LOCUS       NM_001153               2651 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens annexin A4 (ANXA4), transcript variant 2, mRNA.
ACCESSION   NM_001153
VERSION     NM_001153.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Vicic,N., Guo,X., Chan,D., Flanagan,J.G., Sigal,I.A. and Sivak,J.M.
  TITLE     Evidence of an Annexin A4 mediated plasma membrane repair response
            to biomechanical strain associated with glaucoma pathogenesis
  JOURNAL   J Cell Physiol 237 (9), 3687-3702 (2022)
   PUBMED   35862065
  REMARK    GeneRIF: Evidence of an Annexin A4 mediated plasma membrane repair
            response to biomechanical strain associated with glaucoma
            pathogenesis.
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   Peng,Y., Zhang,Z., Zhang,A., Liu,C., Sun,Y., Peng,Z. and Liu,Y.
  TITLE     Membrane-cytoplasm translocation of annexin A4 is involved in the
            metastasis of colorectal carcinoma
  JOURNAL   Aging (Albany NY) 13 (7), 10312-10325 (2021)
   PUBMED   33761465
  REMARK    GeneRIF: Membrane-cytoplasm translocation of annexin A4 is involved
            in the metastasis of colorectal carcinoma.
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Liu,J., Wang,H., Zheng,M., Deng,L., Zhang,X. and Lin,B.
  TITLE     p53 and ANXA4/NF-kappaB p50 complexes regulate cell proliferation,
            apoptosis and tumor progression in ovarian clear cell carcinoma
  JOURNAL   Int J Mol Med 46 (6), 2102-2114 (2020)
   PUBMED   33125094
  REMARK    GeneRIF: p53 and ANXA4/NFkappaB p50 complexes regulate cell
            proliferation, apoptosis and tumor progression in ovarian clear
            cell carcinoma.
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Saad,Z.M., Fouad,Y., Ali,L.H. and Hassanin,T.M.
  TITLE     Clinical Significance of Annexin A4 as a Biomarker in the Early
            Diagnosis of Hepatocellular Carcinoma
  JOURNAL   Asian Pac J Cancer Prev 21 (9), 2661-2665 (2020)
   PUBMED   32986366
  REMARK    GeneRIF: Clinical Significance of Annexin A4 as a Biomarker in the
            Early Diagnosis of Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   Tait,J.F., Smith,C., Frankenberry,D.A., Miao,C.H., Adler,D.A. and
            Disteche,C.M.
  TITLE     Chromosomal mapping of the human annexin IV (ANX4) gene
  JOURNAL   Genomics 12 (2), 313-318 (1992)
   PUBMED   1346776
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Freemont,P.S., Driessen,H.P., Verbi,W. and Crumpton,M.J.
  TITLE     Crystallization and preliminary X-ray crystallographic studies of
            human placental annexin IV
  JOURNAL   J Mol Biol 216 (2), 219-221 (1990)
   PUBMED   2254922
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Romisch,J., Grote,M., Weithmann,K.U., Heimburger,N. and Amann,E.
  TITLE     Annexin proteins PP4 and PP4-X. Comparative characterization of
            biological activities of placental and recombinant proteins
  JOURNAL   Biochem J 272 (1), 223-229 (1990)
   PUBMED   2148260
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Romisch,J. and Heimburger,N.
  TITLE     Purification and characterization of six annexins from human
            placenta
  JOURNAL   Biol Chem Hoppe Seyler 371 (5), 383-388 (1990)
   PUBMED   2143074
REFERENCE   10 (bases 1 to 2651)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000182.1, D78152.1,
            AK058017.1, DB562261.1 and AC019206.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001153.4.
            
            Summary: Annexin IV (ANX4) belongs to the annexin family of
            calcium-dependent phospholipid binding proteins. Although their
            functions are still not clearly defined, several members of the
            annexin family have been implicated in membrane-related events
            along exocytotic and endocytotic pathways. ANX4 has 45 to 59%
            identity with other members of its family and shares a similar size
            and exon-intron organization. Isolated from human placenta, ANX4
            encodes a protein that has possible interactions with ATP, and has
            in vitro anticoagulant activity and also inhibits phospholipase A2
            activity. ANX4 is almost exclusively expressed in epithelial cells.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK058017.1, SRR1163655.259565.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394295.6/ ENSP00000377833.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1182              BC000182.1         43-1224
            1183-1960           D78152.1           1157-1934
            1961-2008           AK058017.1         1961-2008
            2009-2016           DB562261.1         409-416
            2017-2651           AC019206.4         77261-77895
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2651
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="annexin A4"
                     /db_xref="GeneID:307"
                     /db_xref="HGNC:HGNC:542"
                     /db_xref="MIM:106491"
     exon            1..42
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            43..97
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1054
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="isoform a is encoded by transcript variant 2;
                     annexin IV (placental anticoagulant protein II);
                     proliferation-inducing gene 28; proliferation-inducing
                     protein 28; annexin-4; endonexin I; lipocortin IV;
                     chromobindin-4; 35-beta calcimedin; carbohydrate-binding
                     protein p33/p41; epididymis secretory protein Li 274"
