LOCUS       NM_004039               1554 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens annexin A2 (ANXA2), transcript variant 3, mRNA.
ACCESSION   NM_004039
VERSION     NM_004039.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Ge,Y., Wang,B., Xiao,J., Wu,H. and Shao,Q.
  TITLE     NUSAP1 promotes gastric cancer radioresistance by inhibiting
            ubiquitination of ANXA2 and is suppressed by miR-129-5p
  JOURNAL   J Cancer Res Clin Oncol 150 (8), 406 (2024)
   PUBMED   39212774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1554)
  AUTHORS   Peng,M., Yang,L., Liao,J., Le,X., Dai,F., Sun,R., Wu,F., Jiang,Y.,
            Tian,R., Shao,B., Zhou,L., Wu,M., Guo,S. and Xiang,T.
  TITLE     The novel DNA methylation marker FIBIN suppresses non-small cell
            lung cancer metastasis by negatively regulating ANXA2
  JOURNAL   Cell Signal 120, 111197 (2024)
   PUBMED   38697447
  REMARK    GeneRIF: The novel DNA methylation marker FIBIN suppresses
            non-small cell lung cancer metastasis by negatively regulating
            ANXA2.
REFERENCE   3  (bases 1 to 1554)
  AUTHORS   Wang,Y., Liu,Y., Chen,H., Xu,Z., Jiang,W., Xu,X., Shan,J.,
            Chang,J., Zhou,T., Wang,J., Chenyan,A., Fan,S., Tao,Z., Shao,K.,
            Li,X., Chen,X., Ji,G. and Wu,X.
  TITLE     PIN1 promotes the metastasis of cholangiocarcinoma cells by
            RACK1-mediated phosphorylation of ANXA2
  JOURNAL   Cell Oncol (Dordr) 47 (4), 1233-1252 (2024)
   PUBMED   38386231
  REMARK    GeneRIF: PIN1 promotes the metastasis of cholangiocarcinoma cells
            by RACK1-mediated phosphorylation of ANXA2.
REFERENCE   4  (bases 1 to 1554)
  AUTHORS   Fujimori,H., Shima-Nakamura,M., Kanno,S.I., Shibuya-Takahashi,R.,
            Mochizuki,M., Mizuma,M., Unno,M., Wakui,Y., Abue,M., Iwai,W.,
            Fukushi,D., Satoh,K., Yamaguchi,K., Shindo,N., Yasuda,J. and
            Tamai,K.
  TITLE     FAXC interacts with ANXA2 and SRC in mitochondria and promotes
            tumorigenesis in cholangiocarcinoma
  JOURNAL   Cancer Sci 115 (6), 1896-1909 (2024)
   PUBMED   38480477
  REMARK    GeneRIF: FAXC interacts with ANXA2 and SRC in mitochondria and
            promotes tumorigenesis in cholangiocarcinoma.
REFERENCE   5  (bases 1 to 1554)
  AUTHORS   Qiu,Y., Pei,D., Wang,M., Wang,Q., Duan,W., Wang,L., Liu,K., Guo,Y.,
            Luo,L., Guo,Z., Guan,F., Wang,Z., Xing,A., Liu,Z., Ma,Z., Jiang,G.,
            Yan,D., Liu,X., Zhang,Z. and Wang,W.
  TITLE     Nuclear autoantigenic sperm protein facilitates glioblastoma
            progression and radioresistance by regulating the ANXA2/STAT3 axis
  JOURNAL   CNS Neurosci Ther 30 (4), e14709 (2024)
   PUBMED   38605477
  REMARK    GeneRIF: Nuclear autoantigenic sperm protein facilitates
            glioblastoma progression and radioresistance by regulating the
            ANXA2/STAT3 axis.
REFERENCE   6  (bases 1 to 1554)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   7  (bases 1 to 1554)
  AUTHORS   Bohn,E., Gerke,V., Kresse,H., Loffler,B.M. and Kunze,H.
  TITLE     Annexin II inhibits calcium-dependent phospholipase A1 and
            lysophospholipase but not triacyl glycerol lipase activities of rat
            liver hepatic lipase
  JOURNAL   FEBS Lett 296 (3), 237-240 (1992)
   PUBMED   1531641
REFERENCE   8  (bases 1 to 1554)
  AUTHORS   Jindal,H.K., Chaney,W.G., Anderson,C.W., Davis,R.G. and
            Vishwanatha,J.K.
  TITLE     The protein-tyrosine kinase substrate, calpactin I heavy chain
            (p36), is part of the primer recognition protein complex that
            interacts with DNA polymerase alpha
  JOURNAL   J Biol Chem 266 (8), 5169-5176 (1991)
   PUBMED   1825830
REFERENCE   9  (bases 1 to 1554)
  AUTHORS   Filipek,A., Gerke,V., Weber,K. and Kuznicki,J.
  TITLE     Characterization of the cell-cycle-regulated protein calcyclin from
            Ehrlich ascites tumor cells. Identification of two binding proteins
            obtained by Ca2(+)-dependent affinity chromatography
  JOURNAL   Eur J Biochem 195 (3), 795-800 (1991)
   PUBMED   1999197
REFERENCE   10 (bases 1 to 1554)
  AUTHORS   Blackwood,R.A. and Ernst,J.D.
  TITLE     Characterization of Ca2(+)-dependent phospholipid binding, vesicle
            aggregation and membrane fusion by annexins
  JOURNAL   Biochem J 266 (1), 195-200 (1990)
   PUBMED   2138016
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC015834.1, D00017.1 and
            AW087150.1.
            
