LOCUS       NM_001014279             949 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens annexin A2 receptor (ANXA2R), transcript variant 1,
            mRNA.
ACCESSION   NM_001014279 XM_371738
VERSION     NM_001014279.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 949)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   2  (bases 1 to 949)
  AUTHORS   Guo,T., Song,H., Zhao,Z., Qi,Z. and Zhao,S.
  TITLE     Overexpression of Annexin A2 Receptor Inhibits Neovascularization
            via the Promotion of Kruppel-Like Transcription Factor 2
  JOURNAL   Cell Physiol Biochem 46 (4), 1617-1627 (2018)
   PUBMED   29694949
  REMARK    GeneRIF: Overexpression of AX2R significantly inhibited cell
            proliferation, migration and tube formation in both types of
            endothelial cells and increased the expression of KLF2, mediating
            VEGF and VEGFR2.
REFERENCE   3  (bases 1 to 949)
  AUTHORS   Zhang,J., Kong,L., Guo,S., Bu,M., Guo,Q., Xiong,Y., Zhu,N., Qiu,C.,
            Yan,X., Chen,Q., Zhang,H., Zhuang,J., Wang,Q., Zhang,S.S., Shen,Y.
            and Chen,M.
  TITLE     hnRNPs and ELAVL1 cooperate with uORFs to inhibit protein
            translation
  JOURNAL   Nucleic Acids Res 45 (5), 2849-2864 (2017)
   PUBMED   27789685
REFERENCE   4  (bases 1 to 949)
  AUTHORS   Zhang,Y., Song,H., Guo,T., Zhu,Y., Tang,H., Qi,Z., Zhao,P. and
            Zhao,S.
  TITLE     Overexpression of Annexin II Receptor-Induced Autophagy Protects
            Against Apoptosis in Uveal Melanoma Cells
  JOURNAL   Cancer Biother Radiopharm 31 (4), 145-151 (2016)
   PUBMED   27183438
  REMARK    GeneRIF: Data highlighted the crucial role of AXIIR in reducing
            Mum2C cell viability through inducing apoptosis, while autophagy
            played a protective role in this process.
REFERENCE   5  (bases 1 to 949)
  AUTHORS   Song,H., Pan,D., Sun,W., Gu,C., Zhang,Y., Zhao,P., Qi,Z. and
            Zhao,S.
  TITLE     SiRNA directed against annexin II receptor inhibits angiogenesis
            via suppressing MMP2 and MMP9 expression
  JOURNAL   Cell Physiol Biochem 35 (3), 875-884 (2015)
   PUBMED   25633185
  REMARK    GeneRIF: these subsequent effects might be via suppressing the
            expression of matrix metalloproteinase 2 and matrix
            metalloproteinase 9. ... AXIIR participates in angiogenesis, and
            may be a potential therapeutic target for angiogenesis related
            diseases
REFERENCE   6  (bases 1 to 949)
  AUTHORS   Xiong,Y., Fan,C., Kong,L., Dong,L., Zhu,N., Zhang,J., Wang,L.,
            Qin,T., Shen,Y. and Chen,M.
  TITLE     Annexin II receptor induces apoptosis independent of Annexin II
  JOURNAL   Apoptosis 18 (8), 925-939 (2013)
   PUBMED   23640736
  REMARK    GeneRIF: AXIIR acts as a novel inducer of apoptosis in human cells,
            partially through activating Caspase-8.
REFERENCE   7  (bases 1 to 949)
  AUTHORS   D'Souza,S., Kurihara,N., Shiozawa,Y., Joseph,J., Taichman,R.,
            Galson,D.L. and Roodman,G.D.
  TITLE     Annexin II interactions with the annexin II receptor enhance
            multiple myeloma cell adhesion and growth in the bone marrow
            microenvironment
  JOURNAL   Blood 119 (8), 1888-1896 (2012)
   PUBMED   22223826
  REMARK    GeneRIF: Results show that AXII and AXIIR play important roles in
            multiple myeloma (MM) and that targeting the AXII/AXIIR axis may be
            a novel therapeutic approach for MM.
REFERENCE   8  (bases 1 to 949)
  AUTHORS   Shiozawa,Y., Havens,A.M., Jung,Y., Ziegler,A.M., Pedersen,E.A.,
            Wang,J., Wang,J., Lu,G., Roodman,G.D., Loberg,R.D., Pienta,K.J. and
            Taichman,R.S.
  TITLE     Annexin II/annexin II receptor axis regulates adhesion, migration,
            homing, and growth of prostate cancer
  JOURNAL   J Cell Biochem 105 (2), 370-380 (2008)
   PUBMED   18636554
  REMARK    GeneRIF: annexin II and its receptor axis play a central role in
            prostate cancer metastasis, and prostate cancer utilizes the
            hematopoietic stem cell homing mechanisms to gain access to the
            niche.
REFERENCE   9  (bases 1 to 949)
  AUTHORS   Lu,G., Maeda,H., Reddy,S.V., Kurihara,N., Leach,R., Anderson,J.L.
            and Roodman,G.D.
