LOCUS       NM_145868               6734 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens annexin A11 (ANXA11), transcript variant b, mRNA.
ACCESSION   NM_145868
VERSION     NM_145868.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6734)
  AUTHORS   Zhang,Y., Huang,Q., Shen,Y., Ren,H., Wu,C. and Zhou,L.
  TITLE     Non-canonical RNA-binding protein ANXA11 regulates microRNA
            resorting into small extracellular vesicles to mediate cisplatin
            resistance
  JOURNAL   FASEB J 38 (17), e70048 (2024)
   PUBMED   39259536
  REMARK    GeneRIF: Non-canonical RNA-binding protein ANXA11 regulates
            microRNA resorting into small extracellular vesicles to mediate
            cisplatin resistance.
REFERENCE   2  (bases 1 to 6734)
  AUTHORS   Robinson,J.L., Suh,E., Xu,Y., Hurtig,H.I., Elman,L., McMillan,C.T.,
            Irwin,D.J., Porta,S., Van Deerlin,V.M. and Lee,E.B.
  TITLE     Annexin A11 aggregation in FTLD-TDP type C and related
            neurodegenerative disease proteinopathies
  JOURNAL   Acta Neuropathol 147 (1), 104 (2024)
   PUBMED   38896345
  REMARK    GeneRIF: Annexin A11 aggregation in FTLD-TDP type C and related
            neurodegenerative disease proteinopathies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6734)
  AUTHORS   Natera-de Benito,D., Olival,J., Garcia-Cabau,C., Jou,C., Roldan,M.,
            Codina,A., Exposito-Escudero,J., Batlle,C., Carrera-Garcia,L.,
            Ortez,C., Salvatella,X., Palau,F., Nascimento,A. and Hoenicka,J.
  TITLE     Common pathophysiology for ANXA11 disorders caused by aspartate 40
            variants
  JOURNAL   Ann Clin Transl Neurol 10 (3), 408-425 (2023)
   PUBMED   36651622
  REMARK    GeneRIF: Common pathophysiology for ANXA11 disorders caused by
            aspartate 40 variants.
REFERENCE   4  (bases 1 to 6734)
  AUTHORS   Jiang,Q., Lin,J., Wei,Q., Li,C., Hou,Y., Cao,B., Zhang,L., Ou,R.,
            Liu,K., Yang,T., Xiao,Y. and Shang,H.
  TITLE     Genetic analysis of and clinical characteristics associated with
            ANXA11 variants in a Chinese cohort with amyotrophic lateral
            sclerosis
  JOURNAL   Neurobiol Dis 175, 105907 (2022)
   PUBMED   36280108
  REMARK    GeneRIF: Genetic analysis of and clinical characteristics
            associated with ANXA11 variants in a Chinese cohort with
            amyotrophic lateral sclerosis.
            Review article
REFERENCE   5  (bases 1 to 6734)
  AUTHORS   Johari,M., Papadimas,G., Papadopoulos,C., Xirou,S., Kanavaki,A.,
            Chrysanthou-Piterou,M., Rusanen,S., Savarese,M., Hackman,P. and
            Udd,B.
  TITLE     Adult-onset dominant muscular dystrophy in Greek families caused by
            Annexin A11
  JOURNAL   Ann Clin Transl Neurol 9 (10), 1660-1667 (2022)
   PUBMED   36134701
  REMARK    GeneRIF: Adult-onset dominant muscular dystrophy in Greek families
            caused by Annexin A11.
REFERENCE   6  (bases 1 to 6734)
  AUTHORS   Sjolin,C. and Dahlgren,C.
  TITLE     Isolation by calcium-dependent translation to neutrophil-specific
            granules of a 42-kD cytosolic protein, identified as being a
            fragment of annexin XI
  JOURNAL   Blood 87 (11), 4817-4823 (1996)
   PUBMED   8639854
REFERENCE   7  (bases 1 to 6734)
  AUTHORS   Misaki,Y., Pruijn,G.J., van der Kemp,A.W. and van Venrooij,W.J.
