LOCUS       NM_004306               1456 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens annexin A13 (ANXA13), transcript variant 1, mRNA.
ACCESSION   NM_004306
VERSION     NM_004306.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1456)
  AUTHORS   Maltseva,D.V., Raigorodskaya,M.P., Zgoda,V.G., Tonevitsky,E.A. and
            Knyazev,E.N.
  TITLE     Intracellular Transport of Ribosome-Inactivating Proteins Depends
            on Annexin 13
  JOURNAL   Dokl Biochem Biophys 494 (1), 219-221 (2020)
   PUBMED   33119820
  REMARK    GeneRIF: Intracellular Transport of Ribosome-Inactivating Proteins
            Depends on Annexin 13.
REFERENCE   2  (bases 1 to 1456)
  AUTHORS   McCulloch,K.M., Yamakawa,I., Shifrin,D.A. Jr., McConnell,R.E.,
            Foegeding,N.J., Singh,P.K., Mao,S., Tyska,M.J. and Iverson,T.M.
  TITLE     An alternative N-terminal fold of the intestine-specific annexin
            A13a induces dimerization and regulates membrane-binding
  JOURNAL   J Biol Chem 294 (10), 3454-3463 (2019)
   PUBMED   30610115
  REMARK    GeneRIF: a mechanism for how the association of the ANX A13a
            isoform with the membrane is regulated
REFERENCE   3  (bases 1 to 1456)
  AUTHORS   Jiang,G., Wang,P., Wang,W., Li,W., Dai,L. and Chen,K.
  TITLE     Annexin A13 promotes tumor cell invasion in vitro and is associated
            with metastasis in human colorectal cancer
  JOURNAL   Oncotarget 8 (13), 21663-21673 (2017)
   PUBMED   28423508
  REMARK    GeneRIF: ANXA13 is associated with colorectal cancer cell invasion
            in vitro, and with lymph node metastasis and poor survival in
            colorectal cancer patients
REFERENCE   4  (bases 1 to 1456)
  AUTHORS   Fernandez-Lizarbe,S., Lecona,E., Santiago-Gomez,A., Olmo,N.,
            Lizarbe,M.A. and Turnay,J.
  TITLE     Structural and lipid-binding characterization of human annexin A13a
            reveals strong differences with its long A13b isoform
  JOURNAL   Biol Chem 398 (3), 359-371 (2017)
   PUBMED   27676605
REFERENCE   5  (bases 1 to 1456)
  AUTHORS   Benjachat,T., Tongyoo,P., Tantivitayakul,P., Somparn,P.,
            Hirankarn,N., Prom-On,S., Pisitkun,P., Leelahavanichkul,A.,
            Avihingsanon,Y. and Townamchai,N.
  TITLE     Biomarkers for Refractory Lupus Nephritis: A Microarray Study of
            Kidney Tissue
  JOURNAL   Int J Mol Sci 16 (6), 14276-14290 (2015)
   PUBMED   26110394
  REMARK    GeneRIF: High ANXA13 expression is associated with Refractory Lupus
            Nephritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1456)
  AUTHORS   Iglesias,J.M., Morgan,R.O., Jenkins,N.A., Copeland,N.G.,
            Gilbert,D.J. and Fernandez,M.P.
  TITLE     Comparative genetics and evolution of annexin A13 as the founder
            gene of vertebrate annexins
  JOURNAL   Mol Biol Evol 19 (5), 608-618 (2002)
   PUBMED   11961095
  REMARK    GeneRIF: The unique, conserved aspects of annexin A13 primary
            structure, gene organization, and genetic maps identify it as the
            probable common ancestor of all vertebrate annexins.
REFERENCE   7  (bases 1 to 1456)
  AUTHORS   Noda,Y., Okada,Y., Saito,N., Setou,M., Xu,Y., Zhang,Z. and
            Hirokawa,N.
  TITLE     KIFC3, a microtubule minus end-directed motor for the apical
            transport of annexin XIIIb-associated Triton-insoluble membranes
  JOURNAL   J Cell Biol 155 (1), 77-88 (2001)
   PUBMED   11581287
REFERENCE   8  (bases 1 to 1456)
  AUTHORS   Plant,P.J., Lafont,F., Lecat,S., Verkade,P., Simons,K. and Rotin,D.
  TITLE     Apical membrane targeting of Nedd4 is mediated by an association of
            its C2 domain with annexin XIIIb
  JOURNAL   J Cell Biol 149 (7), 1473-1484 (2000)
   PUBMED   10871286
REFERENCE   9  (bases 1 to 1456)
  AUTHORS   Morgan,R.O., Bell,D.W., Testa,J.R. and Fernandez,M.P.
  TITLE     Genomic locations of ANX11 and ANX13 and the evolutionary genetics
            of human annexins
  JOURNAL   Genomics 48 (1), 100-110 (1998)
   PUBMED   9503022
REFERENCE   10 (bases 1 to 1456)
  AUTHORS   Wice,B.M. and Gordon,J.I.
  TITLE     A strategy for isolation of cDNAs encoding proteins affecting human
            intestinal epithelial cell growth and differentiation:
            characterization of a novel gut-specific N-myristoylated annexin
  JOURNAL   J Cell Biol 116 (2), 405-422 (1992)
   PUBMED   1530946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011134.15 and AC135166.8.
