (bases 1 to 1638)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 1638)
  AUTHORS   Schlaepfer,D.D., Jones,J. and Haigler,H.T.
  TITLE     Inhibition of protein kinase C by annexin V
  JOURNAL   Biochemistry 31 (6), 1886-1891 (1992)
   PUBMED   1310621
REFERENCE   9  (bases 1 to 1638)
  AUTHORS   Huber,R., Berendes,R., Burger,A., Schneider,M., Karshikov,A.,
            Luecke,H., Romisch,J. and Paques,E.
  TITLE     Crystal and molecular structure of human annexin V after
            refinement. Implications for structure, membrane binding and ion
            channel formation of the annexin family of proteins
  JOURNAL   J Mol Biol 223 (3), 683-704 (1992)
   PUBMED   1311770
REFERENCE   10 (bases 1 to 1638)
  AUTHORS   Tait,J.F., Frankenberry,D.A., Shiang,R., Murray,J.C., Adler,D.A.
            and Disteche,C.M.
  TITLE     Chromosomal localization of the human gene for annexin V (placental
            anticoagulant protein I) to 4q26----q28
  JOURNAL   Cytogenet Cell Genet 57 (4), 187-192 (1991)
   PUBMED   1683830
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312644.1, J03745.1,
            BC001429.2 and AC096730.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001154.3.
            
            Summary: The Annexin 5 gene spans 29 kb containing 13 exons, and
            encodes a single transcript of approximately 1.6 kb and a protein
            product with a molecular weight of about 35 kDa.The protein encoded
            by this gene belongs to the annexin family of calcium-dependent
            phospholipid binding proteins some of which have been implicated in
            membrane-related events along exocytotic and endocytotic pathways.
            Annexin 5 is a phospholipase A2 and protein kinase C inhibitory
            protein with calcium channel activity and a potential role in
            cellular signal transduction, inflammation, growth and
            differentiation. Annexin 5 has also been described as placental
            anticoagulant protein I, vascular anticoagulant-alpha, endonexin
            II, lipocortin V, placental protein 4 and anchorin CII.
            Polymorphisms in this gene have been implicated in various
            obstetric complications. [provided by RefSeq, Dec 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.223191.1,
                                           SRR1803611.253746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296511.10/ ENSP00000296511.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AK312644.1         13-101
            90-1263             J03745.1           96-1269
            1264-1587           BC001429.2         1181-1504
            1588-1638           AC096730.3         114707-114757       c
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..1638
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /note="annexin A5"
                     /db_xref="GeneID:308"
                     /db_xref="HGNC:HGNC:543"
                     /db_xref="MIM:131230"
     exon            1..118
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            119..162
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1116
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /note="endonexin II; anchorin CII; lipocortin V; placental
                     anticoagulant protein I; CBP-I; PAP-I; VAC-alpha; annexin
                     V; annexin-5; calphobindin I; thromboplastin inhibitor;
                     vascular anticoagulant-alpha; placental anticoagulant
                     protein 4; epididymis secretory protein Li 7"
                     /codon_start=1
                     /product="annexin A5"
                     /protein_id="NP_001145.1"
                     /db_xref="CCDS:CCDS3720.1"
                     /db_xref="GeneID:308"
                     /db_xref="HGNC:HGNC:543"
                     /db_xref="MIM:131230"
                     /translation="MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTS
                     RSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKG
                     AGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQAN
                     RDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISG
                     FQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSR
                     SEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD"
     exon            163..247
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            248..342
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            343..456
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            457..547
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            548..627
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            628..684
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            685..778
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            779..874
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            875..933
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1056
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1638
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1564..1569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /note="hexamer: AATAAA"
     polyA_site      1587
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /note="major polyA site"
     regulatory      1617..1622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
                     /note="hexamer: ATTAAA"
     polyA_site      1638
                     /gene="ANXA5"
                     /gene_synonym="ANX5; CPB-I; ENX2; HEL-S-7; PP4; RPRGL3;
                     VAC-alph"
ORIGIN      
        1 agtctaggtg cagctgccgg atccttcagc gtctgcatct cggcgtcgcc ccgcgtaccg
       61 tcgcccggct ctccgccgct ctcccggggt ttcggggcac ttgggtccca cagtctggtc
      121 ctgcttcacc ttcccctgac ctgagtagtc gccatggcac aggttctcag aggcactgtg
      181 actgacttcc ctggatttga tgagcgggct gatgcagaaa ctcttcggaa ggctatgaaa
      241 ggcttgggca cagatgagga gagcatcctg actctgttga catcccgaag taatgctcag
      301 cgccaggaaa tctctgcagc ttttaagact ctgtttggca gggatcttct ggatgacctg
      361 aaatcagaac taactggaaa atttgaaaaa ttaattgtgg ctctgatgaa accctctcgg
      421 ctttatgatg cttatgaact gaaacatgcc ttgaagggag ctggaacaaa tgaaaaagta
      481 ctgacagaaa ttattgcttc aaggacacct gaagaactga gagccatcaa acaagtttat
      541 gaagaagaat atggctcaag cctggaagat gacgtggtgg gggacacttc agggtactac
      601 cagcggatgt tggtggttct ccttcaggct aacagagacc ctgatgctgg aattgatgaa
      661 gctcaagttg aacaagatgc tcaggcttta tttcaggctg gagaacttaa atgggggaca
      721 gatgaagaaa agtttatcac catctttgga acacgaagtg tgtctcattt gagaaaggtg
      781 tttgacaagt acatgactat atcaggattt caaattgagg aaaccattga ccgcgagact
      841 tctggcaatt tagagcaact actccttgct gttgtgaaat ctattcgaag tatacctgcc
      901 taccttgcag agaccctcta ttatgctatg aagggagctg ggacagatga tcataccctc
      961 atcagagtca tggtttccag gagtgagatt gatctgttta acatcaggaa ggagtttagg
     1021 aagaattttg ccacctctct ttattccatg attaagggag atacatctgg ggactataag
     1081 aaagctcttc tgctgctctg tggagaagat gactaacgtg tcacggggaa gagctccctg
     1141 ctgtgtgcct gcaccacccc actgccttcc ttcagcacct ttagctgcat ttgtatgcca
     1201 gtgcttaaca cattgcctta ttcatactag catgctcatg accaacacat acacgtcata
     1261 gaagaaaata gtggtgcttc tttctgatct ctagtggaga tctctttgac tgctgtagta
     1321 ctaaagtgta cttaatgtta ctaagtttaa tgcctggcca ttttccattt atatatattt
     1381 tttaagaggc tagagtgctt ttagcctttt ttaaaaactc catttatatt acatttgtaa
     1441 ccatgatact ttaatcagaa gcttagcctt gaaattgtga actcttggaa atgttattag
     1501 tgaagttcgc aactaaacta aacctgtaaa attatgatga ttgtattcaa aagattaatg
     1561 aaaaataaac atttctgtcc ccctgaatta tgtgtacatg tgtgtttaga tttattatta
     1621 aatttattta acaatgtt
//