  TITLE     Cloning and characterization of the annexin II receptor on human
            marrow stromal cells
  JOURNAL   J Biol Chem 281 (41), 30542-30550 (2006)
   PUBMED   16895901
  REMARK    GeneRIF: analysis of the annexin II receptor on human marrow
            stromal cells
REFERENCE   10 (bases 1 to 949)
  AUTHORS   Menaa,C., Devlin,R.D., Reddy,S.V., Gazitt,Y., Choi,S.J. and
            Roodman,G.D.
  TITLE     Annexin II increases osteoclast formation by stimulating the
            proliferation of osteoclast precursors in human marrow cultures
  JOURNAL   J Clin Invest 103 (11), 1605-1613 (1999)
   PUBMED   10359570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025171.8.
            
            On May 1, 2020 this sequence version replaced NM_001014279.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY032883.1, BC067873.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616064.2/ ENSP00000479862.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            regulatory uORF        :: PMID: 27789685
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-949               AC025171.8         103033-103981
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..949
                     /gene="ANXA2R"
                     /gene_synonym="AX2R; AXIIR; C5orf39"
                     /note="annexin A2 receptor"
                     /db_xref="GeneID:389289"
                     /db_xref="HGNC:HGNC:33463"
                     /db_xref="MIM:611296"
     exon            1..949
                     /gene="ANXA2R"
                     /gene_synonym="AX2R; AXIIR; C5orf39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      50..214
                     /regulatory_class="uORF"
                     /gene="ANXA2R"
                     /gene_synonym="AX2R; AXIIR; C5orf39"
                     /experiment="DESCRIPTION:regulatory uORF[PMID: 27789685]"
                     /note="this uORF is predicted to encode a 54 aa peptide
                     (PMID:27789685)"
     regulatory      101..214
                     /regulatory_class="uORF"
                     /gene="ANXA2R"
                     /gene_synonym="AX2R; AXIIR; C5orf39"
                     /experiment="DESCRIPTION:regulatory uORF[PMID: 27789685]"
                     /note="this uORF is predicted to encode a 37 aa peptide
                     (PMID:27789685)"
     CDS             274..855
                     /gene="ANXA2R"
                     /gene_synonym="AX2R; AXIIR; C5orf39"
                     /note="annexin II receptor"
                     /codon_start=1
                     /product="annexin-2 receptor"
                     /protein_id="NP_001014301.1"
                     /db_xref="CCDS:CCDS34153.1"
                     /db_xref="GeneID:389289"
                     /db_xref="HGNC:HGNC:33463"
                     /db_xref="MIM:611296"
                     /translation="MEQHFLGCVKRAWDSAEVAPEPQPPPIVSSEDRGPWPLPLYPVL
                     GEYSLDSCDLGLLSSPCWRLPGVYWQNGLSPGVQSTLEPSTAKPTEFSWPGTQKQQEA
                     PVEEVGQAEEPDRLRLQQLPWSSPLHPWDRQQDTEVCDSGCLLERRHPPALQPWRHLP
                     GFSDCLEWILRVGFAAFSVLWACCSRICGAKQP"
     regulatory      927..932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA2R"
                     /gene_synonym="AX2R; AXIIR; C5orf39"
                     /note="hexamer: AATAAA"
     polyA_site      949
                     /gene="ANXA2R"
                     /gene_synonym="AX2R; AXIIR; C5orf39"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcaaga tttgcttagt gtcatttcat ttcggtttct tttctcgcca tgtttttctg
       61 tcggaattac ggttcgtttt ggttctatgt actctctaaa atgttatcgt ttttcatttg
      121 tctactaatt ttcgtgcatt tgttactact gagtttctta atatctgact ggcctccgcc
      181 cacgggctct gcagagcata aatactcagg ctgatggtag tgcagagact ctccctcctt
      241 gatcagcgca aacgttggtc tgaggcttga gggatggagc aacattttct tggctgtgtg
      301 aagcgggctt gggattccgc agaggtggcg ccagagcccc agcctccacc tattgtgagt
      361 tcagaagatc gtgggccgtg gcctcttcct ttgtatccag tactaggaga gtactcactg
      421 gacagctgtg atttgggact gctttccagc ccttgctggc ggctgcccgg agtctactgg
      481 caaaacggac tctctcctgg agtccagagc accttggaac caagtacagc gaagcccact
      541 gagttcagtt ggccggggac acagaagcag caagaggcac ccgtagaaga ggtggggcag
      601 gcagaggaac ccgacagact caggctccag cagcttccct ggagcagtcc tctccatccc
      661 tgggacagac agcaggacac cgaggtctgt gacagcgggt gccttttgga acgccgccat
      721 cctcctgccc tccagccgtg gcgccacctc ccgggtttct cagactgcct ggagtggatt
      781 cttcgcgttg gttttgccgc gttctctgta ctctgggcgt gctgttcacg gatctgtgga
      841 gctaagcagc cttagatagc agcagaaggc tttttggatt ctcctccttg aaaagattct
      901 cagttaccaa acgtctccac ctagaaaata aaaatacatt aagatgtgc
//