            On Jun 2, 2019 this sequence version replaced NM_004039.2.
            
            Summary: This gene encodes a member of the annexin family. Members
            of this calcium-dependent phospholipid-binding protein family play
            a role in the regulation of cellular growth and in signal
            transduction pathways. This protein functions as an autocrine
            factor which heightens osteoclast formation and bone resorption.
            This gene has three pseudogenes located on chromosomes 4, 9 and 10,
            respectively. Multiple alternatively spliced transcript variants
            encoding different isoforms have been found for this gene. Annexin
            A2 expression has been found to correlate with resistance to
            treatment against various cancer forms. [provided by RefSeq, Dec
            2019].
            
            Transcript Variant: This variant (3) lacks a segment in the 5'
            region, as compared to variant 1. It uses a downstream AUG start
            codon and encodes isoform 2 which has a shorter N-terminus, as
            compared to isoform 1. Variants 2, 3 and 4 encode the same isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.26837.1,
                                           SRR5189658.137527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451270.7/ ENSP00000387545.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BC015834.1         5-10
            7-1368              D00017.1           1-1362
            1369-1554           AW087150.1         10-195              c
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..1554
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /note="annexin A2"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
     exon            1..44
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            45..103
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1075
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /note="isoform 2 is encoded by transcript variant 3;
                     lipocortin II; placental anticoagulant protein IV;
                     chromobindin 8; annexin II; calpactin I heavy polypeptide;
                     annexin-2; calpactin I heavy chain; calpactin-1 heavy
                     chain; epididymis secretory protein Li 270; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="annexin A2 isoform 2"
                     /protein_id="NP_004030.1"
                     /db_xref="CCDS:CCDS10175.1"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
                     /translation="MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIET
                     AIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGL
                     LKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDII
                     SDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMT
                     ERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYD
                     SMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYL
                     CGGDD"
     exon            104..203
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            204..298
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            299..412
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            413..503
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            504..583
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            584..643
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            644..737
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            738..833
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            834..892
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1015
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1554
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /note="major polyA site"
     regulatory      1545..1550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /note="hexamer: AATAAA"
     polyA_site      1554
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
ORIGIN      
        1 gctcagcatt tggggacgct ctcagctctc ggcgcacggc ccagcttcct tcaaaatgtc
       61 tactgttcac gaaatcctgt gcaagctcag cttggagggt gatcactcta cacccccaag
      121 tgcatatggg tctgtcaaag cctatactaa ctttgatgct gagcgggatg ctttgaacat
      181 tgaaacagcc atcaagacca aaggtgtgga tgaggtcacc attgtcaaca ttttgaccaa
      241 ccgcagcaat gcacagagac aggatattgc cttcgcctac cagagaagga ccaaaaagga
      301 acttgcatca gcactgaagt cagccttatc tggccacctg gagacggtga ttttgggcct
      361 attgaagaca cctgctcagt atgacgcttc tgagctaaaa gcttccatga aggggctggg
      421 aaccgacgag gactctctca ttgagatcat ctgctccaga accaaccagg agctgcagga
      481 aattaacaga gtctacaagg aaatgtacaa gactgatctg gagaaggaca ttatttcgga
      541 cacatctggt gacttccgca agctgatggt tgccctggca aagggtagaa gagcagagga
      601 tggctctgtc attgattatg aactgattga ccaagatgct cgggatctct atgacgctgg
      661 agtgaagagg aaaggaactg atgttcccaa gtggatcagc atcatgaccg agcggagcgt
      721 gccccacctc cagaaagtat ttgataggta caagagttac agcccttatg acatgttgga
      781 aagcatcagg aaagaggtta aaggagacct ggaaaatgct ttcctgaacc tggttcagtg
      841 cattcagaac aagcccctgt attttgctga tcggctgtat gactccatga agggcaaggg
      901 gacgcgagat aaggtcctga tcagaatcat ggtctcccgc agtgaagtgg acatgttgaa
      961 aattaggtct gaattcaaga gaaagtacgg caagtccctg tactattata tccagcaaga
     1021 cactaagggc gactaccaga aagcgctgct gtacctgtgt ggtggagatg actgaagccc
     1081 gacacggcct gagcgtccag aaatggtgct caccatgctt ccagctaaca ggtctagaaa
     1141 accagcttgc gaataacagt ccccgtggcc atccctgtga gggtgacgtt agcattaccc
     1201 ccaacctcat tttagttgcc taagcattgc ctggccttcc tgtctagtct ctcctgtaag
     1261 ccaaagaaat gaacattcca aggagttgga agtgaagtct atgatgtgaa acactttgcc
     1321 tcctgtgtac tgtgtcataa acagatgaat aaactgaatt tgtactttag aaacacgtac
     1381 tttgtggccc tgctttcaac tgaattgttt gaaaattaaa cgtgcttggg gttcagctgg
     1441 tgaggctgtc cctgtaggaa gaaagctctg ggactgagct gtacagtatg gttgccccta
     1501 tccaagtgtc gctatttaag ttaaatttaa atgaaataaa ataaaataaa atca
//