  TITLE     The 56K autoantigen is identical to human annexin XI
  JOURNAL   J Biol Chem 269 (6), 4240-4246 (1994)
   PUBMED   7508441
REFERENCE   8  (bases 1 to 6734)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
REFERENCE   9  (bases 1 to 6734)
  AUTHORS   Minami,H., Tokumitsu,H., Mizutani,A., Watanabe,Y., Watanabe,M. and
            Hidaka,H.
  TITLE     Specific binding of CAP-50 to calcyclin
  JOURNAL   FEBS Lett 305 (3), 217-219 (1992)
   PUBMED   1299619
REFERENCE   10 (bases 1 to 6734)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513174.19 and AL356095.11.
            
            On Nov 26, 2018 this sequence version replaced NM_145868.1.
            
            Summary: This gene encodes a member of the annexin family, a group
            of calcium-dependent phospholipid-binding proteins. Annexins have
            unique N-terminal domains and conserved C-terminal domains, which
            contain calcium-dependent phospholipid-binding sites. The encoded
            protein is a 56-kD antigen recognized by sera from patients with
            various autoimmune diseases. Several transcript variants encoding
            two different isoforms have been identified. [provided by RefSeq,
            Dec 2015].
            
            Transcript Variant: This variant (b) differs in the 5' UTR compared
            to variant a. Variants a, b, c, d, and e all encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.217349.1,
                                           SRR1660807.133217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422982.8/ ENSP00000404412.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AL513174.19        39208-39402         c
            196-244             AL513174.19        9972-10020          c
            245-307             AL513174.19        6672-6734           c
            308-423             AL513174.19        4665-4780           c
            424-813             AL513174.19        2834-3223           c
            814-901             AL356095.11        171170-171257       c
            902-996             AL356095.11        170834-170928       c
            997-1110            AL356095.11        170028-170141       c
            1111-1201           AL356095.11        167997-168087       c
            1202-1281           AL356095.11        167478-167557       c
            1282-1338           AL356095.11        167293-167349       c
            1339-1432           AL356095.11        165879-165972       c
            1433-1528           AL356095.11        163044-163139       c
            1529-1587           AL356095.11        161911-161969       c
            1588-1710           AL356095.11        161585-161707       c
            1711-6734           AL356095.11        154833-159856       c
FEATURES             Location/Qualifiers
     source          1..6734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..6734
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /note="annexin A11"
                     /db_xref="GeneID:311"
                     /db_xref="HGNC:HGNC:535"
                     /db_xref="MIM:602572"
     exon            1..195
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            196..244
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            245..307
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1770
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /note="isoform 1 is encoded by transcript variant b;
                     annexin XI; calcyclin-associated annexin 50; annexin-11;
                     56 kDa autoantigen; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="annexin A11 isoform 1"
