LOCUS       NM_007193               1441 bp    mRNA    linear   PRI 04-JUN-2023
DEFINITION  Homo sapiens annexin A10 (ANXA10), mRNA.
ACCESSION   NM_007193
VERSION     NM_007193.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Bai L, Zhuang Y, Xie J, Liu K, Yin S and Yan F.
  TITLE     SOX2-Induced Linc-ROR Upregulation Inhibits Gastric Carcinoma Cell
            Proliferation and Metastasis Via the miR-580-3p/ANXA10 Pathway
  JOURNAL   Biochem Genet 61 (3), 1113-1127 (2023)
   PUBMED   36451051
  REMARK    GeneRIF: SOX2-Induced Linc-ROR Upregulation Inhibits Gastric
            Carcinoma Cell Proliferation and Metastasis Via the
            miR-580-3p/ANXA10 Pathway.
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Isidro RA, Abukhiran I, Dunseth CD, Gosse MD, Humble RM, Pelletier
            DJ, Varshney N, Bellizzi AM and Hornick JL.
  TITLE     Strong Annexin A10 Expression Supports a Pancreatic Primary and
            Combined Annexin A10, Claudin 18, and SOX2 Expression Supports an
            Esophagogastric Origin in Carcinomas of Unknown Primary
  JOURNAL   Am J Surg Pathol 47 (4), 440-452 (2023)
   PUBMED   36730833
  REMARK    GeneRIF: Strong Annexin A10 Expression Supports a Pancreatic
            Primary and Combined Annexin A10, Claudin 18, and SOX2 Expression
            Supports an Esophagogastric Origin in Carcinomas of Unknown
            Primary.
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   Zhang C, Peng L, Gu H, Wang J, Wang Y and Xu Z.
  TITLE     ANXA10 is a prognostic biomarker and suppressor of hepatocellular
            carcinoma: a bioinformatics analysis and experimental validation
  JOURNAL   Sci Rep 13 (1), 1583 (2023)
   PUBMED   36709331
  REMARK    GeneRIF: ANXA10 is a prognostic biomarker and suppressor of
            hepatocellular carcinoma: a bioinformatics analysis and
            experimental validation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1441)
  AUTHORS   Kobayashi G, Hayashi T, Sentani K, Ikeda K, Babasaki T, Shigematsu
            Y, Sekino Y, Uraoka N, Teishima J, Matsubara A, Hinata N and Oue N.
  TITLE     ANXA10 Expression Is Inversely Associated with Tumor Stage, Grade,
            and TP53 Expression in Upper and Lower Urothelial Carcinoma
  JOURNAL   Pathobiology 90 (2), 94-103 (2023)
   PUBMED   35780773
  REMARK    GeneRIF: ANXA10 Expression Is Inversely Associated with Tumor
            Stage, Grade, and TP53 Expression in Upper and Lower Urothelial
            Carcinoma.
REFERENCE   5  (bases 1 to 1441)
  AUTHORS   Takayama S, Morita Y, Nishimoto A, Nishimura J, Takebe K, Kishimoto
            S, Matsumiya-Matsumoto Y, Matsunaga K, Imai T and Uzawa N.
  TITLE     GATA6 regulates expression of annexin A10 (ANXA10) associated with
            epithelial-mesenchymal transition of oral squamous cell carcinoma
  JOURNAL   Arch Oral Biol 144, 105569 (2022)
   PUBMED   36265396
  REMARK    GeneRIF: GATA6 regulates expression of annexin A10 (ANXA10)
            associated with epithelial-mesenchymal transition of oral squamous
            cell carcinoma.
REFERENCE   6  (bases 1 to 1441)
  AUTHORS   Kim J, Kim MA, Jee CD, Jung EJ and Kim WH.
  TITLE     Reduced expression and homozygous deletion of annexin A10 in
            gastric carcinoma
  JOURNAL   Int J Cancer 125 (8), 1842-1850 (2009)
   PUBMED   19582876
  REMARK    GeneRIF: Reduced expression and homozygous deletion of annexin A10
            is associated with gastric carcinoma.
REFERENCE   7  (bases 1 to 1441)
  AUTHORS   Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO,
            Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS and Kim NS.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 1441)
  AUTHORS   Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS,
            Noh SM, Kim S, Yoo HS, Kim YS and Kim NS.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 1441)
  AUTHORS   Liu SH, Lin CY, Peng SY, Jeng YM, Pan HW, Lai PL, Liu CL and Hsu
            HC.
  TITLE     Down-regulation of annexin A10 in hepatocellular carcinoma is
            associated with vascular invasion, early recurrence, and poor
            prognosis in synergy with p53 mutation
  JOURNAL   Am J Pathol 160 (5), 1831-1837 (2002)
   PUBMED   12000734
REFERENCE   10 (bases 1 to 1441)
  AUTHORS   Morgan RO, Jenkins NA, Gilbert DJ, Copeland NG, Balsara BR, Testa
            JR and Fernandez MP.