            
            On Nov 23, 2018 this sequence version replaced NM_004306.3.
            
            Summary: This gene encodes a member of the annexin family. Members
            of this calcium-dependent phospholipid-binding protein family play
            a role in the regulation of cellular growth and in signal
            transduction pathways. The specific function of this gene has not
            yet been determined; however, it is associated with the plasma
            membrane of undifferentiated, proliferating endothelial cells and
            differentiated villus enterocytes. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript, and encodes the shorter isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z11502.1, SRR5189661.65698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419625.6/ ENSP00000390809.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC011134.15        118038-118111
            75-150              AC135166.8         100399-100474       c
            151-245             AC135166.8         90363-90457         c
            246-416             AC135166.8         86110-86280         c
            417-450             AC135166.8         83409-83442         c
            451-530             AC135166.8         83223-83302         c
            531-599             AC135166.8         81432-81500         c
            600-701             AC135166.8         80918-81019         c
            702-777             AC135166.8         76592-76667         c
            778-890             AC135166.8         72331-72443         c
            891-1456            AC135166.8         68515-69080         c
FEATURES             Location/Qualifiers
     source          1..1456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..1456
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /note="annexin A13"
                     /db_xref="GeneID:312"
                     /db_xref="HGNC:HGNC:536"
                     /db_xref="MIM:602573"
     exon            1..74
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1010
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /note="isoform a is encoded by transcript variant 1;
                     annexin, intestine-specific; annexin XIII;
                     intestine-specific annexin; annexin-13"
                     /codon_start=1
                     /product="annexin A13 isoform a"
                     /protein_id="NP_004297.2"
                     /db_xref="CCDS:CCDS47917.1"
                     /db_xref="GeneID:312"
                     /db_xref="HGNC:HGNC:536"
                     /db_xref="MIM:602573"
                     /translation="MGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGR
                     TSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGL
                     GTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANR
                     NEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGK
                     DIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRA
                     EVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH"
     exon            75..150
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            151..245
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            246..416
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            417..450
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            451..530
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            531..599
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            600..701
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            702..777
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            778..890
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1456
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1376..1381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /note="hexamer: ATTAAA"
     polyA_site      1397
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /note="major polyA site"
     regulatory      1432..1437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /note="hexamer: ATTAAA"
     polyA_site      1456
                     /gene="ANXA13"
                     /gene_synonym="ANX13; ISA"
                     /note="major polyA site"
ORIGIN      
        1 gcctgtagga ggactgatct cttgatgaaa tacagaaaaa ccatctcaga aaaaggaaaa
       61 tgggcaatcg tcatgctaaa gcgagcagtc ctcagggttt tgatgtggat cgagatgcca
      121 aaaagctgaa caaagcctgc aaaggaatgg ggaccaatga agcagccatc attgaaatct
      181 tatcgggcag gacatcagat gagaggcaac aaatcaagca aaagtacaag gcaacgtacg
      241 gcaaggagct ggaggaagta ctcaagagtg agctgagtgg aaacttcgag aagacagcgt
      301 tggcccttct ggaccgtccc agcgagtacg ccgcccggca gctgcagaag gctatgaagg
      361 gtctgggcac agatgagtcc gtcctcattg aggtcctgtg cacgaggacc aataaggaaa
      421 tcatcgccat taaagaggcc taccaaaggc tatttgatag gagcctcgaa tcagatgtca
      481 aaggtgatac aagtggaaac ctaaaaaaaa tcctggtgtc tctgctgcag gctaatcgca
      541 atgaaggaga tgacgtggac aaagatctag ctggtcagga tgccaaagat ctgtatgatg
      601 caggggaagg ccgctggggc actgatgagc ttgcgttcaa tgaagtcctg gccaagagga
      661 gctacaagca gttacgagcc acctttcaag cctatcaaat tctcattggc aaagacatag
      721 aagaagccat tgaagaagaa acatcaggcg acttgcagaa ggcctattta actctcgtga
      781 gatgtgccca ggattgtgag gactattttg ctgaacgtct gtacaagtcg atgaagggtg
      841 cggggaccga tgaggagacg ttgattcgca tagtcgtgac cagggccgag gtggaccttc
      901 aggggatcaa agcaaagttc caagagaagt atcagaagtc tctctctgac atggttcgct
      961 cagatacctc cggggacttc cggaaactgc tagtagccct cttgcactga gccaagccag
     1021 ggcaatagga acacagggtg gaaccgcctt tgtcaagagc acattccaaa tcaaacttgc
     1081 aaatgagact cccgcacgaa aacccttaag agtcccggat tactttcttg gcagcttaag
     1141 tggcgcagcc aggccaagct gtgtaagtta agggcagtaa cgttaagatg cgtgggcagg
     1201 gcaccttgaa ctctggctta gcaagcatct aggctgcctc ttcactttct tttagcatgg
     1261 taactggatg ttttctaaac actaatgaaa tcagcagttg atgaaaaaac tatgcatttg
     1321 taatggcaca tttagaagga tatgcatcac acaagtaagg tacaggaaag acaaaattaa
     1381 acaatttatt aattttcctt ctgtgtgttc aatttgaaag cctcattgtt aattaaagtt
     1441 gtggattatg cctcta
//