                     /protein_id="NP_665875.1"
                     /db_xref="CCDS:CCDS7364.1"
                     /db_xref="GeneID:311"
                     /db_xref="HGNC:HGNC:535"
                     /db_xref="MIM:602572"
                     /translation="MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVAT
                     YAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPP
                     YGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPL
                     PGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGT
                     DEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLF
                     DIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHF
                     QRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLV
                     AVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTK
                     DRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICGGND"
     exon            308..423
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            424..813
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            814..901
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            902..996
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1110
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1201
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1281
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1338
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1432
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1528
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1587
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1710
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..6734
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /note="hexamer: AATAGA"
     polyA_site      2026
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /note="major polyA site"
     polyA_site      2079
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
     polyA_site      2484
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
     regulatory      4991..4996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /note="hexamer: AATAAA"
     polyA_site      5013
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
     regulatory      6712..6717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
                     /note="hexamer: AATAAA"
     polyA_site      6734
                     /gene="ANXA11"
                     /gene_synonym="ALS23; ANX11; CAP-50; CAP50; IBMWMA"
ORIGIN      
        1 ggagttttcc gcccggcgct gacggctgct gcgcccgcgg ctccccagtg ccccgagtgc
       61 cccgcgggcc ccgcgagcgg gagtgggacc cagcccctag gcagaaccca ggcgccgcgc
      121 ccgggacgcc cgcggagaga gccactcccg cccacgtccc atttcgcccc tcgcgtccgg
      181 agtccccgtg gccaggtgtg tgtctgggga agagacttac agaagtggag ttgctgagtc
      241 aaagatctaa ccatgagcta ccctggctat cccccgcccc caggtggcta cccaccagct
      301 gcaccaggtg gtggtccctg gggaggtgct gcctaccctc ctccgcccag catgcccccc
      361 atcgggctgg ataacgtggc cacctatgcg gggcagttca accaggacta tctctcggga
      421 atggcggcca acatgtctgg gacatttgga ggagccaaca tgcccaacct gtaccctggg
      481 gcccctgggg ctggctaccc accagtgccc cctggcggct ttgggcagcc cccctctgcc
      541 cagcagcctg ttcctcccta tgggatgtat ccacccccag gaggaaaccc accctccagg
      601 atgccctcat atccgccata cccaggggcc cctgtgccgg gccagcccat gccacccccc
      661 ggacagcagc ccccaggggc ctaccctggg cagccaccag tgacctaccc tggtcagcct
      721 ccagtgccac tccctgggca gcagcagcca gtgccgagct acccaggata cccggggtct
      781 gggactgtca cccccgctgt gcccccaacc cagtttggaa gccgaggcac catcactgat
      841 gctcccggct ttgaccccct gcgagatgcc gaggtcctgc ggaaggccat gaaaggcttc
