LOCUS       NM_005139               1432 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens annexin A3 (ANXA3), mRNA.
ACCESSION   NM_005139
VERSION     NM_005139.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1432)
  AUTHORS   Xu,L., Li,W., Liu,D., Cao,J., Ge,J., Liu,X., Wang,Y., Teng,Y.,
            Liu,P., Guo,X., He,C., Liu,M. and Tian,L.
  TITLE     ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages
            Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous
            Cell Carcinoma
  JOURNAL   Cancer Immunol Res 12 (5), 614-630 (2024)
   PUBMED   38393971
  REMARK    GeneRIF: ANXA3-Rich Exosomes Derived from Tumor-Associated
            Macrophages Regulate Ferroptosis and Lymphatic Metastasis of
            Laryngeal Squamous Cell Carcinoma.
REFERENCE   2  (bases 1 to 1432)
  AUTHORS   Bley,H., Krisp,C., Schobel,A., Hehner,J., Schneider,L., Becker,M.,
            Stegmann,C., Heidenfels,E., Nguyen-Dinh,V., Schluter,H., Gerold,G.
            and Herker,E.
  TITLE     Proximity labeling of host factor ANXA3 in HCV infection reveals a
            novel LARP1 function in viral entry
  JOURNAL   J Biol Chem 300 (5), 107286 (2024)
   PUBMED   38636657
  REMARK    GeneRIF: Proximity labeling of host factor ANXA3 in HCV infection
            reveals a novel LARP1 function in viral entry.
REFERENCE   3  (bases 1 to 1432)
  AUTHORS   Liu,L., Cai,Y. and Deng,C.
  TITLE     Identification of ANXA3 as a biomarker associated with pyroptosis
            in ischemic stroke
  JOURNAL   Eur J Med Res 28 (1), 596 (2023)
   PUBMED   38102696
  REMARK    GeneRIF: Identification of ANXA3 as a biomarker associated with
            pyroptosis in ischemic stroke.
            Erratum:[Eur J Med Res. 2024 Feb 7;29(1):105. doi:
            10.1186/s40001-024-01693-y.. PMID: 38326912]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1432)
  AUTHORS   Huang,J., Wei,W., Kang,F., Tan,S., Li,Y., Lu,X. and Wang,N.
  TITLE     ANXA3, associated with YAP1 regulation, participates in the
            proliferation and chemoresistance of cervical cancer cells
  JOURNAL   Genes Genomics 45 (12), 1575-1586 (2023)
   PUBMED   37843781
  REMARK    GeneRIF: ANXA3, associated with YAP1 regulation, participates in
            the proliferation and chemoresistance of cervical cancer cells.
REFERENCE   5  (bases 1 to 1432)
  AUTHORS   Jiang,J., Zhan,X., Qu,H., Liang,T., Li,H., Chen,L., Huang,S.,
            Sun,X., Jiang,W., Chen,J., Chen,T., Yao,Y., Wu,S., Zhu,J. and
            Liu,C.
  TITLE     Upregulated of ANXA3, SORL1, and Neutrophils May Be Key Factors in
            the Progressionof Ankylosing Spondylitis
  JOURNAL   Front Immunol 13, 861459 (2022)
   PUBMED   35464477
  REMARK    GeneRIF: Upregulated of ANXA3, SORL1, and Neutrophils May Be Key
            Factors in the Progressionof Ankylosing Spondylitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1432)
  AUTHORS   Tait,J.F., Frankenberry,D.A., Miao,C.H., Killary,A.M., Adler,D.A.
            and Disteche,C.M.
  TITLE     Chromosomal localization of the human annexin III (ANX3) gene
  JOURNAL   Genomics 10 (2), 441-448 (1991)
   PUBMED   1830024
REFERENCE   7  (bases 1 to 1432)
  AUTHORS   Ross,T.S., Tait,J.F. and Majerus,P.W.
  TITLE     Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with
            lipocortin III
  JOURNAL   Science 248 (4955), 605-607 (1990)
   PUBMED   2159184
REFERENCE   8  (bases 1 to 1432)
  AUTHORS   Ernst,J.D., Hoye,E., Blackwood,R.A. and Jaye,D.
  TITLE     Purification and characterization of an abundant cytosolic protein
            from human neutrophils that promotes Ca2(+)-dependent aggregation
            of isolated specific granules
  JOURNAL   J Clin Invest 85 (4), 1065-1071 (1990)
   PUBMED   2138632
REFERENCE   9  (bases 1 to 1432)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
REFERENCE   10 (bases 1 to 1432)
  AUTHORS   Pepinsky,R.B., Tizard,R., Mattaliano,R.J., Sinclair,L.K.,
            Miller,G.T., Browning,J.L., Chow,E.P., Burne,C., Huang,K.S.,
            Pratt,D. et al.