                     /codon_start=1
                     /product="annexin A4 isoform a"
                     /protein_id="NP_001144.1"
                     /db_xref="CCDS:CCDS1894.1"
                     /db_xref="GeneID:307"
                     /db_xref="HGNC:HGNC:542"
                     /db_xref="MIM:106491"
                     /translation="MAMATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLA
                     YRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMK
                     GAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAG
                     GRDEGNYLDDALVRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRIS
                     QKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVS
                     RAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGDD"
     exon            98..185
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            186..280
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            281..394
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            395..485
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            486..565
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            566..622
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            623..716
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            717..812
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            813..871
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            872..994
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     exon            995..2651
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="major polyA site"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="hexamer: ATTAAA"
     polyA_site      2000
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="major polyA site"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="hexamer: ATTAAA"
     regulatory      2629..2634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
                     /note="hexamer: TATAAA"
     polyA_site      2630
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
     polyA_site      2651
                     /gene="ANXA4"
                     /gene_synonym="ANX4; HEL-S-274; P32.5; PAP-II; PIG28;
                     PP4-X; ZAP36"
ORIGIN      
        1 gtgacctccg cagccgcaga ggaggagcgc agcccggcct cgaagaactt ctgcttgggt
       61 ggctgaactc tgatcttgac ctagagtcat ggccatggca accaaaggag gtactgtcaa
      121 agctgcttca ggattcaatg ccatggaaga tgcccagacc ctgaggaagg ccatgaaagg
      181 gctcggcacc gatgaagacg ccattattag cgtccttgcc taccgcaaca ccgcccagcg
      241 ccaggagatc aggacagcct acaagagcac catcggcagg gacttgatag acgacctgaa
      301 gtcagaactg agtggcaact tcgagcaggt gattgtgggg atgatgacgc ccacggtgct
      361 gtatgacgtg caagagctgc gaagggccat gaagggagcc ggcactgatg agggctgcct
      421 aattgagatc ctggcctccc ggacccctga ggagatccgg cgcataagcc aaacctacca
      481 gcagcaatat ggacggagcc ttgaagatga cattcgctct gacacatcgt tcatgttcca
      541 gcgagtgctg gtgtctctgt cagctggtgg gagggatgaa ggaaattatc tggacgatgc
      601 tctcgtgaga caggatgccc aggacctgta tgaggctgga gagaagaaat gggggacaga
      661 tgaggtgaaa tttctaactg ttctctgttc ccggaaccga aatcacctgt tgcatgtgtt
      721 tgatgaatac aaaaggatat cacagaagga tattgaacag agtattaaat ctgaaacatc
      781 tggtagcttt gaagatgctc tgctggctat agtaaagtgc atgaggaaca aatctgcata
      841 ttttgctgaa aagctctata aatcgatgaa gggcttgggc accgatgata acaccctcat
      901 cagagtgatg gtttctcgag cagaaattga catgttggat atccgggcac acttcaagag
      961 actctatgga aagtctctgt actcgttcat caagggtgac acatctggag actacaggaa
     1021 agtactgctt gttctctgtg gaggagatga ttaaaataaa aatcccagaa ggacaggagg
     1081 attctcaaca ctttgaattt ttttaacttc atttttctac actgctatta tcattatctc
     1141 agaatgctta tttccaatta aaacgcctac agctgcctcc tagaatatag actgtctgta
     1201 ttattattca cctataatta gtcattatga tgctttaaag ctgtacttgc atttcaaagc
     1261 ttataagata taaatggaga ttttaaagta gaaataaata tgtattccat gtttttaaaa
     1321 gattactttc tactttgtgt ttcacagaca ttgaatatat taaattattc catattttct
     1381 tttcagtgaa aaatttttta aatggaagac tgttctaaaa tcactttttt ccctaatcca
     1441 atttttagag tggctagtag tttcttcatt tgaaattgta agcatccggt cagtaagaat
     1501 gcccatccag ttttctatat ttcatagtca aagccttgaa agcatctaca aatctctttt
     1561 tttaggtttt gtccatagca tcagttgatc cttactaagt ttttcatggg agacttcctt
     1621 catcacatct tatgttgaaa tcactttctg tagtcaaagt ataccaaaac caatttatct
     1681 gaactaaatt ctaaagtatg gttatacaaa ccatatacat ctggttacca aacataaatg
     1741 ctgaacattc catattatta tagttaatgt cttaatccag cttgcaagtg aatggaaaaa
     1801 aaaataagct tcaaactagg tattctggga atgatgtaat gctctgaatt tagtatgata
     1861 taaagaaaac ttttttgtgc taaaaatact ttttaaaatc aattttgttg attgtagtaa
     1921 tttctatttg cactgtgcct ttcaactcca gaaacattct gaagatgtac ttggatttaa
     1981 ttaaaaagtt cactttgtaa gaacgtggaa aaataatttt aatttaaaaa tggtgttttt
     2041 aggccggggg cgggggctca cgccagtaat cccaacactt tgggaggcca aggcgggtgg
     2101 atcacctaag gtcaggagtt caagactagc ctggccaaca tggagaaact gcatctctac
     2161 taaaaatata aaaattagcc gggtgtggtg gctggtgcct gtaatcccag ccactcggag
     2221 gctgagtcag ggagaactgc ttgaacccag gaggcaggag gcaaaggttg cagtgagccg
     2281 agatcacgcc agcctgggcg acagagcgag aatccatcta aaaaaaaaaa aaaaaaaagt
     2341 gtctttaaag tgaggtatag tctttctctg atccactttt caccttctga ggtttttcat
     2401 cttggcccct gaaaggagct atttttgaag gacttgtgtt actcagtttc tacaggaatt
     2461 acaagataag aaaaaaaaaa tcatatttag tcttatgcgt gcctactggc taatgttcac
     2521 atatgccaaa cactactcaa taacataaaa taatgtatga acttattctc tggaaatgag
     2581 tgatgccctc tgctctaagt agaccattta tattaaatat cataaatgta taaaggacat
     2641 tcatattctt a
//