      901 gggacggatg agcaggccat cattgactgc ctggggagtc gctccaacaa gcagcggcag
      961 cagatcctac tttccttcaa gacggcttac ggcaaggatt tgatcaaaga tctgaaatct
     1021 gaactgtcag gaaactttga gaagacaatc ttggctctga tgaagacccc agtcctcttt
     1081 gacatttatg agataaagga agccatcaag ggggttggca ctgatgaagc ctgcctgatt
     1141 gagatcctcg cttcccgcag caatgagcac atccgagaat taaacagagc ctacaaagca
     1201 gaattcaaaa agaccctgga agaggccatt cgaagcgaca catcagggca cttccagcgg
     1261 ctcctcatct ctctctctca gggaaaccgt gatgaaagca caaacgtgga catgtcactc
     1321 gcccagagag atgcccagga gctgtatgcg gccggggaga accgcctggg aacagacgag
     1381 tccaagttca atgcggttct gtgctcccgg agccgggccc acctggtagc agttttcaat
     1441 gagtaccaga gaatgacagg ccgggacatt gagaagagca tctgccggga gatgtccggg
     1501 gacctggagg agggcatgct ggccgtggtg aaatgtctca agaatacccc agccttcttt
     1561 gcggagaggc tcaacaaggc catgaggggg gcaggaacaa aggaccggac cctgattcgc
     1621 atcatggtgt ctcgcagcga gaccgacctc ctggacatca gatcagagta taagcggatg
     1681 tacggcaagt cgctgtacca cgacatctcg ggagatactt caggggatta ccggaagatt
     1741 ctgctgaaga tctgtggtgg caatgactga acagtgactg gtggctcact tctgcccacc
     1801 tgccggcaac accagtgcca ggaaaaggcc aaaagaatgt ctgtttctaa caaatccaca
     1861 aatagccccg agattcaccg tcctagagct taggcctgtc ttccacccct cctgacccgt
     1921 atagtgtgcc acaggacctg ggtcggtcta gaactctctc aggatgcctt ttctacccca
     1981 tccctcacag cctcttgctg ctaaaataga tgtttcattt ttctgactca tgcaatcatt
     2041 cccctttgcc tgtggctaag acttggcttc atttcgtcat gtaattgtat atttttattt
     2101 ggaggcatat tttcttttct tacagtcatt gccagacaga ggcatacaag tctgtttgct
     2161 gcatacacat ttctggtgag ggcgactggg tgggtgaagc accgtgtcct cgctgaggag
     2221 agaaagggag gcgtgcctga gaaggtagcc tgtgcatctg gtgagtgtgt cacgagcttt
     2281 gttactgcca aactcactcc tttttagaaa aaacaaaaaa aaagggccag aaagtcattc
     2341 cttccatctt ccttgcagaa accacgagaa caaagccagt tccctgtcag tgacagggct
     2401 tcttgtaatt tgtggtatgt gccttaaacc tgaatgtctg tagccaaaac ttgtttccac
     2461 attaagagtc agccagctct ggaatggtct ggaaatgtct tcctggtacc aacttgtttt
     2521 cttctgcttg attctgccct gtggctcaga ggtctggcct tatcagccag tgaaagttca
     2581 tgtaacctta cgtagagatt tgtgtgcagg aaaccctgag catacactag tttgcaggga
     2641 ctcgtaagga catgggaagg gaggttcccg aaatccaggc aggaggccca gacacctgaa
     2701 aggcaaaggg atcttggttg gttgcaggtg cagtgaagtc cactgaaggt gtggtgcgaa
     2761 gaatgcagtc cttcacccag gtcccaggag ggaagaaggg tgtgtgctaa ttcctggtgc
     2821 ccctcggcgg gggccagaga gaaggatggg gacaacccag agagtcacaa gaccagtgcc
     2881 tcccctcagg gtgcctccag gctgaaaggg gctcctggct ctggtctctg gggaccctgt
     2941 gcccgttggt tggtggtgtg agggaagaga atccataaga gagtttctga gaattatggt
     3001 gtcatgtcca gaagctagag cttaccttgc atcaggggtc tccacccact ccttttccaa
     3061 cctcctgcgt tgaggtttag aaaagagaga atcgactagg cactatggct cacgcctgta
     3121 atccaaggac tttgggaagc tgaggtgaga ggatcacttg agctcaggag ttcaagacta
     3181 gcctagccaa cagcgagacc cctgtctcta ctaaaaaatt tggccaggcg tggtggctca
     3241 cggctgtaat cccagcactt tgggaggtga ggcgggcaga tcacctgagg tcaggagttc
     3301 gagacccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca aaaattagcc
     3361 aggcatggtg gcacattcct gtaatcccag ctacacagga tgctgaggca ggagaatcac
     3421 ttgaacccag gaggcagagg ttgtagtgag ctgagatcac accattgcac ttcaacctgg
     3481 gtggacagag tgagactctg tctcaaaaaa aaaaaaaaat ttacctggca ttgtagtgca
     3541 ttccctatag tcggctactc tggaggctga ggcaggaaga tccttagagc ccaagaaatt
     3601 gaggccgtag taagctgtga ttacaccact gcactccagc ctggacaaca gagcgagacc
     3661 ttgtctcaaa tgagaaaaaa acaaaaagaa atgggagaat ccagagagac taggctagat
     3721 caagcctgct gggtcctggc aggagcccca gggagtagct catctgcaga catttgcttg
     3781 aggactaccc cctaaacata aaggaagaat gacatccgaa gggtgtggag cagccatgag