  TITLE     Five distinct calcium and phospholipid binding proteins share
            homology with lipocortin I
  JOURNAL   J Biol Chem 263 (22), 10799-10811 (1988)
   PUBMED   2968983
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000871.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005139.2.
            
            Summary: This gene encodes a member of the annexin family.  Members
            of this calcium-dependent phospholipid-binding protein family play
            a role in the regulation of cellular growth and in signal
            transduction pathways.  This protein functions in the inhibition of
            phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to
            form inositol 1-phosphate. This protein may also play a role in
            anti-coagulation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000871.1, SRR3476690.1173121.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264908.11/ ENSP00000264908.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1432              BC000871.1         15-1446
FEATURES             Location/Qualifiers
     source          1..1432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..1432
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /note="annexin A3"
                     /db_xref="GeneID:306"
                     /db_xref="HGNC:HGNC:541"
                     /db_xref="MIM:106490"
     exon            1..90
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            91..143
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1100
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /EC_number="3.1.4.43"
                     /note="calcimedin 35-alpha; Annexin III (lipocortin III);
                     annexin III (lipocortin III, 1,2-cyclic-inositol-phosphate
                     phosphodiesterase, placental anticoagulant protein III,
                     calcimedin 35-alpha); PAP-III; annexin-3; 35-alpha
                     calcimedin; inositol 1,2-cyclic phosphate
                     2-phosphohydrolase"
                     /codon_start=1
                     /product="annexin A3"
                     /protein_id="NP_005130.1"
                     /db_xref="CCDS:CCDS3584.1"
                     /db_xref="GeneID:306"
                     /db_xref="HGNC:HGNC:541"
                     /db_xref="MIM:106490"
                     /translation="MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISI
                     LTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKS
                     MKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLA
                     DGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRN
                     ISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIM
                     VSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD"
     exon            144..231
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            232..326
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            327..440
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..531
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            532..611
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            612..668
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..762
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..858
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..917
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1040
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1432
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1407..1412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /note="hexamer: AATAAA"
     polyA_site      1432
                     /gene="ANXA3"
                     /gene_synonym="ANX3"
                     /note="major polyA site"
ORIGIN      
        1 agcgcggagc acctgcgccc gcggctgaca ccttcgctcg cagtttgttc gcagtttact
       61 cgcacaccag tttcccccac cgcgctttgg attagtgtga tctcagctca aggcaaaggt
      121 gggatatcat ggcatctatc tgggttggac accgaggaac agtaagagat tatccagact
      181 ttagcccatc agtggatgct gaagctattc agaaagcaat cagaggaatt ggaactgatg
      241 agaaaatgct catcagcatt ctgactgaga ggtcaaatgc acagcggcag ctgattgtta
      301 aggaatatca agcagcatat ggaaaggagc tgaaagatga cttgaagggt gatctctctg
      361 gccactttga gcatctcatg gtggccctag tgactccacc agcagtcttt gatgcaaagc
      421 agctaaagaa atccatgaag ggcgcgggaa caaacgaaga tgccttgatt gaaatcttaa
      481 ctaccaggac aagcaggcaa atgaaggata tctctcaagc ctattataca gtatacaaga
      541 agagtcttgg agatgacatt agttccgaaa catctggtga cttccggaaa gctctgttga
      601 ctttggcaga tggcagaaga gatgaaagtc tgaaagtgga tgagcatctg gccaaacaag
      661 atgcccagat tctctataaa gctggtgaga acagatgggg cacggatgaa gacaaattca
      721 ctgagatcct gtgtttaagg agctttcctc aattaaaact aacatttgat gaatacagaa
      781 atatcagcca aaaggacatt gtggacagca taaaaggaga attatctggg cattttgaag
      841 acttactgtt ggccatagtt aattgtgtga ggaacacgcc ggccttttta gccgaaagac
      901 tgcatcgagc cttgaagggt attggaactg atgagtttac tctgaaccga ataatggtgt
      961 ccagatcaga aattgacctt ttggacattc gaacagagtt caagaagcat tatggctatt
     1021 ccctatattc agcaattaaa tcggatactt ctggagacta tgaaatcaca ctcttaaaaa
     1081 tctgtggtgg agatgactga accaagaaga taatctccaa aggtccacga tgggctttcc
     1141 caacagctcc accttacttc ttctcatact atttaagaga acaagcaaat ataaacagca
     1201 acttgtgttc ctaacaggaa ttttcattgt tctataacaa caacaacaaa agcgattatt
     1261 attttagagc atctcattta taatgtagca gctcataaat gaaattgaaa atggtattaa
     1321 agatctgcaa ctactatcca acttatattt ctgctttcaa agttaagaat ctttatagtt
     1381 ctactccatt aaatataaag caagataata aaaattgttg cttttgttaa aa
//