  TITLE     Novel human and mouse annexin A10 are linked to the genome
            duplications during early chordate evolution
  JOURNAL   Genomics 60 (1), 40-49 (1999)
   PUBMED   10458909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM768053.1, BC007320.2 and
            AC068989.36.
            
            On May 17, 2019 this sequence version replaced NM_007193.4.
            
            Summary: This gene encodes a member of the annexin family.  Members
            of this calcium-dependent phospholipid-binding protein family play
            a role in the regulation of cellular growth and in signal
            transduction pathways.  The function of this gene has not yet been
            determined. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007320.2, AF196478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359299.8/ ENSP00000352248.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BM768053.1         1-58
            59-1389             BC007320.2         39-1369
            1390-1441           AC068989.36        183069-183120       c
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..1441
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /note="annexin A10"
                     /db_xref="GeneID:11199"
                     /db_xref="HGNC:HGNC:534"
                     /db_xref="MIM:608008"
     exon            1..182
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1139
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /note="annexin 14; annexin-10"
                     /codon_start=1
                     /product="annexin A10"
                     /protein_id="NP_009124.2"
                     /db_xref="CCDS:CCDS34096.1"
                     /db_xref="GeneID:11199"
                     /db_xref="HGNC:HGNC:534"
                     /db_xref="MIM:608008"
                     /translation="MFCGDYVQGTIFPAPNFNPIMDAQMLGGALQGFDCDKDMLINIL
                     TQRCNAQRMMIAEAYQSMYGRDLIGDMREQLSDHFKDVMAGLMYPPPLYDAHELWHAM
                     KGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQ
                     GTREEGYTDPAMAAQDAMVLWEACQQKTGEHKTMLQMILCNKSYQQLRLVFQEFQNIS
                     GQDMVDAINECYDGYFQELLVAIVLCVRDKPAYFAYRLYSAIHDFGFHNKTVIRILIA
                     RSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAICAGDAEDY"
     exon            183..264
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            265..359
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            360..473
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            474..564
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            565..644
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            645..698
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            699..792
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            793..888
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            889..947
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1070
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1441
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1364..1369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /note="hexamer: AATAAA"
     polyA_site      1395
                     /gene="ANXA10"
                     /gene_synonym="ANX14"
                     /note="major polyA site"
ORIGIN      
        1 atccagattt gcttttacat tttcttgcct gagtctgagg tgaacagtga acatatttac
       61 atttgattta acagtgaacc ttaattcttt ctggcttcac agtgaaacaa gtttatgcaa
      121 tcgatcaaat attttcatcc ctgaggttaa caattaccat caaaatgttt tgtggagact
      181 atgtgcaagg aaccatcttc ccagctccca atttcaatcc cataatggat gcccaaatgc
      241 taggaggagc actccaagga tttgactgtg acaaagacat gctgatcaac attctgactc
      301 agcgctgcaa tgcacaaagg atgatgattg cagaggcata ccagagcatg tatggccggg
      361 acctgattgg ggatatgagg gagcagcttt cggatcactt caaagatgtg atggctggcc
      421 tcatgtaccc accaccactg tatgatgctc atgagctctg gcatgccatg aagggagtag
      481 gcactgatga gaattgcctc attgaaatac tagcttcaag aacaaatgga gaaattttcc
      541 agatgcgaga agcctactgc ttgcaataca gcaataacct ccaagaggac atttattcag
      601 agacctcagg acacttcaga gatactctca tgaacttggt ccaggggacc agagaggaag
      661 gatatacaga ccctgcgatg gctgctcagg atgcaatggt cctatgggaa gcctgtcagc
      721 agaagacggg ggagcacaaa accatgctgc aaatgatcct gtgcaacaag agctaccagc
      781 agctgcggct ggttttccag gaatttcaaa atatttctgg gcaagatatg gtagatgcca
      841 ttaatgaatg ttatgatgga tactttcagg agctgctggt tgcaattgtt ctctgtgttc
      901 gagacaaacc agcctatttt gcttatagat tatatagtgc aattcatgac tttggtttcc
      961 ataataaaac tgtaatcagg attctcattg ccagaagtga aatagacctg ctgaccataa
     1021 ggaaacgata caaagagcga tatggaaaat ccctatttca tgatatcaga aattttgctt
     1081 cagggcatta taagaaagca ctgcttgcca tctgtgctgg tgatgctgag gactactaaa
     1141 atgaagagga cttggagtac tgtgcactcc tctttctaga cacttccaaa tagagatttt
     1201 ctcacaaatt tgtactgttc atggcactat taacaaaact atacaatcat attttctctt
     1261 ctatctttga aattattcta agccaaagaa aactatgaat gaaagtatat gatactgaat
     1321 ttgcctacta tcctgaattt gcctactatc taatcagcaa ttaaataaat tgtgcatgat
     1381 ggaataatag aaaaattgca ttggaataga ttttatttaa atgtgaacca tcaacaacct
     1441 a
//