     3841 ctgagaacta gcctggtcta cctgagattg atggcaggtc ctggtcaaca cgtcagctct
     3901 gcgtcagagt ccatgcctca agcccaagct gaagccccat ccctgctgct ctcccaagaa
     3961 ctcctctgct agggcaggcc ccttgccctt gggtgccagg tgggacctgc ctgatgggat
     4021 ggggtgcttg gcatatacaa cttgccatga actcaaggtg accctggggg cctcctgaat
     4081 tgtgatgggg cctagaacca atgtgctctg atgtgaccat attctgtgac attaccttgc
     4141 cctgtttact ccaaagttcc cagcctggtg cccagcaggc aatattgcac ctacagacac
     4201 atttactttg gtttccaaag tgtttttaga catttgaatt tgttgccaac atttaaacat
     4261 tgagagattt catattttta aaaatctgga attctggctt ctcttgaaaa ctcagaaatt
     4321 ctggcactat ggggcttgca ttcctgcatg gctggagctg agttgcagct gcccctttag
     4381 gcctgtactc cttatttgct ataggctccg tcttgtatta cactaagccc atgtcaccca
     4441 tttggctcct gcaggccttt gggtttgaga ccctggtcta cacacttgga gaccacctgt
     4501 tgtaaagtac atggatgtgc tttggtcaag gaatagacca aggtggatat ccaggccaga
     4561 gtgactcagc gagtttaggt cacaggcgta tactccactt gttatataac ctgcttgtgt
     4621 aagttcatac ttggctcaaa gccactattg tttggaaaag gtataactgc cctgctgacg
     4681 ctgtacagat gttcttgggc tcggatgggc atggctccac gtggtgtgca ctagcaccca
     4741 gagagagtga agctattgac ccctgtaagg gagagtgacc atctggcaga tagatagagg
     4801 ggagccagga catggctcag cttgtgccca gagggagagt taagccgctg accctgtagc
     4861 cagggagtgc acctgcaagc atgggggtgg caggagccac agagctggct gctgagagga
     4921 gctgcagatc tggagaagac agcctaggta aaggtggaca gtgtgagagc tgctgatgag
     4981 atagctgctg aataaaacta cattttacct gcctatggcc cgccaggttt tctttcagct
     5041 atcgcccatc cacccagtcc cctcgaacct cagcatgggc tggaacctga ccctgggcat
     5101 gacatttggc atagttgtgg acctgacacc tgtgtttgtc ctagtcctgt ttctccctgc
     5161 cttcctgttc ctctcgctgc cctcatggtc actcccaaga gatccaaccc atgttaagta
     5221 tgggctggag gactgcatga atgcctcatg atcttcccag aggcaaaggc acctactgcc
     5281 ttccaaggtc agtgggaggt tgggatcaac actgtttatt atgcttagga caaaaaagat
     5341 agggagaaag atgtgcaacc ttacaggtca tctttctggg atagaacaca atgggtcttc
     5401 tcctgcctcc tggatatgtt agtcaaggcc agtccatgct acacatctag tctgacttct
     5461 aaaatagaag caccagatga attcagccct gagagaattt tcagcagctg tgggggcgct
     5521 ggaggaaaca ctattaaata gttttgcacc tgagacagat agcctcactc gcctcaccct
     5581 agtcctggtg gcatttgtct caggtgcaaa atttaagaaa gaaaccttgg agtgctcacc
     5641 ctgtggctgg gtagatggtc ctaaagtggt ggttttcaag cctgagtgtg tatcaggatc
     5701 atcaggggag cttgctaaag agcagttcct gcggtcagac cctcatgcat tttgagcagg
     5761 tgtggggact gggaaactgc atctgtaacc tgctgtaatc taacgcttat ctaaatacta
     5821 ctgtgctcac acagagaaca ccgcaaaagt agaggtgttc ctccagaggg caggtgagca
     5881 gatggcacag tctgcttgga attcagtcag gtgatgagag atgagatgag gcactcctag
     5941 ctttgggaag agggagctga aagatgaacc tttgcaggtg cccacggtca aagtggtggt
     6001 ttaatgccat gccatgccca ttttctgttg gccttggcag ggagttacag ccctacctta
     6061 ggacctggct ccttatttct gctgtaggct ctttcctgcc ctggccgaga tggagtggaa
     6121 tgagacctag aaacatcaag ctaaatacat gtcctcagaa agataaaggt ttacattttc
     6181 acccccatca aatctgaaag ctctctgcct gtgtttttct aagggatagg gacatcatta
     6241 ctcagtccac aacctggact catgtagggt cccctgtcag taaaggagtc agtcaagccc
     6301 accaggtata ccaaggactc ttaccctcag cccctactcc ttggaaagct gccccttggc
     6361 ctaatattgg tgtttagctt gagcctgact ccttctcaac actaagagct gatgaagtcc
     6421 tgaagcagaa agagctctga cctgagagtc aaacatcctt attctgatct cagctcagcc
     6481 cctgatttgt tgtgtgaccc tggatatgtc acttcctgtc tttttgactt tttaaaatga
     6541 agggtagact agaggagagc ttctaaaact ttaatgtggt caacgaaatg gaataggaaa
     6601 ttccacaagt ctgtccttcc acaaaagcag caaataaggt ggcaaaaact caaatttatg
     6661 ggaactctgg aaacgaattg aaagtttaca gcaatcaggt gaatacctaa gaataaaagc
     6721 tggatttagt aaga
//
